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Article ; Online: Site-specific incorporation of quadricyclane into a protein and photocleavage of the quadricyclane ligation adduct.

Tomlin, Frederick M / Gordon, Chelsea G / Han, Yisu / Wu, Taia S / Sletten, Ellen M / Bertozzi, Carolyn R

2018 Volume 26, Issue 19, Page(s) 5280–5290

Abstract: The quadricyclane (QC) ligation is a bioorthogonal reaction between a quadricyclane moiety and a nickel bis(dithiolene) derivative. Here we show that a QC amino acid can be incorporated into a protein site-specifically using the pyrrolysine-based genetic ...

Abstract	The quadricyclane (QC) ligation is a bioorthogonal reaction between a quadricyclane moiety and a nickel bis(dithiolene) derivative. Here we show that a QC amino acid can be incorporated into a protein site-specifically using the pyrrolysine-based genetic code expansion platform, and subsequently used for ligation chemistry. Additionally, we exploited the photolability of the QC ligation product to render the adduct cleavable with a handheld UV lamp. We further developed a protein purification method that involves QC ligation of biotin to a protein of interest, capture on streptavidin resin, and finally release using only UV light. The QC ligation thus brings novel chemical manipulations to the realm of bioorthogonal chemistry.
MeSH term(s)	Biotin/chemistry ; Biotin/metabolism ; Bridged-Ring Compounds/chemistry ; Coordination Complexes/chemistry ; Lysine/analogs & derivatives ; Lysine/chemistry ; Nickel/chemistry ; Photolysis/radiation effects ; Streptavidin/chemistry ; Streptavidin/metabolism ; Ultraviolet Rays
Chemical Substances	Bridged-Ring Compounds ; Coordination Complexes ; Biotin (6SO6U10H04) ; Nickel (7OV03QG267) ; quadricyclane (8E0K9BG24C) ; Streptavidin (9013-20-1) ; pyrrolysine (H3214Y96LP) ; Lysine (K3Z4F929H6)
Language	English
Publishing date	2018-04-04
Publishing country	England
Document type	Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't ; Research Support, U.S. Gov't, Non-P.H.S.
ZDB-ID	1161284-8
ISSN	1464-3391 ; 0968-0896
ISSN (online)	1464-3391
ISSN	0968-0896
DOI	10.1016/j.bmc.2018.04.009
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Article ; Online: Modeling collective cell behavior in cancer: Perspectives from an interdisciplinary conversation.

Adler, Frederick R / Anderson, Alexander R A / Bhushan, Abhinav / Bogdan, Paul / Bravo-Cordero, Jose Javier / Brock, Amy / Chen, Yun / Cukierman, Edna / DelGiorno, Kathleen E / Denis, Gerald V / Ferrall-Fairbanks, Meghan C / Gartner, Zev Jordan / Germain, Ronald N / Gordon, Deborah M / Hunter, Ginger / Jolly, Mohit Kumar / Karacosta, Loukia Georgiou / Mythreye, Karthikeyan / Katira, Parag /

Cell systems

2023 Volume 14, Issue 4, Page(s) 252–257

Abstract: Collective cell behavior contributes to all stages of cancer progression. Understanding how collective behavior emerges through cell-cell interactions and decision-making will advance our understanding of cancer biology and provide new therapeutic ... ...

Abstract	Collective cell behavior contributes to all stages of cancer progression. Understanding how collective behavior emerges through cell-cell interactions and decision-making will advance our understanding of cancer biology and provide new therapeutic approaches. Here, we summarize an interdisciplinary discussion on multicellular behavior in cancer, draw lessons from other scientific disciplines, and identify future directions.
MeSH term(s)	Humans ; Mass Behavior ; Neoplasms ; Communication
Language	English
Publishing date	2023-04-20
Publishing country	United States
Document type	Journal Article ; Research Support, N.I.H., Extramural
ZDB-ID	2854138-8
ISSN	2405-4720 ; 2405-4712
ISSN (online)	2405-4720
ISSN	2405-4712
DOI	10.1016/j.cels.2023.03.002
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article: Inhibition of NGLY1 Inactivates the Transcription Factor Nrf1 and Potentiates Proteasome Inhibitor Cytotoxicity.

