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  1. Article ; Online: Prescription opioid misusers exhibit blunted parasympathetic regulation during inhibitory control challenge.

    Garland, Eric L / Howard, Matthew O

    Psychopharmacology

    2021  Volume 238, Issue 3, Page(s) 765–774

    Abstract: Rationale: Among opioid-treated chronic pain patients, response inhibition deficits in emotional contexts may contribute to opioid misuse.: Objectives: Using high-frequency heart rate variability (HF-HRV) to index-impaired response inhibition, we ... ...

    Abstract Rationale: Among opioid-treated chronic pain patients, response inhibition deficits in emotional contexts may contribute to opioid misuse.
    Objectives: Using high-frequency heart rate variability (HF-HRV) to index-impaired response inhibition, we examined associations between opioid misuse and response inhibition in emotional and neutral contexts in a sample of opioid-treated chronic pain patients.
    Method: Chronic pain patients taking opioid analgesics (N = 97) for ≥ 90 days completed an Emotional Go/NoGo task that presented an inhibitory control challenge in the context of neutral, opioid, negative affective, and positive affective background images while HF-HRV was computed. Opioid misuse and craving were assessed. Using a validated cut-point on the Current Opioid Misuse Measure, participants were classified as opioid misusers or non-misusers. Opioid misuse was examined as a predictor of behavioral and HF-HRV metrics of response inhibition.
    Results: Negative affective and opioid images elicited more errors of commission (p = .002, η
    Conclusion: Reduced parasympathetic regulation during inhibitory control challenge may indicate heightened opioid misuse risk among opioid-treated chronic pain patients.
    MeSH term(s) Adult ; Analgesics, Opioid/adverse effects ; Analgesics, Opioid/therapeutic use ; Autonomic Nervous System/drug effects ; Chronic Pain/drug therapy ; Craving/drug effects ; Emotions/drug effects ; Female ; Heart Rate/drug effects ; Humans ; Male ; Middle Aged ; Opioid-Related Disorders/psychology ; Prescription Drugs
    Chemical Substances Analgesics, Opioid ; Prescription Drugs
    Language English
    Publishing date 2021-01-07
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 130601-7
    ISSN 1432-2072 ; 0033-3158
    ISSN (online) 1432-2072
    ISSN 0033-3158
    DOI 10.1007/s00213-020-05729-z
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Corrigendum.

    Qasim, Amna / Pham, Tam D / Kim, Jeffrey J / Valdes, Santiago O / Howard, Taylor / Diaz, Matthew A / Morris, Shaine A / Miyake, Christina Y

    Journal of cardiovascular electrophysiology

    2022  Volume 34, Issue 1, Page(s) 249–250

    Language English
    Publishing date 2022-11-30
    Publishing country United States
    Document type Journal Article ; Published Erratum
    ZDB-ID 1025989-2
    ISSN 1540-8167 ; 1045-3873
    ISSN (online) 1540-8167
    ISSN 1045-3873
    DOI 10.1111/jce.15753
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  3. Article: Inter-Rater Reliability of EyeSpy Mobile for Pediatric Visual Acuity Assessments by Parent Volunteers.

    Rosenthal, Elyssa / O'Neil, James / Hoyt, Briggs / Howard, Matthew

    Clinical ophthalmology (Auckland, N.Z.)

    2024  Volume 18, Page(s) 235–245

    Abstract: Purpose: To assess the inter-rater test reliability of the EyeSpy Mobile visual acuity smartphone algorithm when administered to children by eye professionals and parent volunteers.: Patients and methods: Visual acuity test-retest results were ... ...

    Abstract Purpose: To assess the inter-rater test reliability of the EyeSpy Mobile visual acuity smartphone algorithm when administered to children by eye professionals and parent volunteers.
    Patients and methods: Visual acuity test-retest results were analyzed for 106 children assigned to one of three different screenings: (1) An eye technician and pediatric ophthalmologist using their typical visual acuity testing method on a M&S computer; (2) An eye technician and pediatric ophthalmologist using EyeSpy Mobile; (3) An eye technician and parent volunteer using EyeSpy Mobile.
    Results: All three phases demonstrated a strong agreement between the two testers, with mean test-retest equivalency results within 0.05 logMAR (2.5 letters, 90% CI). Whether testing using their typical technique on an M&S computer or using EyeSpy Mobile, eye professionals obtained statistically closer mean test-retest results than parent volunteers by 1 letter, with equivalency results within 0.03 logMAR (1.5 letters, 90% CI). Conversely, the number of retests within 2 vision lines was statistically greater when EyeSpy mobile was used by parents as compared to eye professional's customary technique on the M&S computer.
    Conclusion: EyeSpy Mobile provides clinically useful visual acuity test-retest results even when used by first-time parent volunteers. Adaptive visual acuity algorithms have the potential to improve reliability, lessen training requirements, and expand the number of vision screening volunteers in community settings.
    Language English
    Publishing date 2024-01-24
    Publishing country New Zealand
    Document type Journal Article
    ISSN 1177-5467
    ISSN 1177-5467
    DOI 10.2147/OPTH.S440439
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  4. Article ; Online: Editorial.

