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  1. Article ; Online: The authors respond: Blood sampling and analyses.

    Inoue, Fumiya / Inoue, Akihiko / Ishihara, Satoshi

    The American journal of emergency medicine

    2023  Volume 73, Page(s) 201–202

    Language English
    Publishing date 2023-09-18
    Publishing country United States
    Document type Letter
    ZDB-ID 605890-5
    ISSN 1532-8171 ; 0735-6757
    ISSN (online) 1532-8171
    ISSN 0735-6757
    DOI 10.1016/j.ajem.2023.09.023
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 2005: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
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    Jg. 1995 - 2021: Lesesall (1.OG)
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  2. Article ; Online: The authors respond: Spontaneous gasping during CPR and PCO2.

    Inoue, Fumiya / Inoue, Akihiko / Ishihara, Satoshi

    The American journal of emergency medicine

    2023  Volume 73, Page(s) 199

    Language English
    Publishing date 2023-09-21
    Publishing country United States
    Document type Letter
    ZDB-ID 605890-5
    ISSN 1532-8171 ; 0735-6757
    ISSN (online) 1532-8171
    ISSN 0735-6757
    DOI 10.1016/j.ajem.2023.09.027
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 2005: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
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    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  3. Article ; Online: Potential repurposing of DPP4 inhibitors for target therapy resistance in renal cell carcinoma.

    Horie, Kuniko / Inoue, Satoshi

    Oncotarget

    2023  Volume 14, Page(s) 807–808

    MeSH term(s) Humans ; Dipeptidyl-Peptidase IV Inhibitors/pharmacology ; Dipeptidyl-Peptidase IV Inhibitors/therapeutic use ; Carcinoma, Renal Cell/drug therapy ; Carcinoma, Renal Cell/genetics ; Kidney Neoplasms/drug therapy
    Chemical Substances Dipeptidyl-Peptidase IV Inhibitors
    Language English
    Publishing date 2023-09-15
    Publishing country United States
    Document type Editorial
    ZDB-ID 2560162-3
    ISSN 1949-2553 ; 1949-2553
    ISSN (online) 1949-2553
    ISSN 1949-2553
    DOI 10.18632/oncotarget.28463
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Role of RNA binding proteins of the

    Takeiwa, Toshihiko / Ikeda, Kazuhiro / Horie, Kuniko / Inoue, Satoshi

    RNA biology

    2024  Volume 21, Issue 1, Page(s) 1–17

    Abstract: RNA-binding proteins (RBPs) play crucial roles in the functions and homoeostasis of various tissues by regulating multiple events of RNA processing including RNA splicing, intracellular RNA transport, and mRNA translation. ... ...

    Abstract RNA-binding proteins (RBPs) play crucial roles in the functions and homoeostasis of various tissues by regulating multiple events of RNA processing including RNA splicing, intracellular RNA transport, and mRNA translation. The
    MeSH term(s) Male ; Animals ; Humans ; Drosophila/genetics ; Drosophila/metabolism ; RNA-Binding Proteins/metabolism ; RNA Splicing ; RNA/metabolism ; Neoplasms/genetics ; PTB-Associated Splicing Factor/metabolism ; Mammals/genetics
    Chemical Substances RNA-Binding Proteins ; RNA (63231-63-0) ; PTB-Associated Splicing Factor ; PSPC1 protein, human
    Language English
    Publishing date 2024-03-29
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 2159587-2
    ISSN 1555-8584 ; 1555-8584
    ISSN (online) 1555-8584
    ISSN 1555-8584
    DOI 10.1080/15476286.2024.2332855
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Sex Pheromone of the Azalea Mealybug: Absolute Configuration and Kairomonal Activity.

    Sugawara, Yuma / Inoue, Hiromitsu / Toda, Satoshi / Tabata, Jun

    Journal of chemical ecology

    2024  

    Abstract: The sex pheromone of the azalea mealybug, Crisicoccus azaleae (Tinsley, 1898) (Hemiptera: Pseudococcidae), includes esters of a methyl-branched medium-chain fatty acid, ethyl and isopropyl (E)-7-methyl-4-nonenoate. These compounds are exceptional among ... ...