Tomlin, Frederick M / Gerling-Driessen, Ulla I M / Liu, Yi-Chang / Flynn, Ryan A / Vangala, Janakiram R / Lentz, Christian S / Clauder-Muenster, Sandra / Jakob, Petra / Mueller, William F / Ordoñez-Rueda, Diana / Paulsen, Malte / Matsui, Naoko / Foley, Deirdre / Rafalko, Agnes / Suzuki, Tadashi / Bogyo, Matthew / Steinmetz, Lars M / Radhakrishnan, Senthil K / Bertozzi, Carolyn R

ACS central science

2017 Volume 3, Issue 11, Page(s) 1143–1155

Abstract: Proteasome inhibitors are used to treat blood cancers such as multiple myeloma (MM) and mantle cell lymphoma. The efficacy of these drugs is frequently undermined by acquired resistance. One mechanism of proteasome inhibitor resistance may involve the ... ...

Abstract	Proteasome inhibitors are used to treat blood cancers such as multiple myeloma (MM) and mantle cell lymphoma. The efficacy of these drugs is frequently undermined by acquired resistance. One mechanism of proteasome inhibitor resistance may involve the transcription factor Nuclear Factor, Erythroid 2 Like 1 (NFE2L1, also referred to as Nrf1), which responds to proteasome insufficiency or pharmacological inhibition by upregulating proteasome subunit gene expression. This "bounce-back" response is achieved through a unique mechanism. Nrf1 is constitutively translocated into the ER lumen, N-glycosylated, and then targeted for proteasomal degradation via the ER-associated degradation (ERAD) pathway. Proteasome inhibition leads to accumulation of cytosolic Nrf1, which is then processed to form the active transcription factor. Here we show that the cytosolic enzyme N-glycanase 1 (NGLY1, the human PNGase) is essential for Nrf1 activation in response to proteasome inhibition. Chemical or genetic disruption of NGLY1 activity results in the accumulation of misprocessed Nrf1 that is largely excluded from the nucleus. Under these conditions, Nrf1 is inactive in regulating proteasome subunit gene expression in response to proteasome inhibition. Through a small molecule screen, we identified a cell-active NGLY1 inhibitor that disrupts the processing and function of Nrf1. The compound potentiates the cytotoxicity of carfilzomib, a clinically used proteasome inhibitor, against MM and T cell-derived acute lymphoblastic leukemia (T-ALL) cell lines. Thus, NGLY1 inhibition prevents Nrf1 activation and represents a new therapeutic approach for cancers that depend on proteasome homeostasis.
Language	English
Publishing date	2017-10-25
Publishing country	United States
Document type	Journal Article
ISSN	2374-7943
ISSN	2374-7943
DOI	10.1021/acscentsci.7b00224
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Article ; Online: Inhibition of NGLY1 Inactivates the Transcription Factor Nrf1 and Potentiates Proteasome Inhibitor Cytotoxicity

Frederick M. Tomlin / Ulla I. M. Gerling-Driessen / Yi-Chang Liu / Ryan A. Flynn / Janakiram R. Vangala / Christian S. Lentz / Sandra Clauder-Muenster / Petra Jakob / William F. Mueller / Diana Ordoñez-Rueda / Malte Paulsen / Naoko Matsui / Deirdre Foley / Agnes Rafalko / Tadashi Suzuki / Matthew Bogyo / Lars M. Steinmetz / Senthil K. Radhakrishnan / Carolyn R. Bertozzi

ACS Central Science, Vol 3, Iss 11, Pp 1143-

2017 Volume 1155

Keywords	Chemistry ; QD1-999
Language	English
Publishing date	2017-10-01T00:00:00Z
Publisher	American Chemical Society
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article: Determining Critical Topics for Undergraduate Surgical Education in Rwanda: Results of a Modified Delphi Process and a Consensus Conference.

