LIVIVO - Search results -

Search results

Result 1 - 10 of total 32

Search options

Article ; Online: Immunomodulatory effects of colchicine on peripheral blood mononuclear cell subpopulations in human obesity: Data from a randomized controlled trial.

Patel, Tushar P / Levine, Jordan A / Elizondo, Diana M / Arner, Brooke E / Jain, Arad / Saxena, Ankit / Lopez-Ocasio, Maria / Dagur, Pradeep K / Famuyiwa, Olufisola / Gupta, Suryaa / Sarrafan-Chaharsoughi, Zahra / Biancotto, Angelique / McCoy, J Philip / Demidowich, Andrew P / Yanovski, Jack A

Obesity (Silver Spring, Md.)

2023 Volume 31, Issue 2, Page(s) 466–478

Abstract: Objective: Colchicine is known to reduce inflammation and improve endothelial cell function and atherosclerosis in obesity, but there is little knowledge of the specific circulating leukocyte populations that are modulated by colchicine.: Methods: A ... ...

Abstract	Objective: Colchicine is known to reduce inflammation and improve endothelial cell function and atherosclerosis in obesity, but there is little knowledge of the specific circulating leukocyte populations that are modulated by colchicine. Methods: A secondary analysis of a double-blind randomized controlled trial of colchicine 0.6 mg or placebo twice daily for 3 months on circulating leukocyte populations and regulation of the immune secretome in 35 adults with obesity was performed. Results: Colchicine altered multiple innate immune cell populations, including dendritic cells and lymphoid progenitor cells, monocytes, and natural killer cells when compared with placebo. Among all subjects and within the colchicine group, changes in natural killer cells were significantly positively associated with reductions in biomarkers of inflammation, including cyclooxygenase 2, pulmonary surfactant-associated protein D, myeloperoxidase, proteinase 3, interleukin-16, and resistin. Changes in dendritic cells were positively correlated with changes in serum heart-type fatty acid-binding protein concentrations. Additionally, colchicine treatment reduced cluster of differentiation (CD) CD4+ T effector cells and CD8+ T cytotoxic cells. Conversely, colchicine increased CD4+ and CD8+ T central memory cells and activated CD38 Conclusions: In adults with obesity, colchicine significantly affects circulating leukocyte populations involved in both innate and adaptive immune systems along with the associated inflammatory secretome.
MeSH term(s)	Adult ; Humans ; Colchicine/pharmacology ; Colchicine/therapeutic use ; Leukocytes, Mononuclear ; Obesity/complications ; Inflammation/metabolism ; Fatty Acid-Binding Proteins/therapeutic use
Chemical Substances	Colchicine (SML2Y3J35T) ; Fatty Acid-Binding Proteins
Language	English
Publishing date	2023-01-11
Publishing country	United States
Document type	Randomized Controlled Trial ; Journal Article ; Research Support, N.I.H., Intramural
ZDB-ID	2230457-5
ISSN	1930-739X ; 1071-7323 ; 1930-7381
ISSN (online)	1930-739X
ISSN	1071-7323 ; 1930-7381
DOI	10.1002/oby.23632
Database	MEDical Literature Analysis and Retrieval System OnLINE

In stock of ZB MED Cologne/Königswinter

Zs.A 4061: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (2.OG) ab Jg. 2022: Lesesaal (EG)
Zs.MG 87: Show issues

Order via subito

This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

Details ▾
- See ZB MED holdings
- Order with fees

Article ; Online: Association between radioulnar impingement and salvage surgical procedures of the distal radioulnar joint: influence of confounding variables.

Hernández-Cortés, Pedro / Catena, Andrés / Hernández-Peregrina, Pedro / Elizondo-Espósito, Diana / Pajares-López, Miguel / Rosales, Roberto S

The Journal of hand surgery, European volume

2023 Volume 49, Issue 1, Page(s) 73–81

Abstract: We conducted an ambispective cohort study to assess the association between symptomatic radioulnar impingement syndrome (SRUIS) and distal radioulnar joint (DRUJ) salvage surgery to examine the influence of confounders on the final effect. The outcome ... ...

