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Article ; Online: Comparison of Race Time-Differences Between and Within Para and Able-Bodied Cross-Country Skiers.

Carlsen, Camilla H / Severin, Cecilia / Sandbakk, Øyvind / Baumgart, Julia K

Frontiers in sports and active living

2022 Volume 3, Page(s) 823014

Abstract: Purpose: To compare differences in race time (i.e., the average percent difference in race time for each skier compared to the winner, RT: Methods: Race data from World Cups (WCs), World Championships (WCHs), and Paralympic/Olympic Winter Games (PWG/ ... ...

Abstract	Purpose: To compare differences in race time (i.e., the average percent difference in race time for each skier compared to the winner, RT Methods: Race data from World Cups (WCs), World Championships (WCHs), and Paralympic/Olympic Winter Games (PWG/OWGs) of the 2011-2020 seasons was extracted from the website of the International Paralympic Committee and the International Ski Federation. All individual distance races for female and male visually impaired standing (VI), physically impaired sitting (SIT) and standing (STAND), and AB skiers with ≥10 competitors were included in the analyses. We investigated the main effect of skiing groups (i.e., VI, STAND, SIT, and AB skiers) and sex on RT Results: RT Conclusion: The larger RT
Language	English
Publishing date	2022-02-08
Publishing country	Switzerland
Document type	Journal Article
ISSN	2624-9367
ISSN (online)	2624-9367
DOI	10.3389/fspor.2021.823014
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Article ; Online: Epigenome-wide association study of DNA methylation in maternal blood leukocytes with BMI in pregnancy and gestational weight gain.

Opsahl, J O / Fragoso-Bargas, N / Lee, Y / Carlsen, E Ø / Lekanova, N / Qvigstad, E / Sletner, L / Jenum, A K / Lee-Ødegård, S / Prasad, R B / Birkeland, K I / Moen, G-H / Sommer, C

International journal of obesity (2005)

2024 Volume 48, Issue 4, Page(s) 584–593

MeSH term(s)	Pregnancy ; Child ; Humans ; Female ; DNA Methylation/genetics ; Epigenome ; Body Mass Index ; Cohort Studies ; Gestational Weight Gain/genetics ; Epigenesis, Genetic/genetics ; Leukocytes ; Cardiovascular Diseases/genetics ; Genome-Wide Association Study
Language	English
Publishing date	2024-01-13
Publishing country	England
Document type	Meta-Analysis ; Journal Article
ZDB-ID	752409-2
ISSN	1476-5497 ; 0307-0565
ISSN (online)	1476-5497
ISSN	0307-0565
DOI	10.1038/s41366-024-01458-x
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Article ; Online: Helicobacter pylori in early childhood and asthma in adolescence.

Melby, Kjetil K / Carlsen, Karin L / Håland, Geir / Samdal, Helvi H / Carlsen, Kai-Håkon

BMC research notes

2020 Volume 13, Issue 1, Page(s) 79

Abstract: Objective: An inverse effect of Helicobacter pylori (H. pylori) on the occurrence of asthma is ... debated and early acquisition of H. pylori may be important. We analyzed sera from 197 children ... from Environment and Childhood Asthma (ECA) study in Oslo for Helicobacter pylori (H. pylori) at 2 and 10 years ...

Abstract	Objective: An inverse effect of Helicobacter pylori (H. pylori) on the occurrence of asthma is debated and early acquisition of H. pylori may be important. We analyzed sera from 197 children from Environment and Childhood Asthma (ECA) study in Oslo for Helicobacter pylori (H. pylori) at 2 and 10 years, and symptoms and signs of asthma at 16 years of age. Results: While 16.4% of children who were H. pylori negative at 2 and 10 years had current asthma at 16 years, none of the 12 children who were H. pylori positive at 2 years of age had asthma at the age of 16 years, regardless of H. pylori status at 10 years. This trend for less current asthma in children who were H. pylori positive at 2 years compared to persistent or transient negative status at 10 years was not statistically significant, probably due to low number of H. pylori positive children at 2 years of age. Acquisition of H. pylori in school age did not appear to influence the risk of current asthma. Much larger prospective studies are probably required to document whether or not early H. pylori infection may be involved in the risk of asthma development in later childhood.
MeSH term(s)	Adolescent ; Asthma/blood ; Asthma/epidemiology ; Asthma/microbiology ; Child ; Child, Preschool ; Helicobacter Infections/blood ; Helicobacter Infections/epidemiology ; Helicobacter pylori/physiology ; Humans ; Immunoglobulin G/blood
Chemical Substances	Immunoglobulin G
Language	English
Publishing date	2020-02-18
Publishing country	England
Document type	Journal Article
ZDB-ID	2413336-X
ISSN	1756-0500 ; 1756-0500
ISSN (online)	1756-0500
ISSN	1756-0500
DOI	10.1186/s13104-020-04941-6
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Article ; Online: JFH1-based Core-NS2 genotype variants of HCV with genetic stability in vivo and in vitro: Important tools in evaluation of virus neutralization.

