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Article: [Sequential therapy with inotuzumab ozogamicin followed by CAR T-cell therapy for Philadelphia chromosome-negative acute lymphoblastic leukemia].

Mizutani, Yo / Kusakabe, Shinsuke / Fukushima, Kentaro / Murakami, Hiraku / Hamada, Masataka / Hasegawa, Chihiro / Mizuta, Emiko / Yamaguchi, Yuta / Nakai, Ritsuko / Kurashige, Ryumei / Hino, Akihisa / Ueda, Tomoaki / Fujita, Jiro / Miyamura, Takako / Hosen, Naoki

Rinsho ketsueki] The Japanese journal of clinical hematology

2024 Volume 65, Issue 2, Page(s) 78–83

Abstract: ... for chimeric antigen receptor T-cell (CAR-T, Tisagenlecleucel [Tisa-cel]). She received two cycles ...

Abstract	A 25-year-old woman with a history of B-cell acute lymphoblastic leukemia over ten years ago was referred to our hospital with a chief complaint of leukoblastosis. She was participating in a JPLSG (Japanese Pediatric Leukemia/Lymphoma Study Group) clinical study at that time. We diagnosed ALL relapse by multi-color flow cytometric analysis of bone marrow samples at admission, with reference to previous JPLSG data. Because her leukemic cells were resistant to conventional cytotoxic agents, she proceeded to lymphocyte apheresis for chimeric antigen receptor T-cell (CAR-T, Tisagenlecleucel [Tisa-cel]). She received two cycles of inotuzumab ozogamicin as a bridging therapy to Tisa-cel, resulting in a hematological complete remission (minimal residual disease measured by polymerase chain reaction [PCR-MRD] was positive at 1.0×10
MeSH term(s)	Humans ; Adolescent ; Female ; Child ; Young Adult ; Adult ; Inotuzumab Ozogamicin/therapeutic use ; Immunotherapy, Adoptive ; Philadelphia Chromosome ; Precursor Cell Lymphoblastic Leukemia-Lymphoma/therapy ; Burkitt Lymphoma
Chemical Substances	Inotuzumab Ozogamicin (P93RUU11P7)
Language	Japanese
Publishing date	2024-03-06
Publishing country	Japan
Document type	Case Reports ; English Abstract ; Journal Article
ZDB-ID	390900-1
ISSN	0485-1439
ISSN	0485-1439
DOI	10.11406/rinketsu.65.78
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Article ; Online: The Balance of CD8-Positive T Cells and PD-L1 Expression in the Myocardium Predicts Prognosis in Lymphocytic Fulminant Myocarditis.

Hiraiwa, Hiroaki / Morimoto, Ryota / Tsuyuki, Yuta / Ushida, Kaori / Ito, Ryota / Kazama, Shingo / Kimura, Yuki / Araki, Takashi / Mizutani, Takashi / Oishi, Hideo / Kuwayama, Tasuku / Kondo, Toru / Okumura, Takahiro / Murohara, Toyoaki

Cardiology

2023 Volume 149, Issue 1, Page(s) 28–39

Abstract: Introduction: The clinical significance and prognostic value of T cell involvement and ... myocarditis (FM). We investigated the prognostic impact of the number of CD4+, CD8+, FoxP3+, and PD-1+ T ... CD4+ T cell ratio were higher in the cardiac event group (Event+) than in the group without cardiac ...

