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  1. Article ; Online: Letter to the Editor From Mukhopadhyay and Ghosh: "The Use of Levothyroxine Absorption Tests in Clinical Practice".

    Mukhopadhyay, Pradip / Ghosh, Sujoy

    The Journal of clinical endocrinology and metabolism

    2023  Volume 108, Issue 11, Page(s) e1460

    MeSH term(s) Humans ; Thyroxine ; Hypothyroidism/diagnosis ; Hypothyroidism/drug therapy
    Chemical Substances Thyroxine (Q51BO43MG4)
    Language English
    Publishing date 2023-05-09
    Publishing country United States
    Document type Letter ; Comment
    ZDB-ID 3029-6
    ISSN 1945-7197 ; 0021-972X
    ISSN (online) 1945-7197
    ISSN 0021-972X
    DOI 10.1210/clinem/dgad239
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  2. Article ; Online: Strategy for Pre-Clinical Development of Active Targeting MicroRNA Oligonucleotide Therapeutics for Unmet Medical Needs.

    Thibonnier, Marc / Ghosh, Sujoy

    International journal of molecular sciences

    2023  Volume 24, Issue 8

    Abstract: We present here an innovative modular and outsourced model of drug research and development for microRNA oligonucleotide therapeutics (miRNA ONTs). This model is being implemented by a biotechnology company, namely AptamiR Therapeutics, in collaboration ... ...

    Abstract We present here an innovative modular and outsourced model of drug research and development for microRNA oligonucleotide therapeutics (miRNA ONTs). This model is being implemented by a biotechnology company, namely AptamiR Therapeutics, in collaboration with Centers of Excellence in Academic Institutions. Our aim is to develop safe, effective and convenient active targeting miRNA ONT agents for the metabolic pandemic of obesity and metabolic-associated fatty liver disease (MAFLD), as well as deadly ovarian cancer.
    MeSH term(s) Humans ; MicroRNAs/genetics ; MicroRNAs/metabolism ; Oligonucleotides/therapeutic use ; Non-alcoholic Fatty Liver Disease
    Chemical Substances MicroRNAs ; Oligonucleotides
    Language English
    Publishing date 2023-04-12
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2019364-6
    ISSN 1422-0067 ; 1422-0067 ; 1661-6596
    ISSN (online) 1422-0067
    ISSN 1422-0067 ; 1661-6596
    DOI 10.3390/ijms24087126
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  3. Article: An optimized method for gene knockdown in differentiating human and mouse adipocyte cultures.

    Chua, Ruiming / Ghosh, Sujoy

    bioRxiv : the preprint server for biology

    2023  

    Abstract: Adipocyte cultures are a mainstay of metabolic disease research, yet loss-of-function studies in differentiating adipocytes is complicated by the refractoriness of lipid-containing adipocytes to standard siRNA transfections. Alternative methods, such as ... ...

    Abstract Adipocyte cultures are a mainstay of metabolic disease research, yet loss-of-function studies in differentiating adipocytes is complicated by the refractoriness of lipid-containing adipocytes to standard siRNA transfections. Alternative methods, such as electroporation or adenovirus/lentivirus-based delivery systems are complex, expensive and often accompanied with unacceptable levels of cell death. To address this problem, we have tested two commercially available siRNA delivery systems in this study using a multi-parameter optimization approach. Our results identified a uniform siRNA transfection protocol that can be applied to human and mouse adipocyte cultures throughout the time course of differentiation, beginning with pre-differentiated cells and continuing up to lipid-accumulated differentiated adipocytes. Our findings allow for efficient transfection of human and mouse adipocyte cultures using standard and readily available methodologies, and should help significantly expand the scope of gene manipulation studies in these cell types.
    Language English
    Publishing date 2023-12-15
    Publishing country United States
    Document type Preprint
    DOI 10.1101/2023.12.14.571780
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  4. Article ; Online: Functional and Multi-Omics Effects of an Optimized CRISPR-Mediated FURIN Depletion in U937 Monocytes.

    Chua, Ruiming / Wang, Lijin / Singaraja, Roshni / Ghosh, Sujoy

    Cells

    2024  Volume 13, Issue 7

    Abstract: The pro-protein convertase FURIN (PCSK3) is implicated in a wide range of normal and pathological biological processes such as infectious diseases, cancer and cardiovascular diseases. Previously, we performed a systemic inhibition of FURIN in a mouse ... ...

