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  1. Article ; Online: Recent Advances in the Total Synthesis of Spirotryprostatin Alkaloids.

    Hu, Jing / Niu, Zhen-Xi / Wang, Jun-Feng

    Molecules (Basel, Switzerland)

    2024  Volume 29, Issue 7

    Abstract: Spirotryprostatin alkaloids, a class of alkaloids with a unique spirocyclic indoledionepiperazine structure, were first extracted from the fermentation broth of Aspergillus fumigatus and have garnered significant attention in the fields of biology and ... ...

    Abstract Spirotryprostatin alkaloids, a class of alkaloids with a unique spirocyclic indoledionepiperazine structure, were first extracted from the fermentation broth of Aspergillus fumigatus and have garnered significant attention in the fields of biology and pharmacology. The investigation into the pharmacological potential of this class of alkaloids has unveiled promising applications in drug discovery and development. Notably, certain spirotryprostatin alkaloids have demonstrated remarkable anti-cancer activity, positioning them as potential candidates for anti-tumor drug development. In recent years, organic synthetic chemists have dedicated efforts to devise efficient and viable strategies for the total synthesis of spirotryprostatin alkaloids, aiming to meet the demands within the pharmaceutical domain. The construction of the spiro-C atom within the spirotryprostatin scaffold and the chirality control at the spiro atomic center emerge as pivotal aspects in the synthesis of these compounds. This review categorically delineates the synthesis of spirotryprostatin alkaloids based on the formation mechanism of the spiro-C atom.
    MeSH term(s) Fermentation ; Alkaloids ; Aspergillus fumigatus ; Drug Discovery
    Chemical Substances Alkaloids
    Language English
    Publishing date 2024-04-07
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 1413402-0
    ISSN 1420-3049 ; 1431-5165 ; 1420-3049
    ISSN (online) 1420-3049
    ISSN 1431-5165 ; 1420-3049
    DOI 10.3390/molecules29071655
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.MO 81: Show issues

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  2. Article ; Online: Advances in the diagnosis and treatment of multiple primary lung cancers.

    Huang, Yu / Zhang, Hai-Mei / Cai, Hua-Rong / Hu, Jun-Feng

    Asian journal of surgery

    2024  

    Language English
    Publishing date 2024-03-27
    Publishing country Netherlands
    Document type Letter
    ZDB-ID 1068461-x
    ISSN 0219-3108 ; 1015-9584
    ISSN (online) 0219-3108
    ISSN 1015-9584
    DOI 10.1016/j.asjsur.2024.03.022
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.B 2831: Show issues Location:
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  3. Book: China's agriculture and rural development in the post-reform era

    Feng, Jun / Youming, Wang / Yunchao, Hu / Ji, Yu

    (Understanding modern china)

    2017  

    Author's details by Feng Jun, Wang Youming, Hu Yunchao and Yu Ji
    Series title Understanding modern china
    Language English
    Size XIV, 114 Seiten, Illustrationen
    Publisher ACA Publishing
    Publishing place London
    Publishing country Great Britain
    Document type Book
    HBZ-ID HT019455116
    ISBN 978-1-910760-11-6 ; 1-910760-11-0
    Database Catalogue ZB MED Nutrition, Environment, Agriculture

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    In stock of ZB MED Bonn / Germany

    Shelf markLoan statusLocation
    178/439 available for loan (reading room) Freihandmagazin (U1)

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  4. Article ; Online: Piezoelectric manipulation of spin-orbit coupling in a Wurtzite heterostructure.

    Hu, Gongwei / Huang, Fobao / Liu, Jun-Feng

    Physical chemistry chemical physics : PCCP

    2023  Volume 25, Issue 34, Page(s) 23001–23011

    Abstract: The combination of piezoelectricity and spin-orbit coupling (SOC) effect makes wurtzite semiconductors attractive for the development of exotic spin-related physics as well as spintronic applications. Triggering piezoelectricity, particularly by an ... ...