Abstract	We conducted an ambispective cohort study to assess the association between symptomatic radioulnar impingement syndrome (SRUIS) and distal radioulnar joint (DRUJ) salvage surgery to examine the influence of confounders on the final effect. The outcome variable was the incidence of SRUIS and the exposure variable was the surgical procedure. Seventy-two patients with median age of 48 years (IQR 25-78) were examined using bivariate and logistic regression multivariate analyses, and confounders were analysed in 15 multivariate models. Overall, SRUIS occurred in 21 patients (29%). Bivariate analysis showed a significant association between SRUIS and type of surgical procedure, observed in 71% after Sauvé-Kapandji, 50% after Bowers and 15% after Darrach procedure. When adjusted for age, aetiology and previous surgery, the significant association disappeared. Confounding is an important factor when accounting for SRUIS after DRUJ salvage surgery. The risk of SRUIS did not depend on the procedure, but rather on patient's age, aetiology and previous surgery.
MeSH term(s)	Humans ; Adult ; Middle Aged ; Aged ; Osteoarthritis/surgery ; Ulna/surgery ; Cohort Studies ; Confounding Factors, Epidemiologic ; Wrist Joint/surgery
Language	English
Publishing date	2023-09-07
Publishing country	England
Document type	Journal Article
ZDB-ID	2272801-6
ISSN	2043-6289 ; 1753-1934
ISSN (online)	2043-6289
ISSN	1753-1934
DOI	10.1177/17531934231192848
Database	MEDical Literature Analysis and Retrieval System OnLINE

In stock of ZB MED Cologne/Königswinter

Zs.A 1940: Show issues

Location:
Je nach Verfügbarkeit (siehe Angabe bei Bestand)
bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
Jg. 1995 - 2021: Lesesall (1.OG)
ab Jg. 2022: Lesesaal (EG)

Order via subito

Details ▾
- See ZB MED holdings
- Order with fees

Article ; Online: Pancreatic islets seeded in a novel bioscaffold forms an organoid to rescue insulin production and reverse hyperglycemia in models of type 1 diabetes.

Elizondo, Diana M / Brandy, Nailah Z D / da Silva, Ricardo L L / de Moura, Tatiana R / Ali, Jamel / Yang, Dazhi / Lipscomb, Michael W

Scientific reports

2020 Volume 10, Issue 1, Page(s) 4362

Abstract: Therapeutic approaches to combat type 1 diabetes (T1D) include donor pancreas transplantation, exogenous insulin administration and immunosuppressive therapies. However, these clinical applications are limited due to insufficient tissue compatible donors, ...

Abstract	Therapeutic approaches to combat type 1 diabetes (T1D) include donor pancreas transplantation, exogenous insulin administration and immunosuppressive therapies. However, these clinical applications are limited due to insufficient tissue compatible donors, side effects of exogenous insulin administration and/or increased onset of opportunistic infections attributable to induced global immunosuppression. An alternative approach to alleviate disease states is to utilize insulin-producing pancreatic islets seeded in a bioscaffold for implantation into diabetic recipients. The present studies now report that a newly developed cationic polymer biomaterial serves as an efficient bioscaffold for delivery of donor syngeneic pancreatic islet cells to reverse hyperglycemia in murine streptozotocin induced- or non-obese diabetic mouse models of T1D. Intraperitoneal implantation of pancreatic islets seeded within the copolymer bioscaffold supports long-term cell viability, response to extracellular signaling cues and ability to produce soluble factors into the microenvironment. Elevated insulin levels were measured in recipient diabetic mice upon implantation of the islet-seeded biomaterial coupled with reduced blood glucose levels, collectively resulting in increased survival and stabilization of metabolic indices. Importantly, the implanted islet-seeded biomaterial assembled into a solid organoid substructure that reorganized the extracellular matrix compartment and recruited endothelial progenitors for neovascularization. This allowed survival of the graft long-term in vivo and access to the blood for monitoring glucose levels. These results highlight the novelty, simplicity and effectiveness of this biomaterial for tissue regeneration and in vivo restoration of organ functions.
MeSH term(s)	Animals ; Blood Glucose ; Cell Survival ; Diabetes Mellitus, Experimental ; Diabetes Mellitus, Type 1 ; Graft Survival ; Hyperglycemia/blood ; Hyperglycemia/therapy ; Insulin/biosynthesis ; Islets of Langerhans/metabolism ; Islets of Langerhans Transplantation ; Mice ; Organoids ; Tissue Culture Techniques ; Tissue Scaffolds
Chemical Substances	Blood Glucose ; Insulin
Language	English
Publishing date	2020-03-09
Publishing country	England
Document type	Journal Article ; Research Support, N.I.H., Extramural ; Research Support, U.S. Gov't, Non-P.H.S.
ZDB-ID	2615211-3
ISSN	2045-2322 ; 2045-2322
ISSN (online)	2045-2322
ISSN	2045-2322
DOI	10.1038/s41598-020-60947-x
Database	MEDical Literature Analysis and Retrieval System OnLINE

Order via subito

Article ; Online: Allograft inflammatory factor-1 in myeloid cells drives autoimmunity in type 1 diabetes.

