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  1. Article ; Online: Site Specific Preparation of N-Glycosylated Peptides: Thioamide-Directed Activation of Aspartate.

    Taresh, Ameer B / Hutton, Craig A

    Angewandte Chemie (International ed. in English)

    2022  Volume 61, Issue 43, Page(s) e202210367

    Abstract: A site-specific method for the preparation of N-glycosylated peptides is described. Incorporation of a peptide backbone thioamide linkage adjacent to an Asp residue facilitates a Ag ... I ... -promoted, site-specific conversion to N-glycosylated Asn ... ...

    Abstract A site-specific method for the preparation of N-glycosylated peptides is described. Incorporation of a peptide backbone thioamide linkage adjacent to an Asp residue facilitates a Ag<sup>I</sup> -promoted, site-specific conversion to N-glycosylated Asn residues in peptides.
    MeSH term(s) Aspartic Acid/metabolism ; Glycopeptides/chemistry ; Thioamides ; Glycosylation ; Peptides/metabolism
    Chemical Substances Aspartic Acid (30KYC7MIAI) ; Glycopeptides ; Thioamides ; Peptides
    Language English
    Publishing date 2022-09-21
    Publishing country Germany
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2011836-3
    ISSN 1521-3773 ; 1433-7851
    ISSN (online) 1521-3773
    ISSN 1433-7851
    DOI 10.1002/anie.202210367
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Backbone thioamide directed macrocyclisation: lactam stapling of peptides.

    Taresh, Ameer B / Hutton, Craig A

    Organic & biomolecular chemistry

    2022  Volume 20, Issue 7, Page(s) 1488–1492

    Abstract: A novel method for lactam stapling of Asp/Lys-containing peptides has been developed that does not require coupling agents. A backbone thioamide is incorporated at the N-terminal side of the aspartate residue. Ag(I)-promoted activation of the thioamide ... ...

    Abstract A novel method for lactam stapling of Asp/Lys-containing peptides has been developed that does not require coupling agents. A backbone thioamide is incorporated at the N-terminal side of the aspartate residue. Ag(I)-promoted activation of the thioamide in the vicinity of the Asp carboxylate generates a cyclic isoimide intermediate that is trapped by the Lys amine to generate the macrolactam. This method is suitable for generation of
    MeSH term(s) Lactams/chemistry ; Macromolecular Substances/chemical synthesis ; Macromolecular Substances/chemistry ; Molecular Structure ; Peptides, Cyclic/chemical synthesis ; Peptides, Cyclic/chemistry ; Thioamides/chemistry
    Chemical Substances Lactams ; Macromolecular Substances ; Peptides, Cyclic ; Thioamides
    Language English
    Publishing date 2022-02-16
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2097583-1
    ISSN 1477-0539 ; 1477-0520
    ISSN (online) 1477-0539
    ISSN 1477-0520
    DOI 10.1039/d1ob02461b
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Depsipeptide synthesis using a late-stage Ag(i)-promoted macrolactonisation of peptide thioamides.

    Shabani, Sadegh / Hutton, Craig A

    Chemical communications (Cambridge, England)

    2021  Volume 57, Issue 16, Page(s) 2081–2084

    Abstract: Macrolactonisation of peptides to generate cyclic depsipeptides is often challenging due to the low nucleophilicity of hydroxyl groups, epimerisation, cyclodimerisation, and potential acyl transfer reactions of the ester. Herein, we report a novel ... ...

    Abstract Macrolactonisation of peptides to generate cyclic depsipeptides is often challenging due to the low nucleophilicity of hydroxyl groups, epimerisation, cyclodimerisation, and potential acyl transfer reactions of the ester. Herein, we report a novel macrolactonisation strategy employing a Ag(i)-promoted conversion of peptide thioamides to isoimide intermediates, which undergo site-selective intramolecular acyl transfer to serine/threonine side chains to generate the macrolactone.
    MeSH term(s) Depsipeptides/chemical synthesis ; Protein Conformation ; Silver/chemistry ; Thioamides/chemistry
    Chemical Substances Depsipeptides ; Thioamides ; Silver (3M4G523W1G)
    Language English
    Publishing date 2021-01-29
    Publishing country England
    Document type Journal Article
    ZDB-ID 1472881-3
    ISSN 1364-548X ; 1359-7345 ; 0009-241X
    ISSN (online) 1364-548X
    ISSN 1359-7345 ; 0009-241X
    DOI 10.1039/d0cc07747j
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Bonding, bridging and linking social capital combinations for food access; A gendered case study exploring temporal differences in southern Malawi

    Craig, Ailish / Hutton, Craig / Musa, Frank B. / Sheffield, Justin

    Journal of Rural Studies. 2023 July, v. 101 p.103039-

    2023  

    Abstract: In 2018–2020, 82% of Malawian's were classed as moderately or severely food insecure. For decades, Malawian's have used their social capital as a coping mechanism to access food in times of need. Yet social capital has started to decline in other sub- ... ...