Alayande, Barnabas T / Forbes, Callum W / Iradakunda, Jules / Majyambere, Jean Paul / Hey, Matthew T / Powell, Brittany L / Perl, Juliana / McCall, Natalie / Paul, Tomlin / Ingabire, Jc Allen / Shimelash, Natnael / Mutabazi, Emmanuel / Kimto, Emmanuel O / Danladi, Gambo Musa / Tubasiime, Ronald / Rickard, Jennifer / Karekezi, Claire / Makiriro, Gabriel / Bigirimana, Simon Pierre /

Harelimana, James G / ElSayed, Ahmed / Ndibanje, Alain Jules / Mpirimbanyi, Christophe / Masimbi, Ornella / Ndayishimiye, Mick / Ntabana, Frederick / Haonga, Billy Thomson / Anderson, Geoffrey A / Byringyiro, Jean Claude / Ntirenganya, Faustin / Riviello, Robert R / Bekele, Abebe

Cureus

2023 Volume 15, Issue 8, Page(s) e43625

Abstract: Background Developing a contextually appropriate curriculum is critical to train physicians who can address surgical challenges in sub-Saharan Africa. An innovative modified Delphi process was used to identify contextually optimized curricular content to ...

Abstract	Background Developing a contextually appropriate curriculum is critical to train physicians who can address surgical challenges in sub-Saharan Africa. An innovative modified Delphi process was used to identify contextually optimized curricular content to meet sub-Saharan Africa and Rwanda's surgical needs. Methods Participants were surgeons from East, Central, Southern, and West Africa and general practitioners with surgical experience. Delphi participants excluded or prioritized surgical topic areas generated from extensive grey and formal literature review. Surgical educators first screened and condensed identified topics. Round 1 screened and prioritized identified topics, with a 75% consensus cut-off based on the content validity index and a prioritization score. Topics that reached consensus were screened again in round 2 and re-prioritized, following controlled feedback. Frequencies for aggregate prioritization scores, experts in agreement, item-level content validity index, universal agreement and scale-level content validity index based on the average method (S-CVI/Ave) using proportion relevance, and intra-class correlation (ICC) (based on a mean-rating, consistency, two-way mixed-effects model) were performed. We also used arithmetic mean values and modal frequency. Cronbach's Alpha was also calculated to ascertain reliability. Results were validated through a multi-institution consensus conference attended by Rwanda-based surgical specialists, general practitioners, medical students, surgical educators, and surgical association representatives using an inclusive, participatory, collaborative, agreement-seeking, and cooperative,
Language	English
Publishing date	2023-08-17
Publishing country	United States
Document type	Journal Article
ZDB-ID	2747273-5
ISSN	2168-8184
ISSN	2168-8184
DOI	10.7759/cureus.43625
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Achievement of Target Gain Larger than Unity in an Inertial Fusion Experiment.

Abu-Shawareb, H / Acree, R / Adams, P / Adams, J / Addis, B / Aden, R / Adrian, P / Afeyan, B B / Aggleton, M / Aghaian, L / Aguirre, A / Aikens, D / Akre, J / Albert, F / Albrecht, M / Albright, B J / Albritton, J / Alcala, J / Alday, C /

