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  1. Article ; Online: Application of HepaRG cells for genotoxicity assessment: a review.

    Guo, Xiaoqing / Xu, Hannah / Seo, Ji-Eun

    Journal of environmental science and health. Part C, Toxicology and carcinogenesis

    2024  , Page(s) 1–24

    Abstract: There has been growing interest in the use of human-derived metabolically competent cells for genotoxicity testing. The HepaRG cell line is considered one of the most promising cell models because it is TP53-proficient and retains many characteristics of ...

    Abstract There has been growing interest in the use of human-derived metabolically competent cells for genotoxicity testing. The HepaRG cell line is considered one of the most promising cell models because it is TP53-proficient and retains many characteristics of primary human hepatocytes. In recent years, HepaRG cells, cultured in both a traditional two-dimensional (2D) format and as more advanced in-vivo-like 3D spheroids, have been employed in assays that measure different types of genetic toxicity endpoints, including DNA damage, mutations, and chromosomal damage. This review summarizes published studies that have used HepaRG cells for genotoxicity assessment, including cell model evaluation studies and risk assessment for various compounds. Both 2D and 3D HepaRG models can be adapted to several high-throughput genotoxicity assays, generating a large number of data points that facilitate quantitative benchmark concentration modeling. With further validation, HepaRG cells could serve as a unique, human-based new alternative methodology for
    Language English
    Publishing date 2024-04-02
    Publishing country United States
    Document type Journal Article ; Review
    ISSN 2689-6591
    ISSN (online) 2689-6591
    DOI 10.1080/26896583.2024.2331956
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Association of socioeconomic status and poststroke cognitive function: A systematic review and meta-analysis.

    Tian, Jingyuan / Wang, Qiuyi / Guo, Shuang / Zhao, Xiaoqing

    International journal of geriatric psychiatry

    2024  Volume 39, Issue 4, Page(s) e6082

    Abstract: Background: Stroke survivors are at high risk of coping with cognitive problems after stroke. In recent decades, the relationship between socioeconomic status (SES) and health-related outcomes has been a topic of considerable interest. Learning more ... ...

    Abstract Background: Stroke survivors are at high risk of coping with cognitive problems after stroke. In recent decades, the relationship between socioeconomic status (SES) and health-related outcomes has been a topic of considerable interest. Learning more about the potential impact of SES on poststroke cognitive dysfunction is of great importance.
    Objective: The purpose of this systematic review and meta-analysis was to summarize the association between SES and poststroke cognitive function by quantifying the effect sizes of the existing studies.
    Method: We searched studies from PubMed, Ovid, Embase, Cochrane, Scopus, and PsychINFO up to January 30
    Results: Thirty-four studies were eligible for this systematic review and meta-analysis. Of which, 19 studies reported poststroke cognitive impairment (PSCI) as the outcome, 13 reported poststroke dementia (PSD), one reported both PSCI and PSD, and one reported vascular cognitive impairment no dementia. The findings showed that individuals with lower SES levels had a higher risk of combined poststroke cognitive dysfunction (odds ratio (OR) = 1.91, 95% confidence interval (CI) = 1.59-2.29), PSCI (OR = 2.09, 95% CI = 1.57-2.78), and PSD (OR = 1.95, 95% CI = 1.48-2.57). Subgroup analyses stratified by SES indicators demonstrated the protective effects of education and occupation against the diagnoses of combined poststroke cognitive dysfunction, PSCI, and PSD.
    Conclusions: Stroke survivors belonging to a low SES are at high risk of poststroke cognitive dysfunction. Our findings add evidence for public health strategies to reduce the risk of poststroke cognitive dysfunction by reducing SES inequalities.
    MeSH term(s) Humans ; Cognition ; Cognitive Dysfunction/etiology ; Stroke/complications ; Learning ; Social Class
    Language English
    Publishing date 2024-04-03
    Publishing country England
    Document type Meta-Analysis ; Systematic Review ; Journal Article ; Review
    ZDB-ID 806736-3
    ISSN 1099-1166 ; 0885-6230
    ISSN (online) 1099-1166
    ISSN 0885-6230
    DOI 10.1002/gps.6082
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    Zs.A 2208: Show issues Location:
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  3. Article ; Online: Disentangle Then Calibrate With Gradient Guidance: A Unified Framework for Common and Rare Disease Diagnosis.

