LIVIVO - Search results -

Search results

Result 1 - 10 of total 77

Search options

Article: Inhibition of late sodium current to reduce electrical and mechanical dysfunction of ischaemic myocardium.

Shryock, J C / Belardinelli, L

2007 Volume 153, Issue 6, Page(s) 1128–1132

Abstract: This commentary on the review by DA Saint in the current issue of the British Journal of Pharmacology focuses on the pathological role of late I(Na) in the heart, the evidence supporting inhibition of late I(Na) as a therapeutic target in ischaemic heart ...

Abstract	This commentary on the review by DA Saint in the current issue of the British Journal of Pharmacology focuses on the pathological role of late I(Na) in the heart, the evidence supporting inhibition of late I(Na) as a therapeutic target in ischaemic heart disease, and the therapeutic applications and challenges for development of new late I(Na) inhibitors. Recent reports from a large clinical outcome trial (MERLIN) of ranolazine, a drug known to inhibit late I(Na), indicated that it was safe and reduced recurrent ischaemia and arrhythmic activity. In combination with other results indicating that inhibition of late I(Na) reduces ischaemia, myocardial Ca(2+) overload, and electrical and mechanical dysfunction when late I(Na) is increased, the new clinical trial results suggest that reduction of cardiac late I(Na) is safe and therapeutically beneficial.
MeSH term(s)	Acetanilides/pharmacology ; Animals ; Calcium/metabolism ; Controlled Clinical Trials as Topic ; Drug Delivery Systems ; Drug Design ; Electrophysiology ; Enzyme Inhibitors/pharmacology ; Humans ; Myocardial Ischemia/drug therapy ; Myocardial Ischemia/physiopathology ; Piperazines/pharmacology ; Ranolazine ; Sodium Channel Blockers/pharmacology ; Sodium Channels/drug effects ; Sodium Channels/metabolism
Chemical Substances	Acetanilides ; Enzyme Inhibitors ; Piperazines ; Sodium Channel Blockers ; Sodium Channels ; Ranolazine (A6IEZ5M406) ; Calcium (SY7Q814VUP)
Language	English
Publishing date	2007-12-10
Publishing country	England
Document type	Comment ; Journal Article
ZDB-ID	80081-8
ISSN	1476-5381 ; 0007-1188
ISSN (online)	1476-5381
ISSN	0007-1188
DOI	10.1038/sj.bjp.0707522
Database	MEDical Literature Analysis and Retrieval System OnLINE

Full text online

Accessible to users with ZB MED library card

In stock of ZB MED Cologne/Königswinter

Uf I Zs.146: Show issues

Location:
Je nach Verfügbarkeit (siehe Angabe bei Bestand)
bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
ab Jg. 2022: Lesesaal (EG)

Order via subito

This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

Details ▾

Article ; Online: Unprecedented distribution data for Joshua trees (Yucca brevifolia and Y. jaegeriana) reveal contemporary climate associations of a Mojave Desert icon

Todd C. Esque / Daniel F. Shryock / Gabrielle A. Berry / Felicia C. Chen / Lesley A. DeFalco / Sabrina M. Lewicki / Brent L. Cunningham / Eddie J. Gaylord / Caitlan S. Poage / Gretchen E. Gantz / Ross A. Van Gaalen / Ben O. Gottsacker / Amanda M. McDonald / Jeremy B. Yoder / Christopher I. Smith / Kenneth E. Nussear

Frontiers in Ecology and Evolution, Vol

2023 Volume 11

Abstract: IntroductionForecasting range shifts in response to climate change requires accurate species distribution models (SDMs), particularly at the margins of species' ranges. However, most studies producing SDMs rely on sparse species occurrence datasets from ... ...

