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Article: Inhaled Nebulized Sodium Pyruvate Use in COVID-19 Patients.

Hidvégi, Máté

The Israel Medical Association journal : IMAJ

2020 Volume 22, Issue 5, Page(s) 278

MeSH term(s)	Administration, Inhalation ; Betacoronavirus ; COVID-19 ; Coronavirus Infections/therapy ; Humans ; Nebulizers and Vaporizers ; Pandemics ; Pneumonia, Viral/therapy ; Pyruvates/therapeutic use ; SARS-CoV-2 ; Sodium/therapeutic use
Chemical Substances	Pyruvates ; Sodium (9NEZ333N27)
Keywords	covid19
Language	English
Publishing date	2020-05-27
Publishing country	Israel
Document type	Letter
ZDB-ID	2008291-5
ISSN	1565-1088 ; 0021-2180
ISSN	1565-1088 ; 0021-2180
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Article: Inhaled Nebulized Sodium Pyruvate Use in COVID-19 Patients

Hidvégi, Máté

Isr Med Assoc J

Keywords	covid19
Publisher	WHO
Document type	Article
Note	WHO #Covidence: #32378817
Database	COVID19

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Article: Bacillus Calmette-Guerin vaccination Policy and Consumption of Ammonium Chloride-Enriched Confectioneries May Be Factors Reducing COVID-19 Death Rates in Europe.

Hidvégi, Máté / Nichelatti, Michele

The Israel Medical Association journal : IMAJ

2020 Volume 22, Issue 8, Page(s) 501–504

Abstract: Background: The 2019 severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) pandemic continued into 2020, and the coronavirus disease-2019 (COVID-19) associated death toll increased.: Objectives: To analyze COVID-19 death rates in European ... ...

Abstract	Background: The 2019 severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) pandemic continued into 2020, and the coronavirus disease-2019 (COVID-19) associated death toll increased. Objectives: To analyze COVID-19 death rates in European countries or regions to determine whether there was a significant association between bacillus Calmette-Guérin (BCG) vaccination policy and lower rates of COVID-19 related deaths. Methods: Certain Northern European countries or regions had low death rates regardless of BCG policy. The authors assumed the consumption of foods containing salmiak (NH4Cl) was a common and peculiar cause of the reduced COVID-19 related death rates in these countries, because NH4Cl is a known lysosomotropic agent, which has been indicated to inhibit or prevent SARS-CoV infection. To check the possible effectiveness of salmiak consumption against COVID-19 related death, the authors used a linear regression model with the death rate as the dependent variable and BCG-policy and salmiak consumption score as independent variables. Results: Using least squares regression and a robust standard error algorithm, the authors found a significant effect exerted by the independent variables (P < 0.0005 for BCG and P = 0.001 for salmiak). Salmiak score alone was significant (P = 0.016) when using least squares regression with robust error algorithm. Conclusions: The results seem to confirm an association between BCG-positive vaccination policy and salmiak consumption, and lower death rates from COVID-19. Implementing BCG vaccination policy and fortification of foods with salmiak (NH4Cl) may have a significant impact on the control of SARS-CoV epidemic.
MeSH term(s)	Ammonium Chloride/administration & dosage ; Area Under Curve ; BCG Vaccine ; COVID-19/mortality ; Candy ; Diet/statistics & numerical data ; Europe/epidemiology ; Health Policy ; Humans ; Middle Aged ; Protective Factors ; ROC Curve ; SARS-CoV-2 ; Vaccination/statistics & numerical data
Chemical Substances	BCG Vaccine ; Ammonium Chloride (01Q9PC255D)
Language	English
Publishing date	2020-11-24
Publishing country	Israel
Document type	Journal Article
ZDB-ID	2008291-5
ISSN	1565-1088 ; 0021-2180
ISSN	1565-1088 ; 0021-2180
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Article: Bacillus Calmette-Guerin vaccination Policy and Consumption of Ammonium Chloride-Enriched Confectioneries May Be Factors Reducing COVID-19 Death Rates in Europe

Hidvégi, Máté Nichelatti Michele

The Israel Medical Association journal : IMAJ

Abstract: BACKGROUND: The 2019 severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) pandemic continued into 2020, and the coronavirus disease-2019 (COVID-19) associated death toll increased OBJECTIVES: To analyze COVID-19 death rates in European countries ... ...