    Chen, Yuanyuan / Guo, Xiaoqing / Xia, Yong / Yuan, Yixuan

    IEEE transactions on medical imaging

    2024  Volume 43, Issue 5, Page(s) 1816–1827

    Abstract: The computer-aided diagnosis (CAD) for rare diseases using medical imaging poses a significant challenge due to the requirement of large volumes of labeled training data, which is particularly difficult to collect for rare diseases. Although Few-shot ... ...

    Abstract The computer-aided diagnosis (CAD) for rare diseases using medical imaging poses a significant challenge due to the requirement of large volumes of labeled training data, which is particularly difficult to collect for rare diseases. Although Few-shot learning (FSL) methods have been developed for this task, these methods focus solely on rare disease diagnosis, failing to preserve the performance in common disease diagnosis. To address this issue, we propose the Disentangle then Calibrate with Gradient Guidance (DCGG) framework under the setting of generalized few-shot learning, i.e., using one model to diagnose both common and rare diseases. The DCGG framework consists of a network backbone, a gradient-guided network disentanglement (GND) module, and a gradient-induced feature calibration (GFC) module. The GND module disentangles the network into a disease-shared component and a disease-specific component based on gradient guidance, and devises independent optimization strategies for both components, respectively, when learning from rare diseases. The GFC module transfers only the disease-shared channels of common-disease features to rare diseases, and incorporates the optimal transport theory to identify the best transport scheme based on the semantic relationship among different diseases. Based on the best transport scheme, the GFC module calibrates the distribution of rare-disease features at the disease-shared channels, deriving more informative rare-disease features for better diagnosis. The proposed DCGG framework has been evaluated on three public medical image classification datasets. Our results suggest that the DCGG framework achieves state-of-the-art performance in diagnosing both common and rare diseases.
    MeSH term(s) Humans ; Rare Diseases/diagnostic imaging ; Algorithms ; Image Interpretation, Computer-Assisted/methods ; Databases, Factual ; Magnetic Resonance Imaging/methods ; Machine Learning
    Language English
    Publishing date 2024-05-02
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Research Support, N.I.H., Extramural
    ZDB-ID 622531-7
    ISSN 1558-254X ; 0278-0062
    ISSN (online) 1558-254X
    ISSN 0278-0062
    DOI 10.1109/TMI.2023.3349284
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    Zs.A 2546: Show issues Location:
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  4. Article ; Online: A rare case of massive hemorrhagic ascites secondary to endometriosis.

    Wang, Huimin / Cai, Bailian / Guo, Xiaoqing / Lu, Wen

    International journal of gynaecology and obstetrics: the official organ of the International Federation of Gynaecology and Obstetrics

    2023  Volume 161, Issue 2, Page(s) 675–677

    MeSH term(s) Female ; Humans ; Ascites/etiology ; Ascites/complications ; Endometriosis/complications ; Gonadotropin-Releasing Hormone ; Recurrence
    Chemical Substances Gonadotropin-Releasing Hormone (33515-09-2)
    Language English
    Publishing date 2023-01-24
    Publishing country United States
    Document type Case Reports ; Journal Article
    ZDB-ID 80149-5
    ISSN 1879-3479 ; 0020-7292
    ISSN (online) 1879-3479
    ISSN 0020-7292
    DOI 10.1002/ijgo.14640
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    Zs.A 355: Show issues Location:
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    Zs.MO 183: Show issues

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  5. Article ; Online: The complete chloroplast genome sequence of

    Zhang, Xiaoqing / Xu, Fei / Guo, Ling

    Mitochondrial DNA. Part B, Resources

    2022  Volume 7, Issue 8, Page(s) 1522–1524

    Abstract: ... Ficus ... ...