Abstract	Introduction: The clinical significance and prognostic value of T cell involvement and programmed cell death-1 (PD-1)/programmed cell death ligand-1 (PD-L1) have not been established in lymphocytic fulminant myocarditis (FM). We investigated the prognostic impact of the number of CD4+, CD8+, FoxP3+, and PD-1+ T cells, as well as PD-L1 expression, in cardiomyocytes in lymphocytic FM. Methods: This is a single-center observational cohort study. Myocardial tissue was obtained from 16 consecutive patients at lymphocytic FM onset. The median follow-up was 140 days. Cardiac events were defined as a composite of cardiac death and left ventricular-assist device implantation. CD4, CD8, FoxP3, PD-1, and PD-L1 immunostaining were performed on myocardial specimens. Results: The median age of the patients was 52 years (seven men and nine women). There was no significant difference in the number of CD4+ cells. The number of CD8+ cells and the CD8+/CD4+ T cell ratio were higher in the cardiac event group (Event+) than in the group without cardiac events (Event-) (p = 0.048 and p = 0.022, respectively). The number of FoxP3+ T cells was higher in the Event+ group (p = 0.049). Although there was no difference in the number of PD-1+ cells, cardiomyocyte PD-L1 expression was higher in the Event+ group (p = 0.112). Event-free survival was worse in the group with a high CD8+ cell count (p = 0.012) and high PD-L1 expression (p = 0.049). When divided into three groups based on the number of CD8+ cells and PD-L1 expression (CD8highPD-L1high [n = 8], CD8lowPD-L1high [n = 1], and CD8lowPD-L1low [n = 7]), the CD8highPD-L1high group demonstrated the worst event-free survival, while the CD8lowPD-L1high group had a favorable prognosis without cardiac events (p = 0.041). Conclusion: High myocardial expression of CD8+ T cells and PD-L1 may predict a poor prognosis in lymphocytic FM.
MeSH term(s)	Male ; Humans ; Female ; Middle Aged ; Myocarditis ; B7-H1 Antigen/metabolism ; Programmed Cell Death 1 Receptor/metabolism ; Prognosis ; CD8-Positive T-Lymphocytes/metabolism ; Myocytes, Cardiac/metabolism ; Forkhead Transcription Factors/metabolism
Chemical Substances	B7-H1 Antigen ; Programmed Cell Death 1 Receptor ; Forkhead Transcription Factors
Language	English
Publishing date	2023-10-12
Publishing country	Switzerland
Document type	Observational Study ; Journal Article
ZDB-ID	80092-2
ISSN	1421-9751 ; 0008-6312
ISSN (online)	1421-9751
ISSN	0008-6312
DOI	10.1159/000534518
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Article ; Online: Myocardial repolarization time, J-point to T-peak and T-peak to T-end intervals, have different heart rate dependency and autonomic nerve interference in healthy prepubertal children.

Kusuki, Hirofumi / Mizutani, Yuri / Tsuchiya, Yuka / Nishio, Miki / Oikawa, Shota / Nagata, Rina / Kiriyanagi, Yumi / Horio, Kayo / Hosoi, Misa / Matsuura, Hideaki / Sadanaga, Tsuneaki / Hata, Tadayoshi

Journal of electrocardiology

2021 Volume 67, Page(s) 119–123

Abstract: Objective: The JT interval of the myocardial repolarization time can be divided into Jpoint to T ... peak interval (JTp) and T-peak to T-end interval (Tpe). It is well known that the JT interval is ...

Abstract	Objective: The JT interval of the myocardial repolarization time can be divided into Jpoint to T-peak interval (JTp) and T-peak to T-end interval (Tpe). It is well known that the JT interval is dependent on the heart rate, but little is known regarding heart rate dependence for JTp and Tpe. The aim of the present study was to clarify the heart rate dependence of JTp and Tpe and to elucidate the interference of autonomic nervous activity with these parameters. Methods: We evaluated 50 prepubertal children (mean age: 6.4 ± 0.5 years; male:female, 22:28) without heart disease. JTp, Tpe, and the preceding RR intervals were measured using 120 consecutive beats (lead CM5). First, the relationships between the RR interval and JTp and Tpe were evaluated by Pearson's correlation coefficient. Second, to evaluate autonomic interference with JTp and Tpe, the degree of coherence between RR interval variability and JTp or Tpe variability was calculated using spectral analysis. Results: Significant positive correlations were observed between the RR interval and JTp (y = 0.116x + 105.5; r = 0.594, p < 0.001) and between the RR interval and Tpe (y = 0.037x + 44.7; r = 0.432, p < 0.001). Tpe variability had a lower degree of coherence with RR interval variability (range: 0.039-0.5 Hz) than with JTp variability (0.401 [interquartile range, 0.352-0.460] vs. 0.593 [0.503-0.664], respectively; p < 0.001). Conclusions: Tpe had lower heart rate dependence and a lower degree of autonomic nervous interference than did JTp.
MeSH term(s)	Autonomic Nervous System ; Autonomic Pathways ; Child ; Child, Preschool ; Electrocardiography ; Female ; Heart Rate ; Humans ; Male ; Myocardium
Language	English
Publishing date	2021-06-08
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	410286-1
ISSN	1532-8430 ; 0022-0736
ISSN (online)	1532-8430
ISSN	0022-0736
DOI	10.1016/j.jelectrocard.2021.05.015
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Article ; Online: T-Stent or Half T-Stent-Assisted Embolization of Wide-Necked Aneurysms at the Internal Carotid-Posterior Communicating Artery Bifurcation.

