LIVIVO - The Search Portal for Life Sciences

zur deutschen Oberfläche wechseln
Advanced search

Search results

Result 1 - 10 of total 67

Search options

  1. Article: Pulmonary function and shunt size after single ventricle palliation--classic cardiopulmonary interactions.

    Barr, Frederick E

    Pediatric critical care medicine : a journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies

    2009  Volume 10, Issue 1, Page(s) 139

    MeSH term(s) Child ; Child, Preschool ; Female ; Heart Bypass, Right/methods ; Heart Defects, Congenital/diagnosis ; Heart Defects, Congenital/mortality ; Heart Defects, Congenital/surgery ; Heart Function Tests ; Heart Ventricles/abnormalities ; Heart Ventricles/surgery ; Humans ; Hypoplastic Left Heart Syndrome/mortality ; Hypoplastic Left Heart Syndrome/surgery ; Infant ; Infant, Newborn ; Male ; Palliative Care/methods ; Prognosis ; Respiratory Function Tests ; Survival Rate
    Language English
    Publishing date 2009-01
    Publishing country United States
    Document type Comment ; Editorial
    ZDB-ID 2052349-X
    ISSN 1947-3893 ; 1529-7535
    ISSN (online) 1947-3893
    ISSN 1529-7535
    DOI 10.1097/PCC.0b013e318193762c
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

  2. Article ; Online: Correlates of suicidal behaviors and genetic risk among United States veterans with schizophrenia or bipolar I disorder.

    Bigdeli, Tim B / Barr, Peter B / Rajeevan, Nallakkandi / Graham, David P / Li, Yuli / Meyers, Jacquelyn L / Gorman, Bryan R / Peterson, Roseann E / Sayward, Frederick / Radhakrishnan, Krishnan / Natarajan, Sundar / Nielsen, David A / Wilkinson, Anna V / Malhotra, Anil K / Zhao, Hongyu / Brophy, Mary / Shi, Yunling / O'Leary, Timothy J / Gleason, Theresa /
    Przygodzki, Ronald / Pyarajan, Saiju / Muralidhar, Sumitra / Gaziano, J Michael / Huang, Grant D / Concato, John / Siever, Larry J / DeLisi, Lynn E / Kimbrel, Nathan A / Beckham, Jean C / Swann, Alan C / Kosten, Thomas R / Fanous, Ayman H / Aslan, Mihaela / Harvey, Philip D

    Molecular psychiatry

    2024  

    Abstract: ... of psychotropic medications (e.g., antidepressants, antipsychotics, etc.). PGS for externalizing behaviors ...

    Abstract Persons diagnosed with schizophrenia (SCZ) or bipolar I disorder (BPI) are at high risk for self-injurious behavior, suicidal ideation, and suicidal behaviors (SB). Characterizing associations between diagnosed health problems, prior pharmacological treatments, and polygenic scores (PGS) has potential to inform risk stratification. We examined self-reported SB and ideation using the Columbia Suicide Severity Rating Scale (C-SSRS) among 3,942 SCZ and 5,414 BPI patients receiving care within the Veterans Health Administration (VHA). These cross-sectional data were integrated with electronic health records (EHRs), and compared across lifetime diagnoses, treatment histories, follow-up screenings, and mortality data. PGS were constructed using available genomic data for related traits. Genome-wide association studies were performed to identify and prioritize specific loci. Only 20% of the veterans who reported SB had a corroborating ICD-9/10 EHR code. Among those without prior SB, more than 20% reported new-onset SB at follow-up. SB were associated with a range of additional clinical diagnoses, and with treatment with specific classes of psychotropic medications (e.g., antidepressants, antipsychotics, etc.). PGS for externalizing behaviors, smoking initiation, suicide attempt, and major depressive disorder were associated with SB. The GWAS for SB yielded no significant loci. Among individuals with a diagnosed mental illness, self-reported SB were strongly associated with clinical variables across several EHR domains. Analyses point to sequelae of substance-related and psychiatric comorbidities as strong correlates of prior and subsequent SB. Nonetheless, past SB was frequently not documented in health records, underscoring the value of regular screening with direct, in-person assessments, especially among high-risk individuals.
    Language English
    Publishing date 2024-03-15
    Publishing country England
    Document type Journal Article
    ZDB-ID 1330655-8
    ISSN 1476-5578 ; 1359-4184
    ISSN (online) 1476-5578
    ISSN 1359-4184
    DOI 10.1038/s41380-024-02472-1
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

