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  1. Book ; Thesis: Einfluss der B-Lymphozyten auf die T-Helfer-Zell-Aktivierung

    Glauben, Rainer

    2009  

    Author's details von Rainer Glauben
    Language German
    Edition [Mikrofiche-Ausg.]
    Publishing country Germany
    Document type Book ; Thesis
    Thesis / German Habilitation thesis Berlin, Techn. Univ., Diss., 2009
    HBZ-ID HT016445441
    Database Catalogue ZB MED Medicine, Health

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    In stock of ZB MED Cologne/Königswinter

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  2. Book ; Online ; Thesis: Die Hemmung von Histondeazetylasen in chronisch-entzündlichen Darmerkrankungen

    Glauben, Rainer [Verfasser]

    2021  

    Author's details Rainer Glauben
    Keywords Medizin, Gesundheit ; Medicine, Health
    Subject code sg610
    Language German
    Publisher Medizinische Fakultät Charité - Universitätsmedizin Berlin
    Publishing place Berlin
    Document type Book ; Online ; Thesis
    Database Digital theses on the web

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  3. Article: Fatty Acid Metabolism in Myeloid-Derived Suppressor Cells and Tumor-Associated Macrophages: Key Factor in Cancer Immune Evasion.

    Siddiqui, Sophiya / Glauben, Rainer

    Cancers

    2022  Volume 14, Issue 1

    Abstract: The tumor microenvironment (TME) comprises various cell types, soluble factors, viz, metabolites or cytokines, which together play in promoting tumor metastasis. Tumor infiltrating immune cells play an important role against cancer, and metabolic ... ...

    Abstract The tumor microenvironment (TME) comprises various cell types, soluble factors, viz, metabolites or cytokines, which together play in promoting tumor metastasis. Tumor infiltrating immune cells play an important role against cancer, and metabolic switching in immune cells has been shown to affect activation, differentiation, and polarization from tumor suppressive into immune suppressive phenotypes. Macrophages represent one of the major immune infiltrates into TME. Blood monocyte-derived macrophages and myeloid derived suppressor cells (MDSCs) infiltrating into the TME potentiate hostile tumor progression by polarizing into immunosuppressive tumor-associated macrophages (TAMs). Recent studies in the field of immunometabolism focus on metabolic reprogramming at the TME in polarizing tumor-associated macrophages (TAMs). Lipid droplets (LD), detected in almost every eukaryotic cell type, represent the major source for intra-cellular fatty acids. Previously, LDs were mainly described as storage sites for fatty acids. However, LDs are now recognized to play an integral role in cellular signaling and consequently in inflammation and metabolism-mediated phenotypical changes in immune cells. In recent years, the role of LD dependent metabolism in macrophage functionality and phenotype has been being investigated. In this review article, we discuss fatty acids stored in LDs, their role in modulating metabolism of tumor-infiltrating immune cells and, therefore, in shaping the cancer progression.
    Language English
    Publishing date 2022-01-04
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2527080-1
    ISSN 2072-6694
    ISSN 2072-6694
    DOI 10.3390/cancers14010250
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Fatty Acid-Driven Polarization of Suppressive Bone Marrow-Derived Macrophages Including Metabolic and Functional Analysis.

    Wu, Hao / Glauben, Rainer

    Methods in molecular biology (Clifton, N.J.)

    2021  Volume 2294, Page(s) 197–207

    Abstract: Macrophages represent not only the first line of defense against pathogens and are the main drivers of inflammation but are also involved in the initiation, immune evasion as well as metastasis of tumors. Therefore, it has been suggested that diminishing ...

    Abstract Macrophages represent not only the first line of defense against pathogens and are the main drivers of inflammation but are also involved in the initiation, immune evasion as well as metastasis of tumors. Therefore, it has been suggested that diminishing the immune regulatory function of macrophages would support the natural immune surveillance or antitumor therapies, respectively. However, the plasticity of macrophages represents an obstacle in understanding and manipulating the role of macrophages in tumor tissue or the tumor microenvironment. Here, we describe a protocol to differentiate macrophages, based on changing their metabolic environment, from bone marrow precursors to tumor-associated macrophage-like cells of an immune suppressive phenotype. Based on these protocols, the inhibitory functional phenotype of macrophages can be manipulated and therefore further analyzed as described, by interrupting metabolic pathways.
    MeSH term(s) Animals ; Cell Respiration ; Fatty Acids/metabolism ; Flow Cytometry/methods ; Humans ; Macrophages/cytology ; Macrophages/metabolism ; Metabolic Flux Analysis/methods ; Tumor-Associated Macrophages/metabolism ; Tumor-Associated Macrophages/pathology
    Chemical Substances Fatty Acids
    Language English
    Publishing date 2021-03-19
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ISSN 1940-6029
    ISSN (online) 1940-6029
    DOI 10.1007/978-1-0716-1350-4_14
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Targeting SOCE in Intestinal Epithelial Cells: A New Treatment Concept for Inflammatory Bowel Disease?

