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Article ; Online: Allograft nephrectomy vs. no nephrectomy for failed renal transplants.

McDonald, Michelle

Frontiers in nephrology

2023 Volume 3, Page(s) 1169181

Abstract: The role of allograft nephrectomy (AN) in failed renal transplants is a topic of debate, owing to controversial results reported in the literature and the fact that most of the studies are limited by a retrospective design and small numbers of ... ...

Abstract	The role of allograft nephrectomy (AN) in failed renal transplants is a topic of debate, owing to controversial results reported in the literature and the fact that most of the studies are limited by a retrospective design and small numbers of participants. Allograft nephrectomy is most likely of benefit in the patient with recurrent allograft intolerance syndrome (AIS) following pulse steroids. Immunosuppression weaning in the presence of clinical signs related to a chronic inflammatory state is also reasonable grounds to pursue AN. Studies are mainly inconclusive but suggest that AN has no overall benefit for allograft survival after retransplant. This topic is still of interest in the transplant field and is particularly relevant for patients who are likely to require retransplantation within their lifetime. Further assessment is needed in the form of randomized controlled trials that control for various AN indications and immunosuppression regimens, and have clearly defined survival outcomes.
Language	English
Publishing date	2023-07-20
Publishing country	Switzerland
Document type	Journal Article ; Review
ISSN	2813-0626
ISSN (online)	2813-0626
DOI	10.3389/fneph.2023.1169181
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Article ; Online: Letter to the Editor:

Brown, Robert E / McDonald, Michelle M / Ghosh, Anindita

Annals of clinical and laboratory science

2021 Volume 51, Issue 1, Page(s) 145–146

MeSH term(s)	COVID-19/complications ; COVID-19/pathology ; Cytokine Release Syndrome/virology ; Humans ; Interleukin-6/metabolism ; Molecular Targeted Therapy ; Phosphorylation ; Proteomics ; STAT3 Transcription Factor/metabolism ; Thrombosis/virology ; Viral Load
Chemical Substances	Interleukin-6 ; STAT3 Transcription Factor
Language	English
Publishing date	2021-03-02
Publishing country	United States
Document type	Journal Article
ZDB-ID	193092-8
ISSN	1550-8080 ; 0091-7370 ; 0095-8905
ISSN (online)	1550-8080
ISSN	0091-7370 ; 0095-8905
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Zs.A 942: Show issues

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Article ; Online: The performance of artificial intelligence chatbot large language models to address skeletal biology and bone health queries.

Cung, Michelle / Sosa, Branden / Yang, He S / McDonald, Michelle M / Matthews, Brya G / Vlug, Annegreet G / Imel, Erik A / Wein, Marc N / Stein, Emily Margaret / Greenblatt, Matthew B

Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research

2024

Abstract: Artificial intelligence (AI) chatbots utilizing large language models (LLMs) have recently garnered significant interest due to their ability to generate humanlike responses to user inquiries in an interactive dialog format. While these models are being ... ...

Abstract	Artificial intelligence (AI) chatbots utilizing large language models (LLMs) have recently garnered significant interest due to their ability to generate humanlike responses to user inquiries in an interactive dialog format. While these models are being increasingly utilized to obtain medical information by patients, scientific and medical providers, and trainees to address biomedical questions, their performance may vary from field to field. The opportunities and risks these chatbots pose to the widespread understanding of skeletal health and science are unknown. Here we assess the performance of 3 high-profile LLM chatbots, Chat Generative Pre-Trained Transformer (ChatGPT) 4.0, BingAI, and Bard, to address 30 questions in 3 categories: basic and translational skeletal biology, clinical practitioner management of skeletal disorders, and patient queries to assess the accuracy and quality of the responses. Thirty questions in each of these categories were posed, and responses were independently graded for their degree of accuracy by four reviewers. While each of the chatbots was often able to provide relevant information about skeletal disorders, the quality and relevance of these responses varied widely, and ChatGPT 4.0 had the highest overall median score in each of the categories. Each of these chatbots displayed distinct limitations that included inconsistent, incomplete, or irrelevant responses, inappropriate utilization of lay sources in a professional context, a failure to take patient demographics or clinical context into account when providing recommendations, and an inability to consistently identify areas of uncertainty in the relevant literature. Careful consideration of both the opportunities and risks of current AI chatbots is needed to formulate guidelines for best practices for their use as source of information about skeletal health and biology.
Language	English
Publishing date	2024-01-04
Publishing country	England
Document type	Journal Article
ZDB-ID	632783-7
ISSN	1523-4681 ; 0884-0431
ISSN (online)	1523-4681
ISSN	0884-0431
DOI	10.1093/jbmr/zjad007
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Zs.A 2142: Show issues

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Article ; Online: New Horizons: Translational Aspects of Osteomorphs.

