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  1. Article ; Online: Mechanistic similarities in recognition of histone tails and DNA by epigenetic readers.

    Vann, Kendra R / Klein, Brianna J / Kutateladze, Tatiana G

    Current opinion in structural biology

    2021  Volume 71, Page(s) 1–6

    Abstract: The past two decades have witnessed rapid advances in the identification and characterization of epigenetic readers, capable of recognizing or reading post-translational modifications in histones. More recently, a new set of readers with the ability to ... ...

    Abstract The past two decades have witnessed rapid advances in the identification and characterization of epigenetic readers, capable of recognizing or reading post-translational modifications in histones. More recently, a new set of readers with the ability to interact with the nucleosome through concomitant binding to histones and DNA has emerged. In this review, we discuss mechanistic insights underlying bivalent histone and DNA recognition by newly characterized readers and highlight the importance of binding to DNA for their association with chromatin.
    MeSH term(s) Chromatin ; DNA/genetics ; Epigenesis, Genetic ; Histones/metabolism ; Nucleosomes ; Protein Processing, Post-Translational
    Chemical Substances Chromatin ; Histones ; Nucleosomes ; DNA (9007-49-2)
    Language English
    Publishing date 2021-05-13
    Publishing country England
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Review
    ZDB-ID 1068353-7
    ISSN 1879-033X ; 0959-440X
    ISSN (online) 1879-033X
    ISSN 0959-440X
    DOI 10.1016/j.sbi.2021.04.003
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 3206: Show issues Location:
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  2. Article ; Online: Topoisomerase II Poisons: Converting Essential Enzymes into Molecular Scissors.

    Vann, Kendra R / Oviatt, Alexandria A / Osheroff, Neil

    Biochemistry

    2021  Volume 60, Issue 21, Page(s) 1630–1641

    Abstract: The extensive length, compaction, and interwound nature of DNA, together with its controlled and restricted movement in eukaryotic cells, create a number of topological issues that profoundly affect all of the functions of the genetic material. ... ...

    Abstract The extensive length, compaction, and interwound nature of DNA, together with its controlled and restricted movement in eukaryotic cells, create a number of topological issues that profoundly affect all of the functions of the genetic material. Topoisomerases are essential enzymes that modulate the topological structure of the double helix, including the regulation of DNA under- and overwinding and the removal of tangles and knots from the genome. Type II topoisomerases alter DNA topology by generating a transient double-stranded break in one DNA segment and allowing another segment to pass through the DNA gate. These enzymes are involved in a number of critical nuclear processes in eukaryotic cells, such as DNA replication, transcription, and recombination, and are required for proper chromosome structure and segregation. However, because type II topoisomerases generate double-stranded breaks in the genetic material, they also are intrinsically dangerous enzymes that have the capacity to fragment the genome. As a result of this dualistic nature, type II topoisomerases are the targets for a number of widely prescribed anticancer drugs. This article will describe the structure and catalytic mechanism of eukaryotic type II topoisomerases and will go on to discuss the actions of topoisomerase II poisons, which are compounds that stabilize DNA breaks generated by the type II enzyme and convert these essential enzymes into "molecular scissors." Topoisomerase II poisons represent a broad range of structural classes and include anticancer drugs, dietary components, and environmental chemicals.
    MeSH term(s) Antineoplastic Agents/chemistry ; DNA/chemistry ; DNA Damage/genetics ; DNA Damage/physiology ; DNA Topoisomerases, Type II/metabolism ; DNA Topoisomerases, Type II/physiology ; DNA Topoisomerases, Type II/ultrastructure ; Eukaryota/genetics ; Eukaryota/metabolism ; Genome/genetics ; Humans ; Topoisomerase II Inhibitors/chemistry ; Topoisomerase II Inhibitors/pharmacology ; Translocation, Genetic/genetics
    Chemical Substances Antineoplastic Agents ; Topoisomerase II Inhibitors ; DNA (9007-49-2) ; DNA Topoisomerases, Type II (EC 5.99.1.3)
    Language English
    Publishing date 2021-05-19
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, U.S. Gov't, Non-P.H.S. ; Review
    ZDB-ID 1108-3
    ISSN 1520-4995 ; 0006-2960
    ISSN (online) 1520-4995
    ISSN 0006-2960
    DOI 10.1021/acs.biochem.1c00240
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    Zs.A 217: Show issues Location:
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  3. Article ; Online: Inhibition of translation and immune responses by the virulence factor Nsp1 of SARS-CoV-2.