Abstract	BACKGROUND: The 2019 severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) pandemic continued into 2020, and the coronavirus disease-2019 (COVID-19) associated death toll increased OBJECTIVES: To analyze COVID-19 death rates in European countries or regions to determine whether there was a significant association between bacillus Calmette-Guérin (BCG) vaccination policy and lower rates of COVID-19 related deaths METHODS: Certain Northern European countries or regions had low death rates regardless of BCG policy The authors assumed the consumption of foods containing salmiak (NH4Cl) was a common and peculiar cause of the reduced COVID-19 related death rates in these countries, because NH4Cl is a known lysosomotropic agent, which has been indicated to inhibit or prevent SARS-CoV infection To check the possible effectiveness of salmiak consumption against COVID-19 related death, the authors used a linear regression model with the death rate as the dependent variable and BCG-policy and salmiak consumption score as independent variables RESULTS: Using least squares regression and a robust standard error algorithm, the authors found a significant effect exerted by the independent variables (P < 0 0005 for BCG and P = 0 001 for salmiak) Salmiak score alone was significant (P = 0 016) when using least squares regression with robust error algorithm CONCLUSIONS: The results seem to confirm an association between BCG-positive vaccination policy and salmiak consumption, and lower death rates from COVID-19 Implementing BCG vaccination policy and fortification of foods with salmiak (NH4Cl) may have a significant impact on the control of SARS-CoV epidemic
Keywords	covid19
Publisher	WHO
Document type	Article
Note	WHO #Covidence: #722546
Database	COVID19

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Article ; Online: The effects of Avemar treatment on feline immunodeficiency virus infected cell cultures.

Tarcsai, Katalin Réka / Hidvégi, Máté / Corolciuc, Oliga / Nagy, Károly / Abbas, Anna Anoir / Ablashi, Dharam V / Kövesdi, Valéria / Ongrádi, József

Veterinary medicine and science

2023 Volume 9, Issue 4, Page(s) 1446–1455

Abstract: Introduction: In addition to standard highly active antiretroviral therapy protocols, complementary therapies using natural compounds are widely used by human immunodeficiency virus (HIV)-infected human patients. One such compound is the fermented wheat ...

Abstract	Introduction: In addition to standard highly active antiretroviral therapy protocols, complementary therapies using natural compounds are widely used by human immunodeficiency virus (HIV)-infected human patients. One such compound is the fermented wheat germ extract (FWGE), named Avemar. Materials and methods: In this study, we investigate the effects of Avemar in a feline-acquired immunodeficiency syndrome model. MBM lymphoid cells were acutely infected by the American feline immunodeficiency virus (FIV)-Petaluma (FIV-Pet) and the European FIV Pisa-M2 strains. FL-4 lymphoid cells, continuously producing FIV-Pet, served as a model for chronic infection. Crandell Rees feline kidney (CRFK) cells were infected by either FIV-Pet or feline adenovirus (FeAdV) as a model for transactivation and opportunistic viral infection. Cell cultures were treated pre- and post-infection with serial dilutions of spray-dried FWGE (Avemar pulvis, AP), a standardized active ingredient in commercial Avemar products. Residual FIV and FeAdV infectivity was quantified. Results: In a concentration-dependent manner, AP inhibited replication of FIV strains in MBM and CRFK cells by 3-5 log. Low AP concentration prevented FIV-Pet release from FL-4 cells. Higher concentrations destroyed virus-producing cells with cytopathic effects resembling apoptosis. AP strongly inhibited FeAdV production inside CRFK cells but not in HeLa cells. Adenovirus particles are then released via the disintegration of CRFK cells. Discussion: This report is the first to describe the antiviral effects of Avemar. Further studies are required to confirm its in vitro and in vivo effects and to investigate the potential for its use as a nutraceutical in FIV-infected felines or HIV-infected humans. Conclusion: Avemar, as a single nutraceutical, inhibits FIV replication and destroys retrovirus carrier cells. An important conclusion is that prolonged Avemar treatment might reduce the number of retrovirus-producing cells in the host.
MeSH term(s)	Cats ; Humans ; Animals ; Immunodeficiency Virus, Feline/physiology ; HeLa Cells ; Cell Culture Techniques/veterinary ; HIV Infections/veterinary ; Cat Diseases
Chemical Substances	Avemar
Language	English
Publishing date	2023-04-20
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2819409-3
ISSN	2053-1095 ; 2053-1095
ISSN (online)	2053-1095
ISSN	2053-1095
DOI	10.1002/vms3.1141
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Article ; Online: The effects of Avemar treatment on feline immunodeficiency virus infected cell cultures

Katalin Réka Tarcsai / Máté Hidvégi / Oliga Corolciuc / Károly Nagy / Anna Anoir Abbas / Dharam V. Ablashi / Valéria Kövesdi / József Ongrádi

Veterinary Medicine and Science, Vol 9, Iss 4, Pp 1446-

2023 Volume 1455

Abstract: Abstract Introduction In addition to standard highly active antiretroviral therapy protocols, complementary therapies using natural compounds are widely used by human immunodeficiency virus (HIV)‐infected human patients. One such compound is the ... ...