Abstract	IntroductionForecasting range shifts in response to climate change requires accurate species distribution models (SDMs), particularly at the margins of species' ranges. However, most studies producing SDMs rely on sparse species occurrence datasets from herbarium records and public databases, along with random pseudoabsences. While environmental covariates used to fit SDMS are increasingly precise due to satellite data, the availability of species occurrence records is still a large source of bias in model predictions. We developed distribution models for hybridizing sister species of western and eastern Joshua trees (Yucca brevifolia and Y. jaegeriana, respectively), iconic Mojave Desert species that are threatened by climate change and habitat loss.MethodsWe conducted an intensive visual grid search of online satellite imagery for 672,043 0.25 km2 grid cells to identify the two species' presences and absences on the landscape with exceptional resolution, and field validated 29,050 cells in 15,001 km of driving. We used the resulting presence/absence data to train SDMs for each Joshua tree species, revealing the contemporary environmental gradients (during the past 40 years) with greatest influence on the current distribution of adult trees.ResultsWhile the environments occupied by Y. brevifolia and Y. jaegeriana were similar in total aridity, they differed with respect to seasonal precipitation and temperature ranges, suggesting the two species may have differing responses to climate change. Moreover, the species showed differing potential to occupy each other's geographic ranges: modeled potential habitat for Y. jaegeriana extends throughout the range of Y. brevifolia, while potential habitat for Y. brevifolia is not well represented within the range of Y. jaegeriana.DiscussionBy reproducing the current range of the Joshua trees with high fidelity, our dataset can serve as a baseline for future research, monitoring, and management of this species, including an increased understanding of dynamics at the ...
Keywords	Joshua tree ; Yucca brevifolia ; Yucca jaegeriana ; species distribution modeling ; habitat map ; remote sensing ; Evolution ; QH359-425 ; Ecology ; QH540-549.5
Language	English
Publishing date	2023-12-01T00:00:00Z
Publisher	Frontiers Media S.A.
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

Full text online

Full text

Inter-library loan at ZB MED

Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

Article ; Online: Inhibition of the late sodium current as a potential cardioprotective principle: effects of the late sodium current inhibitor ranolazine.

Belardinelli, L / Shryock, J C / Fraser, H

Heart (British Cardiac Society)

2006 Volume 92 Suppl 4, Page(s) iv6–iv14

Abstract: Pathological conditions linked to imbalances in oxygen supply and demand (for example, ischaemia, hypoxia and heart failure) are associated with disruptions in intracellular sodium ([Na(+)](i)) and calcium ([Ca(2+)](i)) concentration homeostasis of ... ...

Abstract	Pathological conditions linked to imbalances in oxygen supply and demand (for example, ischaemia, hypoxia and heart failure) are associated with disruptions in intracellular sodium ([Na(+)](i)) and calcium ([Ca(2+)](i)) concentration homeostasis of myocardial cells. A decreased efflux or increased influx of sodium may cause cellular sodium overload. Sodium overload is followed by an increased influx of calcium through sodium-calcium exchange. Failure to maintain the homeostasis of [Na(+)](i) and [Ca(2+)](i) leads to electrical instability (arrhythmias), mechanical dysfunction (reduced contractility and increased diastolic tension) and mitochondrial dysfunction. These events increase ATP hydrolysis and decrease ATP formation and, if left uncorrected, they cause cell injury and death. The relative contributions of various pathways (sodium channels, exchangers and transporters) to the rise in [Na(+)](i) remain a matter of debate. Nevertheless, both the sodium-hydrogen exchanger and abnormal sodium channel conductance (that is, increased late sodium current (I(Na))) are likely to contribute to the rise in [Na(+)](i). The focus of this review is on the role of the late (sustained/persistent) I(Na) in the ionic disturbances associated with ischaemia/hypoxia and heart failure, the consequences of these ionic disturbances, and the cardioprotective effects of the antianginal and anti-ischaemic drug ranolazine. Ranolazine selectively inhibits late I(Na), reduces [Na(+)](i)-dependent calcium overload and attenuates the abnormalities of ventricular repolarisation and contractility that are associated with ischaemia/reperfusion and heart failure. Thus, inhibition of late I(Na) can reduce [Na(+)](i)-dependent calcium overload and its detrimental effects on myocardial function.
MeSH term(s)	Acetanilides ; Animals ; Arrhythmias, Cardiac/drug therapy ; Arrhythmias, Cardiac/metabolism ; Calcium/metabolism ; Enzyme Inhibitors/therapeutic use ; Homeostasis/physiology ; Humans ; Myocytes, Cardiac/metabolism ; Piperazines/therapeutic use ; Ranolazine ; Sodium/metabolism ; Sodium Channel Blockers/therapeutic use ; Sodium Channels/metabolism ; Sodium-Calcium Exchanger/physiology ; Sodium-Potassium-Exchanging ATPase/physiology
Chemical Substances	Acetanilides ; Enzyme Inhibitors ; Piperazines ; Sodium Channel Blockers ; Sodium Channels ; Sodium-Calcium Exchanger ; Sodium (9NEZ333N27) ; Ranolazine (A6IEZ5M406) ; Sodium-Potassium-Exchanging ATPase (EC 7.2.2.13) ; Calcium (SY7Q814VUP)
Language	English
Publishing date	2006-06-15
Publishing country	England
Document type	Journal Article
ZDB-ID	1303417-0
ISSN	1468-201X ; 1355-6037
ISSN (online)	1468-201X
ISSN	1355-6037
DOI	10.1136/hrt.2005.078790
Database	MEDical Literature Analysis and Retrieval System OnLINE

