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  1. Article ; Online: Inhaled corticosteroids in virus pandemics: a treatment for COVID-19?

    Nicolau, Dan V / Bafadhel, Mona

    The Lancet. Respiratory medicine

    2020  Volume 8, Issue 9, Page(s) 846–847

    MeSH term(s) Administration, Inhalation ; Adrenal Cortex Hormones/administration & dosage ; Betacoronavirus ; COVID-19 ; Coronavirus Infections/drug therapy ; Humans ; Pandemics ; Pneumonia, Viral/drug therapy ; SARS-CoV-2
    Chemical Substances Adrenal Cortex Hormones
    Keywords covid19
    Language English
    Publishing date 2020-07-30
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2686754-0
    ISSN 2213-2619 ; 2213-2600
    ISSN (online) 2213-2619
    ISSN 2213-2600
    DOI 10.1016/S2213-2600(20)30314-3
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 7041: Show issues Location:
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  2. Article ; Online: Investigation of air bubble behaviour after gas embolism events induced in a microfluidic network mimicking microvasculature.

    Mardanpour, Mohammad Mahdi / Sudalaiyadum Perumal, Ayyappasamy / Mahmoodi, Zahra / Baassiri, Karine / Montiel-Rubies, Gala / LeDez, Kenneth M / Nicolau, Dan V

    Lab on a chip

    2024  Volume 24, Issue 9, Page(s) 2518–2536

    Abstract: Gas embolism is a medical condition that occurs when gas bubbles are present in veins or arteries, decreasing blood flow and potentially reducing oxygen delivery to vital organs, such as the brain. Although usually reported as rare, gas embolism can lead ...

    Abstract Gas embolism is a medical condition that occurs when gas bubbles are present in veins or arteries, decreasing blood flow and potentially reducing oxygen delivery to vital organs, such as the brain. Although usually reported as rare, gas embolism can lead to severe neurological damage or death. However, presently, only limited understanding exists regarding the microscale processes leading to the formation, persistence, movement, and resolution of gas emboli, as modulated by microvasculature geometrical features and blood properties. Because gas embolism is initially a physico-chemical-only process, with biological responses starting later, the opportunity exists to fully study the genesis and evolution of gas emboli using
    MeSH term(s) Embolism, Air ; Microvessels/diagnostic imaging ; Humans ; Microfluidic Analytical Techniques/instrumentation ; Lab-On-A-Chip Devices
    Language English
    Publishing date 2024-04-30
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2056646-3
    ISSN 1473-0189 ; 1473-0197
    ISSN (online) 1473-0189
    ISSN 1473-0197
    DOI 10.1039/d4lc00087k
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Effects of defective motors on the active transport in biosensors powered by biomolecular motors.

    Kang'iri, Samuel Macharia / Salem, Andrew / Nicolau, Dan V / Nitta, Takahiro

    Biosensors & bioelectronics

    2022  Volume 203, Page(s) 114011

    Abstract: Motor proteins, such as myosin and kinesin, are biological molecular motors involved in force generation and intracellular transport in living cells. They were proposed to drive molecular shuttles for the active transport of analytes, thus significantly ... ...

    Abstract Motor proteins, such as myosin and kinesin, are biological molecular motors involved in force generation and intracellular transport in living cells. They were proposed to drive molecular shuttles for the active transport of analytes, thus significantly accelerating the sensing process of biosensors. Integrating motor proteins into biosensors requires their immobilisation on the operating surfaces. However, this process makes some motor proteins defective, slowing analyte detection. Here, we investigated the movements of molecular shuttles on surfaces in the presence of active and defective motors using a Brownian dynamics simulation, and elucidated the effects of defective motor proteins on the transport efficiency of the shuttles. We found that the motility of shuttles depends on the fraction of active motors relative to defective ones and that over 90% of the surface-bound motor proteins must remain active for efficient transport. The high fraction of active motors required for efficient transport can be attributed to the difference in the binding lifetimes of active and defective motors to shuttles. These results provide insights into how motors accumulate on sensor surfaces and set a guideline for the choice of polymer materials for biosensors powered by motor proteins.
    MeSH term(s) Biological Transport, Active ; Biosensing Techniques ; Kinesins ; Microtubules/chemistry ; Microtubules/metabolism ; Myosins
    Chemical Substances Myosins (EC 3.6.4.1) ; Kinesins (EC 3.6.4.4)
    Language English
    Publishing date 2022-01-19
    Publishing country England
    Document type Journal Article
    ZDB-ID 1011023-9
    ISSN 1873-4235 ; 0956-5663
    ISSN (online) 1873-4235
    ISSN 0956-5663
    DOI 10.1016/j.bios.2022.114011
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 2275: Show issues Location:
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  4. Article ; Online: Biosensing using antibody-modulated motility of actin filaments on myosin-coated surfaces.