Abstract	Abstract Introduction In addition to standard highly active antiretroviral therapy protocols, complementary therapies using natural compounds are widely used by human immunodeficiency virus (HIV)‐infected human patients. One such compound is the fermented wheat germ extract (FWGE), named Avemar. Materials and methods In this study, we investigate the effects of Avemar in a feline‐acquired immunodeficiency syndrome model. MBM lymphoid cells were acutely infected by the American feline immunodeficiency virus (FIV)‐Petaluma (FIV‐Pet) and the European FIV Pisa‐M2 strains. FL‐4 lymphoid cells, continuously producing FIV‐Pet, served as a model for chronic infection. Crandell Rees feline kidney (CRFK) cells were infected by either FIV‐Pet or feline adenovirus (FeAdV) as a model for transactivation and opportunistic viral infection. Cell cultures were treated pre‐ and post‐infection with serial dilutions of spray‐dried FWGE (Avemar pulvis, AP), a standardized active ingredient in commercial Avemar products. Residual FIV and FeAdV infectivity was quantified. Results In a concentration‐dependent manner, AP inhibited replication of FIV strains in MBM and CRFK cells by 3–5 log. Low AP concentration prevented FIV‐Pet release from FL‐4 cells. Higher concentrations destroyed virus‐producing cells with cytopathic effects resembling apoptosis. AP strongly inhibited FeAdV production inside CRFK cells but not in HeLa cells. Adenovirus particles are then released via the disintegration of CRFK cells. Discussion This report is the first to describe the antiviral effects of Avemar. Further studies are required to confirm its in vitro and in vivo effects and to investigate the potential for its use as a nutraceutical in FIV‐infected felines or HIV‐infected humans. Conclusion Avemar, as a single nutraceutical, inhibits FIV replication and destroys retrovirus carrier cells. An important conclusion is that prolonged Avemar treatment might reduce the number of retrovirus‐producing cells in the host.
Keywords	AIDS ; Avemar pulvis ; destruction of retrovirus carrier cells ; feline adenovirus ; feline immunodeficiency virus ; fermented wheat germ extract ; Veterinary medicine ; SF600-1100
Subject code	570
Language	English
Publishing date	2023-07-01T00:00:00Z
Publisher	Wiley
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Book ; Conference proceedings: Amino acid composition and biological value of cereal proteins

Lásztity, Radomir / Hidvégi, Máté

proceedings of the International Association for General Chemistry Symposium on Amino Acid Composition and Biological Value of Cereal Proteins Budapest, Hungary May 31-June 1, 1983

1985

Event/congress	Symposium on Amino Acid Composition and Biological Value of Cereal Proteins (1983, Budapest)
Author's details	edited by Radomir Lásztity and Máté Hidvégi
Keywords	Ernährung ; Getreideprotein
Subject	Nutrition ; Ernährungsstatus ; Ernährungszustand
Size	XV, 662 S. : Ill.
Publisher	Reidel
Publishing place	Dordrecht u.a.
Publishing country	Great Britain
Document type	Book ; Conference proceedings
Note	Includes bibliographies and index
HBZ-ID	HT007556164
ISBN	9027719373 ; 9789027719379
Database	Catalogue ZB MED Nutrition, Environment, Agriculture

In stock of ZB MED Bonn / Germany

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878/823	order for loan	Geschlossenes Magazin (U2)

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Article ; Online: BCG Vaccination Policy and Salmiak Consumption Are Inversely Associated with COVID-19 Death Rates in Europe

Hidvegi, Mate / Nichelatti, Michele

SSRN Electronic Journal ; ISSN 1556-5068

2020

Keywords	covid19
Language	English
Publisher	Elsevier BV
Publishing country	us
Document type	Article ; Online
DOI	10.2139/ssrn.3596914
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article: Fermented Wheat Germ Extract (FWGE) as a Treatment Additive for Castration-Resistant Prostate Cancer: A Pilot Clinical Trial

Weitzen, Rony / Epstein, Nava / Oberman, Bernice / Shevetz, Rebecca / Hidvegi, Mate / Berger, Raanan

Nutrition and cancer. 2022 Apr. 21, v. 74, no. 4

2022

Abstract: Castration-resistant prostate cancer (CRPC) is a devastating and incurable disease. Combined therapy using conventional anticancer drugs and a proprietary medical nutriment, fermented wheat germ extract (FWGE), also known as Avemar, has been suggested as ...

