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  1. Article ; Online: Cystoisospora belli: A Cause of Chronic Diarrhea in Immunocompromised Patients.

    Kanaujia, Rimjhim / Mewara, Abhishek

    The American journal of tropical medicine and hygiene

    2023  Volume 108, Issue 6, Page(s) 1084–1085

    MeSH term(s) Humans ; Isosporiasis/diagnosis ; Isosporiasis/drug therapy ; Isospora ; Diarrhea ; Immunocompromised Host ; Coccidiosis
    Language English
    Publishing date 2023-04-10
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2942-7
    ISSN 1476-1645 ; 0002-9637
    ISSN (online) 1476-1645
    ISSN 0002-9637
    DOI 10.4269/ajtmh.23-0012
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article: Masquerading facial lesion: An unusual mycosis.

    Kanaujia, Rimjhim / Rudramurthy, Shivaprakash M

    The Indian journal of medical research

    2022  Volume 152, Issue Suppl 1, Page(s) S194–S195

    MeSH term(s) Diagnosis, Differential ; Humans ; Mycoses/diagnosis
    Language English
    Publishing date 2022-03-28
    Publishing country India
    Document type Journal Article
    ZDB-ID 390883-5
    ISSN 0971-5916 ; 0019-5340
    ISSN 0971-5916 ; 0019-5340
    DOI 10.4103/ijmr.IJMR_2307_19
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: A fatal case of Strongyloides hyperinfection with obscure risk factors.

    Mewara, Abhishek / Gudisa, Rajendra / Sharma, Nikita / Kanaujia, Rimjhim

    European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology

    2023  Volume 42, Issue 5, Page(s) 661–663

    MeSH term(s) Animals ; Humans ; Strongyloides ; Strongyloidiasis/complications ; Strongyloidiasis/diagnosis ; Immunocompromised Host ; Risk Factors
    Language English
    Publishing date 2023-03-17
    Publishing country Germany
    Document type Letter ; Comment
    ZDB-ID 603155-9
    ISSN 1435-4373 ; 0934-9723 ; 0722-2211
    ISSN (online) 1435-4373
    ISSN 0934-9723 ; 0722-2211
    DOI 10.1007/s10096-023-04588-8
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article: Aspergillosis: an Update on Clinical Spectrum, Diagnostic Schemes, and Management.

    Kanaujia, Rimjhim / Singh, Shreya / Rudramurthy, Shivaprakash M

    Current fungal infection reports

    2023  , Page(s) 1–12

    Abstract: Purpose of review: This review gives an overview of the diseases caused by : Recent findings: The risk factors for this infection continue to evolve with the development of many biological agents that target the immune system and the increase of ... ...

    Abstract Purpose of review: This review gives an overview of the diseases caused by
    Recent findings: The risk factors for this infection continue to evolve with the development of many biological agents that target the immune system and the increase of viral illnesses such as coronavirus disease. Due to the limitations of present mycological test methods, establishing a fast diagnosis is frequently difficult, and reports of developing antifungal resistance further complicate the management of aspergillosis. Many commercial assays, like AsperGenius®, MycAssay Aspergillus®, and MycoGENIE®, have the advantage of better species-level identification and concomitant resistance-associated mutations. Fosmanogepix, ibrexafungerp, rezafungin, and olorofim are newer antifungal agents in the pipeline exhibiting remarkable activity against
    Summary: The fungus
    Language English
    Publishing date 2023-05-04
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 2391647-3
    ISSN 1936-377X ; 1936-3761
    ISSN (online) 1936-377X
    ISSN 1936-3761
    DOI 10.1007/s12281-023-00461-5
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Extra-intestinal complications of Ascaris lumbricoides infections in India: A systematic review and meta-analysis.

    Mewara, Abhishek / Kanaujia, Rimjhim / Malla, Nancy

    Transactions of the Royal Society of Tropical Medicine and Hygiene

    2023  Volume 117, Issue 11, Page(s) 765–772

    Abstract: The aberrant migration of Ascaris lumbricoides may cause extra-intestinal ascariasis (EIA) involving hepato-biliary-pancreatic (HBP) or other extra-gastro-intestinal (EGI) organs. We performed a systematic review and meta-analysis to study the risk ... ...