    Abstract Ficus pandurata
    Language English
    Publishing date 2022-08-22
    Publishing country England
    Document type Journal Article
    ISSN 2380-2359
    ISSN (online) 2380-2359
    DOI 10.1080/23802359.2022.2110005
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Sex difference in association between suicide attempts and lipid profile in first-episode and drug naive patients with major depressive disorder.

    Guo, Junru / Wang, Li / Zhao, Xiaoqing / Wang, Dongmei / Zhang, Xiangyang

    Journal of psychiatric research

    2024  Volume 172, Page(s) 24–33

    Abstract: Background: The relationship between suicide attempts and lipid profiles in patients with major depressive disorder (MDD) remains uncertain. The purpose of this study was to investigate sex differences in the relationship between suicide attempts and ... ...

    Abstract Background: The relationship between suicide attempts and lipid profiles in patients with major depressive disorder (MDD) remains uncertain. The purpose of this study was to investigate sex differences in the relationship between suicide attempts and plasma lipid profiles in a large sample of first-episode and drug naive (FEDN) MDD patients.
    Methods: We recruited 1718 FEDN MDD patients and gathered demographic, clinical, and blood lipid data. The Hamilton Depression Rating Scale, Hamilton Anxiety Rating Scale and the Positive and Negative Syndrome Scale were used to assess the symptoms of patients.
    Results: There was no significant difference in the prevalence of suicide attempts between male and female MDD patients. The suicide attempt group had higher levels of depression, anxiety, psychotic symptoms, total cholesterol (TC), and low-density lipoprotein cholesterol (LDL-C), but lower levels of high-density lipoprotein cholesterol (HDL-C) levels than the non-suicide attempt group. Binary logistic regression showed that TC levels were significantly correlated with suicidal attempts in both male and female patients. Correlation analysis revealed that the levels of TC, HDL-C and LDL-C were significantly associated with the number of suicide attempts in both male and female patients. Further multiple linear regression revealed that TC levels were significantly associated with the number of suicide attempts in male patients only.
    Conclusions: Lipid biomarkers, particularly high TC levels, are associated with suicide attempts in both male and female MDD patients. However, there is gender difference in association between lipid biomarkers, especially TC levels, and the number of suicide attempts in MDD patients.
    MeSH term(s) Humans ; Female ; Male ; Depressive Disorder, Major ; Suicide, Attempted ; Cholesterol, LDL ; Sex Factors ; Sex Characteristics ; Lipids ; Biomarkers
    Chemical Substances Cholesterol, LDL ; Lipids ; Biomarkers
    Language English
    Publishing date 2024-02-08
    Publishing country England
    Document type Journal Article
    ZDB-ID 3148-3
    ISSN 1879-1379 ; 0022-3956
    ISSN (online) 1879-1379
    ISSN 0022-3956
    DOI 10.1016/j.jpsychires.2024.02.026
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    Ui I Zs.243: Show issues Location:
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  7. Article ; Online: Multiple-ion Management of Perovskites by Regulating Spatial Distribution of Hydroxyls in Oligosaccharides.

    Liu, Xiaotao / Jiang, Xiaoqing / Zhang, Jiafeng / Li, Can / Guo, Xin

    Small (Weinheim an der Bergstrasse, Germany)

    2023  Volume 19, Issue 33, Page(s) e2301437

    Abstract: Suppressing migrations of intrinsic and extrinsic ions (e.g., ... ...

    Abstract Suppressing migrations of intrinsic and extrinsic ions (e.g., Pb
    Language English
    Publishing date 2023-04-22
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 2168935-0
    ISSN 1613-6829 ; 1613-6810
    ISSN (online) 1613-6829
    ISSN 1613-6810
    DOI 10.1002/smll.202301437
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  8. Article: Projecting the Global Potential Geographical Distribution of

    Rao, Jiawei / Zhang, Yu / Zhao, Haoxiang / Guo, Jianyang / Wan, Fanghao / Xian, Xiaoqing / Yang, Nianwan / Liu, Wanxue

    Biology

    2024  Volume 13, Issue 3

    Abstract: The Mediterranean fruit fly, ...