  3. Article: Calpain: A new target in pulmonary hypertension?

    Barr, Frederick E

    Critical care medicine

    2005  Volume 33, Issue 3, Page(s) 693

    MeSH term(s) Animals ; Animals, Newborn ; Calpain/antagonists & inhibitors ; Calpain/metabolism ; Cardiopulmonary Bypass/adverse effects ; Endothelin-1/drug effects ; Endothelin-1/metabolism ; Humans ; Hypertension, Pulmonary/prevention & control ; Reperfusion Injury/etiology ; Reperfusion Injury/prevention & control ; Swine
    Chemical Substances Endothelin-1 ; Calpain (EC 3.4.22.-)
    Language English
    Publishing date 2005-03
    Publishing country United States
    Document type Comment ; Editorial
    ZDB-ID 197890-1
    ISSN 1530-0293 ; 0090-3493
    ISSN (online) 1530-0293
    ISSN 0090-3493
    DOI 10.1097/01.ccm.0000155913.35077.db
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

  4. Article ; Online: Youth Adversities Amplify the Association between Adult Stressors and Chronic Inflammation in a Domain Specific Manner: Nuancing the Early Life Sensitivity Model.

    Simons, Ronald L / Woodring, David / Simons, Leslie Gordon / Sutton, Tara E / Lei, Man-Kit / Beach, Steven R H / Barr, Ashley B / Gibbons, Frederick X

    Journal of youth and adolescence

    2019  Volume 48, Issue 1, Page(s) 1–16

    Abstract: There is strong evidence that chronic, systemic inflammation hastens onset of the diseases of old age that ultimately lead to death. Importantly, several studies suggest that childhood adversity predicts chronic inflammation. Unfortunately, this research ...

    Abstract There is strong evidence that chronic, systemic inflammation hastens onset of the diseases of old age that ultimately lead to death. Importantly, several studies suggest that childhood adversity predicts chronic inflammation. Unfortunately, this research has been plagued by retrospective reports of childhood adversity, an absence of controls for adult stressors, and a failure to investigate various competing models of the link between childhood adversity and chronic inflammation. The present study was designed to address these limitations. Using 18 years of data collected from 413 African Americans (58% female) included in the Family and Community Health Study, hierarchical regression analyses provided support for a nuanced early life sensitivity explanation for the link between early adversity and adult chronic inflammation. Controlling for health risk behaviors and adult SES, late childhood (ages 10-12) adversity amplified the association between adult adversity (age 29) and chronic inflammation. This interaction operated in a domain-specific fashion. Harsh parenting amplified the relation between intimate partner hostility and inflammation, whereas early discrimination amplified the relation between adult discrimination and inflammation. These findings suggest that individuals may be primed to respond physiologically to adverse adult circumstances that resemble those experienced earlier in life.
    MeSH term(s) Adolescent ; Adult ; African Americans/psychology ; African Americans/statistics & numerical data ; Child ; Female ; Humans ; Inflammation/etiology ; Inflammation/psychology ; Life Change Events ; Male ; Retrospective Studies ; Risk Factors ; Sexual Partners
    Language English
    Publishing date 2019-01-02
    Publishing country United States
    Document type Journal Article
    ZDB-ID 186743-x
    ISSN 1573-6601 ; 0047-2891
    ISSN (online) 1573-6601
    ISSN 0047-2891
    DOI 10.1007/s10964-018-0977-4
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

  5. Article: Inhaled nitric oxide and related therapies.

    Barr, Frederick E / Macrae, Duncan

    Pediatric critical care medicine : a journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies

    2010  Volume 11, Issue 2 Suppl, Page(s) S30–6

    Abstract: Children with congenital heart defects are at risk for perioperative pulmonary hypertension if they require corrective or palliative surgery in the first week of life or if they have defects associated with significant pulmonary overcirculation. In ... ...