    Abstract The sex pheromone of the azalea mealybug, Crisicoccus azaleae (Tinsley, 1898) (Hemiptera: Pseudococcidae), includes esters of a methyl-branched medium-chain fatty acid, ethyl and isopropyl (E)-7-methyl-4-nonenoate. These compounds are exceptional among mealybug pheromones, which are commonly monoterpenes. Determination of the absolute configuration is challenging, because both chromatographic and spectrometric separations of stereoisomers of fatty acids with a methyl group distant from the carboxyl group are difficult. To solve this problem, we synthesized the enantiomers via the Johnson-Claisen rearrangement to build (E)-4-alkenoic acid by using (R)- and (S)-3-methylpentanal as chiral blocks, which were readily available from the amino acids L-(+)-alloisoleucine and L-(+)-isoleucine, respectively. Each pure enantiomer, as well as the natural pheromone, was subsequently derivatized with a highly potent chiral labeling reagent used in the Ohrui-Akasaka method. Through NMR spectral comparisons of these derivatives, the absolute configuration of the natural pheromone was determined to be S. Field-trap bioassays showed that male mealybugs were attracted more to (S)-enantiomers and preferred the natural stereochemistry. Moreover, the synthetic pheromones attracted Anagyrus wasps, indicating that the azalea mealybug pheromone has kairomonal activity.
    Language English
    Publishing date 2024-02-03
    Publishing country United States
    Document type Journal Article
    ZDB-ID 800130-3
    ISSN 1573-1561 ; 0098-0331
    ISSN (online) 1573-1561
    ISSN 0098-0331
    DOI 10.1007/s10886-024-01473-2
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Bonn / Germany

    Z 76/724: Show issues

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  6. Article: Steerable microcatheter for distal access of a giant cavernous carotid artery aneurysm during treatment with Pipeline Embolization Device: A case report and review of the literature.

    Inoue, Satoshi / Fujita, Atsushi / Kurihara, Eiji / Sasayama, Takashi

    Surgical neurology international

    2024  Volume 15, Page(s) 40

    Abstract: Background: In the treatment of giant cerebral aneurysms with flow-diverting stents, access to the distal parent artery is critical but occasionally challenging. This article provides our experience with a novel steerable microcatheter in such a ... ...

    Abstract Background: In the treatment of giant cerebral aneurysms with flow-diverting stents, access to the distal parent artery is critical but occasionally challenging. This article provides our experience with a novel steerable microcatheter in such a situation, as well as a review of the literature.
    Case description: A 73-year-old woman presented with right ptosis and external ophthalmoplegia. Magnetic resonance angiography revealed a giant right cavernous internal carotid artery aneurysm. Endovascular treatment was planned with flow diversion, but distal access was not possible using the standard technique. A 2.4-Fr steerable microcatheter, Leonis Mova Selective, was implemented, and by bending the catheter tip toward the distal parent artery, a guidewire could be guided distally. After the catheter exchange, two flow-diverting stents were deployed successfully.
    Conclusion: Steerable microcatheters may provide an option in treatment with flow-diverting stents for giant cerebral aneurysms where access to the distal parent artery is compromised.
    Language English
    Publishing date 2024-02-09
    Publishing country United States
    Document type Case Reports
    ISSN 2229-5097
    ISSN 2229-5097
    DOI 10.25259/SNI_974_2023
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: Exploring androgen receptor signaling pathway in prostate cancer: A path to new discoveries.

    Obinata, Daisuke / Takayama, Kenichi / Inoue, Satoshi / Takahashi, Satoru

    International journal of urology : official journal of the Japanese Urological Association

    2024  

    Abstract: Androgen deprivation therapy has achieved significant success in treating prostate cancer through strategies centered on the androgen receptor. However, the emergence of castration-resistant prostate cancer highlights this therapy limitation, ... ...

    Abstract Androgen deprivation therapy has achieved significant success in treating prostate cancer through strategies centered on the androgen receptor. However, the emergence of castration-resistant prostate cancer highlights this therapy limitation, underscoring the need to elucidate the mechanisms of treatment resistance. This review aimed to focus on multifaceted resistance mechanisms, including androgen receptor overexpression, splice variants, missense mutations, the involvement of the glucocorticoid receptor, and alterations in coregulators and transcription factors, revealing their roles in castration-resistant prostate cancer progression. These mechanisms promote cell survival and proliferation, depending on the androgen receptor signaling pathway, leading to resistance to conventional therapies. Amplification and mutations in the androgen receptor gene facilitate selective adaptation in treatment-resistant cells, consequently diminishing therapeutic efficacy. Furthermore, the activation of glucocorticoid receptors and aberrant regulation of specific coregulators and transcription factors contribute to the activation of androgen receptor-independent signaling pathways, promoting cell survival and proliferation. These findings hold promise for identifying new targets for treating castration-resistant prostate cancer and developing personalized treatment strategies. The development of future therapies will hinge on precisely targeting the androgen receptor signaling pathway, necessitating a deeper understanding of the molecular targets unique to castration-resistant prostate cancer.
    Language English
    Publishing date 2024-02-12
    Publishing country Australia
    Document type Journal Article ; Review
    ZDB-ID 1328401-0
    ISSN 1442-2042 ; 0919-8172
    ISSN (online) 1442-2042
    ISSN 0919-8172
    DOI 10.1111/iju.15424
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 4460: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
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    Jg. 1995 - 2021: Lesesall (2.OG)
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    Zs.MO 278: Show issues

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  8. Article: Gene editing technology to improve antitumor T-cell functions in adoptive immunotherapy.