Elizondo, Diana M / Brandy, Nailah Zd / da Silva, Ricardo L / de Moura, Tatiana R / Lipscomb, Michael W

JCI insight

2020 Volume 5, Issue 10

Abstract: Allograft inflammatory factor-1 (AIF1) is a calcium-responsive cytoplasmic scaffold protein that directs hematopoiesis and immune responses within dendritic cells (DC) and macrophages. Although the role of AIF1 in transplant rejection and rheumatoid ... ...

Abstract	Allograft inflammatory factor-1 (AIF1) is a calcium-responsive cytoplasmic scaffold protein that directs hematopoiesis and immune responses within dendritic cells (DC) and macrophages. Although the role of AIF1 in transplant rejection and rheumatoid arthritis has been explored, little is known about its role in type 1 diabetes. Here, we show that in vivo silencing of AIF1 in NOD mice restrained infiltration of immune cells into the pancreas and inhibited diabetes incidence. Analyses of FACS-sorted CD45neg nonleukocyte populations from resected pancreatic islets showed markedly higher expression of insulin in the AIF1-silenced groups. Evaluation of CD45+ leukocytes revealed diminished infiltration of effector T cells and DC in the absence of AIF1. Transcriptional profiling further revealed a marked decrease in cDC1 DC-associated genes CD103, BATF3, and IRF8, which are required for orchestrating polarized type 1 immunity. Reduced T cell numbers within the islets were observed, with concomitant lower levels of IFN-γ and T-bet in AIF1-silenced cohorts. In turn, there was a reciprocal increase in functionally suppressive pancreas-resident CD25+Foxp3+CD4+ Tregs. Taken together, results show that AIF1 expression in myeloid cells plays a pivotal role in promoting type 1 diabetes and that its suppression restrains insulitis by shifting the immune microenvironment toward tolerance.
MeSH term(s)	Animals ; Calcium-Binding Proteins/immunology ; Diabetes Mellitus, Experimental/immunology ; Diabetes Mellitus, Experimental/pathology ; Diabetes Mellitus, Type 1/immunology ; Diabetes Mellitus, Type 1/pathology ; Female ; Male ; Mice ; Mice, Inbred NOD ; Mice, SCID ; Microfilament Proteins/immunology ; Myeloid Cells/immunology ; Myeloid Cells/pathology ; T-Lymphocytes, Regulatory/immunology ; T-Lymphocytes, Regulatory/pathology
Chemical Substances	Aif1 protein, mouse ; Calcium-Binding Proteins ; Microfilament Proteins
Language	English
Publishing date	2020-05-21
Publishing country	United States
Document type	Journal Article ; Research Support, N.I.H., Extramural ; Research Support, U.S. Gov't, Non-P.H.S.
ISSN	2379-3708
ISSN (online)	2379-3708
DOI	10.1172/jci.insight.136092
Database	MEDical Literature Analysis and Retrieval System OnLINE

Order via subito

Inter-library loan at ZB MED

Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

Article: Inhibition of Allograft Inflammatory Factor-1 in Dendritic Cells Restrains CD4

Elizondo, Diana M / Andargie, Temesgen E / Yang, Dazhi / Kacsinta, Apollo D / Lipscomb, Michael W

Frontiers in immunology

2017 Volume 8, Page(s) 1502

Abstract: Allograft inflammatory factor-1 (AIF1) is a cytoplasmic scaffold protein shown to influence immune responses in macrophages and microglial cells. The protein contains ... ...

Abstract	Allograft inflammatory factor-1 (AIF1) is a cytoplasmic scaffold protein shown to influence immune responses in macrophages and microglial cells. The protein contains Ca
Language	English
Publishing date	2017-11-08
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2606827-8
ISSN	1664-3224
ISSN	1664-3224
DOI	10.3389/fimmu.2017.01502
Database	MEDical Literature Analysis and Retrieval System OnLINE

Order via subito

Article ; Online: Drebrin 1 in dendritic cells regulates phagocytosis and cell surface receptor expression through recycling for efficient antigen presentation.