In stock of ZB MED Cologne/Königswinter

Ui IV Zs.40: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular ab Jg. 2022: Lesesaal (EG)
Zs.MO 112: Show issues

Order via subito

Details ▾
- See ZB MED holdings
- Order with fees

Article ; Online: SOCS2-induced proteasome-dependent TRAF6 degradation: a common anti-inflammatory pathway for control of innate immune responses.

McBerry, Cortez / Gonzalez, Rosa Maria Salazar / Shryock, Nathaniel / Dias, Alexandra / Aliberti, Julio

PloS one

2012 Volume 7, Issue 6, Page(s) e38384

Abstract: Pattern recognition receptors and receptors for pro-inflammatory cytokines provide critical signals to drive the development of protective immunity to infection. Therefore, counter-regulatory pathways are required to ensure that overwhelming inflammation ...

Abstract	Pattern recognition receptors and receptors for pro-inflammatory cytokines provide critical signals to drive the development of protective immunity to infection. Therefore, counter-regulatory pathways are required to ensure that overwhelming inflammation harm host tissues. Previously, we showed that lipoxins modulate immune response during infection, restraining inflammation during infectious diseases in an Aryl hydrocarbon receptor (AhR)/suppressors of cytokine signaling (SOCS)2-dependent-manner. Recently, Indoleamine-pyrrole 2,3- dioxygenase (IDO)-derived tryptophan metabolites, including L-kynurenine, were also shown to be involved in several counter-regulatory mechanisms. Herein, we addressed whether the intracellular molecular events induced by lipoxins mediating control of innate immune signaling are part of a common regulatory pathway also shared by L-kynurenine exposure. We demonstrate that Tumor necrosis factor receptor-associated factor (TRAF)6--member of a family of adapter molecules that couple the TNF receptor and interleukin-1 receptor/Toll-like receptor families to intracellular signaling events essential for the development of immune responses--is targeted by both lipoxins and L-kynurenine via an AhR/SOCS2-dependent pathway. Furthermore, we show that LXA₄- and L-kynurenine-induced AhR activation, its subsequent nuclear translocation, leading SOCS2 expression and TRAF6 Lys47-linked poly-ubiquitination and proteosome-mediated degradation of the adapter proteins. The in vitro consequences of such molecular interactions included inhibition of TLR- and cytokine receptor-driven signal transduction and cytokine production. Subsequently, in vivo proteosome inhibition led to unresponsiveness to lipoxins, as well as to uncontrolled pro-inflammatory reactions and elevated mortality during toxoplasmosis. In summary, our results establish proteasome degradation of TRAF6 as a key molecular target for the anti-inflammatory pathway triggered by lipoxins and L-kynurenine, critical counter-regulatory mediators in the innate and adaptive immune systems.
MeSH term(s)	Animals ; Flow Cytometry ; Immunity, Innate/genetics ; Immunity, Innate/physiology ; Interferon-gamma/genetics ; Interferon-gamma/metabolism ; Mice ; Mice, Inbred C57BL ; Proteasome Endopeptidase Complex/metabolism ; Real-Time Polymerase Chain Reaction ; Suppressor of Cytokine Signaling Proteins/genetics ; Suppressor of Cytokine Signaling Proteins/metabolism ; TNF Receptor-Associated Factor 6/genetics ; TNF Receptor-Associated Factor 6/metabolism ; Tumor Necrosis Factor Receptor-Associated Peptides and Proteins/genetics ; Tumor Necrosis Factor Receptor-Associated Peptides and Proteins/metabolism ; Ubiquitination/genetics ; Ubiquitination/physiology