    Abstract Children with congenital heart defects are at risk for perioperative pulmonary hypertension if they require corrective or palliative surgery in the first week of life or if they have defects associated with significant pulmonary overcirculation. In addition, children undergoing cavopulmonary connections for single ventricle lesions require low pulmonary vascular resistance for surgical success. Treatment of perioperative pulmonary hypertension with inhaled nitric oxide has become standard therapy in many centers. Related drugs that increase nitric oxide synthesis, including arginine and citrulline, have also been studied in the perioperative period. In this article, previous clinical trials of inhaled nitric oxide, intravenous arginine, and intravenous and oral citrulline in children with perioperative pulmonary hypertension or elevated pulmonary vascular resistance after a cavopulmonary connection are reviewed. In addition, recommendations are presented for each agent on the clinical use in the perioperative setting including clinical indications, assessment of clinical effect, and length of therapy.
    MeSH term(s) Administration, Inhalation ; Administration, Oral ; Arginine/administration & dosage ; Cardiac Surgical Procedures ; Child ; Child, Preschool ; Citrulline/administration & dosage ; Clinical Trials as Topic ; Endothelium-Dependent Relaxing Factors/administration & dosage ; Humans ; Hypertension, Pulmonary/drug therapy ; Hypertension, Pulmonary/physiopathology ; Infant ; Infant, Newborn ; Injections, Intravenous ; Nitric Oxide/administration & dosage ; Postoperative Complications/drug therapy
    Chemical Substances Endothelium-Dependent Relaxing Factors ; Citrulline (29VT07BGDA) ; Nitric Oxide (31C4KY9ESH) ; Arginine (94ZLA3W45F)
    Language English
    Publishing date 2010-02-26
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't ; Review
    ZDB-ID 2052349-X
    ISSN 1947-3893 ; 1529-7535
    ISSN (online) 1947-3893
    ISSN 1529-7535
    DOI 10.1097/PCC.0b013e3181c76b42
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

  6. Article: Correlates of suicidal behaviors and genetic risk among United States veterans with schizophrenia or bipolar I disorder.

    Bigdeli, Tim B / Barr, Peter B / Rajeevan, Nallakkandi / Graham, David P / Li, Yuli / Meyers, Jacquelyn L / Gorman, Bryan R / Peterson, Roseann E / Sayward, Frederick / Radhakrishnan, Krishnan / Natarajan, Sundar / Nielsen, David A / Wilkinson, Anna V / Malhotra, Anil K / Zhao, Hongyu / Brophy, Mary / Shi, Yunling / O'Leary, Timothy J / Gleason, Theresa /
    Przygodzki, Ronald / Pyarajan, Saiju / Muralidhar, Sumitra / Gaziano, J Michael / Huang, Grant D / Concato, John / Siever, Larry J / DeLisi, Lynn E / Kimbrel, Nathan A / Beckham, Jean C / Swann, Alan C / Kosten, Thomas R / Fanous, Ayman H / Aslan, Mihaela / Harvey, Philip D

    medRxiv : the preprint server for health sciences

    2023  

    Abstract: ... non-psychiatric diagnoses, and with treatment with specific classes of psychotropic medications (e.g ...

    Abstract Objective: Persons diagnosed with schizophrenia (SCZ) or bipolar I disorder (BPI) are at high risk for self-injurious behavior, suicidal ideation, and suicidal behaviors (SB). Characterizing associations between diagnosed mental and physical health problems, prior pharmacological treatments, and aggregate genetic factors has potential to inform risk stratification and mitigation strategies.
    Methods: In this study of 3,942 SCZ and 5,414 BPI patients receiving VA care, self-reported SB and ideation were assessed using the Columbia Suicide Severity Rating Scale (C-SSRS). These cross-sectional data were integrated with electronic health records (EHR), and compared by lifetime diagnoses, treatment histories, follow-up screenings, and mortality data. Polygenic scores (PGS) for traits related to psychiatric disorders, substance use, and cognition were constructed using available genomic data, and exploratory genome-wide association studies were performed to identify and prioritize specific loci.
    Results: Only 20% of veterans who self-reported SB had a corroborating ICD-9/10 code in their EHR; and among those who denied prior behaviors, more than 20% reported new-onset SB at follow-up. SB were associated with a range of psychiatric and non-psychiatric diagnoses, and with treatment with specific classes of psychotropic medications (e.g., antidepressants, antipsychotics, etc.). PGS for externalizing behaviors, smoking, suicide attempt, and major depressive disorder were also associated with attempt and ideation.
    Conclusions: Among individuals with a diagnosed mental illness, a GWAS for SB did not yield any significant loci. Self-reported SB were strongly associated with clinical variables across several EHR domains. Overall, clinical and polygenic analyses point to sequelae of substance-use related behaviors and other psychiatric comorbidities as strong correlates of prior and subsequent SB. Nonetheless, past SB was frequently not documented in clinical settings, underscoring the value of regular screening based on direct, in-person assessments, especially among high-risk individuals.
    Language English
    Publishing date 2023-03-08
    Publishing country United States
    Document type Preprint
    DOI 10.1101/2023.03.06.23286866
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

  7. Article ; Online: Romantic relationship transitions and changes in health among rural, White young adults.

    Barr, Ashley B / Sutton, Tara E / Simons, Leslie Gordon / Wickrama, K A S / Lorenz, Frederick O

    Journal of family psychology : JFP : journal of the Division of Family Psychology of the American Psychological Association (Division 43)

    2016  Volume 30, Issue 7, Page(s) 832–842

    Abstract: ... the transition to adulthood when instability in romantic relationships is expected to be common. Barr, Culatta ... among the rural, White young adults in the current study was less than that found in Barr et al.'s (2013) study ...