Alessi, D A / Alexander, N / Alfonso, J / Alfonso, N / Alger, E / Ali, S J / Ali, Z A / Allen, A / Alley, W E / Amala, P / Amendt, P A / Amick, P / Ammula, S / Amorin, C / Ampleford, D J / Anderson, R W / Anklam, T / Antipa, N / Appelbe, B / Aracne-Ruddle, C / Araya, E / Archuleta, T N / Arend, M / Arnold, P / Arnold, T / Arsenlis, A / Asay, J / Atherton, L J / Atkinson, D / Atkinson, R / Auerbach, J M / Austin, B / Auyang, L / Awwal, A A S / Aybar, N / Ayers, J / Ayers, S / Ayers, T / Azevedo, S / Bachmann, B / Back, C A / Bae, J / Bailey, D S / Bailey, J / Baisden, T / Baker, K L / Baldis, H / Barber, D / Barberis, M / Barker, D / Barnes, A / Barnes, C W / Barrios, M A / Barty, C / Bass, I / Batha, S H / Baxamusa, S H / Bazan, G / Beagle, J K / Beale, R / Beck, B R / Beck, J B / Bedzyk, M / Beeler, R G / Behrendt, W / Belk, L / Bell, P / Belyaev, M / Benage, J F / Bennett, G / Benedetti, L R / Benedict, L X / Berger, R L / Bernat, T / Bernstein, L A / Berry, B / Bertolini, L / Besenbruch, G / Betcher, J / Bettenhausen, R / Betti, R / Bezzerides, B / Bhandarkar, S D / Bickel, R / Biener, J / Biesiada, T / Bigelow, K / Bigelow-Granillo, J / Bigman, V / Bionta, R M / Birge, N W / Bitter, M / Black, A C / Bleile, R / Bleuel, D L / Bliss, E / Blue, B / Boehly, T / Boehm, K / Boley, C D / Bonanno, R / Bond, E J / Bond, T / Bonino, M J / Borden, M / Bourgade, J-L / Bousquet, J / Bowers, J / Bowers, M / Boyd, R / Boyle, D / Bozek, A / Bradley, D K / Bradley, K S / Bradley, P A / Bradley, L / Brannon, L / Brantley, P S / Braun, D / Braun, T / Brienza-Larsen, K / Briggs, R / Briggs, T M / Britten, J / Brooks, E D / Browning, D / Bruhn, M W / Brunner, T A / Bruns, H / Brunton, G / Bryant, B / Buczek, T / Bude, J / Buitano, L / Burkhart, S / Burmark, J / Burnham, A / Burr, R / Busby, L E / Butlin, B / Cabeltis, R / Cable, M / Cabot, W H / Cagadas, B / Caggiano, J / Cahayag, R / Caldwell, S E / Calkins, S / Callahan, D A / Calleja-Aguirre, J / Camara, L / Camp, D / Campbell, E M / Campbell, J H / Carey, B / Carey, R / Carlisle, K / Carlson, L / Carman, L / Carmichael, J / Carpenter, A / Carr, C / Carrera, J A / Casavant, D / Casey, A / Casey, D T / Castillo, A / Castillo, E / Castor, J I / Castro, C / Caughey, W / Cavitt, R / Celeste, J / Celliers, P M / Cerjan, C / Chandler, G / Chang, B / Chang, C / Chang, J / Chang, L / Chapman, R / Chapman, T D / Chase, L / Chen, H / Chen, K / Chen, L-Y / Cheng, B / Chittenden, J / Choate, C / Chou, J / Chrien, R E / Chrisp, M / Christensen, K / Christensen, M / Christiansen, N S / Christopherson, A R / Chung, M / Church, J A / Clark, A / Clark, D S / Clark, K / Clark, R / Claus, L / Cline, B / Cline, J A / Cobble, J A / Cochrane, K / Cohen, B / Cohen, S / Collette, M R / Collins, G W / Collins, L A / Collins, T J B / Conder, A / Conrad, B / Conyers, M / Cook, A W / Cook, D / Cook, R / Cooley, J C / Cooper, G / Cope, T / Copeland, S R / Coppari, F / Cortez, J / Cox, J / Crandall, D H / Crane, J / Craxton, R S / Cray, M / Crilly, A / Crippen, J W / Cross, D / Cuneo, M / Cuotts, G / Czajka, C E / Czechowicz, D / Daly, T / Danforth, P / Danly, C / Darbee, R / Darlington, B / Datte, P / Dauffy, L / Davalos, G / Davidovits, S / Davis, P / Davis, J / Dawson, S / Day, R D / Day, T H / Dayton, M / Deck, C / Decker, C / Deeney, C / DeFriend, K A / Deis, G / Delamater, N D / Delettrez, J A / Demaret, R / Demos, S / Dempsey, S M / Desjardin, R / Desjardins, T / Desjarlais, M P / Dewald, E L / DeYoreo, J / Diaz, S / Dimonte, G / Dittrich, T R / Divol, L / Dixit, S N / Dixon, J / Do, A / Dodd, E S / Dolan, D / Donovan, A / Donovan, M / Döppner, T / Dorrer, C / Dorsano, N / Douglas, M R / Dow, D / Downie, J / Downing, E / Dozieres, M / Draggoo, V / Drake, D / Drake, R P / Drake, T / Dreifuerst, G / Drury, O / DuBois, D F / DuBois, P F / Dunham, G / Durocher, M / Dylla-Spears, R / Dymoke-Bradshaw, A K L / Dzenitis, B / Ebbers, C / Eckart, M / Eddinger, S / Eder, D / Edgell, D / Edwards, M J / Efthimion, P / Eggert, J H / Ehrlich, B / Ehrmann, P / Elhadj, S / Ellerbee, C / Elliott, N S / Ellison, C L / Elsner, F / Emerich, M / Engelhorn, K / England, T / English, E / Epperson, P / Epstein, R / Erbert, G / Erickson, M A / Erskine, D J / Erlandson, A / Espinosa, R J / Estes, C / Estabrook, K G / Evans, S / Fabyan, A / Fair, J / Fallejo, R / Farmer, N / Farmer, W A / Farrell, M / Fatherley, V E / Fedorov, M / Feigenbaum, E / Fehrenbach, T / Feit, M / Felker, B / Ferguson, W / Fernandez, J C / Fernandez-Panella, A / Fess, S / Field, J E / Filip, C V / Fincke, J R / Finn, T / Finnegan, S M / Finucane, R G / Fischer, M / Fisher, A / Fisher, J / Fishler, B / Fittinghoff, D / Fitzsimmons, P / Flegel, M / Flippo, K A / Florio, J / Folta, J / Folta, P / Foreman, L R / Forrest, C / Forsman, A / Fooks, J / Foord, M / Fortner, R / Fournier, K / Fratanduono, D E / Frazier, N / Frazier, T / Frederick, C / Freeman, M S / Frenje, J / Frey, D / Frieders, G / Friedrich, S / Froula, D H / Fry, J / Fuller, T / Gaffney, J / Gales, S / Le Galloudec, B / Le Galloudec, K K / Gambhir, A / Gao, L / Garbett, W J / Garcia, A / Gates, C / Gaut, E / Gauthier, P / Gavin, Z / Gaylord, J / Geddes, C G R / Geissel, M / Génin, F / Georgeson, J / Geppert-Kleinrath, H / Geppert-Kleinrath, V / Gharibyan, N / Gibson, J / Gibson, C / Giraldez, E / Glebov, V / Glendinning, S G / Glenn, S / Glenzer, S H / Goade, S / Gobby, P L / Goldman, S R / Golick, B / Gomez, M / Goncharov, V / Goodin, D / Grabowski, P / Grafil, E / Graham, P / Grandy, J / Grasz, E / Graziani, F R / Greenman, G / Greenough, J A / Greenwood, A / Gregori, G / Green, T / Griego, J R / Grim, G P / Grondalski, J / Gross, S / Guckian, J / Guler, N / Gunney, B / Guss, G / Haan, S / Hackbarth, J / Hackel, L / Hackel, R / Haefner, C / Hagmann, C / Hahn, K D / Hahn, S / Haid, B J / Haines, B M / Hall, B M / Hall, C / Hall, G N / Hamamoto, M / Hamel, S / Hamilton, C E / Hammel, B A / Hammer, J H / Hampton, G / Hamza, A / Handler, A / Hansen, S / Hanson, D / Haque, R / Harding, D / Harding, E / Hares, J D / Harris, D B / Harte, J A / Hartouni, E P / Hatarik, R / Hatchett, S / Hauer, A A / Havre, M / Hawley, R / Hayes, J / Hayes, S / Hayes-Sterbenz, A / Haynam, C A / Haynes, D A / Headley, D / Heal, A / Heebner, J E / Heerey, S / Heestand, G M / Heeter, R / Hein, N / Heinbockel, C / Hendricks, C / Henesian, M / Heninger, J / Henrikson, J / Henry, E A / Herbold, E B / Hermann, M R / Hermes, G / Hernandez, J E / Hernandez, V J / Herrmann, M C / Herrmann, H W / Herrera, O D / Hewett, D / Hibbard, R / Hicks, D G / Higginson, D P / Hill, D / Hill, K / Hilsabeck, T / Hinkel, D E / Ho, D D / Ho, V K / Hoffer, J K / Hoffman, N M / Hohenberger, M / Hohensee, M / Hoke, W / Holdener, D / Holdener, F / Holder, J P / Holko, B / Holunga, D / Holzrichter, J F / Honig, J / Hoover, D / Hopkins, D / Berzak Hopkins, L F / Hoppe, M / Hoppe, M L / Horner, J / Hornung, R / Horsfield, C J / Horvath, J / Hotaling, D / House, R / Howell, L / Hsing, W W / Hu, S X / Huang, H / Huckins, J / Hui, H / Humbird, K D / Hund, J / Hunt, J / Hurricane, O A / Hutton, M / Huynh, K H-K / Inandan, L / Iglesias, C / Igumenshchev, I V / Ivanovich, I / Izumi, N / Jackson, M / Jackson, J / Jacobs, S D / James, G / Jancaitis, K / Jarboe, J / Jarrott, L C / Jasion, D / Jaquez, J / Jeet, J / Jenei, A E / Jensen, J / Jimenez, J / Jimenez, R / Jobe, D / Johal, Z / Johns, H M / Johnson, D / Johnson, M A / Gatu Johnson, M / Johnson, R J / Johnson, S / Johnson, S A / Johnson, T / Jones, K / Jones, O / Jones, M / Jorge, R / Jorgenson, H J / Julian, M / Jun, B I / Jungquist, R / Kaae, J / Kabadi, N / Kaczala, D / Kalantar, D / Kangas, K / Karasiev, V V / Karasik, M / Karpenko, V / Kasarky, A / Kasper, K / Kauffman, R / Kaufman, M I / Keane, C / Keaty, L / Kegelmeyer, L / Keiter, P A / Kellett, P A / Kellogg, J / Kelly, J H / Kemic, S / Kemp, A J / Kemp, G E / Kerbel, G D / Kershaw, D / Kerr, S M / Kessler, T J / Key, M H / Khan, S F / Khater, H / Kiikka, C / Kilkenny, J / Kim, Y / Kim, Y-J / Kimko, J / Kimmel, M / Kindel, J M / King, J / Kirkwood, R K / Klaus, L / Klem, D / Kline, J L / Klingmann, J / Kluth, G / Knapp, P / Knauer, J / Knipping, J / Knudson, M / Kobs, D / Koch, J / Kohut, T / Kong, C / Koning, J M / Koning, P / Konior, S / Kornblum, H / Kot, L B / Kozioziemski, B / Kozlowski, M / Kozlowski, P M / Krammen, J / Krasheninnikova, N S / Krauland, C M / Kraus, B / Krauser, W / Kress, J D / Kritcher, A L / Krieger, E / Kroll, J J / Kruer, W L / Kruse, M K G / Kucheyev, S / Kumbera, M / Kumpan, S / Kunimune, J / Kur, E / Kustowski, B / Kwan, T J T / Kyrala, G A / Laffite, S / Lafon, M / LaFortune, K / Lagin, L / Lahmann, B / Lairson, B / Landen, O L / Land, T / Lane, M / Laney, D / Langdon, A B / Langenbrunner, J / Langer, S H / Langro, A / Lanier, N E / Lanier, T E / Larson, D / Lasinski, B F / Lassle, D / LaTray, D / Lau, G / Lau, N / Laumann, C / Laurence, A / Laurence, T A / Lawson, J / Le, H P / Leach, R R / Leal, L / Leatherland, A / LeChien, K / Lechleiter, B / Lee, A / Lee, M / Lee, T / Leeper, R J / Lefebvre, E / Leidinger, J-P / LeMire, B / Lemke, R W / Lemos, N C / Le Pape, S / Lerche, R / Lerner, S / Letts, S / Levedahl, K / Lewis, T / Li, C K / Li, H / Li, J / Liao, W / Liao, Z M / Liedahl, D / Liebman, J / Lindford, G / Lindman, E L / Lindl, J D / Loey, H / London, R A / Long, F / Loomis, E N / Lopez, F E / Lopez, H / Losbanos, E / Loucks, S / Lowe-Webb, R / Lundgren, E / Ludwigsen, A P / Luo, R / Lusk, J / Lyons, R / Ma, T / Macallop, Y / MacDonald, M J / MacGowan, B J / Mack, J M / Mackinnon, A J / MacLaren, S A / MacPhee, A G / Magelssen, G R / Magoon, J / Malone, R M / Malsbury, T / Managan, R / Mancini, R / Manes, K / Maney, D / Manha, D / Mannion, O M / Manuel, A M / Manuel, M J-E / Mapoles, E / Mara, G / Marcotte, T / Marin, E / Marinak, M M / Mariscal, D A / Mariscal, E F / Marley, E V / Marozas, J A / Marquez, R / Marshall, C D / Marshall, F J / Marshall, M / Marshall, S / Marticorena, J / Martinez, J I / Martinez, D / Maslennikov, I / Mason, D / Mason, R J / Masse, L / Massey, W / Masson-Laborde, P-E / Masters, N D / Mathisen, D / Mathison, E / Matone, J / Matthews, M J / Mattoon, C / Mattsson, T R / Matzen, K / Mauche, C W / Mauldin, M / McAbee, T / McBurney, M / Mccarville, T / McCrory, R L / McEvoy, A M / McGuffey, C / Mcinnis, M / McKenty, P / McKinley, M S / McLeod, J B / McPherson, A / Mcquillan, B / Meamber, M / Meaney, K D / Meezan, N B / Meissner, R / Mehlhorn, T A / Mehta, N C / Menapace, J / Merrill, F E / Merritt, B T / Merritt, E C / Meyerhofer, D D / Mezyk, S / Mich, R J / Michel, P A / Milam, D / Miller, C / Miller, D / Miller, D S / Miller, E / Miller, E K / Miller, J / Miller, M / Miller, P E / Miller, T / Miller, W / Miller-Kamm, V / Millot, M / Milovich, J L / Minner, P / Miquel, J-L / Mitchell, S / Molvig, K / Montesanti, R C / Montgomery, D S / Monticelli, M / Montoya, A / Moody, J D / Moore, A S / Moore, E / Moran, M / Moreno, J C 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Physical review letters