Chemical Substances	Socs2 protein, mouse ; Suppressor of Cytokine Signaling Proteins ; TNF Receptor-Associated Factor 6 ; Tumor Necrosis Factor Receptor-Associated Peptides and Proteins ; Interferon-gamma (82115-62-6) ; Proteasome Endopeptidase Complex (EC 3.4.25.1)
Language	English
Publishing date	2012-06-05
Publishing country	United States
Document type	Journal Article ; Research Support, N.I.H., Extramural
ISSN	1932-6203
ISSN (online)	1932-6203
DOI	10.1371/journal.pone.0038384
Database	MEDical Literature Analysis and Retrieval System OnLINE

Order via subito

Inter-library loan at ZB MED

Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

Article ; Online: Population-Based Newborn Screening for Mucopolysaccharidosis Type II in Illinois: The First Year Experience.

Burton, Barbara K / Hoganson, George E / Fleischer, Julie / Grange, Dorothy K / Braddock, Stephen R / Hickey, Rachel / Hitchins, Lauren / Groepper, Daniel / Christensen, Katherine M / Kirby, Amelia / Moody, Conny / Shryock, Heather / Ashbaugh, Laura / Shao, Rong / Basheeruddin, Khaja

The Journal of pediatrics

2019 Volume 214, Page(s) 165–167.e1

Abstract: Objectives: To assess the outcome of population-based newborn screening for mucopolysaccharidosis type II (MPS II) during the first year of screening in Illinois.: Study design: Tandem mass spectrometry was used to measure iduronate-2-sulfatase (I2S) ...

Abstract	Objectives: To assess the outcome of population-based newborn screening for mucopolysaccharidosis type II (MPS II) during the first year of screening in Illinois. Study design: Tandem mass spectrometry was used to measure iduronate-2-sulfatase (I2S) activity in dried blood spot specimens obtained from 162 000 infant samples sent to the Newborn Screening Laboratory of the Illinois Department of Public Health in Chicago. Results: One case of MPS II and 14 infants with pseudodeficiency for I2S were identified. Conclusions: Newborn screening for MPS II by measurement of I2S enzyme activity was successfully integrated into the statewide newborn screening program in Illinois.
MeSH term(s)	Biomarkers/blood ; Dried Blood Spot Testing/methods ; Follow-Up Studies ; Humans ; Iduronic Acid/analogs & derivatives ; Iduronic Acid/blood ; Illinois/epidemiology ; Incidence ; Infant, Newborn ; Mucopolysaccharidosis II/blood ; Mucopolysaccharidosis II/diagnosis ; Mucopolysaccharidosis II/epidemiology ; Neonatal Screening/methods ; Reproducibility of Results ; Retrospective Studies ; Tandem Mass Spectrometry/methods ; Time Factors
Chemical Substances	Biomarkers ; Iduronic Acid (3402-98-0) ; iduronate 2-sulfate (89846-17-3)
Language	English
Publishing date	2019-08-30
Publishing country	United States
Document type	Journal Article ; Multicenter Study ; Research Support, Non-U.S. Gov't
ZDB-ID	3102-1
ISSN	1097-6833 ; 0022-3476
ISSN (online)	1097-6833
ISSN	0022-3476
DOI	10.1016/j.jpeds.2019.07.053
Database	MEDical Literature Analysis and Retrieval System OnLINE

