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Article ; Online: Adjuvant Docetaxel in Nonmetastatic Prostate Cancer: The King Is Dead, Long Live the King!

Van den Broeck, Thomas / Joniau, Steven / Everaerts, Wouter

2023 Volume 84, Issue 2, Page(s) 164–165

MeSH term(s)	Male ; Humans ; Docetaxel/therapeutic use ; Prostatic Neoplasms/drug therapy ; Prostatic Neoplasms/pathology ; Adjuvants, Immunologic ; Chronic Disease
Chemical Substances	Docetaxel (15H5577CQD) ; Adjuvants, Immunologic
Language	English
Publishing date	2023-06-01
Publishing country	Switzerland
Document type	Editorial ; Comment
ZDB-ID	193790-x
ISSN	1873-7560 ; 1421-993X ; 0302-2838
ISSN (online)	1873-7560 ; 1421-993X
ISSN	0302-2838
DOI	10.1016/j.eururo.2023.05.033
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Article ; Online: "Keep It Short and Simple": Perceptions of patients and healthcare professionals on the use of a mobile health app in the care for patients undergoing radical prostatectomy.

Clinckaert, Andries / Schreurs, Lucas / Wouters, Lars / Everaerts, Wouter / De Cock, Diederik

BJUI compass

2023 Volume 5, Issue 1, Page(s) 150–158

Abstract: Background: Patients undergoing radical prostatectomy for localised prostate cancer generally have good long-term survival rates. However, late recurrences can occur and require lifelong follow-up.: Objective: This research aims to investigate ... ...

Abstract	Background: Patients undergoing radical prostatectomy for localised prostate cancer generally have good long-term survival rates. However, late recurrences can occur and require lifelong follow-up. Objective: This research aims to investigate different stakeholders' perceptions on the use of mobile health (mHealth) applications for prostate cancer follow-up after radical prostatectomy. Methods: A cross-sectional qualitative study was conducted to explore stakeholders' perceptions of an mHealth application for follow-up after radical prostatectomy. Urologists, nurses, and patients treated with radical prostatectomy were interviewed, and data were transcribed and analysed using thematic analysis according to Qualitative Analysis Guide of Leuven. Recommended features for an ideal mHealth application were grouped according to the Persuasive Systems Design model. Results and limitations: A total of 30 stakeholders, consisting of nurse specialists ( Conclusions: Stakeholders indicate that an mHealth app in the care for post-prostatectomy patients can improve patient care and promote disease management but consider app compliance as a major challenge. Patient summary: We interviewed patients, nurses, and urologists about using an mHealth application for follow-up after radical prostatectomy. The participants agreed that an mHealth app could improve care optimisation and disease management, but some concerns and barriers were expressed. This resulted in a list of recommended features for an ideal app.
Language	English
Publishing date	2023-07-15
Publishing country	United States
Document type	Journal Article
ISSN	2688-4526
ISSN (online)	2688-4526
DOI	10.1002/bco2.270
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Article ; Online: Transient receptor potential channels in sensory mechanisms of the lower urinary tract.

Vanneste, Matthias / Segal, Andrei / Voets, Thomas / Everaerts, Wouter

Nature reviews. Urology

2021 Volume 18, Issue 3, Page(s) 139–159

Abstract: Disruptions to sensory pathways in the lower urinary tract commonly occur and can give rise to lower urinary tract symptoms (LUTS). The unmet clinical need for treatment of LUTS has stimulated research into the molecular mechanisms that underlie neuronal ...

Abstract	Disruptions to sensory pathways in the lower urinary tract commonly occur and can give rise to lower urinary tract symptoms (LUTS). The unmet clinical need for treatment of LUTS has stimulated research into the molecular mechanisms that underlie neuronal control of the bladder and transient receptor potential (TRP) channels have emerged as key regulators of the sensory processes that regulate bladder function. TRP channels function as molecular sensors in urothelial cells and afferent nerve fibres and can be considered the origin of bladder sensations. TRP channels in the lower urinary tract contribute to the generation of normal and abnormal bladder sensations through a variety of mechanisms, and have demonstrated potential as targets for the treatment of LUTS in functional disorders of the lower urinary tract.
MeSH term(s)	Female ; Humans ; Lower Urinary Tract Symptoms/metabolism ; Lower Urinary Tract Symptoms/physiopathology ; Male ; Muscle, Smooth/innervation ; Muscle, Smooth/metabolism ; Muscle, Smooth/physiopathology ; Prostate/metabolism ; Prostate/physiopathology ; Sensation/physiology ; TRPA1 Cation Channel/metabolism ; TRPM Cation Channels/metabolism ; TRPV Cation Channels/metabolism ; Transient Receptor Potential Channels/metabolism ; Urethra/metabolism ; Urethra/physiopathology ; Urinary Bladder/innervation ; Urinary Bladder/metabolism ; Urinary Bladder/physiopathology ; Urothelium/innervation ; Urothelium/metabolism ; Visceral Afferents/physiopathology
Chemical Substances	TRPA1 Cation Channel ; TRPM Cation Channels ; TRPV Cation Channels ; Transient Receptor Potential Channels
Language	English
Publishing date	2021-02-03
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't ; Review
ZDB-ID	2493737-X
ISSN	1759-4820 ; 1759-4812
ISSN (online)	1759-4820
ISSN	1759-4812
DOI	10.1038/s41585-021-00428-6
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Article ; Online: Re: Andrea Mari, Riccardo Tellini, Francesco Porpiglia, et al. Perioperative and Mid-term Oncological and Functional Outcomes After Partial Nephrectomy for Complex (PADUA Score ≥10) Renal Tumors: A Prospective Multicenter Observational Study (the RECORD2 Project). Eur Urol Focus. In press. https://doi.org/10.1016/j.euf.2020.07.004.