    Abstract The combination of piezoelectricity and spin-orbit coupling (SOC) effect makes wurtzite semiconductors attractive for the development of exotic spin-related physics as well as spintronic applications. Triggering piezoelectricity, particularly by an external stimulus, provides a new perspective for manipulating SOC, but until now, a comprehensive understanding of this mechanism is lacking. Herein, by means of self-consistent calculations and Löwdin perturbation approach, we have explored the manipulation of SOC in the wurtzite (Al, Ga)N/GaN heterostructure by external stress-induced piezoelectric polarization. The results suggest that the Rashba SOC depends weakly on stress due to the wide-gap feature of the wurtzite crystal that makes Rashba SOC predominant by a bulk term instead of the structural inversion term. The piezoelectric polarization diminishes and even turns off Dresselhaus coupling by reducing the interfacial electric field. Moreover, piezoelectricity is shown to improve the poorly gate-tunable SOC. In the heterostructure with two occupied subbands, the Dresselhaus coupling of the second subband is more sensitive than the first one in response to stress. As an extension, we further demonstrate that the correlation effect in the wurtzite heterostructure can be significantly enhanced by piezoelectric polarization. This study offers an in-depth insight into piezoelectric modulation of spin-orbit physics, which has the potential for stimulating new quantum correlation states or designing functional spintronic devices.
    Language English
    Publishing date 2023-08-30
    Publishing country England
    Document type Journal Article
    ZDB-ID 1476244-4
    ISSN 1463-9084 ; 1463-9076
    ISSN (online) 1463-9084
    ISSN 1463-9076
    DOI 10.1039/d3cp02902f
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article: A mouthpart transcriptome for

    Dong, Jun-Feng / Hu, Zhen-Jie / Dong, Bing-Xin / Tian, Cai-Hong

    Frontiers in physiology

    2023  Volume 14, Page(s) 1193085

    Abstract: Moth mouthparts, consisting of labial palps and proboscis, not only are the feeding device but also are chemosensory organs for the detection of chemical signals from surrounding environment. Up to now, the chemosensory systems in the mouthpart of moths ... ...

    Abstract Moth mouthparts, consisting of labial palps and proboscis, not only are the feeding device but also are chemosensory organs for the detection of chemical signals from surrounding environment. Up to now, the chemosensory systems in the mouthpart of moths are largely unknown. Here, we performed systematic analyses of the mouthpart transcriptome of adult
    Language English
    Publishing date 2023-04-25
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2564217-0
    ISSN 1664-042X
    ISSN 1664-042X
    DOI 10.3389/fphys.2023.1193085
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Evaluation of virulence of Klebsiella pneumoniae using zebrafish behavior as a biological indicator.

    Shen, Lan-Feng / He, Tian / Zhuang, Jia-Ru / Hu, Xi-Chi / Rui, Xiao-Hong / Huang, Jun / Bao, Jun-Feng / Hu, Ren-Jing

    Journal of infection and chemotherapy : official journal of the Japan Society of Chemotherapy

    2023  Volume 29, Issue 12, Page(s) 1145–1151

    Abstract: Introduction: Klebsiella pneumoniae is one of the common pathogenic bacteria that can cause infections in hospitals and communities and can cause respiratory, urinary, and other multi-system infections. In recent years, the emergence of highly virulent ... ...

    Abstract Introduction: Klebsiella pneumoniae is one of the common pathogenic bacteria that can cause infections in hospitals and communities and can cause respiratory, urinary, and other multi-system infections. In recent years, the emergence of highly virulent and drug-resistant Klebsiella pneumoniae has greatly increased the difficulty of treatment for infection. Clinically, it is very important to accurately judge the virulence of isolated Klebsiella pneumoniae for treatment, but there is no better method to evaluate its virulence.
    Methods: In this study, zebrafish were used as a model organism, and the swimming distance was used as a detection index to identify clinically isolated Klebsiella pneumoniae. In this study, we selected two different strains of Klebsiella pneumoniae, i.e., NTUH-K2044 and ATCC BAA-1705, with known high and low virulence, respectively, to infect zebrafish juveniles and evaluated their behavioral ability according to different bacterial concentrations and different developmental times.
    Results: It was found that highly virulent Klebsiella pneumoniae caused a significant decrease in the behavioral ability of zebrafish larvae, while low-virulence Klebsiella pneumoniae had relatively little effect.
    Conclusions: These results indicate that it is entirely feasible to assess the virulence of Klebsiella pneumoniae based on behavioral ability.
    Language English
    Publishing date 2023-08-22
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 1355399-9
    ISSN 1437-7780 ; 1341-321X
    ISSN (online) 1437-7780
    ISSN 1341-321X
    DOI 10.1016/j.jiac.2023.08.014
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 5236: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
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  7. Article ; Online: High-sensitivity silicon carbide divacancy-based temperature sensing.