2024 Volume 132, Issue 6, Page(s) 65102

Abstract: On December 5, 2022, an indirect drive fusion implosion on the National Ignition Facility (NIF) achieved a target gain G_{target} of 1.5. This is the first laboratory demonstration of exceeding "scientific breakeven" (or G_{target}>1) where 2.05 MJ of ... ...

Abstract	On December 5, 2022, an indirect drive fusion implosion on the National Ignition Facility (NIF) achieved a target gain G_{target} of 1.5. This is the first laboratory demonstration of exceeding "scientific breakeven" (or G_{target}>1) where 2.05 MJ of 351 nm laser light produced 3.1 MJ of total fusion yield, a result which significantly exceeds the Lawson criterion for fusion ignition as reported in a previous NIF implosion [H. Abu-Shawareb et al. (Indirect Drive ICF Collaboration), Phys. Rev. Lett. 129, 075001 (2022)PRLTAO0031-900710.1103/PhysRevLett.129.075001]. This achievement is the culmination of more than five decades of research and gives proof that laboratory fusion, based on fundamental physics principles, is possible. This Letter reports on the target, laser, design, and experimental advancements that led to this result.
Language	English
Publishing date	2024-02-23
Publishing country	United States
Document type	Journal Article
ZDB-ID	208853-8
ISSN	1079-7114 ; 0031-9007
ISSN (online)	1079-7114
ISSN	0031-9007
DOI	10.1103/PhysRevLett.132.065102
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Article ; Online: Lawson Criterion for Ignition Exceeded in an Inertial Fusion Experiment.

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Zaka, F / Ze, F / Zeiger, B / Zika, M / Zimmerman, G B / Zobrist, T / Zuegel, J D / Zylstra, A B

Physical review letters

2021 Volume 129, Issue 7, Page(s) 75001

Abstract: For more than half a century, researchers around the world have been engaged in attempts to achieve fusion ignition as a proof of principle of various fusion concepts. Following the Lawson criterion, an ignited plasma is one where the fusion heating ... ...

Abstract	For more than half a century, researchers around the world have been engaged in attempts to achieve fusion ignition as a proof of principle of various fusion concepts. Following the Lawson criterion, an ignited plasma is one where the fusion heating power is high enough to overcome all the physical processes that cool the fusion plasma, creating a positive thermodynamic feedback loop with rapidly increasing temperature. In inertially confined fusion, ignition is a state where the fusion plasma can begin "burn propagation" into surrounding cold fuel, enabling the possibility of high energy gain. While "scientific breakeven" (i.e., unity target gain) has not yet been achieved (here target gain is 0.72, 1.37 MJ of fusion for 1.92 MJ of laser energy), this Letter reports the first controlled fusion experiment, using laser indirect drive, on the National Ignition Facility to produce capsule gain (here 5.8) and reach ignition by nine different formulations of the Lawson criterion.
Language	English
Publishing date	2021-03-18
Publishing country	United States
Document type	Journal Article
ZDB-ID	208853-8
ISSN	1079-7114 ; 0031-9007
ISSN (online)	1079-7114
ISSN	0031-9007
DOI	10.1103/PhysRevLett.129.075001
Database	MEDical Literature Analysis and Retrieval System OnLINE

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