Collignon, Laura / Holmbeck, Kenn / Just, Ashley / Verhoye, Lieven / Velázquez-Moctezuma, Rodrigo / Fahnøe, Ulrik / Carlsen, Thomas H R / Law, Mansun / Prentoe, Jannick / Scheel, Troels K H / Gottwein, Judith M / Meuleman, Philip / Bukh, Jens

Hepatology (Baltimore, Md.)

2024

Abstract: Background aims: HCV infection continues to be a major global health burden, despite effective antiviral treatments. The urgent need for a protective vaccine is hindered by the scarcity of suitable HCV permissive animal models tractable in vaccination ... ...

Abstract	Background aims: HCV infection continues to be a major global health burden, despite effective antiviral treatments. The urgent need for a protective vaccine is hindered by the scarcity of suitable HCV permissive animal models tractable in vaccination and challenge studies. Currently, only antibody neutralization studies in infectious cell culture systems or studies of protection by passive immunization of human-liver chimeric mice offer the possibility to evaluate the effect of vaccine-induced antibodies. However, differences between culture-permissive and in vivo-permissive viruses make it a challenge to compare analyses between platforms. To address this problem, we aimed at developing genotype-specific virus variants with genetic stability both in vitro and in vivo. Approach results: We demonstrated infection of human-liver chimeric mice with cell culture-adapted HCV JFH1-based Core-NS2 recombinants of genotype 1-6, with a panel of 10 virus strains used extensively in neutralization and receptor studies. Clonal re-engineering of mouse-selected mutations resulted in virus variants with robust replication both in Huh7.5 cells and human-liver chimeric mice, with genetic stability. Furthermore, we showed that overall, these virus variants have similar in vitro neutralization profiles as their parent strains and demonstrated their use for in vivo neutralization studies. Conclusions: These mouse-selected HCV recombinants enable triage of new vaccine-relevant antibodies in vitro and further allow characterization of protection from infection in vivo using identical viruses in human-liver chimeric mice. As such, these viruses will serve as important resources in testing novel antibodies and can thus guide strategies to develop an efficient protective vaccine against HCV infection.
Language	English
Publishing date	2024-04-23
Publishing country	United States
Document type	Journal Article
ZDB-ID	604603-4
ISSN	1527-3350 ; 0270-9139
ISSN (online)	1527-3350
ISSN	0270-9139
DOI	10.1097/HEP.0000000000000897
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Zs.A 1660: Show issues

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Article ; Online: Comparison of Physiological and Biomechanical Responses to Flat and Uphill Cross-Country Sit-Skiing in Able-Bodied Athletes.

Carlsen, Camilla H / McGhie, David / Baumgart, Julia K / Sandbakk, Øyvind

International journal of sports physiology and performance

2021 Volume 16, Issue 11, Page(s) 1596–1602

Abstract: Purpose: To compare peak work rate (WRpeak) and associated physiological and biomechanical performance-determining variables between flat and uphill cross-country (XC) sit-skiing.: Methods: Fifteen able-bodied male XC skiers completed 2 test sessions, ...