    Luo, Qin-Yue / Zhao, Shuang / Hu, Qi-Cheng / Quan, Wei-Ke / Zhu, Zi-Qi / Li, Jia-Jun / Wang, Jun-Feng

    Nanoscale

    2023  Volume 15, Issue 18, Page(s) 8432–8436

    Abstract: Color centers in silicon carbide have become potentially versatile quantum sensors. Particularly, wide temperature-range temperature sensing has been realized in recent years. However, the sensitivity is limited due to the short dephasing time of the ... ...

    Abstract Color centers in silicon carbide have become potentially versatile quantum sensors. Particularly, wide temperature-range temperature sensing has been realized in recent years. However, the sensitivity is limited due to the short dephasing time of the color centers. In this work, we developed a high-sensitivity silicon carbide divacancy-based thermometer using the thermal Carr-Purcell-Meiboom-Gill (TCPMG) method. First, the zero-field splitting
    Language English
    Publishing date 2023-05-11
    Publishing country England
    Document type Journal Article
    ZDB-ID 2515664-0
    ISSN 2040-3372 ; 2040-3364
    ISSN (online) 2040-3372
    ISSN 2040-3364
    DOI 10.1039/d3nr00430a
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article: Total cucurbitacins from

    Liu, Wen-Ya / Xu, Di / Hu, Zi-Yun / Meng, Hui-Hui / Zheng, Qi / Wu, Feng-Ye / Feng, Xin / Wang, Jun-Song

    Frontiers in pharmacology

    2024  Volume 15, Page(s) 1344983

    Abstract: The pericarp ... ...

    Abstract The pericarp of
    Language English
    Publishing date 2024-02-22
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2587355-6
    ISSN 1663-9812
    ISSN 1663-9812
    DOI 10.3389/fphar.2024.1344983
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: The association between flavonoids intake and hypertension in U.S. adults: A cross-sectional study from The National Health and Nutrition Examination Survey.

    Hu, Ben / Wang, Yan / Feng, Jun / Hou, Linlin

    Journal of clinical hypertension (Greenwich, Conn.)

    2024  

    Abstract: Although in vitro experiments have demonstrated the potential of flavonoid compounds in regulating blood pressure, there is still a lack of evidence from large population studies. We conducted a cross-sectional study using the National Health and ... ...

    Abstract Although in vitro experiments have demonstrated the potential of flavonoid compounds in regulating blood pressure, there is still a lack of evidence from large population studies. We conducted a cross-sectional study using the National Health and Nutrition Examination Survey to investigate the relationship between flavonoid intake levels (natural log transformation) and hypertension events. A total of 15 752 participants aged over 20 years were included, and a weighted multivariable logistic regression analysis was performed to explore the relationship between total flavonoids, five sub types intake, and hypertension events. Smooth curve fitting was used to explore potential nonlinear relationships. Higher total flavonoids intake was associated with a lower risk of hypertension than the lowest group. The adjusted odds ratios (95% CIs) were 0.79 (0.70-0.88) for total flavonoids intake. Elevated total flavonoids intake levels were significantly and linearly associated with a lower risk of hypertension. For each unit increase in the total flavonoids intake level, the adjusted ORs for risk of hypertension decrease by 5% (OR 0.95; 95% CI, 0.92-0.98). In addition, in restricted cubic spline regression, we found that flavan-3-ols, anthocyanidins, and flavonols intake were linearly and negatively related to prevalence of hypertension. Flavones intake showed nonlinear associations with prevalence of hypertension with inflection points of -1.90. Within a certain range, a negative correlation exists between flavonoids intake and hypertension events. This finding provides insights into dietary modifications in the prevention of hypertension.
    Language English
    Publishing date 2024-04-17
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2077222-1
    ISSN 1751-7176 ; 1524-6175
    ISSN (online) 1751-7176
    ISSN 1524-6175
    DOI 10.1111/jch.14807
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 5723: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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  10. Article: Case report: Recreational nitrous oxide abuse triggered peripheral neuropathy possibly through the immune-mediated pathogenesis.

    Dong, Mei-Xue / Wang, Qing / Xu, Jun-Feng / Hu, Ling / Yu, Ying / Li, Tao

    Frontiers in neurology

    2022  Volume 13, Page(s) 1033327

    Abstract: Nitrous oxide ( ... ...

    Abstract Nitrous oxide (N
    Language English
    Publishing date 2022-11-14
    Publishing country Switzerland
    Document type Case Reports
    ZDB-ID 2564214-5
    ISSN 1664-2295
    ISSN 1664-2295
    DOI 10.3389/fneur.2022.1033327
    Database MEDical Literature Analysis and Retrieval System OnLINE

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