    Abstract The aberrant migration of Ascaris lumbricoides may cause extra-intestinal ascariasis (EIA) involving hepato-biliary-pancreatic (HBP) or other extra-gastro-intestinal (EGI) organs. We performed a systematic review and meta-analysis to study the risk factors and clinical presentations of EIA, and differences in HBP and EGI ascariasis. Medline, Web of Science and Embase were searched for cases of EIA in the English language from India. From 1204 articles, 86 studies (105 cases) were included. The majority of the cases involved the HBP system (78%). Among HBP ascariasis, the most commonly involved site was the bile duct (53.6%). Females had 11.3 times higher odds (95% CI 2.852 to 44.856; p=0.001) of HBP ascariasis, while the pediatric population had lower odds (OR=0.323). Previous gallbladder disease was significantly associated with HBP ascariasis in adults (p=0.046), while a significantly higher number of cases of EGI ascariasis were observed among pediatric patients (p=0.003). Ocular symptoms occurred exclusively in the pediatric population (p=0.017). Overall, death was reported in 3.8% of patients (n=4). This review emphasizes the importance of the complications of EIA. It encourages future research into issues such as the reasons of higher gall bladder ascariasis in females and the implications of Ascaris-related complications following biliary tract interventions. It also suggests considering Ascaris as a differential diagnosis for airway obstuction in intubated critically ill patients.
    MeSH term(s) Adult ; Animals ; Female ; Child ; Humans ; Ascariasis/complications ; Ascariasis/epidemiology ; Ascaris lumbricoides ; Intestines ; Gastrointestinal Tract ; India/epidemiology
    Language English
    Publishing date 2023-06-01
    Publishing country England
    Document type Meta-Analysis ; Systematic Review ; Journal Article
    ZDB-ID 441375-1
    ISSN 1878-3503 ; 0035-9203
    ISSN (online) 1878-3503
    ISSN 0035-9203
    DOI 10.1093/trstmh/trad033
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Budding yeast in a child with acute leukemia: Nothing CRYPT(O)IC about it.

    Kanaujia, Rimjhim / Ramanathan, Subramaniam / Sarode, Rahul / Kanaujia, Rachana / Rudramurthy, Shivaprakash M / Gupta, Swati

    Indian journal of pathology & microbiology

    2022  Volume 65, Issue 2, Page(s) 468–471

    Abstract: A 13-year-old girl child with B-cell precursor acute lymphoblastic leukemia presented with complaints of fever, fatigue and left-sided iliac mass of 20 days duration. Preliminary blood culture from the peripherally inserted central catheter (PICC) ... ...

    Abstract A 13-year-old girl child with B-cell precursor acute lymphoblastic leukemia presented with complaints of fever, fatigue and left-sided iliac mass of 20 days duration. Preliminary blood culture from the peripherally inserted central catheter (PICC) demonstrated the presence of budding yeast cells. This is a rare form of "Disseminated cryptococcosis". Budding yeast cells emphasizes the significance of various differentials of yeast in positive blood cultures bottles, as identifying Cryptococcus from gram stain can be complicated. This manuscript also highlights the presence of crystalloid geometric appearance like "Buckminsterfullerene", which is derived from the mucopolysaccharide capsule in Cryptococcus. These structures are rarely observed, and in this case, are exceptionally remarkable.
    MeSH term(s) Adolescent ; Blood Culture ; Child ; Cryptococcosis/complications ; Female ; Humans ; Leukemia, Myeloid, Acute/complications ; Precursor Cell Lymphoblastic Leukemia-Lymphoma/complications ; Precursor Cell Lymphoblastic Leukemia-Lymphoma/diagnosis ; Saccharomycetales
    Language English
    Publishing date 2022-03-18
    Publishing country India
    Document type Case Reports
    ZDB-ID 197621-7
    ISSN 0974-5130 ; 0377-4929
    ISSN (online) 0974-5130
    ISSN 0377-4929
    DOI 10.4103/IJPM.IJPM_1107_20
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: Polymorphisms in Innate and Adaptive Immune Genes in Subjects with Allergic Bronchopulmonary Aspergillosis Complicating Asthma.