    Abstract The pro-protein convertase FURIN (PCSK3) is implicated in a wide range of normal and pathological biological processes such as infectious diseases, cancer and cardiovascular diseases. Previously, we performed a systemic inhibition of FURIN in a mouse model of atherosclerosis and demonstrated significant plaque reduction and alterations in macrophage function. To understand the cellular mechanisms affected by FURIN inhibition in myeloid cells, we optimized a CRISPR-mediated gene deletion protocol for successfully deriving hemizygous (HZ) and nullizygous (NZ)
    MeSH term(s) Animals ; Humans ; Mice ; Clustered Regularly Interspaced Short Palindromic Repeats ; Cytokines/genetics ; Furin/genetics ; Furin/metabolism ; Monocytes/metabolism ; Multiomics ; RNA, Guide, CRISPR-Cas Systems ; U937 Cells ; Gene Editing
    Chemical Substances Cytokines ; Furin (EC 3.4.21.75) ; RNA, Guide, CRISPR-Cas Systems
    Language English
    Publishing date 2024-03-28
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2661518-6
    ISSN 2073-4409 ; 2073-4409
    ISSN (online) 2073-4409
    ISSN 2073-4409
    DOI 10.3390/cells13070588
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  5. Article ; Online: Promote to protect: data-driven computational model of peer influence for vaccine perception.

    Ghosh, Sayantari / Bhattacharya, Saumik / Mukherjee, Shagata / Chakravarty, Sujoy

    Scientific reports

    2024  Volume 14, Issue 1, Page(s) 306

    Abstract: Vaccine hesitancy and acceptance, driven by social influence, is usually explored by most researchers using exhaustive survey-based studies, which investigate public preferences, fundamental values, beliefs, barriers, and drivers through closed or open- ... ...

    Abstract Vaccine hesitancy and acceptance, driven by social influence, is usually explored by most researchers using exhaustive survey-based studies, which investigate public preferences, fundamental values, beliefs, barriers, and drivers through closed or open-ended questionnaires. Commonly used simple statistical tools do not do justice to the richness of this data. Considering the gradual development of vaccine acceptance in a society driven by multiple local/global factors as a compartmental contagion process, we propose a novel methodology where drivers and barriers of these dynamics are detected from survey participants' responses, instead of heuristic arguments. Applying rigorous natural language processing analysis to the survey responses of participants from India, who are from various socio-demographics, education, and perceptions, we identify and categorize the most important factors as well as interactions among people of different perspectives on COVID-19 vaccines. With a goal to achieve improvement in vaccine perception, we also analyze the resultant behavioral transitions through platforms of unsupervised machine learning and natural language processing to derive a compartmental contagion model from the data. Analysis of the model shows that positive peer influence plays a very important role and causes a bifurcation in the system that reflects threshold-sensitive dynamics.
    MeSH term(s) Humans ; COVID-19 Vaccines ; Peer Influence ; Vaccines ; Educational Status ; Perception ; Vaccination
    Chemical Substances COVID-19 Vaccines ; Vaccines
    Language English
    Publishing date 2024-01-03
    Publishing country England
    Document type Journal Article
    ZDB-ID 2615211-3
    ISSN 2045-2322 ; 2045-2322
    ISSN (online) 2045-2322
    ISSN 2045-2322
    DOI 10.1038/s41598-023-50756-3
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  6. Article ; Online: Promote to protect

    Sayantari Ghosh / Saumik Bhattacharya / Shagata Mukherjee / Sujoy Chakravarty

    Scientific Reports, Vol 14, Iss 1, Pp 1-

    data-driven computational model of peer influence for vaccine perception

    2024  Volume 15

    Abstract: Abstract Vaccine hesitancy and acceptance, driven by social influence, is usually explored by most researchers using exhaustive survey-based studies, which investigate public preferences, fundamental values, beliefs, barriers, and drivers through closed ... ...

    Abstract Abstract Vaccine hesitancy and acceptance, driven by social influence, is usually explored by most researchers using exhaustive survey-based studies, which investigate public preferences, fundamental values, beliefs, barriers, and drivers through closed or open-ended questionnaires. Commonly used simple statistical tools do not do justice to the richness of this data. Considering the gradual development of vaccine acceptance in a society driven by multiple local/global factors as a compartmental contagion process, we propose a novel methodology where drivers and barriers of these dynamics are detected from survey participants’ responses, instead of heuristic arguments. Applying rigorous natural language processing analysis to the survey responses of participants from India, who are from various socio-demographics, education, and perceptions, we identify and categorize the most important factors as well as interactions among people of different perspectives on COVID-19 vaccines. With a goal to achieve improvement in vaccine perception, we also analyze the resultant behavioral transitions through platforms of unsupervised machine learning and natural language processing to derive a compartmental contagion model from the data. Analysis of the model shows that positive peer influence plays a very important role and causes a bifurcation in the system that reflects threshold-sensitive dynamics.
    Keywords Medicine ; R ; Science ; Q
    Language English
    Publishing date 2024-01-01T00:00:00Z
    Publisher Nature Portfolio
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  7. Article: Quality of life in Sheehan Syndrome.

    Mandal, Soumita / Mukhopadhyay, Pradip / Ghosh, Sujoy

    Indian journal of endocrinology and metabolism

    2022  Volume 26, Issue 3, Page(s) 282–283

    Language English
    Publishing date 2022-08-04
    Publishing country India
    Document type Journal Article
    ZDB-ID 2600211-5
    ISSN 2230-9500 ; 2230-8210
    ISSN (online) 2230-9500
    ISSN 2230-8210
    DOI 10.4103/ijem.ijem_100_22
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  8. Article ; Online: Blink-Related Oscillations Provide Naturalistic Assessments of Brain Function and Cognitive Workload within Complex Real-World Multitasking Environments.