    Howard, Matthew O / Mackridge, Adam J

    Journal of addictive diseases

    2016  Volume 35, Issue 2, Page(s) 71–72

    Language English
    Publishing date 2016
    Publishing country England
    Document type Comment ; Journal Article
    ZDB-ID 1077616-3
    ISSN 1545-0848 ; 1055-0887
    ISSN (online) 1545-0848
    ISSN 1055-0887
    DOI 10.1080/10550887.2016.1156412
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  5. Article ; Online: The impact of sexual victimization on substance use disorder treatment completion: A systematic review and meta-analysis.

    Parisi, Anna / Jordan, Brooke / Jensen, Todd / Howard, Matthew O

    Substance abuse

    2020  Volume 43, Issue 1, Page(s) 131–142

    Abstract: Background: ...

    Abstract Background:
    MeSH term(s) Crime Victims ; Humans ; Sexual Behavior ; Substance-Related Disorders/therapy
    Language English
    Publishing date 2020-05-20
    Publishing country United States
    Document type Journal Article ; Meta-Analysis ; Systematic Review
    ZDB-ID 1458030-5
    ISSN 1547-0164 ; 0889-7077
    ISSN (online) 1547-0164
    ISSN 0889-7077
    DOI 10.1080/08897077.2020.1748168
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  6. Article: Enhancing Natural Reward Responsiveness Among Opioid Users Predicts Chronic Pain Relief: EEG Analyses From a Trial of Mindfulness-Oriented Recovery Enhancement.

    Garland, Eric L / Howard, Matthew O

    Journal of the Society for Social Work and Research

    2018  Volume 9, Issue 2, Page(s) 285–303

    Abstract: Objective: Although opioid-treated chronic pain patients evidence blunted responsiveness to natural rewards, focusing on naturally rewarding stimuli can produce analgesia in these patients. A prior randomized controlled trial (RCT) demonstrated that a ... ...

    Abstract Objective: Although opioid-treated chronic pain patients evidence blunted responsiveness to natural rewards, focusing on naturally rewarding stimuli can produce analgesia in these patients. A prior randomized controlled trial (RCT) demonstrated that a social work intervention-Mindfulness-Oriented Recovery Enhancement (MORE)-enhanced natural reward processing as indicated by event-related brain potentials (ERPs). The aim of the present study was to perform a secondary data analysis on ERPs collected in this RCT to explore whether improvements in electrocortical response to natural reward predicted pain relief.
    Method: The sample for this secondary analysis included opioid-treated chronic pain patients with complete ERP data (
    Results: Increases in ERP reward response were significantly associated with decreased pain severity from pretreatment to posttreatment (β = -.48,
    Conclusions: Chronic pain may be alleviated by enhancing brain response to natural rewards.
    Language English
    Publishing date 2018-04-27
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2598656-9
    ISSN 1948-822X
    ISSN 1948-822X
    DOI 10.1086/697685
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  7. Article ; Online: Mindfulness-based treatment of addiction: current state of the field and envisioning the next wave of research.

    Garland, Eric L / Howard, Matthew O

    Addiction science & clinical practice

    2018  Volume 13, Issue 1, Page(s) 14

    Abstract: Contemporary advances in addiction neuroscience have paralleled increasing interest in the ancient mental training practice of mindfulness meditation as a potential therapy for addiction. In the past decade, mindfulness-based interventions (MBIs) have ... ...

    Abstract Contemporary advances in addiction neuroscience have paralleled increasing interest in the ancient mental training practice of mindfulness meditation as a potential therapy for addiction. In the past decade, mindfulness-based interventions (MBIs) have been studied as a treatment for an array addictive behaviors, including drinking, smoking, opioid misuse, and use of illicit substances like cocaine and heroin. This article reviews current research evaluating MBIs as a treatment for addiction, with a focus on findings pertaining to clinical outcomes and biobehavioral mechanisms. Studies indicate that MBIs reduce substance misuse and craving by modulating cognitive, affective, and psychophysiological processes integral to self-regulation and reward processing. This integrative review provides the basis for manifold recommendations regarding the next wave of research needed to firmly establish the efficacy of MBIs and elucidate the mechanistic pathways by which these therapies ameliorate addiction. Issues pertaining to MBI treatment optimization and sequencing, dissemination and implementation, dose-response relationships, and research rigor and reproducibility are discussed.
    MeSH term(s) Attention/physiology ; Behavior, Addictive/physiopathology ; Behavior, Addictive/therapy ; Combined Modality Therapy ; Craving/physiology ; Data Accuracy ; Executive Function/physiology ; Humans ; Mentalization/physiology ; Mindfulness/methods ; Reproducibility of Results ; Research Design ; Reward ; Socioeconomic Factors ; Stress, Psychological/physiopathology
    Language English
    Publishing date 2018-04-18
    Publishing country England
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Review
    ZDB-ID 2492632-2
    ISSN 1940-0640 ; 1940-0640
    ISSN (online) 1940-0640
    ISSN 1940-0640
    DOI 10.1186/s13722-018-0115-3
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  8. Article ; Online: Editorial.