Grivas, Nikolaos / Goonewardene, Sanchia / Everaerts, Wouter / Kalampokis, Nikolaos

European urology focus

2020 Volume 7, Issue 5, Page(s) 1210–1211

MeSH term(s)	Humans ; Kidney Neoplasms/surgery ; Medical Oncology ; Nephrectomy ; Prospective Studies
Language	English
Publishing date	2020-12-24
Publishing country	Netherlands
Document type	Letter ; Comment
ISSN	2405-4569
ISSN (online)	2405-4569
DOI	10.1016/j.euf.2020.11.007
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Article ; Online: TRiPping down the oesophagus.

Everaerts, Wouter

The Journal of physiology

2011 Volume 589, Issue Pt 14, Page(s) 3415–3416

MeSH term(s)	Adenosine Triphosphate/metabolism ; Animals ; Calcium/metabolism ; Esophagus/metabolism ; Keratinocytes/metabolism ; Male ; TRPV Cation Channels/metabolism
Chemical Substances	TRPV Cation Channels ; Trpv4 protein, mouse ; Adenosine Triphosphate (8L70Q75FXE) ; Calcium (SY7Q814VUP)
Language	English
Publishing date	2011-07-14
Publishing country	England
Document type	Journal Article ; Comment
ZDB-ID	3115-x
ISSN	1469-7793 ; 0022-3751
ISSN (online)	1469-7793
ISSN	0022-3751
DOI	10.1113/jphysiol.2011.212977
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Article: Double trouble for prostate cancer: synergistic action of AR blockade and PARPi in non-HRR mutated patients.

Giesen, Alexander / Baekelandt, Loïc / Devlies, Wout / Devos, Gaëtan / Dumez, Herlinde / Everaerts, Wouter / Claessens, Frank / Joniau, Steven

Frontiers in oncology

2023 Volume 13, Page(s) 1265812

Abstract: Prostate cancer (PCa) is the most common cancer in men worldwide. Despite better and more intensive treatment options in earlier disease stages, a large subset of patients still progress to metastatic castration-resistant PCa (mCRPC). Recently, poly-(ADP- ...

Abstract	Prostate cancer (PCa) is the most common cancer in men worldwide. Despite better and more intensive treatment options in earlier disease stages, a large subset of patients still progress to metastatic castration-resistant PCa (mCRPC). Recently, poly-(ADP-ribose)-polymerase (PARP)-inhibitors have been introduced in this setting. The TALAPRO-2 and PROpel trials both showed a marked benefit of PARPi in combination with an androgen receptor signaling inhibitor (ARSI), compared with an ARSI alone in both the homologous recombination repair (HRR)-mutated, as well as in the HRR-non-mutated subgroup. In this review, we present a comprehensive overview of how maximal AR-blockade via an ARSI in combination with a PARPi has a synergistic effect at the molecular level, leading to synthetic lethality in both HRR-mutated and HRR-non-mutated PCa patients. PARP2 is known to be a cofactor of the AR complex, needed for decompacting the chromatin and start of transcription of AR target genes (including HRR genes). The inhibition of PARP thus reinforces the effect of an ARSI. The deep androgen deprivation caused by combining androgen deprivation therapy (ADT) with an ARSI, induces an HRR-like deficient state, often referred to as "BRCA-ness". Further, PARPi will prevent the repair of single-strand DNA breaks, leading to the accumulation of DNA double-strand breaks (DSBs). Due to the induced HRR-deficient state, DSBs cannot be repaired, leading to apoptosis.
Language	English
Publishing date	2023-09-21
Publishing country	Switzerland
Document type	Journal Article ; Review
ZDB-ID	2649216-7
ISSN	2234-943X
ISSN	2234-943X
DOI	10.3389/fonc.2023.1265812
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Article ; Online: Machine learning-assisted fluoroscopy of bladder function in awake mice.