In stock of ZB MED Cologne/Königswinter

Um IV Zs.116: Show issues

Location:
Je nach Verfügbarkeit (siehe Angabe bei Bestand)
bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
ab Jg. 2022: Lesesaal (EG)

Order via subito

Details ▾
- See ZB MED holdings
- Order with fees

Article: Adenosine and adenosine receptors in the cardiovascular system: biochemistry, physiology, and pharmacology.

Shryock, J C / Belardinelli, L

The American journal of cardiology

1997 Volume 79, Issue 12A, Page(s) 2–10

Abstract: Cardiomyocytes and vascular cells readily form, transport, and metabolize the endogenous adenine nucleoside adenosine and act to regulate both interstitial and plasma adenosine concentrations. Cardiovascular cells also have membrane adenosine receptors. ... ...

Abstract	Cardiomyocytes and vascular cells readily form, transport, and metabolize the endogenous adenine nucleoside adenosine and act to regulate both interstitial and plasma adenosine concentrations. Cardiovascular cells also have membrane adenosine receptors. Cell and tissue distributions, signal transduction pathways, and pharmacology of each of the four subtypes of adenosine receptors are subjects of intense investigation. The A1-adenosine receptors mediate the negative dromotropic, chronotropic, inotropic, and the anti-beta-adrenergic actions of adenosine. Activation of A(2A)- and perhaps A(2B)-adenosine receptors causes vasodilation. Evidence of novel actions mediated by A(2B)- and A3-adenosine receptors is accumulating. Adenosine is cardioprotective during episodes of cardiac hypoxia/ischemia; several potential mechanisms may be involved. Pharmacologic tools are currently available for laboratory investigation of the actions of adenosine, and the development of adenosine receptor subtype-selective agonists and antagonists for therapeutic purposes is beginning.
MeSH term(s)	Adenosine/metabolism ; Adenosine/pharmacology ; Animals ; Cardiovascular Agents/pharmacology ; Heart/drug effects ; Humans ; Myocardium/metabolism ; Receptors, Purinergic P1/metabolism
Chemical Substances	Cardiovascular Agents ; Receptors, Purinergic P1 ; Adenosine (K72T3FS567)
Language	English
Publishing date	1997-06-19
Publishing country	United States
Document type	Journal Article ; Review
ZDB-ID	80014-4
ISSN	1879-1913 ; 0002-9149
ISSN (online)	1879-1913
ISSN	0002-9149
DOI	10.1016/s0002-9149(97)00256-7
Database	MEDical Literature Analysis and Retrieval System OnLINE

In stock of ZB MED Cologne/Königswinter

Ui IV Zs.73: Show issues

Location:
Je nach Verfügbarkeit (siehe Angabe bei Bestand)
bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
ab Jg. 2022: Lesesaal (EG)

Order via subito

Details ▾
- See ZB MED holdings
- Order with fees

Article ; Online: Newborn Screening for Lysosomal Storage Disorders in Illinois: The Initial 15-Month Experience.

Burton, Barbara K / Charrow, Joel / Hoganson, George E / Waggoner, Darrell / Tinkle, Brad / Braddock, Stephen R / Schneider, Michael / Grange, Dorothy K / Nash, Claudia / Shryock, Heather / Barnett, Rebecca / Shao, Rong / Basheeruddin, Khaja / Dizikes, George

The Journal of pediatrics

2017 Volume 190, Page(s) 130–135

Abstract: Objectives: To assess the outcomes of newborn screening for 5 lysosomal storage disorders (LSDs) in the first cohort of infants tested in the state of Illinois.: Study design: Tandem mass spectrometry was used to assay for the 5 LSD-associated ... ...