Nakajo, Takato / Terada, Tomoaki / Okada, Hideo / Sakaguchi, Hiroaki / Takano, Syun / Nishiyama, Akira / Umezaki, Arisa / Tanaka, Yuko / Yamaga, Hiroo / Matsumoto, Hiroaki / Mizutani, Tohru

Journal of neuroendovascular therapy

2021 Volume 15, Issue 10, Page(s) 681–687

Abstract: Objective: We report the usefulness and pitfalls of coil embolization using the T or half T-stent ... with a hypoplastic P1 segment.: Case presentations: Two cases were treated using the T-stent technique and two ... were treated using the half T-stent technique. The average age of the patients was 70.3 years and ...

Abstract	Objective: We report the usefulness and pitfalls of coil embolization using the T or half T-stent technique for aneurysms located at internal carotid artery-posterior communicating artery (ICA-P-com) bifurcation in which the neck is wide and the P-com must be kept patent due to it being the fetal-type with a hypoplastic P1 segment. Case presentations: Two cases were treated using the T-stent technique and two were treated using the half T-stent technique. The average age of the patients was 70.3 years and all were females. One aneurysm ruptured. The average size of aneurysms and neck was 12 mm and 8.5 mm, respectively, in the T-stent group, and 7.4 mm and 6.7 mm, respectively, in the half T-stent group. An S- or pigtail-shaped microcatheter (MC) was used to navigate into the P-com. Stent deployment was successful in all the cases. Retreatment was required in one case treated using the T-stent technique due to major recurrence. Conclusion: T or half T-stent-assisted coil embolization can be an alternative endovascular treatment method for wide-necked ICA-P-com aneurysms in which the P-com must be kept patent due to it being the fetal-type with a hypoplastic P1 segment.
Language	English
Publishing date	2021-01-28
Publishing country	Japan
Document type	Journal Article
ISSN	2186-2494
ISSN (online)	2186-2494
DOI	10.5797/jnet.tn.2020-0122
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Article ; Online: Molecular hydrogen has a positive impact on pregnancy maintenance through enhancement of mitochondrial function and immunomodulatory effects on T cells.

Aoki, Chieko / Imai, Kenji / Mizutani, Teruyuki / Sugiyama, Daisuke / Miki, Rika / Koya, Yoshihiro / Kobayashi, Tomoko / Ushida, Takafumi / Iitani, Yukako / Nakamura, Noriyuki / Owaki, Taro / Nishikawa, Hiroyoshi / Toyokuni, Shinya / Kajiyama, Hiroaki / Kotani, Tomomi

Life sciences

2022 Volume 308, Page(s) 120955

Abstract: Aims: Molecular hydrogen (H: Main methods: Exhaled H: Key findings: Our prospective observational study revealed that maternal production of H: Significance: Measuring maternal ... ...

Abstract	Aims: Molecular hydrogen (H Main methods: Exhaled H Key findings: Our prospective observational study revealed that maternal production of H Significance: Measuring maternal H
MeSH term(s)	Animals ; Biomarkers ; Cytokines ; Female ; Humans ; Hydrogen/pharmacology ; Infant, Newborn ; Mice ; Mitochondria ; Pregnancy ; Pregnancy Maintenance ; Premature Birth ; T-Lymphocytes
Chemical Substances	Biomarkers ; Cytokines ; Hydrogen (7YNJ3PO35Z)
Language	English
Publishing date	2022-09-15
Publishing country	Netherlands
Document type	Journal Article ; Observational Study
ZDB-ID	3378-9
ISSN	1879-0631 ; 0024-3205
ISSN (online)	1879-0631
ISSN	0024-3205
DOI	10.1016/j.lfs.2022.120955
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Article ; Online: Derivative Chromosome 3 Loss from t(3;6)(q12;q14) Followed by Differential

Mizutani, Kosuke / Yokoi, Shigeaki / Sawada, Seiya / Sakamoto, Ippei / Kameyama, Koji / Kamei, Shingo / Hirade, Kouseki / Sugiyama, Seiji / Matsunaga, Kengo / Yamada, Tetsuya / Kato, Yasutaka / Nishihara, Hiroshi / Ishihara, Satoshi / Deguchi, Takashi

Cancer genomics & proteomics

2022 Volume 19, Issue 6, Page(s) 740–746

Abstract: ... analysis revealed a germline translocation between 3 and 6, t(3;6)(q12;q14).: Conclusion: Chromosome 3 ...