    Kanaujia, Rimjhim / Arora, Amit / Chakrabarti, Arunaloke / Rudramurthy, Shivaprakash M / Agarwal, Ritesh

    Mycopathologia

    2024  Volume 189, Issue 2, Page(s) 23

    Abstract: Innate and adaptive immunity play a crucial role in allergic bronchopulmonary aspergillosis (ABPA) pathogenesis. We performed next-generation sequencing using the Illumina TruSight One panel (4,811 human disease-associated genes, at least 20 × coverage) ... ...

    Abstract Innate and adaptive immunity play a crucial role in allergic bronchopulmonary aspergillosis (ABPA) pathogenesis. We performed next-generation sequencing using the Illumina TruSight One panel (4,811 human disease-associated genes, at least 20 × coverage) and selected 22 known immune genes (toll-like receptors (TLRs), C-type lectin, interleukin-4 receptor, and others). We included ABPA (n = 18), asthma without ABPA (n = 12), and healthy controls (n = 8). We analyzed 3011 SNPs from 22 genes and identified 145 SNPs (13 genes) that were present only in the disease groups and absent in controls. The SNP frequency overall was significantly higher in ABPA than in asthmatics (89/145 [61.4%] vs. 56/145 [38.6%], p = 0.0001). The SNP frequency in the TLR10 gene was also significantly higher in ABPA than in asthma (p = 0.017). Association analysis further revealed three genes having significant associations. Of these, NOS3 and HLA-DQB1 are associated with antimicrobial activity and adaptive immunity. More extensive studies are required to confirm our findings.
    MeSH term(s) Humans ; Aspergillosis, Allergic Bronchopulmonary/complications ; Aspergillosis, Allergic Bronchopulmonary/genetics ; Polymorphism, Single Nucleotide ; Asthma/complications ; Asthma/genetics ; High-Throughput Nucleotide Sequencing ; Lectins, C-Type
    Chemical Substances Lectins, C-Type
    Language English
    Publishing date 2024-02-26
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 391081-7
    ISSN 1573-0832 ; 0369-299X ; 0301-486X ; 0027-5530
    ISSN (online) 1573-0832
    ISSN 0369-299X ; 0301-486X ; 0027-5530
    DOI 10.1007/s11046-024-00834-5
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: Diagnostic accuracy of the metagenomic next-generation sequencing (mNGS) for detection of bacterial meningoencephalitis: a systematic review and meta-analysis.

    Kanaujia, Rimjhim / Biswal, Manisha / Angrup, Archana / Ray, Pallab

    European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology

    2022  Volume 41, Issue 6, Page(s) 881–891

    Abstract: The early diagnosis of bacterial meningoencephalitis (BM/E) is difficult, and delay in diagnosis can cause complications leading to neurological impairment/death. In cases of unexplained BM/E, the metagenomic NGS (mNGS) offers an advantage over ... ...

    Abstract The early diagnosis of bacterial meningoencephalitis (BM/E) is difficult, and delay in diagnosis can cause complications leading to neurological impairment/death. In cases of unexplained BM/E, the metagenomic NGS (mNGS) offers an advantage over conventional methods, especially when a rare pathogen is implicated or the patient is on antibiotics. This study aims to evaluate and compare the diagnostic efficacy of mNGS for the diagnosis of BM/E using cerebrospinal fluid (CSF) specimens versus a composite reference standard (CRS). The electronic databases (Embase, PubMed, and Web of Science) were searched up to 15 June 2021. Studies such as cohort, case-control, prospective, or retrospective studies that assessed the diagnostic efficacy of mNGS in suspected bacterial meningitis/encephalitis cases were included. Ten studies met the inclusion criteria, including three retrospective and seven prospective studies. The sensitivity of mNGS for diagnosis of BM/E from CSF samples ranged from 33 (95% CI: 13-62) to 98% (95% CI: 76-99). The specificity of mNGS ranged from 67 (95% CI: 55-78) to 98% (95% CI: 95-99). The estimated AUC (area under curve) by hierarchical summary receiver operating characteristic (HSROC) of the studies being analyzed was 0.912. The meta-regression analysis demonstrated that the different types of studies (single-center vs. multi-center) had an effect on the specificity of mNGS for BM/E compared with CRS (90% vs. 96%, meta-regression P < 0.05). The current analysis revealed moderate diagnostic accuracy of mNGS. This approach can be helpful, especially in cases of undiagnosed BM/E by identification of organism and subsequently accelerating the patient management.
    MeSH term(s) High-Throughput Nucleotide Sequencing/methods ; Humans ; Infectious Encephalitis ; Meningitis, Bacterial/cerebrospinal fluid ; Meningoencephalitis/diagnosis ; Metagenomics/methods ; Prospective Studies ; Retrospective Studies ; Sensitivity and Specificity
    Language English
    Publishing date 2022-04-26
    Publishing country Germany
    Document type Journal Article ; Meta-Analysis ; Systematic Review
    ZDB-ID 603155-9
    ISSN 1435-4373 ; 0934-9723 ; 0722-2211
    ISSN (online) 1435-4373
    ISSN 0934-9723 ; 0722-2211
    DOI 10.1007/s10096-022-04445-0
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: In Reply to the Letter to the Editor Regarding "Multicompartmental Epidermoid Cyst Causing Chronic Parotid Gland and Masticator Space Muscle Atrophy".