Abstract	Objectives: To assess the outcomes of newborn screening for 5 lysosomal storage disorders (LSDs) in the first cohort of infants tested in the state of Illinois. Study design: Tandem mass spectrometry was used to assay for the 5 LSD-associated enzymes in dried blood spot specimens obtained from 219 973 newborn samples sent to the Newborn Screening Laboratory of the Illinois Department of Public Health in Chicago. Results: The total number of cases with a positive diagnosis and the incidence for each disorder were as follows: Fabry disease, n = 26 (1 in 8454, including the p.A143T variant); Pompe disease, n = 10 (1 in 21 979); Gaucher disease, n = 5 (1 in 43 959); mucopolysaccharidosis (MPS) type 1, n = 1 (1 in 219 793); and Niemann-Pick disease type A/B, n = 2 (1 in 109 897). Twenty-two infants had a positive screen for 1 of the 5 disorders but could not be classified as either affected or unaffected after follow-up testing, including genotyping. Pseudodeficiencies for alpha-L-iduronidase and alpha-glucosidase were detected more often than true deficiencies. Conclusions: The incidences of Fabry disease and Pompe disease were significantly higher than published estimates, although most cases detected were predicted to be late onset. The incidences of Gaucher disease, MPS I, and Niemann-Pick disease were comparable with previously published estimates. A total of 16 infants could not be positively identified as either affected or unaffected. To validate the true risks and benefits of newborn screening for LSD, long term follow-up in these infants and those detected with later-onset disorders will be essential.
MeSH term(s)	Dried Blood Spot Testing ; Genotype ; Humans ; Illinois/epidemiology ; Incidence ; Infant ; Infant, Newborn ; Lysosomal Storage Diseases/diagnosis ; Lysosomal Storage Diseases/epidemiology ; Neonatal Screening/methods ; Tandem Mass Spectrometry
Language	English
Publishing date	2017-07-17
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	3102-1
ISSN	1097-6833 ; 0022-3476
ISSN (online)	1097-6833
ISSN	0022-3476
DOI	10.1016/j.jpeds.2017.06.048
Database	MEDical Literature Analysis and Retrieval System OnLINE

In stock of ZB MED Cologne/Königswinter

Um IV Zs.116: Show issues

Location:
Je nach Verfügbarkeit (siehe Angabe bei Bestand)
bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
ab Jg. 2022: Lesesaal (EG)

Order via subito

Details ▾
- See ZB MED holdings
- Order with fees

Article ; Online: Ranolazine attenuates hypoxia- and hydrogen peroxide-induced increases in sodium channel late openings in ventricular myocytes.

Ma, Jihua / Song, Yejia / Shryock, John C / Hu, Liangkun / Wang, Weiping / Yan, Xisheng / Zhang, Peihua / Belardinelli, Luiz

Journal of cardiovascular pharmacology

2014 Volume 64, Issue 1, Page(s) 60–68

Abstract: Ranolazine attenuates cardiac arrhythmic activity associated with hypoxia and hydrogen peroxide (H2O2) by inhibition of late sodium current (late INa). The mechanism of ranolazine's action on Na channels was investigated using whole-cell and single- ... ...