Abstract	Background/aim: The Von Hippel-Lindau (VHL) gene encodes a protein (pVHL) that plays an important role in proteasome degradation of hypoxia inducible factor α (HIFα) through E3 activation. Accumulation of HIFα by loss of functional pVHL promotes tumorigenesis, thus, VHL has tumor suppressor gene capability in clear cell renal cell carcinoma (ccRCC). VHL is the most frequently mutated gene in ccRCC. The complete loss of VHL is mainly achieved by loss of chromosome 3p, which has a VHL coding region in combination with mutation or hypermethylation of the remaining copy of VHL. Given the risk of constitutional chromosome 3 translocation for RCC, it is important to detect the translocation and understand the mechanism underlying the development of multifocal ccRCC. Case report: A 67-year-old female patient diagnosed with multifocal RCC underwent robot-assisted partial nephrectomy (RAPN) for three kidney tumors. A cancer gene panel test using next generation sequencing (NGS) detected differential VHL mutations (c.533T>G; p.L178R, c.465_466insTA; p.T157Ifs3, c.343C>A; p.H115N), while VHL mutation was not detected in peripheral blood DNA. A tendency toward copy number loss of genes on der(3) was also detected in all tumors, but not in the germline one. A karyotype analysis revealed a germline translocation between 3 and 6, t(3;6)(q12;q14). Conclusion:* Chromosome 3 translocation and loss of derivative chromosome containing 3p and subsequent somatic differential VHL mutations in this case strongly support the previously proposed three-step model to explain the development of familial conventional ccRCC.
MeSH term(s)	Female ; Humans ; Aged ; Carcinoma, Renal Cell/genetics ; Carcinoma, Renal Cell/pathology ; Chromosomes, Human, Pair 3/genetics ; Kidney Neoplasms/pathology ; Mutation ; Translocation, Genetic ; Von Hippel-Lindau Tumor Suppressor Protein/genetics
Chemical Substances	VHL protein, human (EC 6.3.2.-) ; Von Hippel-Lindau Tumor Suppressor Protein (EC 2.3.2.27)
Language	English
Publishing date	2022-10-31
Publishing country	Greece
Document type	Case Reports ; Journal Article
ZDB-ID	2144517-5
ISSN	1790-6245 ; 1109-6535
ISSN (online)	1790-6245
ISSN	1109-6535
DOI	10.21873/cgp.20356
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Article: Cervical Local Cytokine Release Syndrome Following Chimeric Antigen Receptor T-cell Therapy in Patients With Relapsed or Refractory Diffuse Large B-cell Lymphoma.

Inoue, Yu / Fujino, Takahiro / Chinen, Shotaro / Niiyama-Uchibori, Yui / Ide, Daisuke / Kawata, Moe / Hashimoto, Keiko / Takimoto-Shimomura, Tomoko / Nakayama, Ai / Tsukamoto, Taku / Mizutani, Shinsuke / Shimura, Yuji / Hirano, Shigeru / Kuroda, Junya

Cureus

2023 Volume 15, Issue 5, Page(s) e38905

Abstract: The use of chimeric antigen receptor T-cell (CAR-T) therapy for hematologic malignancies is rapidly ... a common AE of CAR-T therapy, characterized by systemic symptoms such as fever and respire-circulatory ... after CAR-T infusion. Case 1: A 60-year-old gentleman with diffuse large B cell lymphoma (DLBCL ...