De Bruyn, Helene / Corthout, Nikky / Munck, Sebastian / Everaerts, Wouter / Voets, Thomas

eLife

2022 Volume 11

Abstract: Understanding the lower urinary tract (LUT) and development of highly needed novel therapies to treat LUT disorders depends on accurate techniques to monitor LUT (dys)function in preclinical models. We recently developed videocystometry in rodents, which ...

Abstract	Understanding the lower urinary tract (LUT) and development of highly needed novel therapies to treat LUT disorders depends on accurate techniques to monitor LUT (dys)function in preclinical models. We recently developed videocystometry in rodents, which combines intravesical pressure measurements with X-ray-based fluoroscopy of the LUT, allowing the in vivo analysis of the process of urine storage and voiding with unprecedented detail. Videocystometry relies on the precise contrast-based determination of the bladder volume at high temporal resolution, which can readily be achieved in anesthetized or otherwise motion-restricted mice but not in awake and freely moving animals. To overcome this limitation, we developed a machine-learning method, in which we trained a neural network to automatically detect the bladder in fluoroscopic images, allowing the automatic analysis of bladder filling and voiding cycles based on large sets of time-lapse fluoroscopic images (>3 hr at 30 images/s) from behaving mice and in a noninvasive manner. With this approach, we found that urethane, an injectable anesthetic that is commonly used in preclinical urological research, has a profound, dose-dependent effect on urethral relaxation and voiding duration. Moreover, both in awake and in anesthetized mice, the bladder capacity was decreased ~fourfold when cystometry was performed acutely after surgical implantation of a suprapubic catheter. Our findings provide a paradigm for the noninvasive, in vivo monitoring of a hollow organ in behaving animals and pinpoint important limitations of the current gold standard techniques to study the LUT in mice.
MeSH term(s)	Animals ; Fluoroscopy ; Machine Learning ; Mice ; Urethane ; Urinary Bladder/diagnostic imaging ; Urodynamics ; Wakefulness
Chemical Substances	Urethane (3IN71E75Z5)
Language	English
Publishing date	2022-09-06
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2687154-3
ISSN	2050-084X ; 2050-084X
ISSN (online)	2050-084X
ISSN	2050-084X
DOI	10.7554/eLife.79378
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Article ; Online: Inhibition of TRPM8 by the urinary tract analgesic drug phenazopyridine.

Luyts, Noémie / Daniluk, Jan / Freitas, Ana Cristina Nogueira / Bazeli, Bahar / Janssens, Annelies / Mulier, Marie / Everaerts, Wouter / Voets, Thomas

European journal of pharmacology

2023 Volume 942, Page(s) 175512

Abstract: Background: and purpose: Phenazopyridine (PAP) is an over-the-counter drug widely used to provide symptomatic relief of bladder pain in conditions such as cystitis or bladder pain syndrome (BPS). Whereas the analgesic effect of PAP has been attributed ... ...

Abstract	Background: and purpose: Phenazopyridine (PAP) is an over-the-counter drug widely used to provide symptomatic relief of bladder pain in conditions such as cystitis or bladder pain syndrome (BPS). Whereas the analgesic effect of PAP has been attributed to a local effect on the mucosa of the lower urinary tract (LUT), the molecular targets of PAP remain unknown. We investigated the effect of PAP on pain-related Transient Receptor Potential (TRP) channels expressed in sensory neurons that innervate the bladder wall. Experimental approach: The effects of PAP on the relevant TRP channels (TRPV1, TRPA1, TRPM8, TRPM3) expressed in HEK293 or CHO cells was investigated using Fura-2-based calcium measurements and whole-cell patch-clamp recordings. Activity of PAP on TRPM8 was further analysed using Fura-2-based calcium imaging on sensory neurons isolated from lumbosacral dorsal root ganglia (DRG) of mice. Key results: PAP rapidly and reversibly inhibits responses of TRPM8 expressed in HEK293 cells to cold and menthol, with IC Conclusion and implications: PAP inhibits TRPM8 in a concentration range consistent with PAP levels in the urine of treated patients. Since TRPM8 is expressed in bladder afferent neurons and upregulated in patients with painful bladder disorders, TRPM8 inhibition may underlie the analgesic activity of PAP.
MeSH term(s)	Animals ; Cricetinae ; Humans ; Mice ; Calcium/metabolism ; Cricetulus ; Fura-2/pharmacology ; Ganglia, Spinal/metabolism ; HEK293 Cells ; Menthol/pharmacology ; Pain ; Phenazopyridine/pharmacology ; Sensory Receptor Cells/metabolism ; Transient Receptor Potential Channels ; TRPA1 Cation Channel ; TRPM Cation Channels ; Urinary Bladder/metabolism
Chemical Substances	Calcium (SY7Q814VUP) ; Fura-2 (TSN3DL106G) ; Menthol (1490-04-6) ; Phenazopyridine (K2J09EMJ52) ; Transient Receptor Potential Channels ; TRPA1 Cation Channel ; TRPM Cation Channels ; TRPM3 protein, mouse ; TRPM8 channel-associated factor 1 protein, human ; TRPM8 protein, human ; TRPM8 protein, mouse
Language	English
Publishing date	2023-01-16
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	80121-5
ISSN	1879-0712 ; 0014-2999
ISSN (online)	1879-0712
ISSN	0014-2999
DOI	10.1016/j.ejphar.2023.175512
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Zs.A 522: Show issues