    Howard, Matthew O / Mackridge, Adam J

    Journal of addictive diseases

    2016  Volume 35, Issue 1, Page(s) 1–2

    MeSH term(s) Behavior, Addictive ; History, 20th Century ; History, 21st Century ; Humans ; Periodicals as Topic/history ; Substance-Related Disorders
    Language English
    Publishing date 2016
    Publishing country England
    Document type Editorial ; Historical Article
    ZDB-ID 1077616-3
    ISSN 1545-0848 ; 1055-0887
    ISSN (online) 1545-0848
    ISSN 1055-0887
    DOI 10.1080/10550887.2015.1108687
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  9. Article ; Online: Therapeutic mechanisms of Mindfulness-Oriented Recovery Enhancement for internet gaming disorder: Reducing craving and addictive behavior by targeting cognitive processes.

    Li, Wen / Garland, Eric L / Howard, Matthew O

    Journal of addictive diseases

    2018  Volume 37, Issue 1-2, Page(s) 5–13

    Abstract: ... ...

    Abstract Background
    MeSH term(s) Adult ; Behavior, Addictive/psychology ; Cognition ; Craving ; Female ; Humans ; Internet ; Male ; Mindfulness ; Young Adult
    Language English
    Publishing date 2018-03-22
    Publishing country England
    Document type Journal Article ; Randomized Controlled Trial ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
    ZDB-ID 1077616-3
    ISSN 1545-0848 ; 1055-0887
    ISSN (online) 1545-0848
    ISSN 1055-0887
    DOI 10.1080/10550887.2018.1442617
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  10. Article ; Online: Associations between short-term ambient temperature exposure and emergency department visits for amphetamine, cocaine, and opioid use in California from 2005 to 2019.

    Chang, Howard H / Zhang, Haisu / Latimore, Amanda D / Murray, Brian P / D'Souza, Rohan R / Scovronick, Noah / Gribble, Matthew O / Ebelt, Stefanie T

    Environment international

    2023  Volume 181, Page(s) 108233

    Abstract: Substance use disorder is a growing public health challenge in the United States. People who use drugs may be more vulnerable to ambient heat due to the effects of drugs on thermoregulation and their risk environment. There have been limited population- ... ...

    Abstract Substance use disorder is a growing public health challenge in the United States. People who use drugs may be more vulnerable to ambient heat due to the effects of drugs on thermoregulation and their risk environment. There have been limited population-based studies of ambient temperature and drug-related morbidity. We examined short-term associations between daily ambient temperature and emergency department (ED) visits for use or overdose of amphetamine, cocaine and opioids in California during the period 2005 to 2019. Daily ZIP code-level maximum, mean, and minimum temperature exposures were derived from 1-km data Daymet products. A time-stratified case-crossover design was used to estimate cumulative non-linear associations of daily temperature for lag days 0 to 3. Stratified analyses by patient sex, race, and ethnicity were also conducted. The study included over 3.4 million drug-related ED visits. We found positive associations between daily temperature and ED visits for all outcomes examined. An increase in daily mean temperature from the 50th to the 95th percentile was associated with ED visits for amphetamine use (OR = 1.072, 95% CI: 1.058, 1.086), cocaine use (OR = 1.044, 95% CI: 1.021, 1.068 and opioid use (OR = 1.041, 95% CI: 1.025, 1.057). Stronger positive associations were also observed for overdose: amphetamine overdose (OR = 1.150, 95% CI: 1.085, 1.218), cocaine overdose (OR = 1.159, 95% CI: 1.053, 1.276), and opioid overdose (OR = 1.079, 95% CI: 1.054, 1.106). In summary, people who use stimulants and opioids may be a subpopulation sensitive to short-term higher ambient temperature. Mitigating heat exposure can be considered in harm reduction strategies in response to the substance use epidemic and global climate change.
    MeSH term(s) Humans ; Amphetamine/adverse effects ; Analgesics, Opioid/adverse effects ; California/epidemiology ; Cocaine ; Drug Overdose/epidemiology ; Emergency Service, Hospital ; Temperature ; United States ; Cross-Over Studies
    Chemical Substances Amphetamine (CK833KGX7E) ; Analgesics, Opioid ; Cocaine (I5Y540LHVR)
    Language English
    Publishing date 2023-09-27
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 554791-x
    ISSN 1873-6750 ; 0160-4120
    ISSN (online) 1873-6750
    ISSN 0160-4120
    DOI 10.1016/j.envint.2023.108233
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