Abstract	The use of chimeric antigen receptor T-cell (CAR-T) therapy for hematologic malignancies is rapidly increasing, and appropriately managing adverse events (AEs) is crucial. Cytokine release syndrome (CRS) is a common AE of CAR-T therapy, characterized by systemic symptoms such as fever and respire-circulatory failure. We present two cases with relapsed or refractory diffuse large B-cell lymphoma (DLBCL) accompanied by a rare complication of cervical local CRS as an acute inflammatory reaction at a specific site after CAR-T infusion. Case 1: A 60-year-old gentleman with diffuse large B cell lymphoma (DLBCL) developed grade 1 CRS on day one that required three doses of tocilizumab. Then he developed remarkable cervical edema as local CRS on day five. His local CRS spontaneously improved from day seven without additional therapy. Case 2: A 70-year-old gentleman with DLBCL developed grade 1 CRS on day two that required three doses of tocilizumab. Then he developed remarkable cervical edema and muffled voice as local CRS on day three. He received dexamethasone because of concerns about airway obstruction, and his local CRS improved immediately after dexamethasone administration. Before Tisa-Cel infusion, neither patients had a lymphoma lesion in their necks. To summarize, local CRS may occur at the site without lymphoma involvement after CAR-T therapy. An appropriate diagnosis and careful observation are required to determine the need for additional treatment.
Language	English
Publishing date	2023-05-11
Publishing country	United States
Document type	Case Reports
ZDB-ID	2747273-5
ISSN	2168-8184
ISSN	2168-8184
DOI	10.7759/cureus.38905
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Article: High-level resistance to non-nucleos(t)ide reverse transcriptase inhibitor based first-line antiretroviral therapy in Ghana; A 2017 study.

Parbie, Prince Kofi / Abana, Christopher Zaab-Yen / Kushitor, Dennis / Asigbee, Theodore Worlanyo / Ntim, Nana Afia Asante / Addo-Tetebo, Gifty / Ansong, Maclean Richard Darko / Ofori, Sampson Badu / Mizutani, Taketoshi / Runtuwene, Lucky Ronald / Nishizawa, Masako / Ishikawa, Koichi / Kiyono, Hiroshi / Ampofo, William Kwabena / Matano, Tetsuro / Bonney, Evelyn Yayra / Kikuchi, Tadashi

Frontiers in microbiology

2022 Volume 13, Page(s) 973771

Abstract: ... for reverse transcriptase inhibitors. The predominant drug resistance mutations were against nucleos(t)ide ... reverse transcriptase inhibitors (NRTI)-M184V/I and non-nucleos(t)ide reverse transcriptase inhibitors (NNRTI)-K103N. In the ART ...

Abstract	Expanding access to effective antiretroviral therapy (ART) is a major tool for management of Human Immunodeficiency Virus (HIV) infection. However, rising levels of HIV drug-resistance have significantly hampered the anticipated success of ART in persons living with HIV (PLWH), particularly those from Africa. Though great strides have been made in Ghana toward achieving the UNAIDS "95-95-95" target, a substantial number of PLWH receiving ART have not attained viral suppression. This study investigated patterns of drug resistance mutations in ART naïve as well as ART-experienced PLWH receiving first-line regimen drugs from Ghana. In a cross-sectional study, blood samples were collected from HIV-1 infected adults (≥18 years) attending HIV/AIDS clinic at the Eastern Regional Hospital, Koforidua, Ghana from September to October 2017. Viral RNA isolated from plasma were subjected to genotypic drug resistance testing for Protease Inhibitors (PI), Reverse Transcriptase Inhibitors (RTI), and Integrase Strand Transfer Inhibitors (INSTI). A total of 95 (84 ART experienced, 11 ART naïve) HIV-1 infected participants were sampled in this study. Sixty percent (50/84) of the ART-experienced participants were controlling viremia (viral load < 1,000 copies/ml). Of the 95 patient samples, 32, 34, and 33 were successfully sequenced for protease, reverse-transcriptase, and integrase regions, respectively. The dominant HIV-1 subtypes detected were CRF02_AG (70%), and A3 (10%). Major drug resistance associated mutations were only detected for reverse transcriptase inhibitors. The predominant drug resistance mutations were against nucleos(t)ide reverse transcriptase inhibitors (NRTI)-M184V/I and non-nucleos(t)ide reverse transcriptase inhibitors (NNRTI)-K103N. In the ART-experienced group, M184V/I and K103N were detected in 54% (15/28) and 46% (13/28) of individuals, respectively. Both mutations were each detected in 33% (2/6) of ART naïve individuals. Multiclass resistance to NRTI and NNRTI was detected in 57% of ART-experienced individuals and two ART naïve individuals. This study reports high-level resistance to NNRTI-based antiretroviral therapy in PLWH in Ghana. However, the absence of major PI and INSTI associated-mutations is a good signal that the current WHO recommendation of Dolutegravir in combination with an NRTI backbone will yield maximum benefits as first-line regimen for PLWH in Ghana.
Language	English
Publishing date	2022-08-25
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2587354-4
ISSN	1664-302X
ISSN	1664-302X
DOI	10.3389/fmicb.2022.973771
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Article ; Online: Enhanced dendritic cells and regulatory T cells in the dermis of porokeratosis.