Abstract	Purpose: To compare peak work rate (WRpeak) and associated physiological and biomechanical performance-determining variables between flat and uphill cross-country (XC) sit-skiing. Methods: Fifteen able-bodied male XC skiers completed 2 test sessions, each comprising four 4-minute submaximal stages, followed by an incremental test to exhaustion and a verification test in a sit-ski on a roller-ski treadmill. The test sessions were counterbalanced by the incline, being either 0.5% (FLAT) or 5% (UPHILL). The authors compared WRpeak and peak oxygen uptake, as well as physiological variables, rating of perceived exertion, gross efficiency, and cycle characteristics at identical submaximal work rate, between FLAT and UPHILL. Results: In UPHILL, WRpeak was 35% higher compared to FLAT (P < .001), despite no difference in peak oxygen uptake (P = .9). The higher WRpeak in UPHILL was achieved through more work per cycle, which was enabled by the twice as long poling time, compared to FLAT (P < .001). Submaximal gross efficiency was 0.5 to 2 percentage points lower in FLAT compared to UPHILL (P < .001), with an increasing difference as work rate increased (P < .001). Neither cycle rate nor work per cycle differed between inclines when compared at identical submaximal work rate (P > .16). Conclusions: The longer poling times utilized in uphill XC sit-skiing enable more work per cycle and better gross efficiency, thereby allowing skiers to achieve a higher WRpeak compared to flat XC sit-skiing. However, the similar values of peak oxygen uptake between inclines indicate that XC sit-skiers can tax their cardiorespiratory capacity similarly in both conditions.
MeSH term(s)	Athletes ; Biomechanical Phenomena ; Exercise Test ; Humans ; Male ; Oxygen Consumption/physiology ; Skiing/physiology
Language	English
Publishing date	2021-04-08
Publishing country	United States
Document type	Journal Article
ISSN	1555-0273
ISSN (online)	1555-0273
DOI	10.1123/ijspp.2020-0752
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Article: Validation of a Digital Headache Calendar at a Tertiary Referral Center.

Kjerrumgaard, Amalie / Hvedstrup, Jeppe / Carlsen, Louise Ninett / Dyre, Kristine / Schytz, Henrik

Diagnostics (Basel, Switzerland)

2023 Volume 14, Issue 1

Abstract: Background: Headache calendars are essential tools in monitoring changes in headache frequency and type. They are used in clinical practice for long-term monitoring, but their validation remains limited. The aim of this study was to validate the use of ... ...

Abstract	Background: Headache calendars are essential tools in monitoring changes in headache frequency and type. They are used in clinical practice for long-term monitoring, but their validation remains limited. The aim of this study was to validate the use of a digital calendar in monitoring single migraine and tension-type headache attacks. Methods: From July 2022 to February 2023, patients diagnosed with migraine and tension-type headache were enrolled. The validation of the digital calendar involved the comparison of self-reported single headache attacks in the digital calendar with the diagnostic headache diary based on the ICHD-3 criteria for migraine and tension-type headache. Sensitivity and specificity were calculated to assess reliability, and the level of agreement was calculated using kappa statistics. Results: This study included 30 patients (87% women) diagnosed with migraine and tension-type headache. The level of agreement in the classification of a single migraine attack revealed a sensitivity of 82% and a specificity of 78%, representing a substantial level of agreement (κ = 0.60). The classification of a single tension-type headache attack revealed a sensitivity of 84% and a specificity of 72%, with a moderate level of agreement (κ = 0.54). Conclusions: The digital calendar proves effective in monitoring single headache attacks in patients with migraine and tension-type headache. In clinical practice, we recommend using the digital calendar as a monitoring tool for headache patients, as they can accurately identify true migraine and tension-type headache days.
Language	English
Publishing date	2023-12-22
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2662336-5
ISSN	2075-4418
ISSN	2075-4418
DOI	10.3390/diagnostics14010021
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Article ; Online: Maximizing Solid Organ and Face Transplant Procurement Team Coordination: The Posterior Tibial Artery Flap as an Ideal Sentinel Flap.

Suchyta, Marissa A / Carlsen, Brian / Bakri, Karim / Amer, Hatem / Mardini, Samir

Mayo Clinic proceedings. Innovations, quality & outcomes

2023 Volume 7, Issue 4, Page(s) 244–247

Abstract: Face transplantation became a reality with the first case performed in 2005. Facial tissue allograft procurement is technically complex and time-intensive. Brain-dead deceased donors are frequently, if not always, multiorgan donors. Every effort should ... ...