Park-Min, Kyung-Hyun / Mun, Se Hwan / Bockman, Richard / McDonald, Michelle M

The Journal of clinical endocrinology and metabolism

2023 Volume 109, Issue 5, Page(s) e1373–e1378

Abstract: Osteomorphs are a newly described osteoclast lineage cell in mice, which are suggested to play a significant role in the maintenance of bone resorption. Preclinical investigations revealed that osteomorphs are generated through the fission of ... ...

Abstract	Osteomorphs are a newly described osteoclast lineage cell in mice, which are suggested to play a significant role in the maintenance of bone resorption. Preclinical investigations revealed that osteomorphs are generated through the fission of multinucleated bone-resorbing osteoclasts and can also re-fuse with existing osteoclasts. Modifications to RANKL signaling have been shown to alter cycles of fission and re-fusion of osteomorphs in mice. These novel findings were also shown to contribute to the rebound phenomenon after cessation of anti-RANKL therapy in mice. Moreover, the absence of osteomorph-specific genes in mice exhibits bone structural and quality phenotypes. Given these insights, it could be speculated that osteomorphs play a significant role in bone homeostasis, bone metabolic diseases, and response to therapeutics. In this review, we discuss these potential translational roles for osteomorphs. Importantly, we highlight the need for future preclinical and clinical studies to verify the presence of osteomorphs in humans and explore further the translational implications of this discovery.
MeSH term(s)	Humans ; Animals ; Mice ; Osteoclasts/metabolism ; Bone Resorption/metabolism ; Bone and Bones/metabolism ; RANK Ligand/metabolism ; Cell Differentiation
Chemical Substances	RANK Ligand
Language	English
Publishing date	2023-12-06
Publishing country	United States
Document type	Review ; Journal Article
ZDB-ID	3029-6
ISSN	1945-7197 ; 0021-972X
ISSN (online)	1945-7197
ISSN	0021-972X
DOI	10.1210/clinem/dgad711
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Uh III Zs.134: Show issues

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Article ; Online: Osteoclast Recycling and the Rebound Phenomenon Following Denosumab Discontinuation.

Kim, Albert S / Girgis, Christian M / McDonald, Michelle M

Current osteoporosis reports

2022 Volume 20, Issue 6, Page(s) 505–515

Abstract: Purpose of review: Inhibition of receptor activator of nuclear factor kappa-B ligand (RANKL) with denosumab is an effective treatment in a number of conditions including osteoporosis where suppression of bone resorption is desired. However, denosumab ... ...

Abstract	Purpose of review: Inhibition of receptor activator of nuclear factor kappa-B ligand (RANKL) with denosumab is an effective treatment in a number of conditions including osteoporosis where suppression of bone resorption is desired. However, denosumab discontinuation is associated with rebound increase in bone resorption and subsequent loss in bone mass and a rapid return to baseline fracture risk. We review recent data on the rebound increase in bone resorption following denosumab discontinuation and the potential mechanisms behind this phenomenon. Recent findings: Osteoclasts have been considered to be highly specialised cells that undergo apoptosis after fulfilling their function of bone resorption. However, recent studies suggest that osteoclasts are longer lived cells which migrate through vasculature and are capable of undergoing fission into a novel cell type (the osteomorph) and re-fusion in a process termed osteoclast recycling. The life cycle of the osteoclast is more complex than previously appreciated. Osteoclast recycling provides a novel mechanistic framework to examine changes in osteoclast biology in response to treatment of bone diseases and provides an exciting new avenue towards personalised medicine.
MeSH term(s)	Humans ; Osteoclasts ; Denosumab/pharmacology ; Denosumab/therapeutic use ; RANK Ligand ; Bone Resorption/drug therapy ; Osteoporosis/drug therapy
Chemical Substances	Denosumab (4EQZ6YO2HI) ; RANK Ligand
Language	English
Publishing date	2022-10-06
Publishing country	United States
Document type	Journal Article ; Review ; Research Support, Non-U.S. Gov't
ZDB-ID	2186581-4
ISSN	1544-2241 ; 1544-1873
ISSN (online)	1544-2241
ISSN	1544-1873
DOI	10.1007/s11914-022-00756-5
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Zs.A 6146: Show issues