    Abstract The Mediterranean fruit fly,
    Language English
    Publishing date 2024-03-08
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2661517-4
    ISSN 2079-7737
    ISSN 2079-7737
    DOI 10.3390/biology13030177
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  9. Article ; Online: Freezing and thawing of cells on a microfluidic device: a simple and time-saving experimental procedure.

    Lv, Xiaoqing / Ma, Zhengtai / Guo, Lin

    Bioscience, biotechnology, and biochemistry

    2023  Volume 87, Issue 12, Page(s) 1478–1484

    Abstract: Developing cell cryopreservation methods on chips is not only crucial for biomedical science but also represents an innovative approach for preserving traditional cell samples. This study presents a simple method for direct cell freezing and thawing on ... ...

    Abstract Developing cell cryopreservation methods on chips is not only crucial for biomedical science but also represents an innovative approach for preserving traditional cell samples. This study presents a simple method for direct cell freezing and thawing on chip, allowing for long-term storage of cells. During the freezing process, cells were injected into the microchannel along with a conventional cell cryopreservation solution, and the chip was packed using a self-sealing bag containing isopropyl alcohol and then stored in a -80°C refrigerator until needed. During the thawing process, microcolumn arrays with a spacing of 8 µm were strategically incorporated into the microfluidic chip design to effectively inhibit cells from the channel. The breast cancer cell lines MDA-MB-231 and B47D demonstrated successful thawing and growth after cryopreservation for 1 month to 1 year. These findings offer a direct cell freezing and thawing method on a microfluidic chip for subsequent experiments.
    MeSH term(s) Freezing ; Cryopreservation/methods ; Lab-On-A-Chip Devices
    Language English
    Publishing date 2023-09-02
    Publishing country England
    Document type Journal Article
    ZDB-ID 1106450-x
    ISSN 1347-6947 ; 0916-8451
    ISSN (online) 1347-6947
    ISSN 0916-8451
    DOI 10.1093/bbb/zbad123
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    Zs.A 4647: Show issues Location:
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  10. Article ; Online: Evaluation of InSAR Tropospheric Delay Correction Methods in the Plateau Monsoon Climate Region Considering Spatial-Temporal Variability.

    Yang, Qihang / Zuo, Xiaoqing / Guo, Shipeng / Zhao, Yanxi

    Sensors (Basel, Switzerland)

    2023  Volume 23, Issue 23

    Abstract: The tropospheric delay caused by the temporal and spatial variation of meteorological parameters is the main error source in interferometric synthetic aperture radar (InSAR) applications for geodesy. To minimize the impact of tropospheric delay errors, ... ...

    Abstract The tropospheric delay caused by the temporal and spatial variation of meteorological parameters is the main error source in interferometric synthetic aperture radar (InSAR) applications for geodesy. To minimize the impact of tropospheric delay errors, it is necessary to select the appropriate tropospheric delay correction method for different regions. In this study, the interferogram results of the InSAR, corrected for tropospheric delay using the Linear, Generic Atmospheric Correction Online Service for InSAR (GACOS) and ERA-5 atmospheric reanalysis dataset (ERA5) methods, are presented for the study area of the junction of the Hengduan Mountains and the Yunnan-Kweichow Plateau, which is significantly influenced by the plateau monsoon climate. Four representative regions, Eryuan, Binchuan, Dali, and Yangbi, are selected for the study and analysis. The phase standard deviation (STD), phase-height correlation, and global navigation satellite system (GNSS) data were used to evaluate the effect of tropospheric delay correction by integrating topographic, seasonal, and meteorological factors. The results show that all three methods can attenuate the tropospheric delay, but the correction effect varies with spatial and temporal characteristics.
    Language English
    Publishing date 2023-12-02
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2052857-7
    ISSN 1424-8220 ; 1424-8220
    ISSN (online) 1424-8220
    ISSN 1424-8220
    DOI 10.3390/s23239574
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