    Glauben, Rainer / Letizia, Marilena / Weidinger, Carl

    Cellular and molecular gastroenterology and hepatology

    2022  Volume 14, Issue 1, Page(s) 243–244

    MeSH term(s) Epithelial Cells ; Humans ; Inflammatory Bowel Diseases/therapy ; Intestines
    Language English
    Publishing date 2022-05-04
    Publishing country United States
    Document type Editorial ; Comment
    ZDB-ID 2819778-1
    ISSN 2352-345X ; 2352-345X
    ISSN (online) 2352-345X
    ISSN 2352-345X
    DOI 10.1016/j.jcmgh.2022.04.008
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  6. Article: Histone Deacetylases in the Inflamed Intestinal Epithelium-Promises of New Therapeutic Strategies.

    Gerbeth, Lorenz / Glauben, Rainer

    Frontiers in medicine

    2021  Volume 8, Page(s) 655956

    Abstract: The intestinal epithelium is a complex, dynamic barrier that separates luminal contents from the immune compartment while mediating nutrient absorption and controlled passage of antigens to convey oral tolerance. A compromised epithelial barrier often ... ...

    Abstract The intestinal epithelium is a complex, dynamic barrier that separates luminal contents from the immune compartment while mediating nutrient absorption and controlled passage of antigens to convey oral tolerance. A compromised epithelial barrier often leads to inflammation because immune cells in the lamina propria come into direct contact with luminal antigens. Defects in epithelial cell function were also shown to be involved in the etiology of inflammatory bowel diseases. These are severe, chronically relapsing inflammatory conditions of the gastrointestinal tract that also increase the risk of developing colorectal cancer. Despite major efforts of the scientific community, the precise causes and drivers of these conditions still remain largely obscured impeding the development of a permanent cure. Current therapeutic approaches mostly focus on alleviating symptoms by targeting immune cell signaling. The protein family of histone deacetylases (HDACs) has gained increasing attention over the last years, as HDAC inhibitors were shown to be potent tumor cell suppressors and also alleviate morbid inflammatory responses. Recent research continuously identifies new roles for specific HDACs suggesting that HDACs influence the cell signaling network from many different angles. This makes HDACs very interesting targets for therapeutic approaches but predicting effects after system manipulations can be difficult. In this review, we want to provide a comprehensive overview of current knowledge about the individual roles of HDACs in the intestinal epithelium to evaluate their therapeutic potential for inflammatory conditions of the gut.
    Language English
    Publishing date 2021-03-26
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2775999-4
    ISSN 2296-858X
    ISSN 2296-858X
    DOI 10.3389/fmed.2021.655956
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  7. Article ; Online: Frequent, high density expression of surface CD38 as a potential therapeutic target in adult T-lineage acute lymphoblastic leukemia.

    Koslowski, Sebastian / Glauben, Rainer / Habringer, Stefan / Burmeister, Thomas / Keller, Ulrich / Brüggemann, Monika / Gökbuget, Nicola / Schwartz, Stefan

    Haematologica

    2024  Volume 109, Issue 2, Page(s) 661–665

    MeSH term(s) Adult ; Humans ; ADP-ribosyl Cyclase 1/genetics ; ADP-ribosyl Cyclase 1/metabolism ; Antigens, CD ; Precursor T-Cell Lymphoblastic Leukemia-Lymphoma/drug therapy ; Precursor T-Cell Lymphoblastic Leukemia-Lymphoma/genetics ; Precursor T-Cell Lymphoblastic Leukemia-Lymphoma/metabolism
    Chemical Substances ADP-ribosyl Cyclase 1 (EC 3.2.2.6) ; Antigens, CD
    Language English
    Publishing date 2024-02-01
    Publishing country Italy
    Document type Journal Article
    ZDB-ID 2333-4
    ISSN 1592-8721 ; 0017-6567 ; 0390-6078
    ISSN (online) 1592-8721
    ISSN 0017-6567 ; 0390-6078
    DOI 10.3324/haematol.2023.283814
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: Histone Deacetylases in the Inflamed Intestinal Epithelium—Promises of New Therapeutic Strategies

    Lorenz Gerbeth / Rainer Glauben

    Frontiers in Medicine, Vol

    2021  Volume 8

    Abstract: The intestinal epithelium is a complex, dynamic barrier that separates luminal contents from the immune compartment while mediating nutrient absorption and controlled passage of antigens to convey oral tolerance. A compromised epithelial barrier often ... ...