Elizondo, Diana M / Andargie, Temesgen E / Haddock, Naomi L / Boddie, Thomas A / Lipscomb, Michael W

Immunology

2018 Volume 156, Issue 2, Page(s) 136–146

Abstract: Phagocytosis, macropinocytosis and antigen presentation by dendritic cells (DC) requires reorganization of the actin cytoskeleton. Drebrin (Dbn1) is an actin binding and stabilizing protein with roles in endocytosis, formation of dendrite spines in ... ...

Abstract	Phagocytosis, macropinocytosis and antigen presentation by dendritic cells (DC) requires reorganization of the actin cytoskeleton. Drebrin (Dbn1) is an actin binding and stabilizing protein with roles in endocytosis, formation of dendrite spines in neurons and coordinating cell-cell synapses in immune cells. However, its role in DC phagocytosis and antigen presentation is unknown. These studies now report that silencing of Dbn1 in DC resulted in restrained cell surface display of receptors, most notably MHC class I and II and co-stimulatory molecules. This, as expected, resulted in impaired antigen-specific T-cell activation and proliferation. Studies additionally revealed that knockdown of Dbn1 in DC impaired macropinocytosis and phagocytosis. However, there was a concomitant increase in fluid-phase uptake, suggesting that Dbn1 is responsible for the differential control of macropinocytosis versus micropinocytosis activities. Taken together, these findings now reveal that Dbn1 plays a major role in coordinating the actin cytoskeletal activities responsible for antigen presentation in DC.
MeSH term(s)	Animals ; Antigen Presentation ; Cytoskeleton/genetics ; Cytoskeleton/immunology ; Dendritic Cells/cytology ; Dendritic Cells/immunology ; Gene Expression Regulation/immunology ; Gene Knockout Techniques ; Histocompatibility Antigens Class I/genetics ; Histocompatibility Antigens Class I/immunology ; Histocompatibility Antigens Class II/genetics ; Histocompatibility Antigens Class II/immunology ; Immunological Synapses/genetics ; Immunological Synapses/immunology ; Lymphocyte Activation/genetics ; Mice ; Mice, Transgenic ; Neuropeptides/genetics ; Neuropeptides/immunology ; Phagocytosis ; T-Lymphocytes/cytology ; T-Lymphocytes/immunology
Chemical Substances	Histocompatibility Antigens Class I ; Histocompatibility Antigens Class II ; Neuropeptides ; drebrins
Language	English
Publishing date	2018-11-08
Publishing country	England
Document type	Journal Article ; Research Support, N.I.H., Extramural ; Research Support, U.S. Gov't, Non-P.H.S.
ZDB-ID	80124-0
ISSN	1365-2567 ; 0019-2805 ; 0953-4954
ISSN (online)	1365-2567
ISSN	0019-2805 ; 0953-4954
DOI	10.1111/imm.13010
Database	MEDical Literature Analysis and Retrieval System OnLINE

In stock of ZB MED Cologne/Königswinter

Ud II Zs.181: Show issues

Location:
Je nach Verfügbarkeit (siehe Angabe bei Bestand)
bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
ab Jg. 2022: Lesesaal (EG)

Order via subito

Details ▾
- See ZB MED holdings
- Order with fees

Article: siRNA Immunological Fishing Training (SIFT) Experience as a Novel Research Education Tool for Students Studying Immunology.

Elizondo, Diana M / Andargie, Temesgen E / Kubhar, Dineeta S / Marshall, Karis M / Zariwala, Aamir M / Lee, Clarence M / Lipscomb, Michael W

Journal of microbiology & biology education

2017 Volume 18, Issue 1

Language	English
Publishing date	2017-04-21
Publishing country	United States
Document type	Journal Article
ISSN	1935-7877
ISSN	1935-7877
DOI	10.1128/jmbe.v18i1.1288
Database	MEDical Literature Analysis and Retrieval System OnLINE

Full text online

Accessible to users with ZB MED library card

Order via subito

Inter-library loan at ZB MED

Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

Details ▾
- Full text online
- Order with fees

Article ; Online: Leishmania donovani infection suppresses Allograft Inflammatory Factor-1 in monocytes and macrophages to inhibit inflammatory responses.

da Silva, Ricardo Louzada / Elizondo, Diana M / Brandy, Nailah Z D / Haddock, Naomi L / Boddie, Thomas A / de Oliveira, Laís Lima / de Jesus, Amélia Ribeiro / de Almeida, Roque Pacheco / de Moura, Tatiana Rodrigues / Lipscomb, Michael W

Scientific reports

2021 Volume 11, Issue 1, Page(s) 946

Abstract: Macrophages and monocytes are important for clearance of Leishmania infections. However, immune evasion tactics employed by the parasite results in suppressed inflammatory responses, marked by deficient macrophage functions and increased accumulation of ... ...