Abstract	Ranolazine attenuates cardiac arrhythmic activity associated with hypoxia and hydrogen peroxide (H2O2) by inhibition of late sodium current (late INa). The mechanism of ranolazine's action on Na channels was investigated using whole-cell and single-channel recording from guinea pig isolated ventricular myocytes. Hypoxia increased whole-cell late INa from -0.48 ± 0.02 to -3.99 ± 0.07 pA/pF. Ranolazine at 3 and 9 μmol/L reduced the hypoxia-induced late INa by 16% ± 3% and 55% ± 3%, respectively. Hypoxia increased the mean open probability and open time of Na-channel late openings from 0.016 ± 0.001 to 0.064 ± 0.007 milliseconds and from 0.693 ± 0.043 to 1.081 ± 0.098 milliseconds, respectively. Ranolazine at 3 and 9 μmol/L attenuated the hypoxia-induced increase of open probability by 19% ± 7% and 61% ± 1%, and increase of open time by 26% ± 19% and 74 ± 21%, respectively. H2O2 increased the mean open probability and open time of Na-channel late openings from 0.013 ± 0.002 to 0.107 ± 0.015 milliseconds and from 0.689 ± 0.075 to 1.487 ± 0.072 milliseconds, respectively. Ranolazine at 3 and 6 μmol/L reduced the H2O2-induced increase of mean open probability by 60% ± 7% and 95% ± 2%, and the increase of mean open time by 31% ± 21% and 82% ± 8%. In conclusion, the inhibition by ranolazine of hypoxia- and H2O2-stimulated late INa is due to reduction of both the open probability and open time of Na-channel late openings.
MeSH term(s)	Acetanilides/administration & dosage ; Acetanilides/pharmacology ; Animals ; Anti-Arrhythmia Agents/administration & dosage ; Anti-Arrhythmia Agents/pharmacology ; Cell Hypoxia ; Dose-Response Relationship, Drug ; Female ; Guinea Pigs ; Hydrogen Peroxide/pharmacology ; Male ; Myocytes, Cardiac/drug effects ; Myocytes, Cardiac/metabolism ; Piperazines/administration & dosage ; Piperazines/pharmacology ; Ranolazine ; Sodium Channels/drug effects ; Sodium Channels/metabolism ; Time Factors
Chemical Substances	Acetanilides ; Anti-Arrhythmia Agents ; Piperazines ; Sodium Channels ; Ranolazine (A6IEZ5M406) ; Hydrogen Peroxide (BBX060AN9V)
Language	English
Publishing date	2014-07
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	391970-5
ISSN	1533-4023 ; 0160-2446
ISSN (online)	1533-4023
ISSN	0160-2446
DOI	10.1097/FJC.0000000000000090
Database	MEDical Literature Analysis and Retrieval System OnLINE

In stock of ZB MED Cologne/Königswinter

Zs.A 1471: Show issues

Location:
Je nach Verfügbarkeit (siehe Angabe bei Bestand)
bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
Jg. 1995 - 2021: Lesesall (1.OG)
ab Jg. 2022: Lesesaal (EG)

Order via subito

Details ▾
- See ZB MED holdings
- Order with fees

Article: Time Spent by Ctenocephalides felis (Siphonaptera: Pulicidae) Larvae in Food Patches of Varying Quality

Shryock, J.A / Houseman, R.M

Environmental entomology. 2006 Apr., v. 35, issue 2

2006

Abstract: ... remained longer in patches containing both feces and eggs (201.9 h). Our data suggest that C. felis larvae ...

Abstract	Individual larval movement was studied in the laboratory to determine whether or not Ctenocephalides felis (Bouche) larvae display differences in the time spent in food patches of varying quality. Both early and late instars were tested. Young instars exhibited marked differences in their response to food patch quality. When no food was present, the mean time these larvae remained at the site was 24.5 h. When food patches contained feces only, eggs only, or equal amounts of feces and eggs, the time spent before leaving increased to 62.6, 120.5, and 192.3 h, respectively. The response by older instars was less dramatic. No differences were observed between food patches with only feces or eggs. Older larvae also remained longer in patches containing both feces and eggs (201.9 h). Our data suggest that C. felis larvae do not respond randomly to food patches of varying quality and that particular dietary components have an influence on movement behavior according to developmental stage. Obtaining all of the essential dietary components seems more critical in the early stages of development.
Keywords	Ctenocephalides felis ; larvae ; instars ; feeding behavior ; foraging ; temporal variation ; nutritional adequacy ; feces ; ova
Language	English
Dates of publication	2006-04
Size	p. 401-404.
Document type	Article
ISSN	0046-225X
Database	NAL-Catalogue (AGRICOLA)

Order via subito

Inter-library loan at ZB MED

Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

Article ; Online: Lipoxin A₄ and 15-epi-lipoxin A₄ protect against experimental cerebral malaria by inhibiting IL-12/IFN-γ in the brain.