    Abstract In 2018–2020, 82% of Malawian's were classed as moderately or severely food insecure. For decades, Malawian's have used their social capital as a coping mechanism to access food in times of need. Yet social capital has started to decline in other sub-Saharan African countries, questioning the usefulness of social capital to alleviate hunger. Food security status and a person's stock of social capital are also dependent on gender. Yet there is limited research that considers gender when exploring how social capital is used to access food. The study aimed to understand the link between social capital and food security, how this varies between men and women, and if social capital use to access food has changed over time. To improve the understanding of how social capital is used to improve food security, qualitative data collection was undertaken in three districts in the Southern Region of Malawi. Rapid rural appraisal methods, including focus group discussions, seasonal calendars and ranking exercises, were used to meet the aims of the study. We found that social capital can be used to alleviate hunger during periods of food insecurity. However, a lack of resources, weather variability, key community group disintegration and a reduction in active NGOs has resulted in changes in social capital and it could not be used as frequently as in the past to access food. This highlighted the importance of considering bonding, bridging and linking social capital separately in research as they are interlinked. The study found men and women have different types of social capital, with women being most active in village savings and loans groups, which were the most important group to improve access to food. Meanwhile, men can utilise their social capital from outside of the village to access food, something women could not do due to their restricted mobility. The changes to social capital use for food access that were uncovered in this study, as well as gender difference, are noteworthy given the increase in food insecurity in Malawi, and globally.
    Keywords case studies ; focus groups ; food security ; gender differences ; hunger ; rapid rural appraisal ; social capital ; villages ; weather ; Malawi ; Gender ; Seasonal
    Language English
    Dates of publication 2023-07
    Publishing place Elsevier Ltd
    Document type Article ; Online
    Note Pre-press version ; Use and reproduction
    ZDB-ID 252458-2
    ISSN 0743-0167
    ISSN 0743-0167
    DOI 10.1016/j.jrurstud.2023.103039
    Database NAL-Catalogue (AGRICOLA)

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    In stock of ZB MED Bonn / Germany

    Z 4225: Show issues

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  5. Article ; Online: Total Synthesis of Seongsanamide B.

    Shabani, Sadegh / Hutton, Craig A

    Organic letters

    2020  Volume 22, Issue 11, Page(s) 4557–4561

    Abstract: The first total synthesis of the bicyclic depsipeptide natural product seongsanamide B is described. The successful approach employed solid-phase peptide synthesis of a core heptapeptide, incorporating on-resin esterification, followed by solution-phase ... ...

    Abstract The first total synthesis of the bicyclic depsipeptide natural product seongsanamide B is described. The successful approach employed solid-phase peptide synthesis of a core heptapeptide, incorporating on-resin esterification, followed by solution-phase macrolactamization and a late stage intramolecular Evans-Chan-Lam coupling to generate the biaryl ether of the isodityrosine unit.
    MeSH term(s) Biological Products/chemical synthesis ; Biological Products/chemistry ; Molecular Conformation
    Chemical Substances Biological Products
    Language English
    Publishing date 2020-05-28
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ISSN 1523-7052
    ISSN (online) 1523-7052
    DOI 10.1021/acs.orglett.0c01642
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Rapid, Traceless, Ag

    Thombare, Varsha J / Hutton, Craig A

    Angewandte Chemie (International ed. in English)

    2019  Volume 58, Issue 15, Page(s) 4998–5002

    Abstract: Peptide macrocyclization is often a slow process, plagued by epimerization and cyclodimerization. Herein, we describe a new method for peptide macrocyclization employing the ... ...

    Abstract Peptide macrocyclization is often a slow process, plagued by epimerization and cyclodimerization. Herein, we describe a new method for peptide macrocyclization employing the Ag
    Language English
    Publishing date 2019-03-08
    Publishing country Germany
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2011836-3
    ISSN 1521-3773 ; 1433-7851
    ISSN (online) 1521-3773
    ISSN 1433-7851
    DOI 10.1002/anie.201900243
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  7. Book ; Online: Deltas in the Anthropocene

    Nicholls, Robert J. / Adger, W. Neil / Hutton, Craig W. / Hanson, Susan E.