Abstract	Macrophages and monocytes are important for clearance of Leishmania infections. However, immune evasion tactics employed by the parasite results in suppressed inflammatory responses, marked by deficient macrophage functions and increased accumulation of monocytes. This results in an ineffective ability to clear parasite loads. Allograft Inflammatory Factor-1 (AIF1) is expressed in myeloid cells and serves to promote immune responses. However, AIF1 involvement in monocyte and macrophage functions during parasitic infections has not been explored. This study now shows that Leishmania donovani inhibits AIF1 expression in macrophages to block pro-inflammatory responses. Mice challenged with the parasite had markedly reduced AIF1 expression in splenic macrophages. Follow-up studies using in vitro approaches confirmed that L. donovani infection in macrophages suppresses AIF1 expression, which correlated with reduction in pro-inflammatory cytokine production and increased parasite load. Ectopic overexpression of AIF1 in macrophages provided protection from infection, marked by robust pro-inflammatory cytokine production and efficient pathogen clearance. Further investigations found that inhibiting AIF1 expression in bone marrow cells or monocytes impaired differentiation into functional macrophages. Collectively, results show that AIF1 is a critical regulatory component governing monocyte and macrophage immune functions and that L. donovani infection can suppress the gene as an immune evasion tactic.
MeSH term(s)	Animals ; Apoptosis ; Bone Marrow Cells/cytology ; Calcium-Binding Proteins/metabolism ; Calcium-Binding Proteins/physiology ; Cell Differentiation ; Female ; Immune Evasion/immunology ; Immune Evasion/physiology ; Inflammation/immunology ; Inflammation/metabolism ; Leishmania donovani/metabolism ; Leishmania donovani/pathogenicity ; Macrophages/immunology ; Macrophages/metabolism ; Male ; Mice ; Mice, Inbred C57BL ; Microfilament Proteins/metabolism ; Microfilament Proteins/physiology ; Monocytes/immunology ; Monocytes/metabolism
Chemical Substances	Aif1 protein, mouse ; Calcium-Binding Proteins ; Microfilament Proteins
Language	English
Publishing date	2021-01-13
Publishing country	England
Document type	Journal Article ; Research Support, N.I.H., Extramural ; Research Support, U.S. Gov't, Non-P.H.S.
ZDB-ID	2615211-3
ISSN	2045-2322 ; 2045-2322
ISSN (online)	2045-2322
ISSN	2045-2322
DOI	10.1038/s41598-020-79068-6
Database	MEDical Literature Analysis and Retrieval System OnLINE

Order via subito

Article ; Online: CD40-CD40L cross-talk drives fascin expression in dendritic cells for efficient antigen presentation to CD4+ T cells.

Elizondo, Diana M / Andargie, Temesgen E / Kubhar, Dineeta S / Gugssa, Ayele / Lipscomb, Michael W

International immunology

2017 Volume 29, Issue 3, Page(s) 121–131

Abstract: Fascin is an actin-bundling protein that, among immune cells, is restricted to expression in dendritic cells (DCs). Previous reports have suggested that fascin plays an important role in governing DC antigen presentation to CD4+ T cells. However, no ... ...

Abstract	Fascin is an actin-bundling protein that, among immune cells, is restricted to expression in dendritic cells (DCs). Previous reports have suggested that fascin plays an important role in governing DC antigen presentation to CD4+ T cells. However, no report has clearly linked the receptor-ligand engagement that can direct downstream regulation of fascin expression. In this study, bone marrow-derived DCs from wild-type versus CD40-knockout C57BL/6 mice were used to elucidate the mechanisms of fascin expression and activity upon CD40-CD40 ligand (CD40L) engagement. These investigations now show that CD40 engagement governs fascin expression in DCs to promote CD4+ T-cell cytokine production. Absence of CD40 signaling resulted in diminished fascin expression in DCs and was associated with impaired CD4+ T-cell responses. Furthermore, the study found that loss of CD40-CD40L engagement resulted in reduced DC-T-cell contacts. Rescue by ectopic fascin expression in CD40-deficient DCs was able to re-establish sustained contacts with T cells and restore cytokine production. Taken together, these results show that cross-talk through CD40-CD40L signaling drives elevated fascin expression in DCs to support acquisition of full T-cell responses.
Language	English
Publishing date	2017-03-01
Publishing country	England
Document type	Journal Article
ZDB-ID	1013745-2
ISSN	1460-2377 ; 0953-8178
ISSN (online)	1460-2377
ISSN	0953-8178
DOI	10.1093/intimm/dxx013
Database	MEDical Literature Analysis and Retrieval System OnLINE