Matsuyama, Kanako / Mizutani, Yoko / Takahashi, Tomoko / Shu, En / Kanoh, Hiroyuki / Miyazaki, Tatsuhiko / Seishima, Mariko

Archives of dermatological research

2017 Volume 309, Issue 9, Page(s) 749–756

Abstract: Porokeratosis is characterized clinically by annular lesions and histologically by the presence of a cornoid lamella (CL) in the epidermis. The underlying mechanism of porokeratosis development remains unclear. We performed immunohistochemical staining ... ...

Abstract	Porokeratosis is characterized clinically by annular lesions and histologically by the presence of a cornoid lamella (CL) in the epidermis. The underlying mechanism of porokeratosis development remains unclear. We performed immunohistochemical staining of CD1a, langerin, Ki67, CD3, CD4, CD8, FOXP3, and RANKL (receptor activator of nuclear factor κB ligand) in samples from 17 porokeratosis lesions and analyzed the differences in staining patterns among the CL, the inner part of the annular ridge (IC), and the adjacent normal skin (ANS). Numbers of CD1a
MeSH term(s)	Adult ; Aged ; Aged, 80 and over ; Antigens, CD/analysis ; Antigens, CD1/analysis ; Dendritic Cells/immunology ; Female ; Humans ; Immunohistochemistry ; Ki-67 Antigen/analysis ; Lectins, C-Type/analysis ; Male ; Mannose-Binding Lectins/analysis ; Middle Aged ; Porokeratosis/immunology ; RANK Ligand/analysis ; T-Lymphocytes, Regulatory/immunology
Chemical Substances	Antigens, CD ; Antigens, CD1 ; CD1a antigen ; CD207 protein, human ; Ki-67 Antigen ; Lectins, C-Type ; Mannose-Binding Lectins ; RANK Ligand ; TNFSF11 protein, human
Language	English
Publishing date	2017-11
Publishing country	Germany
Document type	Journal Article
ZDB-ID	130131-7
ISSN	1432-069X ; 0340-3696
ISSN (online)	1432-069X
ISSN	0340-3696
DOI	10.1007/s00403-017-1779-3
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Article: Mosquito Bite-Induced Localized NK/T-Cell Lymphoma Relapsed in a Patient with Complete Remission of Extranodal NK/T-Cell Lymphoma, Nasal Type.

Kondo, Makoto / Mizutani, Minoru / Yamanaka, Keiichi

Case reports in dermatology

2019 Volume 11, Issue 2, Page(s) 194–197

Abstract: We report a rare case of localized NK/T-cell lymphoma following a mosquito bite after achieving ... complete response of extranodal NK/T-cell lymphoma, nasal type (ENKL). T cells and NK cells ... infected by Epstein-Barr virus (EBV) lead to NK/T-cell lymphoma, including ENKL. Lymphoma related to mosquito bites usually ...

Abstract	We report a rare case of localized NK/T-cell lymphoma following a mosquito bite after achieving complete response of extranodal NK/T-cell lymphoma, nasal type (ENKL). T cells and NK cells infected by Epstein-Barr virus (EBV) lead to NK/T-cell lymphoma, including ENKL. Lymphoma related to mosquito bites usually requires a prolonged treatment course, and the disease onset of hypersensitivity begins in early childhood. In the current case, the patient had no history of hypersensitivity to mosquito bites. We speculate that the latently EBV-infected NK/T cells in the blood were reactivated by mosquito gland antigens, expanded abnormally, and accumulated at the site of the mosquito bite.
Language	English
Publishing date	2019-06-26
Publishing country	Switzerland
Document type	Case Reports
ZDB-ID	2505300-0
ISSN	1662-6567
ISSN	1662-6567
DOI	10.1159/000501358
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