    Ito, Yusuke / Inoue, Satoshi / Kagoya, Yuki

    Inflammation and regeneration

    2024  Volume 44, Issue 1, Page(s) 13

    Abstract: Adoptive immunotherapy, in which tumor-reactive T cells are prepared in vitro for adoptive transfer to the patient, can induce an objective clinical response in specific types of cancer. In particular, chimeric antigen receptor (CAR)-redirected T-cell ... ...

    Abstract Adoptive immunotherapy, in which tumor-reactive T cells are prepared in vitro for adoptive transfer to the patient, can induce an objective clinical response in specific types of cancer. In particular, chimeric antigen receptor (CAR)-redirected T-cell therapy has shown robust responses in hematologic malignancies. However, its efficacy against most of the other tumors is still insufficient, which remains an unmet medical need. Accumulating evidence suggests that modifying specific genes can enhance antitumor T-cell properties. Epigenetic factors have been particularly implicated in the remodeling of T-cell functions, including changes to dysfunctional states such as terminal differentiation and exhaustion. Genetic ablation of key epigenetic molecules prevents the dysfunctional reprogramming of T cells and preserves their functional properties.Clustered, regularly interspaced, short palindromic repeats (CRISPR)/CRISPR-associated protein (Cas)-based gene editing is a valuable tool to enable efficient and specific gene editing in cultured T cells. A number of studies have already identified promising targets to improve the therapeutic efficacy of CAR-T cells using genome-wide or focused CRISPR screening. In this review, we will present recent representative findings on molecular insights into T-cell dysfunction and how genetic modification contributes to overcoming it. We will also discuss several technical advances to achieve efficient gene modification using the CRISPR and other novel platforms.
    Language English
    Publishing date 2024-03-11
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 2051471-2
    ISSN 1880-9693 ; 0389-4290
    ISSN 1880-9693 ; 0389-4290
    DOI 10.1186/s41232-024-00324-7
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.B 2929: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
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  9. Article ; Online: Unified picture of vibrational relaxation of OH stretch at the air/water interface.

    Sung, Woongmo / Inoue, Ken-Ichi / Nihonyanagi, Satoshi / Tahara, Tahei

    Nature communications

    2024  Volume 15, Issue 1, Page(s) 1258

    Abstract: The elucidation of the energy dissipation process is crucial for understanding various phenomena occurring in nature. Yet, the vibrational relaxation and its timescale at the water interface, where the hydrogen-bonding network is truncated, are not well ... ...

    Abstract The elucidation of the energy dissipation process is crucial for understanding various phenomena occurring in nature. Yet, the vibrational relaxation and its timescale at the water interface, where the hydrogen-bonding network is truncated, are not well understood and are still under debate. In the present study, we focus on the OH stretch of interfacial water at the air/water interface and investigate its vibrational relaxation by femtosecond time-resolved, heterodyne-detected vibrational sum-frequency generation (TR-HD-VSFG) spectroscopy. The temporal change of the vibrationally excited hydrogen-bonded (HB) OH stretch band (ν=1→2 transition) is measured, enabling us to determine reliable vibrational relaxation (T
    Language English
    Publishing date 2024-02-10
    Publishing country England
    Document type Journal Article
    ZDB-ID 2553671-0
    ISSN 2041-1723 ; 2041-1723
    ISSN (online) 2041-1723
    ISSN 2041-1723
    DOI 10.1038/s41467-024-45388-8
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: Exploration of Chemical Space Guided by PixelCNN for Fragment-Based De Novo Drug Discovery.

    Noguchi, Satoshi / Inoue, Junya

    Journal of chemical information and modeling

    2022  Volume 62, Issue 23, Page(s) 5988–6001

    Abstract: We report a novel framework for achieving fragment-based molecular design using pixel convolutional neural network (PixelCNN) combined with the simplified molecular input line entry system (SMILES) as molecular representation. While a widely used ... ...

    Abstract We report a novel framework for achieving fragment-based molecular design using pixel convolutional neural network (PixelCNN) combined with the simplified molecular input line entry system (SMILES) as molecular representation. While a widely used recurrent neural network (RNN) assumes monotonically decaying correlations in strings, PixelCNN captures a periodicity among characters of SMILES. Thus, PixelCNN provides us with a novel solution for the analysis of chemical space by extracting the periodicity of molecular structures that will be buried in SMILES. Moreover, this characteristic enables us to generate molecules by combining several simple building blocks, such as a benzene ring and side-chain structures, which contributes to the effective exploration of chemical space by step-by-step searching for molecules from a target fragment. In conclusion, PixelCNN could be a powerful approach focusing on the periodicity of molecules to explore chemical space for the fragment-based molecular design.
    Language English
    Publishing date 2022-12-01
    Publishing country United States
    Document type Journal Article
    ZDB-ID 190019-5
    ISSN 1549-960X ; 0095-2338
    ISSN (online) 1549-960X
    ISSN 0095-2338
    DOI 10.1021/acs.jcim.2c01345
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1230: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
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