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  1. Article ; Online: Inhaled liposomal amphotericin-B as a prophylactic treatment for COVID-19-associated pulmonary aspergillosis/aspergillus tracheobronchitis.

    Van Ackerbroeck, Sofie / Rutsaert, Lynn / Roelant, Ella / Dillen, Kathleen / Wauters, Joost / Van Regenmortel, Niels

    Critical care (London, England)

    2021  Volume 25, Issue 1, Page(s) 298

    MeSH term(s) Administration, Inhalation ; Aged ; Amphotericin B/administration & dosage ; Amphotericin B/pharmacology ; Amphotericin B/therapeutic use ; Aspergillosis/drug therapy ; Aspergillosis/epidemiology ; Aspergillosis/prevention & control ; Belgium/epidemiology ; COVID-19/complications ; COVID-19/epidemiology ; Cohort Studies ; Female ; Humans ; Male ; Middle Aged ; Retrospective Studies
    Chemical Substances liposomal amphotericin B ; Amphotericin B (7XU7A7DROE)
    Language English
    Publishing date 2021-08-19
    Publishing country England
    Document type Letter ; Observational Study
    ZDB-ID 2041406-7
    ISSN 1466-609X ; 1364-8535
    ISSN (online) 1466-609X
    ISSN 1364-8535
    DOI 10.1186/s13054-021-03728-w
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Incidence and predisposing factors for the development of disturbed glucose metabolism and DIabetes mellitus AFter Intensive Care admission: the DIAFIC study.

    Van Ackerbroeck, Sofie / Schepens, Tom / Janssens, Karolien / Jorens, Philippe G / Verbrugghe, Walter / Collet, Sandra / Van Hoof, Viviane / Van Gaal, Luc / De Block, Christophe

    Critical care (London, England)

    2015  Volume 19, Page(s) 355

    Abstract: Introduction: Elevated blood glucose levels during intensive care unit (ICU) stay, so-called stress hyperglycaemia (SH), is a common finding. Its relation with a future diabetes risk is unclear. Our objective was to determine the incidence of disturbed ... ...

    Abstract Introduction: Elevated blood glucose levels during intensive care unit (ICU) stay, so-called stress hyperglycaemia (SH), is a common finding. Its relation with a future diabetes risk is unclear. Our objective was to determine the incidence of disturbed glucose metabolism (DGM) post ICU admission and to identify predictors for future diabetes risk with a focus on stress hyperglycaemia.
    Methods: This single center prospective cohort trial (DIAFIC trial) had a study period between September 2011 and March 2013, with follow-up until December 2013. The setting was a mixed medical/surgical ICU in a tertiary teaching hospital in Belgium. 338 patients without known diabetes mellitus were included for analysis. We assessed the level of glucose metabolism disturbance (as diagnosed with a 75 g oral glucose tolerance test (OGTT) and/or HbA1c level) eight months after ICU admission, and investigated possible predictors including stress hyperglycaemia.
    Results: In total 246 patients (73 %) experienced stress hyperglycaemia during the ICU stay. Eight months post-ICU admission, 119 (35 %) subjects had a disturbed glucose metabolism, including 24 (7 %) patients who were diagnosed with diabetes mellitus. A disturbed glucose metabolism tended to be more prevalent in subjects who experienced stress hyperglycaemia during ICU stay as compared to those without stress hyperglycaemia (38 % vs. 28 %, P = 0.065). HbA1c on admission correlated with the degree of stress hyperglycaemia. A diabetes risk score (FINDRISC) (11.0 versus 9.5, P = 0.001), the SAPS3 score (median of 42 in both groups, P = 0.003) and daily caloric intake during ICU stay (197 vs. 222, P = 0.011) were independently associated with a disturbed glucose metabolism.
    Conclusions: Stress hyperglycaemia is frequent in non-diabetic patients and predicts a tendency towards disturbances in glucose metabolism and diabetes mellitus. Clinically relevant predictors of elevated risk included a high FINDRISC score and a high SAPS3 score. These predictors can provide an efficient, quick and inexpensive way to identify patients at risk for a disturbed glucose metabolism or diabetes, and could facilitate prevention and early treatment.
    Trial registration: At ClinicalTrials.gov NCT02180555 . Registered 1 July, 2014.
    MeSH term(s) Adolescent ; Adult ; Aged ; Aged, 80 and over ; Critical Care/statistics & numerical data ; Diabetes Mellitus/epidemiology ; Diabetes Mellitus/etiology ; Female ; Glucose/metabolism ; Glucose Tolerance Test ; Glycated Hemoglobin A/analysis ; Humans ; Hyperglycemia/epidemiology ; Hyperglycemia/etiology ; Incidence ; Male ; Middle Aged ; Prospective Studies ; Risk Factors ; Stress, Physiological ; Young Adult
    Chemical Substances Glycated Hemoglobin A ; hemoglobin A1c protein, human ; Glucose (IY9XDZ35W2)
    Language English
    Publishing date 2015-10-02
    Publishing country England
    Document type Journal Article ; Observational Study ; Research Support, Non-U.S. Gov't
    ZDB-ID 2051256-9
    ISSN 1466-609X ; 1466-609X
    ISSN (online) 1466-609X
    ISSN 1466-609X
    DOI 10.1186/s13054-015-1064-9
    Database MEDical Literature Analysis and Retrieval System OnLINE

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