Shryock, Nathaniel / McBerry, Cortez / Salazar Gonzalez, Rosa Maria / Janes, Steven / Costa, Fabio T M / Aliberti, Julio

PloS one

2013 Volume 8, Issue 4, Page(s) e61882

Abstract: Cerebral malaria is caused by infection with Plasmodium falciparum and can lead to severe neurological manifestations and predominantly affects sub-Saharan African children. The pathogenesis of this disease involves unbalanced over-production of pro- ... ...

Abstract	Cerebral malaria is caused by infection with Plasmodium falciparum and can lead to severe neurological manifestations and predominantly affects sub-Saharan African children. The pathogenesis of this disease involves unbalanced over-production of pro-inflammatory cytokines. It is clear that signaling though IL-12 receptor is a critical step for development of cerebral malaria, IL-12 genetic deficiency failed to show the same effect, suggesting that there is redundancy among the soluble mediators which leads to immunopathology and death. Consequently, counter-regulatory mediators might protect the host during cerebral malaria. We have previously showed that endogenously produced lipoxins, which are anti-inflammatory mediators generated by 5-lipoxygenase (5-LO)-dependent metabolism of arachidonic acid, limit host damage in a model of mouse toxoplasmosis. We postulated here that lipoxins might also play a counter-regulatory role during cerebral malaria. To test this hypothesis, we infected 5-LO-deficient hosts with P. berghei ANKA strain, which induces a mouse model of cerebral malaria (ECM). Our results show accelerated mortality concomitant with exuberant IL-12 and IFN-γ production in the absence of 5-lipoxygenase. Moreover, in vivo administration of lipoxin to 5-LO-deficient hosts prevented early mortality and reduced the accumulation of CD8(+)IFN-γ (+) cells in the brain. Surprisingly, WT animals treated with lipoxin either at the time of infection or 3 days post-inoculum also showed prolonged survival and diminished brain inflammation, indicating that although protective, endogenous lipoxin production is not sufficient to optimally protect the host from brain damage in cerebral malaria. These observations establish 5-LO/LXA4 as a host protective pathway and suggest a new therapeutic approach against human cerebral malaria (HCM). (255 words).
MeSH term(s)	Animals ; Arachidonate 5-Lipoxygenase/genetics ; Arachidonate 5-Lipoxygenase/metabolism ; Brain/drug effects ; Brain/metabolism ; Interferon-gamma/metabolism ; Interleukin-12/metabolism ; Lipoxins/therapeutic use ; Malaria, Cerebral/drug therapy ; Malaria, Cerebral/metabolism ; Mice ; Plasmodium berghei/pathogenicity
Chemical Substances	Lipoxins ; lipoxin A4 ; Interleukin-12 (187348-17-0) ; Interferon-gamma (82115-62-6) ; Arachidonate 5-Lipoxygenase (EC 1.13.11.34)
Language	English
Publishing date	2013-04-16
Publishing country	United States
Document type	Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
ISSN	1932-6203
ISSN (online)	1932-6203
DOI	10.1371/journal.pone.0061882
Database	MEDical Literature Analysis and Retrieval System OnLINE

Order via subito

Inter-library loan at ZB MED

Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

To top

Full text online

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

Full text online

More links

Kategorien

Inter-library loan at ZB MED

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

More links

Kategorien

Order via subito

Inter-library loan at ZB MED

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

More links

Kategorien

Order via subito

Inter-library loan at ZB MED

More links

Kategorien

Order via subito

Inter-library loan at ZB MED