    Kekic, Murat / Hanson, Kristi L / Perumal, Ayyappasamy Sudalaiyadum / Solana, Gerardin / Rajendran, Kavya / Dash, Shantoshini / Nicolau, Dan V / Dobroiu, Serban / Dos Remedios, Cristobal G / Nicolau, Dan V

    Biosensors & bioelectronics

    2023  Volume 246, Page(s) 115879

    Abstract: Motor proteins, such as myosin and kinesin, are biological molecular motors involved in force generation and intracellular transport within living cells. The characteristics of molecular motors, i.e., their motility over long distances, their capacity of ...

    Abstract Motor proteins, such as myosin and kinesin, are biological molecular motors involved in force generation and intracellular transport within living cells. The characteristics of molecular motors, i.e., their motility over long distances, their capacity of transporting cargoes, and their very efficient energy consumption, recommend them as potential operational elements of a new class of dynamic nano-devices, with potential applications in biosensing, analyte concentrators, and biocomputation. A possible design of a biosensor based on protein molecular motor comprises a surface with immobilized motors propelling cytoskeletal filaments, which are decorated with antibodies, presented as side-branches. Upon biomolecular recognition of these branches by secondary antibodies, the 'extensions' on the cytoskeletal filaments can achieve considerable lengths (longer than several diameters of the cytoskeletal filament carrier), thus geometrically impairing or halting motility. Because the filaments are several micrometers long, this sensing mechanism converts an event in the nanometer range, i.e., antibody-antigen sizes, into an event in the micrometer range: the visualization of the halting of motility of microns-long cytoskeletal filaments. Here we demonstrate the proof of concept of a sensing system comprising heavy-mero-myosin immobilized on surfaces propelling actin filaments decorated with actin antibodies, whose movement is halted upon the recognition with secondary anti-actin antibodies. Because antibodies to the actin-myosin system are involved in several rare diseases, the first possible application for such a device may be their prognosis and diagnosis. The results also provide insights into guidelines for designing highly sensitive and very fast biosensors powered by motor proteins.
    MeSH term(s) Actins ; Biosensing Techniques ; Actin Cytoskeleton/metabolism ; Myosins/metabolism ; Cytoskeleton/metabolism ; Antibodies/metabolism ; Kinesins/metabolism
    Chemical Substances Actins ; Myosins (EC 3.6.4.1) ; Antibodies ; Kinesins (EC 3.6.4.4)
    Language English
    Publishing date 2023-11-27
    Publishing country England
    Document type Journal Article
    ZDB-ID 1011023-9
    ISSN 1873-4235 ; 0956-5663
    ISSN (online) 1873-4235
    ISSN 0956-5663
    DOI 10.1016/j.bios.2023.115879
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 2275: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
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    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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  5. Article ; Online: Moving the pathway goalposts: COPD as an immune-mediated inflammatory disease.

    Cass, Steven P / Cope, Andrew P / Nicolau, Dan V / Russell, Richard E K / Bafadhel, Mona

    The Lancet. Respiratory medicine

    2022  Volume 10, Issue 12, Page(s) 1110–1113

    MeSH term(s) Humans ; Pulmonary Disease, Chronic Obstructive
    Language English
    Publishing date 2022-11-03
    Publishing country England
    Document type Journal Article
    ZDB-ID 2686754-0
    ISSN 2213-2619 ; 2213-2600
    ISSN (online) 2213-2619
    ISSN 2213-2600
    DOI 10.1016/S2213-2600(22)00388-5
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 7041: Show issues Location:
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  7. Article ; Online: Inhaled corticosteroids in virus pandemics

    Nicolau, Dan V / Bafadhel, Mona

    The Lancet Respiratory Medicine

    a treatment for COVID-19?