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Article ; Online: Empathy across the ages: "I may be older but I'm still feeling it".

Kelly, Michelle / McDonald, Skye / Wallis, Kimberley

Neuropsychology

2021 Volume 36, Issue 2, Page(s) 116–127

Abstract: Objective: Empathy is the ability to understand and respond to another person's experience and is an important skill for maintaining good relationships across the lifespan. Past research has predominately relied on self-report measures of : Method: ... ...

Abstract	Objective: Empathy is the ability to understand and respond to another person's experience and is an important skill for maintaining good relationships across the lifespan. Past research has predominately relied on self-report measures of Method: Two-hundred and thirty-one adults aged 17-94 years were administered behavioral measures of cognitive and affective empathy alongside traditional trait measures. We also examined the potential impact of advancing age on inhibition of self-relevant information and the relationship between this and the cognitive, affective and motivational components of empathic ability. Results: Age was not a predictor of either Conclusions: The relationship between advancing age and empathic skills is complex, with age possibly conferring both advantages and disadvantages. Inhibition should be examined alongside other general cognitive skills in future studies investigating empathy using behavioural measures. (PsycInfo Database Record (c) 2022 APA, all rights reserved).
MeSH term(s)	Adolescent ; Adult ; Aged ; Aged, 80 and over ; Aging ; Cognition ; Emotions ; Empathy ; Humans ; Middle Aged ; Self Report ; Young Adult
Language	English
Publishing date	2021-12-23
Publishing country	United States
Document type	Journal Article
ZDB-ID	1042412-x
ISSN	1931-1559 ; 0894-4105
ISSN (online)	1931-1559
ISSN	0894-4105
DOI	10.1037/neu0000783
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Zs.A 3002: Show issues

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Article ; Online: Visualisation of tumour cells in bone in vivo at single-cell resolution.

Chai, Ryan C / McDonald, Michelle M

Bone

2021 Volume 158, Page(s) 116113

Abstract: The skeleton is a common site for the establishment of distant metastases. Once cancers occupy bone, the prognosis is poor as disease recurrence and visceral spread is imminent. Understanding the pathways and cellular interactions, which regulate tumour ... ...

Abstract	The skeleton is a common site for the establishment of distant metastases. Once cancers occupy bone, the prognosis is poor as disease recurrence and visceral spread is imminent. Understanding the pathways and cellular interactions, which regulate tumour cell seeding, dormancy and growth in bone, is pertinent to improving outcomes for patients with advanced cancers. Advances in imaging techniques have facilitated the development of the concept that the behavior of bone marrow resident cells dictates the fate of tumour cells upon arrival in bone. This review summarises recent findings achieved through intravital imaging. It highlights the importance of developing both longitudinal static and acute dynamic data to develop our understanding of tumour cell engraftment, dormancy, activation and the subsequent establishment of metastases. We also describe how imaging techniques have developed our knowledge of the elements that make up the complex bone microenvironment which tumour cells interact with to survive and grow. We also discuss how through combining these imaging insights with single cell RNA sequencing data, we are entering a new era of research which has the power to define the cell-cell interactions which control tumour cell growth in bone.
MeSH term(s)	Bone Neoplasms/diagnostic imaging ; Bone Neoplasms/pathology ; Cell Count ; Humans ; Neoplasms/pathology ; Prognosis ; Radiopharmaceuticals ; Tumor Microenvironment
Chemical Substances	Radiopharmaceuticals
Language	English
Publishing date	2021-07-15
Publishing country	United States
Document type	Journal Article ; Review ; Research Support, Non-U.S. Gov't
ZDB-ID	632515-4
ISSN	1873-2763 ; 8756-3282
ISSN (online)	1873-2763
ISSN	8756-3282
DOI	10.1016/j.bone.2021.116113
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Zs.A 1571: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (1.OG) ab Jg. 2022: Lesesaal (EG)
Zs.MO 332: Show issues

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Article ; Online: Corrigendum to "Tyrphostin reduces the organ injury in haemorrhagic shock: Role of inducible nitric oxide synthase" [Resuscitation 58(3) (2003) 349-361].