Abstract	Face transplantation became a reality with the first case performed in 2005. Facial tissue allograft procurement is technically complex and time-intensive. Brain-dead deceased donors are frequently, if not always, multiorgan donors. Every effort should be made during face allograft recovery to minimize any risk to the recovery of lifesaving solid organs. Some programs require the procurement of a myofascial vascularized skin graft to function as a sentinel flap allowing frequent monitoring for rejection without negatively impacting the esthetics of the face graft. Up till now, the flap used has been the radial forearm flap. Procuring the radial forearm flap places the procuring team in close proximity to the head and torso, where the face recovery and the solid organ recovery teams would require unhindered access. Here, we present the posterior tibial artery flap as an alternative flap that would provide benefits to the coordination of the multiple teams working to procure organs from a deceased donor.
Language	English
Publishing date	2023-06-07
Publishing country	Netherlands
Document type	Journal Article
ISSN	2542-4548
ISSN (online)	2542-4548
DOI	10.1016/j.mayocpiqo.2022.04.006
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Article: Deep postnatal phenotyping of a new mouse model of nonketotic hyperglycinemia.

Swanson, Michael A / Jiang, Hua / Busquet, Nicolas / Carlsen, Jessica / Brindley, Connie / Benke, Tim A / Van Hove, Roxanne A / Friederich, Marisa W / MacLean, Kenneth N / Mesches, Michael H / Van Hove, Johan L K

bioRxiv : the preprint server for biology

2024

Abstract: Nonketotic hyperglycinemia due to deficient glycine cleavage enzyme activity causes a severe neonatal epileptic encephalopathy. Current therapies based on mitigating glycine excess have only limited impact. An animal model with postnatal phenotyping is ... ...

Abstract	Nonketotic hyperglycinemia due to deficient glycine cleavage enzyme activity causes a severe neonatal epileptic encephalopathy. Current therapies based on mitigating glycine excess have only limited impact. An animal model with postnatal phenotyping is needed to explore new therapeutic approaches. We developed a Take home message: A mouse model of nonketotic hyperglycinemia is described that shows postnatal abnormalities in glycine levels, neural tube defects, body weight, electroencephalographic recordings, and in activity in young mice making it amenable for the evaluation of novel treatment interventions. Author contributions: Study concept and design: JVH, MHM, NB, KNMAnimal study data: MAS, HJ, NB, MHM, JC, CBBiochemical and genetic studies: MAS, RAVH, MWFStatistical analysis: NB, JVHFirst draft writing: JVH, NB, MHMCritical rewriting: MAS, NB, MHM, TAB, JC, MWF, KNM, JVHFinal responsibility, guarantor, and communicating author: JVH. Competing interest statement: The University of Colorado (JVH, MS, KNM, HJ) has the intention to file Intellectual property protection for certain biochemical treatments of NKH. Otherwise, the authors have stated that they had no interests that might be perceived as posing a conflict or bias to this subject matter. Funding support: Financial support is acknowledged form the NKH Crusaders, Brodyn's Friends, Nora Jane Almany Foundation, the Dickens Family Foundation, the Lucas John Foundation, Les Petits Bourdons, Joseph's Fund, the Barnett Family, Maud & Vic Foundation, Lucy's BEElievers fund, Hope for NKH, Madi's Mission NKH fund, and from Dr. and Ms. Shaw, and the University of Colorado Foundation NKH research fund. The study was supported by a grant (CNS-X-19-103) from the University of Colorado School of Medicine and the Colorado Clinical Translational Science Institute, which is supported by NIH/NCATS Colorado CTSA Grant Number UL1 TR002535. Contents are the authors' sole responsibility and do not necessarily represent official NIH views. All funding sources had no role in the design or execution of the study, the interpretation of data, or the writing of the study. Ethics approval on laboratory animal studies: Mouse studies were carried out with approval from the Institutional Animal Care and Use Committee of the University of Colorado Anschutz Medical Campus (IACUC# 00413). Data sharing statement: The data that support the findings of this study are available from the corresponding author upon reasonable request.
Language	English
Publishing date	2024-03-29
Publishing country	United States
Document type	Preprint
DOI	10.1101/2024.03.26.586818
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Article ; Online: Helicobacter pylori in early childhood and asthma in adolescence

Kjetil K. Melby / Karin L. Carlsen / Geir Håland / Helvi H. Samdal / Kai-Håkon Carlsen

BMC Research Notes, Vol 13, Iss 1, Pp 1-

2020 Volume 4

Abstract: Abstract Objective An inverse effect of Helicobacter pylori (H. pylori) on the occurrence of asthma ... is debated and early acquisition of H. pylori may be important. We analyzed sera from 197 children ... from Environment and Childhood Asthma (ECA) study in Oslo for Helicobacter pylori (H. pylori) at 2 and 10 years ...