    2020  Volume 8, Issue 9, Page(s) 846–847

    Keywords Pulmonary and Respiratory Medicine ; covid19
    Language English
    Publisher Elsevier BV
    Publishing country us
    Document type Article ; Online
    ZDB-ID 2686754-0
    ISSN 2213-2619 ; 2213-2600
    ISSN (online) 2213-2619
    ISSN 2213-2600
    DOI 10.1016/s2213-2600(20)30314-3
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

    Full text online

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  8. Article ; Online: COVID-19 Intensive Care Admissions Have Twice the Corrected Mortality of non-COVID-19 Viral Pneumonia

    Nicolau, Dan V / Hasson, Alexander

    medRxiv

    Abstract: Studying the ICNARC Case Mix Programme Database has yielded results showing intensive care admissions by those infected with COVID-19 have twice the corrected mortality of patients presenting with non-COVID-19 viral pneumonia. A basis of an APACHE-II- ... ...

    Abstract Studying the ICNARC Case Mix Programme Database has yielded results showing intensive care admissions by those infected with COVID-19 have twice the corrected mortality of patients presenting with non-COVID-19 viral pneumonia. A basis of an APACHE-II-like score denoted as "BASCA" is also outlined in this study.
    Keywords covid19
    Language English
    Publishing date 2020-07-24
    Publisher Cold Spring Harbor Laboratory Press
    Document type Article ; Online
    DOI 10.1101/2020.07.23.20161059
    Database COVID19

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  9. Article ; Online: Patterns of bacterial motility in microfluidics-confining environments.

    Tokárová, Viola / Sudalaiyadum Perumal, Ayyappasamy / Nayak, Monalisha / Shum, Henry / Kašpar, Ondřej / Rajendran, Kavya / Mohammadi, Mahmood / Tremblay, Charles / Gaffney, Eamonn A / Martel, Sylvain / Nicolau, Dan V / Nicolau, Dan V

    Proceedings of the National Academy of Sciences of the United States of America

    2021  Volume 118, Issue 17

    Abstract: Understanding the motility behavior of bacteria in confining microenvironments, in which they search for available physical space and move in response to stimuli, is important for environmental, food industry, and biomedical applications. We studied the ... ...

    Abstract Understanding the motility behavior of bacteria in confining microenvironments, in which they search for available physical space and move in response to stimuli, is important for environmental, food industry, and biomedical applications. We studied the motility of five bacterial species with various sizes and flagellar architectures (
    MeSH term(s) Alphaproteobacteria/physiology ; Bacteria/growth & development ; Bacterial Physiological Phenomena/genetics ; Biofilms ; Escherichia coli/physiology ; Flagella/physiology ; Hydrodynamics ; Microfluidics/methods ; Models, Biological ; Movement/physiology ; Pseudomonas putida/physiology ; Vibrio/physiology
    Language English
    Publishing date 2021-11-18
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Research Support, U.S. Gov't, Non-P.H.S.
    ZDB-ID 209104-5
    ISSN 1091-6490 ; 0027-8424
    ISSN (online) 1091-6490
    ISSN 0027-8424
    DOI 10.1073/pnas.2013925118
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 1148: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
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  10. Article: Hydrophobic Recovery of PDMS Surfaces in Contact with Hydrophilic Entities: Relevance to Biomedical Devices.

    Tsuzuki, Tomoo / Baassiri, Karine / Mahmoudi, Zahra / Perumal, Ayyappasamy Sudalaiyadum / Rajendran, Kavya / Rubies, Gala Montiel / Nicolau, Dan V

    Materials (Basel, Switzerland)

    2022  Volume 15, Issue 6

    Abstract: Polydimethylsiloxane (PDMS), a silicone elastomer, is increasingly being used in health and biomedical fields due to its excellent optical and mechanical properties. Its biocompatibility and resistance to biodegradation led to various applications (e.g., ...

    Abstract Polydimethylsiloxane (PDMS), a silicone elastomer, is increasingly being used in health and biomedical fields due to its excellent optical and mechanical properties. Its biocompatibility and resistance to biodegradation led to various applications (e.g., lung on a chip replicating blood flow, medical interventions, and diagnostics). The many advantages of PDMS are, however, partially offset by its inherent hydrophobicity, which makes it unsuitable for applications needing wetting, thus requiring the hydrophilization of its surface by exposure to UV or O
    Language English
    Publishing date 2022-03-21
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2487261-1
    ISSN 1996-1944
    ISSN 1996-1944
    DOI 10.3390/ma15062313
    Database MEDical Literature Analysis and Retrieval System OnLINE

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