In stock of ZB MED Cologne/Königswinter

Zs.A 2619: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (2.OG) ab Jg. 2022: Lesesaal (EG)
Zs.MG 70: Show issues

Order via subito

Details ▾
- See ZB MED holdings
- Order with fees

Article ; Online: Rheumatoid arthritis hand lesions assessed with outcome measures in rheumatoid arthritis clinical trials-rheumatoid arthritis magnetic resonance imaging score – proposing an extended rheumatoid arthritis magnetic resonance imaging score

M. del Carmen Larios-Forte / Mario A. Garza-Elizondo / Cassandra M. Skinner-Taylor / Jorge A. Esquivel-Valerio / David Vega-Morales / Dionicio A. Galarza-Delgado / Diana E. Flores-Alvarado / Rodrigo E. Elizondo-Omaña / Alejandro Quiroga-Garza

Medicina Universitaria, Vol 23, Iss

2021 Volume 2

Abstract: Introduction: The Outcome Measures in Rheumatoid Arthritis Clinical Trials (OMERACT) and Rheumatoid Arthritis Magnetic Resonance Imaging Score (RAMRIS), with the EULAR-OMERACT-2005 MR-Atlas, demonstrate characteristics and lesion degrees (synovitis, ... ...

Abstract	Introduction: The Outcome Measures in Rheumatoid Arthritis Clinical Trials (OMERACT) and Rheumatoid Arthritis Magnetic Resonance Imaging Score (RAMRIS), with the EULAR-OMERACT-2005 MR-Atlas, demonstrate characteristics and lesion degrees (synovitis, erosions, bone marrow edema [BME]) in rheumatoid arthritis (R.A.) clinical diagnosis for follow-up and treatment response. Our study’s objective was to use RAMRIS in patients from three R.A. phases to detect lesions according to their tissue characterization (fluid levels in tissue) using different magnetic resonance imaging (MRI) sequences. Methods: Sixty contrast-enhanced MRIs from R.A. patients (clinical suspect arthralgia [CSA] – 38%, early R.A. [ERA] – 37%, and established [R.A.] – 25%) were evaluated according to the American College of Rheumatology (ACR-EULAR)-2010 criteria. R.A. lesions evaluation was performed with RAMRIS/Atlas/scoring; our analysis added the presence of lesions in the thumb and wrist (tenosynovitis, synovitis, erosions, and BME), proposing an “extended RAMRIS.” Results: Overall, 83% (50/60) women, mean 42 ± 13.5 (19-70) years-of-age, from 1731 evaluated sites, 964 lesions were identified. Synovitis 46% (445/964) was most frequently found in the carpal bones 72% (321/445). Extended RAMRIS demonstrated tenosynovitis and erosions in 1st carpometacarpal, 1st metacarpophalangeal, and hand-wrist tenosynovitis. Gadolinium contrast showed synovial and erosions enhancement indicating active lesions, most predominantly in ERA. Conclusions: Extended RAMRIS score was not statistically different (p = 0.43) from RAMRIS-2005. However, it considers all hand-wrist bone joint sites and tendon lesions needed for assessing a more accurate degree of disease development. A proposed extended RAMRIS should be considered.
Keywords	Rheumatoid arthritis. Magnetic resonance imaging. Outcome measures in rheumatoid arthritis clinical trials-rheumatoid arthritis magnetic resonance imaging score. Extended rheumatoid arthritis magnetic resonance imaging score. ; Medicine (General) ; R5-920
Subject code	610 ; 616
Language	English
Publishing date	2021-04-01T00:00:00Z
Publisher	Permanyer
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

Full text online

Full text

Inter-library loan at ZB MED

Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

To top

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

More links

Kategorien

Order via subito

More links

Kategorien

Order via subito

Inter-library loan at ZB MED

More links

Kategorien

Order via subito

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

Full text online

More links

Kategorien

Order via subito

Inter-library loan at ZB MED

More links

Kategorien

Order via subito

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

Full text online

More links

Kategorien

Inter-library loan at ZB MED