McDonald, Michelle / Abdelrahman, Maha / Cuzzocrea, Salvatore / Thiemermann, Christoph

Resuscitation

2024 Volume 198, Page(s) 110170

Language	English
Publishing date	2024-03-11
Publishing country	Ireland
Document type	Published Erratum
ZDB-ID	189901-6
ISSN	1873-1570 ; 0300-9572
ISSN (online)	1873-1570
ISSN	0300-9572
DOI	10.1016/j.resuscitation.2024.110170
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Zs.A 1048: Show issues

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Article ; Online: Increased Bone Formation and Accelerated Bone Mass Accrual in a Man Presenting with Diffuse Osteosclerosis/High Bone Mass Phenotype and Adenocarcinoma of Unknown Primary.

Diamond, Terrence H / Bryant, Carl / Quinn, Richard / Mohanty, Sindhu T / Bonar, Fiona / Baldock, Paul A / McDonald, Michelle M

JBMR plus

2023 Volume 7, Issue 8, Page(s) e10734

Abstract: A 71-year-old man was referred for evaluation of incidental generalized osteosclerosis. He was found to have a high bone mass (HBM) with an elevated lumbar spine bone mineral density (BMD) Z-score of +5.3. Over an 18-month period, his lumbar spine BMD ... ...

Abstract	A 71-year-old man was referred for evaluation of incidental generalized osteosclerosis. He was found to have a high bone mass (HBM) with an elevated lumbar spine bone mineral density (BMD) Z-score of +5.3. Over an 18-month period, his lumbar spine BMD measured by dual energy X-ray absorptiometry (DXA) had increased by +64% from 1.09 to 1.79 g/cm
Language	English
Publishing date	2023-06-14
Publishing country	England
Document type	Case Reports
ISSN	2473-4039
ISSN (online)	2473-4039
DOI	10.1002/jbm4.10734
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Article ; Online: The Congenital Syphilis Prevention Cascade: Reimagining a Missed Prevention Opportunities Framework for Effective Intervention.

O'Callaghan, Kevin P / Johnson Jones, Michelle L / McDonald, Robert / Jackson, David A / Grey, Jeremy A / Kreisel, Kristen M / Torrone, Elizabeth

Sexually transmitted diseases

2023 Volume 51, Issue 1, Page(s) 8–10

Abstract: Abstract: Congenital syphilis (CS) rates have risen in the United States since 2013. Prevention of CS requires testing and treatment of pregnant and pregnancy-capable persons at high risk for syphilis. We developed a CS Prevention Cascade to assess how ... ...

Abstract	Abstract: Congenital syphilis (CS) rates have risen in the United States since 2013. Prevention of CS requires testing and treatment of pregnant and pregnancy-capable persons at high risk for syphilis. We developed a CS Prevention Cascade to assess how effectively testing and treatment interventions reached pregnant persons with a CS outcome.
MeSH term(s)	Pregnancy ; Female ; Humans ; United States/epidemiology ; Syphilis, Congenital/epidemiology ; Syphilis, Congenital/prevention & control ; Pregnancy Complications, Infectious/diagnosis ; Pregnancy Complications, Infectious/prevention & control ; Infectious Disease Transmission, Vertical/prevention & control ; Syphilis/diagnosis ; Syphilis/epidemiology ; Syphilis/prevention & control
Language	English
Publishing date	2023-10-30
Publishing country	United States
Document type	Journal Article
ZDB-ID	435191-5
ISSN	1537-4521 ; 0148-5717
ISSN (online)	1537-4521
ISSN	0148-5717
DOI	10.1097/OLQ.0000000000001892
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Zs.A 1217: Show issues

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