    Abstract A growing body of research examines how the presence and quality of romantic relationships, from dating to marriage, contribute to health. However, this work oftentimes fails to consider instability in the relationship supports and stressors thought to affect health. This is particularly important during the transition to adulthood when instability in romantic relationships is expected to be common. Barr, Culatta, and Simons (2013) put forth a new model that has shown promise for assessing the degree of this instability and its implications for young adult health. They tested their model, however, with an African American sample, and it remains unclear whether it is generalizable to other groups of young adults. The current study considers the generality of their model by applying it to a rural, White sample drawn from the Iowa Youth and Families Project, the only extant data set able to assess both their proposed measurement of relationship instability and its relation to multidimensional measures of health across the transition to adulthood. Findings lend support to their model, yet the degree of instability found among the rural, White young adults in the current study was less than that found in Barr et al.'s (2013) study. (PsycINFO Database Record
    MeSH term(s) Adult ; European Continental Ancestry Group/ethnology ; Female ; Health Status ; Humans ; Interpersonal Relations ; Iowa/ethnology ; Male ; Rural Population/statistics & numerical data ; Sexual Partners/psychology ; Spouses/ethnology ; Young Adult
    Language English
    Publishing date 2016-10
    Publishing country United States
    Document type Journal Article
    ZDB-ID 619328-6
    ISSN 1939-1293 ; 0893-3200
    ISSN (online) 1939-1293
    ISSN 0893-3200
    DOI 10.1037/fam0000207
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

  8. Article ; Online: A phase 1 dose-finding study of intravenous L-citrulline in sickle cell disease: a potential novel therapy for sickle cell pain crisis.

    Majumdar, Suvankar / Tirona, Rommel / Mashegu, Hafsat / Desai, Jagdish / Shannon, Neil T / Summar, Marshall / Cunningham, Gary / Darbari, Deepika / Nickel, Robert / Campbell, Andrew / Barr, Frederick E

    British journal of haematology

    2018  Volume 184, Issue 4, Page(s) 634–636

    MeSH term(s) Adolescent ; Adult ; Anemia, Sickle Cell/blood ; Anemia, Sickle Cell/drug therapy ; Citrulline/administration & dosage ; Citrulline/pharmacokinetics ; Female ; Humans ; Male ; Pain/blood ; Pain/drug therapy
    Chemical Substances Citrulline (29VT07BGDA)
    Language English
    Publishing date 2018-02-07
    Publishing country England
    Document type Letter ; Research Support, Non-U.S. Gov't
    ZDB-ID 80077-6
    ISSN 1365-2141 ; 0007-1048
    ISSN (online) 1365-2141
    ISSN 0007-1048
    DOI 10.1111/bjh.15124
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

  9. Article ; Online: Implementation of an inhaled nitric oxide protocol decreases direct cost associated with its use.

    Todd Tzanetos, Deanna R / Housley, Jon J / Barr, Frederick E / May, Warren L / Landers, Cheri D

    Respiratory care

    2015  Volume 60, Issue 5, Page(s) 644–650

    Abstract: Background: The objective of this study was to determine whether the implementation of an inhaled nitric oxide protocol (INO) in a pediatric ICU (PICU) would reduce cost associated with its use without negatively affecting patient outcomes.: Methods: ...