    Kanaujia, Reeta / Aggarwal, Ankita / Misra, Ritu Nair

    World neurosurgery

    2022  Volume 158, Page(s) 338

    MeSH term(s) Epidermal Cyst/complications ; Epidermal Cyst/diagnostic imaging ; Epidermal Cyst/surgery ; Graft vs Host Disease ; Humans ; Muscular Atrophy ; Parotid Gland/surgery ; Parotid Neoplasms
    Language English
    Publishing date 2022-08-03
    Publishing country United States
    Document type Letter ; Comment
    ZDB-ID 2534351-8
    ISSN 1878-8769 ; 1878-8750
    ISSN (online) 1878-8769
    ISSN 1878-8750
    DOI 10.1016/j.wneu.2021.11.131
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: Systematic review of ultrasound gel associated Burkholderia cepacia complex outbreaks: Clinical presentation, sources and control of outbreak.

    Angrup, Archana / Kanaujia, Rimjhim / Biswal, Manisha / Ray, Pallab

    American journal of infection control

    2022  Volume 50, Issue 11, Page(s) 1253–1257

    Abstract: Background: Burkholderia cepacia complex (Bcc) is an emerging opportunistic pathogen among immunocompromised patients. It frequently contaminates saline, fluids and ultrasound (US) gel used in hospitals. This systematic review was conducted to analyze ... ...

    Abstract Background: Burkholderia cepacia complex (Bcc) is an emerging opportunistic pathogen among immunocompromised patients. It frequently contaminates saline, fluids and ultrasound (US) gel used in hospitals. This systematic review was conducted to analyze Bcc outbreaks due to ultrasound (US) gel for better management of these outbreaks.
    Methods: As per PRISMA guidelines, electronic databases "Embase" and "Pubmed" and "Web of sciences" were searched from 1991 to April, 2021 to identify studies causing Burkholderia spp outbreak due to contamination of US gels.
    Results: The search identified 14 outbreak reports that met our inclusion criteria. Bacteremia was the most common clinical presentation in ten studies followed by urinary tract infections in 4 studies. In most of the studies B. cepacia was the most common isolated organism. Other members like B. ambifaria, B. contaminans, and B. stabilis caused outbreaks in two studies. Pulsed field gel electrophoresis and multilocus sequence typing were commonly employed methods to study the clonal association. In 8 outbreaks, intrinsic contamination of the gel, that is, contamination from manufacturing site, was present and 4 studies, extrinsic contamination, that is, contamination from environment was responsible for outbreak.
    Conclusion: This review highlights the importance of US gel as a source of outbreak in health-care facilities. Ensuring sterility of US gel, sound epidemiological investigation of outbreak and prompt response by infection control team can prevent these outbreaks.
    Language English
    Publishing date 2022-02-12
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 392362-9
    ISSN 1527-3296 ; 0196-6553
    ISSN (online) 1527-3296
    ISSN 0196-6553
    DOI 10.1016/j.ajic.2022.02.005
    Database MEDical Literature Analysis and Retrieval System OnLINE

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