    Abstract The intestinal epithelium is a complex, dynamic barrier that separates luminal contents from the immune compartment while mediating nutrient absorption and controlled passage of antigens to convey oral tolerance. A compromised epithelial barrier often leads to inflammation because immune cells in the lamina propria come into direct contact with luminal antigens. Defects in epithelial cell function were also shown to be involved in the etiology of inflammatory bowel diseases. These are severe, chronically relapsing inflammatory conditions of the gastrointestinal tract that also increase the risk of developing colorectal cancer. Despite major efforts of the scientific community, the precise causes and drivers of these conditions still remain largely obscured impeding the development of a permanent cure. Current therapeutic approaches mostly focus on alleviating symptoms by targeting immune cell signaling. The protein family of histone deacetylases (HDACs) has gained increasing attention over the last years, as HDAC inhibitors were shown to be potent tumor cell suppressors and also alleviate morbid inflammatory responses. Recent research continuously identifies new roles for specific HDACs suggesting that HDACs influence the cell signaling network from many different angles. This makes HDACs very interesting targets for therapeutic approaches but predicting effects after system manipulations can be difficult. In this review, we want to provide a comprehensive overview of current knowledge about the individual roles of HDACs in the intestinal epithelium to evaluate their therapeutic potential for inflammatory conditions of the gut.
    Keywords histone deacetylase ; HDAC ; inflammatory bowel disease ; intestinal epithelium ; HDAC inhibitor ; inflammation ; Medicine (General) ; R5-920
    Subject code 610
    Language English
    Publishing date 2021-03-01T00:00:00Z
    Publisher Frontiers Media S.A.
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  9. Article ; Online: COVID-19-from mucosal immunology to IBD patients.

    Weidinger, Carl / Hegazy, Ahmed Nabil / Glauben, Rainer / Siegmund, Britta

    Mucosal immunology

    2021  Volume 14, Issue 3, Page(s) 566–573

    Abstract: Viral infections with SARS-CoV-2 can cause a multi-facetted disease, which is not only characterized by pneumonia and overwhelming systemic inflammatory immune responses, but which can also directly affect the digestive system and infect intestinal ... ...

    Abstract Viral infections with SARS-CoV-2 can cause a multi-facetted disease, which is not only characterized by pneumonia and overwhelming systemic inflammatory immune responses, but which can also directly affect the digestive system and infect intestinal epithelial cells. Here, we review the current understanding of intestinal tropism of SARS-CoV-2 infection, its impact on mucosal function and immunology and summarize the effect of immune-suppression in patients with inflammatory bowel disease (IBD) on disease outcome of COVID-19 and discuss IBD-relevant implications for the clinical management of SARS-CoV-2 infected individuals.
    MeSH term(s) Biomarkers ; COVID-19/complications ; COVID-19/diagnosis ; COVID-19/immunology ; COVID-19/virology ; Host-Pathogen Interactions/immunology ; Humans ; Immunity, Innate ; Immunity, Mucosal ; Inflammatory Bowel Diseases/complications ; Inflammatory Bowel Diseases/diagnosis ; Inflammatory Bowel Diseases/immunology ; Intestinal Mucosa/immunology ; Intestinal Mucosa/metabolism ; Intestinal Mucosa/pathology ; SARS-CoV-2/physiology ; Severity of Illness Index ; Symptom Assessment ; Viral Tropism ; Virus Internalization
    Chemical Substances Biomarkers
    Language English
    Publishing date 2021-02-19
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Review
    ZDB-ID 2411370-0
    ISSN 1935-3456 ; 1933-0219
    ISSN (online) 1935-3456
    ISSN 1933-0219
    DOI 10.1038/s41385-021-00384-9
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article: HDAC und HDAC-Inhibition in der klinischen Forschung

    Gerbeth, Lorenz / Glauben, Rainer

    Immunologie

    2019  Volume 3, Issue 4, Page(s) 244

    Language German
    Document type Article
    ZDB-ID 2935137-6
    ISSN 2625-3585 ; 2513-1583
    Database Current Contents Medicine

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    Zs.A 7237: Show issues Location:
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