Abstract	Castration-resistant prostate cancer (CRPC) is a devastating and incurable disease. Combined therapy using conventional anticancer drugs and a proprietary medical nutriment, fermented wheat germ extract (FWGE), also known as Avemar, has been suggested as a treatment for progressing prostate cancer (PCa) patients, who have become resistant to first line hormonal therapy (gonadotropin releasing hormone, GnRH). The primary aim of this study was to test if this combined therapy would slow down disease progression in CRPC patients. We tested the nontoxic, readily available, inexpensive FWGE, together with the conventional treatment, GnRH analogue, in 36 CRPC patients. Although this is a pilot study, with the drawback of a statistically small sample size, some anticancer clinical activity of FWGE could be seen in the CRPC patients, as measured by prostate specific antigen doubling time (PSADT). We found that the intake of GnRH with FWGE for at least 4 months, improved the overall health as well as the quality of life (QOL) in 4 patients (11%) and was instrumental in extending the PSADT in about 17 (out of 26) patients (65.4%), six of whom were significant. Since no mentionable adverse events were noticed, this treatment may permit the postponement of chemotherapy for these patients.
Keywords	clinical trials ; disease progression ; fermentation ; gonadotropins ; hormone replacement therapy ; nutrition ; prostate-specific antigen ; prostatic neoplasms ; quality of life ; sample size ; wheat germ
Language	English
Dates of publication	2022-0421
Size	p. 1338-1346.
Publishing place	Taylor & Francis
Document type	Article
ZDB-ID	424433-3
ISSN	1532-7914 ; 0163-5581
ISSN (online)	1532-7914
ISSN	0163-5581
DOI	10.1080/01635581.2021.1952457
Database	NAL-Catalogue (AGRICOLA)

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Article ; Online: Fermented Wheat Germ Extract (FWGE) as a Treatment Additive for Castration-Resistant Prostate Cancer: A Pilot Clinical Trial.

Weitzen, Rony / Epstein, Nava / Oberman, Bernice / Shevetz, Rebecca / Hidvegi, Mate / Berger, Raanan

Nutrition and cancer

2021 Volume 74, Issue 4, Page(s) 1338–1346

Abstract	Castration-resistant prostate cancer (CRPC) is a devastating and incurable disease. Combined therapy using conventional anticancer drugs and a proprietary medical nutriment, fermented wheat germ extract (FWGE), also known as Avemar, has been suggested as a treatment for progressing prostate cancer (PCa) patients, who have become resistant to first line hormonal therapy (gonadotropin releasing hormone, GnRH). The primary aim of this study was to test if this combined therapy would slow down disease progression in CRPC patients. We tested the nontoxic, readily available, inexpensive FWGE, together with the conventional treatment, GnRH analogue, in 36 CRPC patients. Although this is a pilot study, with the drawback of a statistically small sample size, some anticancer clinical activity of FWGE could be seen in the CRPC patients, as measured by prostate specific antigen doubling time (PSADT). We found that the intake of GnRH with FWGE for at least 4 months, improved the overall health as well as the quality of life (QOL) in 4 patients (11%) and was instrumental in extending the PSADT in about 17 (out of 26) patients (65.4%), six of whom were significant. Since no mentionable adverse events were noticed, this treatment may permit the postponement of chemotherapy for these patients.
MeSH term(s)	Gonadotropin-Releasing Hormone ; Humans ; Male ; Pilot Projects ; Plant Extracts ; Prostatic Neoplasms, Castration-Resistant/drug therapy ; Quality of Life
Chemical Substances	Avemar ; Plant Extracts ; Gonadotropin-Releasing Hormone (33515-09-2)
Language	English
Publishing date	2021-07-21
Publishing country	United States
Document type	Clinical Study ; Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	424433-3
ISSN	1532-7914 ; 0163-5581
ISSN (online)	1532-7914
ISSN	0163-5581
DOI	10.1080/01635581.2021.1952457
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