Abstract	Abstract Objective An inverse effect of Helicobacter pylori (H. pylori) on the occurrence of asthma is debated and early acquisition of H. pylori may be important. We analyzed sera from 197 children from Environment and Childhood Asthma (ECA) study in Oslo for Helicobacter pylori (H. pylori) at 2 and 10 years, and symptoms and signs of asthma at 16 years of age. Results While 16.4% of children who were H. pylori negative at 2 and 10 years had current asthma at 16 years, none of the 12 children who were H. pylori positive at 2 years of age had asthma at the age of 16 years, regardless of H. pylori status at 10 years. This trend for less current asthma in children who were H. pylori positive at 2 years compared to persistent or transient negative status at 10 years was not statistically significant, probably due to low number of H. pylori positive children at 2 years of age. Acquisition of H. pylori in school age did not appear to influence the risk of current asthma. Much larger prospective studies are probably required to document whether or not early H. pylori infection may be involved in the risk of asthma development in later childhood.
Keywords	Anti H. pylori IgG antibodies ; Asthma in adolescence ; Cohort study ; H. pylori carriage in children and adolescence ; Helicobacter pylori ; Medicine ; R ; Biology (General) ; QH301-705.5 ; Science (General) ; Q1-390
Language	English
Publishing date	2020-02-01T00:00:00Z
Publisher	BMC
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: The breathless adolescent asthmatic athlete.

Carlsen, K-H

The European respiratory journal

2011 Volume 38, Issue 3, Page(s) 713–720

Abstract: This article concerns physical activity and sports in asthmatic adolescents. Exercise-induced asthma (EIA) is found in 8-10% of the normal child population and in ∼35% of children with current asthma, as reported in a population-based birth cohort study. ...

Abstract	This article concerns physical activity and sports in asthmatic adolescents. Exercise-induced asthma (EIA) is found in 8-10% of the normal child population and in ∼35% of children with current asthma, as reported in a population-based birth cohort study. The mechanisms of EIA are related to markedly increased ventilation during exercise, which causes increased heat and water loss through respiration, leading to bronchial constriction. In athletes and especially in endurance athletes, the repeated daily physical activity during training will, over time, cause epithelial damage and increase inflammation in the respiratory mucosa. With increased exposure to environmental agents, such as as cold air in skiers and chlorine compounds in swimmers, the athlete may contract symptoms and signs of asthma and bronchial hyperresponsiveness, either worsening existing asthma or causing symptoms in a previous healthy adolescent athlete. There are several causes of breathlessness in adolescents, including EIA, vocal cord dysfunction, poor physical fitness and others, which are important to consider in the diagnostic procedure. The asthmatic athlete should follow the same guidelines for treating their asthma as an ordinary asthmatic patient, with careful consideration of the special diagnostic rules given for the use of asthma drugs in sports, especially for inhaled β(2)-agonists.
MeSH term(s)	Adolescent ; Adrenergic beta-2 Receptor Agonists/therapeutic use ; Asthma, Exercise-Induced/physiopathology ; Asthma, Exercise-Induced/therapy ; Athletes ; Child ; Cohort Studies ; Dyspnea/drug therapy ; Environmental Exposure ; Exercise ; Female ; Humans ; Inflammation ; Male ; Pulmonary Medicine/methods ; Respiration ; Respiratory Mucosa/pathology ; Treatment Outcome
Chemical Substances	Adrenergic beta-2 Receptor Agonists
Language	English
Publishing date	2011-09
Publishing country	England
Document type	Journal Article ; Review
ZDB-ID	639359-7
ISSN	1399-3003 ; 0903-1936
ISSN (online)	1399-3003
ISSN	0903-1936
DOI	10.1183/09031936.00068510
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