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Article ; Online: TRPM8 antagonists to treat lower urinary tract symptoms: don't lose your cool just yet.

Everaerts, Wouter / De Ridder, Dirk

BJU international

2016 Volume 117, Issue 3, Page(s) 384–385

MeSH term(s)	Afferent Pathways/physiology ; Animals ; Female ; TRPM Cation Channels/physiology ; Urinary Bladder/physiology
Chemical Substances	TRPM Cation Channels
Language	English
Publishing date	2016-03
Publishing country	England
Document type	Comment ; Editorial
ZDB-ID	1462191-5
ISSN	1464-410X ; 1464-4096 ; 1358-8672
ISSN (online)	1464-410X
ISSN	1464-4096 ; 1358-8672
DOI	10.1111/bju.13321
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Ui VI Zs.107: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular ab Jg. 2022: Lesesaal (EG)
Zs.MO 13: Show issues

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Article: The Prevalence of Lower Limb and Genital Lymphedema after Prostate Cancer Treatment: A Systematic Review.

Clinckaert, Andries / Callens, Klaas / Cooreman, Anne / Bijnens, Annabel / Moris, Lisa / Van Calster, Charlotte / Geraerts, Inge / Joniau, Steven / Everaerts, Wouter

Cancers

2022 Volume 14, Issue 22

Abstract: 1) Background: Secondary lymphedema is a chronic, progressive, and debilitating condition with an important impact on quality of life. Lymphedema is a frequently reported complication in oncological surgery but has not been systematically studied in the ...

Abstract	(1) Background: Secondary lymphedema is a chronic, progressive, and debilitating condition with an important impact on quality of life. Lymphedema is a frequently reported complication in oncological surgery but has not been systematically studied in the setting of prostate cancer. (2) Methods: Pubmed/MEDLINE and Embase were systematically searched to identify articles reporting on lower limb or genital lymphedema after primary treatment (surgery of radiation therapy) of the prostate and the pelvic lymph nodes in men with prostate cancer. Primary outcome was the prevalence of lower limb and genital lymphedema. (3) Results: Eighteen articles were eligible for qualitative synthesis. Risk of bias was high in all included studies, with only one study providing a prespecified definition of secondary lymphedema. Eleven studies report the prevalence of lower limb (0-14%) and genital (0-1%) lymphedema after radical prostatectomy with pelvic lymph node dissection (PLND) Seven studies report a low prevalence of lower limb (0-9%) and genital (0-8%) lymphedema after irradiation of the pelvic lymph nodes. However, in the patient subgroups that underwent pelvic irradiation after staging pelvic lymph node dissections, the prevalence of lower limb (18-29%) and genital (2-22%) lymphedema is substantially elevated. (4) Conclusion: Prostate cancer patients undergoing surgery or irradiation of the pelvic lymph nodes are at risk of developing secondary lymphedema in the lower limbs and the genital region. Patients receiving pelvic radiation after pelvic lymph node dissection have the highest prevalence of lymphedema. The lack of a uniform definition and standardized diagnostic criteria for lower limb and genital lymphedema hampers the accurate estimation of their true prevalence. Future clinicals trials are needed to specifically evaluate secondary lymphedema in patients undergoing prostate cancer treatments, to identify potential risk factors and to determine the impact on quality of life.
Language	English
Publishing date	2022-11-18
Publishing country	Switzerland
Document type	Journal Article ; Review
ZDB-ID	2527080-1
ISSN	2072-6694
ISSN	2072-6694
DOI	10.3390/cancers14225667
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