    2020  

    Keywords Society & social sciences ; Physical geography & topography ; Environmental management ; Sustainability ; Geography ; Environmental geography ; Environment ; Economic development-Environmental aspects
    Size 1 electronic resource (282 pages)
    Publisher Springer Nature
    Publishing place Cham
    Document type Book ; Online
    Note English ; Open Access
    HBZ-ID HT021029484
    ISBN 978-3-030-23517-8 ; 3-030-23517-3
    Database ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

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  8. Article ; Online: Total Synthesis of the Putative Structure of Asperipin-2a and Stereochemical Reassignment.

    Shabani, Sadegh / White, Jonathan M / Hutton, Craig A

    Organic letters

    2020  Volume 22, Issue 19, Page(s) 7730–7734

    Abstract: The total synthesis of the putative structure of asperipin-2a is described. The synthesis features ether cross-links between the phenolic oxygen of ... ...

    Abstract The total synthesis of the putative structure of asperipin-2a is described. The synthesis features ether cross-links between the phenolic oxygen of Tyr
    Language English
    Publishing date 2020-09-22
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ISSN 1523-7052
    ISSN (online) 1523-7052
    DOI 10.1021/acs.orglett.0c02884
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Book ; Online: Deltas in the Anthropocene

    Nicholls, Robert J. / Adger, W. Neil / Hutton, Craig W. / Hanson, Susan E.

    2020  

    Author's details edited by Robert J. Nicholls, W. Neil Adger, Craig W. Hutton, Susan E. Hanson
    Keywords Environment ; Economic development—Environmental aspects ; Environmental management
    Subject code 333.709
    Language English
    Size 1 Online-Ressource (XXXIII, 282 p. 55 illus., 52 illus. in color)
    Edition 1st ed. 2020
    Publisher Springer International Publishing ; Imprint: Palgrave Macmillan
    Publishing place Cham
    Document type Book ; Online
    HBZ-ID HT020187042
    ISBN 978-3-030-23517-8 ; 9783030235161 ; 9783030235185 ; 9783030235192 ; 3-030-23517-3 ; 3030235165 ; 3030235181 ; 303023519X
    DOI 10.1007/978-3-030-23517-8
    Database ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

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  10. Article ; Online: Progress and perspectives on directing group-assisted palladium-catalysed C-H functionalisation of amino acids and peptides.

    Shabani, Sadegh / Wu, Yuezhou / Ryan, Hannah G / Hutton, Craig A

    Chemical Society reviews

    2021  Volume 50, Issue 16, Page(s) 9278–9343

    Abstract: Peptide modifications can unlock a variety of compounds with structural diversity and abundant biological activity. In nature, peptide modifications, such as functionalisation at the side-chain position of amino acids, are performed using post- ... ...

    Abstract Peptide modifications can unlock a variety of compounds with structural diversity and abundant biological activity. In nature, peptide modifications, such as functionalisation at the side-chain position of amino acids, are performed using post-translational modification enzymes or incorporation of unnatural amino acids. However, accessing these modifications remains a challenge for organic chemists. During the past decades, selective C-H activation/functionalisation has attracted considerable attention in synthetic organic chemistry as a pathway to peptide modification. Various directing group strategies have been discovered that assist selective C-H activation. In particular, bidentate directing groups that enable tuneable and reversible coordination are now recognised as one of the most efficient methods for the site-selective C-H activation and functionalisation of numerous families of organic compounds. Synthetic peptide chemists have harnessed bidentate directing group strategies for selective functionalisation of the β- and γ-positions of amino acids. This method has been expanded and recognised as an effective device for the late stage macrocyclisation and total synthesis of complex peptide natural products. In this review, we discuss various β-, γ-, and δ-C(sp
    MeSH term(s) Amino Acids/chemistry ; Catalysis ; Palladium/chemistry ; Peptides/chemistry
    Chemical Substances Amino Acids ; Peptides ; Palladium (5TWQ1V240M)
    Language English
    Publishing date 2021-07-13
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 1472875-8
    ISSN 1460-4744 ; 0306-0012
    ISSN (online) 1460-4744
    ISSN 0306-0012
    DOI 10.1039/d0cs01441a
    Database MEDical Literature Analysis and Retrieval System OnLINE

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