    Abstract Background: The objective of this study was to determine whether the implementation of an inhaled nitric oxide protocol (INO) in a pediatric ICU (PICU) would reduce cost associated with its use without negatively affecting patient outcomes.
    Methods: This is a retrospective cohort study of 76 subjects who required INO therapy in the PICU during the study period. A nitric oxide setup and weaning protocol was implemented in the PICU. The medical records of subjects who had received INO 18 months after protocol implementation, as well as the medical records of subjects who had received INO in the 18 months before protocol implementation, were reviewed. Length of time on INO, cost of INO per subject, mortality, stay, and ventilator hours were recorded.
    Results: There were 38 subjects in the pre-protocol group and 38 subjects in the post-protocol group. There was a statistically significant decrease in the median per subject cost of INO between the pre- and post-protocol groups (P < .01). There was no statistically significant difference in the median duration of INO use (P = .06), median PICU (P = .42) or hospital (P = .58) stay, median duration of mechanical ventilation (P = .79) or percent mortality (P = .28) between the 2 groups.
    Conclusions: Implementation of an INO setup and weaning protocol in a PICU reduces the cost associated with its use without a statistically significant difference in mortality. In an era of increased awareness regarding healthcare spending, implementation of evidence-based protocols can provide a way to ensure the judicious utilization of medical resources.
    MeSH term(s) Administration, Inhalation ; Adolescent ; Bronchodilator Agents/administration & dosage ; Bronchodilator Agents/economics ; Child ; Child, Preschool ; Clinical Protocols/standards ; Direct Service Costs/statistics & numerical data ; Female ; Hospital Mortality/trends ; Humans ; Infant ; Infant, Newborn ; Intensive Care Units, Pediatric/economics ; Intensive Care Units, Pediatric/standards ; Intensive Care Units, Pediatric/statistics & numerical data ; Length of Stay ; Male ; Nitric Oxide/administration & dosage ; Nitric Oxide/economics ; Respiration, Artificial/statistics & numerical data ; Retrospective Studies ; Treatment Outcome
    Chemical Substances Bronchodilator Agents ; Nitric Oxide (31C4KY9ESH)
    Language English
    Publishing date 2015-05
    Publishing country United States
    Document type Journal Article
    ZDB-ID 603252-7
    ISSN 1943-3654 ; 0098-9142 ; 0020-1324
    ISSN (online) 1943-3654
    ISSN 0098-9142 ; 0020-1324
    DOI 10.4187/respcare.03308
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

  10. Article ; Online: An index of the ratio of inflammatory to antiviral cell types mediates the effects of social adversity and age on chronic illness.

    Simons, Ronald L / Lei, Man-Kit / Beach, Steven R H / Barr, Ashley B / Cutrona, Carolyn E / Gibbons, Frederick X / Philibert, Robert A

    Social science & medicine (1982)

    2017  Volume 185, Page(s) 158–165

    Abstract: ... usually employ single-marker measures of inflammation (e.g., Interleukin-6, C-reactive protein ...

    Abstract Background: It is assumed that both social stress and chronological age increase the risk of chronic illness, in part, through their effect on systemic inflammation. Unfortunately, observational studies usually employ single-marker measures of inflammation (e.g., Interleukin-6, C-reactive protein) that preclude strong tests for mediational effects.
    Objective: The present study investigated the extent to which the effects of socioeconomic disadvantage and age on onset of chronic illness is mediated by dominance of the innate (inflammatory) over the acquired (antiviral) components of the immune system.
    Methods: We assessed inflammation using the ratio of inflammatory to antiviral cell types (ITACT Ratio). This approach provided a stronger test of evolutionary arguments regarding the effect of social stress on chronic inflammation than is the case with cytokine measures, and afforded an opportunity to replicate findings obtained utilizing mRNA. We used structural equation modeling and longitudinal data from a sample of 100 middle-age African American women to perform our analyses.
    Results: Dominance of inflammatory over antiviral cell activity was associated with each of the eight illnesses included in our chronic illness measure. Both socioeconomic disadvantage and age were also associated with inflammatory dominance. Pursuant to the central focus of the study, the effects of socioeconomic adversity and age on increased illness were mediated by our measure of inflammatory dominance. The indirect effect of these variables through inflammatory cell profile was significant, with neither socioeconomic disadvantage nor age showing a significant association with illness once the impact of inflammatory cell profile was taken into account.
    Conclusions: First, the analysis provides preliminary validation of a new measure of inflammation that is calculated based on the ratio of inflammatory to antiviral white blood cells. Second, our results support the hypothesis that socioeconomic disadvantage and chronological age increase risk for chronic illness in part through their effect on inflammatory processes.
    MeSH term(s) Age Factors ; Biomarkers/analysis ; Cells/classification ; Chronic Disease ; Humans ; Inflammation/blood ; Patient Acuity ; Social Norms ; Socioeconomic Factors ; Stress, Psychological/complications
    Chemical Substances Biomarkers
    Language English
    Publishing date 2017-03-27
    Publishing country England
    Document type Journal Article ; Research Support, N.I.H., Extramural
    ZDB-ID 4766-1
    ISSN 1873-5347 ; 0037-7856 ; 0277-9536
    ISSN (online) 1873-5347
    ISSN 0037-7856 ; 0277-9536
    DOI 10.1016/j.socscimed.2017.03.005
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

To top