    Page, Cleo / Liu, Careesa Chang / Meltzer, Jed / Ghosh Hajra, Sujoy

    Sensors (Basel, Switzerland)

    2024  Volume 24, Issue 4

    Abstract: Background: There is a significant need to monitor human cognitive performance in complex environments, with one example being pilot performance. However, existing assessments largely focus on subjective experiences (e.g., questionnaires) and the ... ...

    Abstract Background: There is a significant need to monitor human cognitive performance in complex environments, with one example being pilot performance. However, existing assessments largely focus on subjective experiences (e.g., questionnaires) and the evaluation of behavior (e.g., aircraft handling) as surrogates for cognition or utilize brainwave measures which require artificial setups (e.g., simultaneous auditory stimuli) that intrude on the primary tasks. Blink-related oscillations (BROs) are a recently discovered neural phenomenon associated with spontaneous blinking that can be captured without artificial setups and are also modulated by cognitive loading and the external sensory environment-making them ideal for brain function assessment within complex operational settings.
    Methods: Electroencephalography (EEG) data were recorded from eight adult participants (five F, M = 21.1 years) while they completed the Multi-Attribute Task Battery under three different cognitive loading conditions. BRO responses in time and frequency domains were derived from the EEG data, and comparisons of BRO responses across cognitive loading conditions were undertaken. Simultaneously, assessments of blink behavior were also undertaken.
    Results: Blink behavior assessments revealed decreasing blink rate with increasing cognitive load (
    Conclusion: This study confirms the ability of BRO responses to capture cognitive loading effects as well as preparatory pre-blink cognitive processes in anticipation of the upcoming blink during a complex multitasking situation. These successful results suggest that blink-related neural processing could be a potential avenue for cognitive state evaluation in operational settings-both specialized environments such as cockpits, space exploration, military units, etc. and everyday situations such as driving, athletics, human-machine interactions, etc.-where human cognition needs to be seamlessly monitored and optimized.
    MeSH term(s) Adult ; Humans ; Blinking ; Cognition/physiology ; Electroencephalography/methods ; Brain Waves/physiology ; Brain/physiology
    Language English
    Publishing date 2024-02-07
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2052857-7
    ISSN 1424-8220 ; 1424-8220
    ISSN (online) 1424-8220
    ISSN 1424-8220
    DOI 10.3390/s24041082
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  9. Article ; Online: Model of care for Type 1 diabetes in India: Integrated approach for its incorporation in future national health care policy.

    Yasmin, Masuma / Mukhopadhyay, Pradip / Ghosh, Sujoy

    The Lancet regional health. Southeast Asia

    2022  Volume 3, Page(s) 100014

    Language English
    Publishing date 2022-06-09
    Publishing country England
    Document type Journal Article
    ISSN 2772-3682
    ISSN (online) 2772-3682
    DOI 10.1016/j.lansea.2022.05.003
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  10. Article ; Online: Corneal Confocal Microscopy Identifies Structural Small Fibre Abnormalities in an Adolescent with Type 1 Diabetes and Impaired Awareness of Hypoglycaemia.

    Banerjee, Mainak / Mukhopadhyay, Pradip / Basu, Madhurima / Ghosh, Sujoy

    Journal of the ASEAN Federation of Endocrine Societies

    2023  Volume 38, Issue 2, Page(s) 128–130

    Abstract: Impaired awareness of hypoglycaemia (IAH) is present in around 25-40% of individuals with type 1 diabetes mellitus (T1DM). Herein, we present a case of an adolescent with T1DM and IAH who had worse corneal nerve parameters compared to a T1DM adolescent ... ...

    Abstract Impaired awareness of hypoglycaemia (IAH) is present in around 25-40% of individuals with type 1 diabetes mellitus (T1DM). Herein, we present a case of an adolescent with T1DM and IAH who had worse corneal nerve parameters compared to a T1DM adolescent without IAH. Small fibre abnormalities detected by corneal confocal microscopy in an objective easy-to-perform non-invasive test might be a surrogate indicator of underlying autonomic dysfunction in T1DM and IAH.
    MeSH term(s) Humans ; Adolescent ; Diabetes Mellitus, Type 1/complications ; Hypoglycemia ; Cornea/diagnostic imaging ; Microscopy, Confocal ; Autonomic Nervous System Diseases
    Language English
    Publishing date 2023-07-15
    Publishing country Philippines
    Document type Case Reports
    ZDB-ID 2893162-2
    ISSN 2308-118X ; 0857-1074
    ISSN (online) 2308-118X
    ISSN 0857-1074
    DOI 10.15605/jafes.038.02.21
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