    Vann, Kendra R / Tencer, Adam H / Kutateladze, Tatiana G

    Signal transduction and targeted therapy

    2020  Volume 5, Issue 1, Page(s) 234

    MeSH term(s) Betacoronavirus ; COVID-19 ; Coronavirus Infections ; Immune Evasion ; Pandemics ; Pneumonia, Viral ; SARS-CoV-2 ; Virulence
    Keywords covid19
    Language English
    Publishing date 2020-10-09
    Publishing country England
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Comment
    ZDB-ID 2886872-9
    ISSN 2059-3635 ; 2095-9907
    ISSN (online) 2059-3635
    ISSN 2095-9907
    DOI 10.1038/s41392-020-00350-0
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  4. Article: Topoisomerase II Poisons: Converting Essential Enzymes into Molecular Scissors

    Vann, Kendra R / Oviatt, Alexandria A / Osheroff, Neil

    Biochemistry. 2021 May 19, v. 60, no. 21

    2021  

    Abstract: The extensive length, compaction, and interwound nature of DNA, together with its controlled and restricted movement in eukaryotic cells, create a number of topological issues that profoundly affect all of the functions of the genetic material. ... ...

    Abstract The extensive length, compaction, and interwound nature of DNA, together with its controlled and restricted movement in eukaryotic cells, create a number of topological issues that profoundly affect all of the functions of the genetic material. Topoisomerases are essential enzymes that modulate the topological structure of the double helix, including the regulation of DNA under- and overwinding and the removal of tangles and knots from the genome. Type II topoisomerases alter DNA topology by generating a transient double-stranded break in one DNA segment and allowing another segment to pass through the DNA gate. These enzymes are involved in a number of critical nuclear processes in eukaryotic cells, such as DNA replication, transcription, and recombination, and are required for proper chromosome structure and segregation. However, because type II topoisomerases generate double-stranded breaks in the genetic material, they also are intrinsically dangerous enzymes that have the capacity to fragment the genome. As a result of this dualistic nature, type II topoisomerases are the targets for a number of widely prescribed anticancer drugs. This article will describe the structure and catalytic mechanism of eukaryotic type II topoisomerases and will go on to discuss the actions of topoisomerase II poisons, which are compounds that stabilize DNA breaks generated by the type II enzyme and convert these essential enzymes into “molecular scissors.” Topoisomerase II poisons represent a broad range of structural classes and include anticancer drugs, dietary components, and environmental chemicals.
    Keywords DNA ; DNA replication ; chromosomes ; genome ; topology
    Language English
    Dates of publication 2021-0519
    Size p. 1630-1641.
    Publishing place American Chemical Society
    Document type Article
    Note NAL-AP-2-clean
    ZDB-ID 1108-3
    ISSN 1520-4995 ; 0006-2960
    ISSN (online) 1520-4995
    ISSN 0006-2960
    DOI 10.1021/acs.biochem.1c00240
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    Zs.A 217: Show issues Location:
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  5. Article: Architecture of PRC2 Holo Complexes.

    Vann, Kendra R / Kutateladze, Tatiana G

    Trends in biochemical sciences

    2018  Volume 43, Issue 7, Page(s) 487–489

    Abstract: Polycomb repressive complex 2 (PRC2) is a chief epigenetic regulator. In a new article, Chen et al. describe the crystal structure of the heterotetrameric PRC2 holo complex, which provides important mechanistic insights into the organization of its ... ...

    Abstract Polycomb repressive complex 2 (PRC2) is a chief epigenetic regulator. In a new article, Chen et al. describe the crystal structure of the heterotetrameric PRC2 holo complex, which provides important mechanistic insights into the organization of its subunits and the association of PRC2 with chromatin.
    MeSH term(s) Chromatin ; Histones/genetics ; Polycomb Repressive Complex 2/genetics ; Repressor Proteins/genetics
    Chemical Substances Chromatin ; Histones ; Repressor Proteins ; Polycomb Repressive Complex 2 (EC 2.1.1.43)
    Language English
    Publishing date 2018-05-03
    Publishing country England
    Document type Journal Article ; Comment
    ZDB-ID 194216-5
    ISSN 1362-4326 ; 0968-0004 ; 0376-5067
    ISSN (online) 1362-4326
    ISSN 0968-0004 ; 0376-5067
    DOI 10.1016/j.tibs.2018.04.009
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    Zs.A 1207: Show issues Location:
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  6. Article ; Online: Searching for methyllysine-binding aromatic cages.

    Vann, Kendra R / Vishweshwaraiah, Yashavantha L / Dokholyan, Nikolay V / Kutateladze, Tatiana G

    The Biochemical journal

    2021  Volume 478, Issue 19, Page(s) 3613–3619

    Abstract: Methylation of lysine residues plays crucial roles in a wide variety of cell signaling processes. While the biological importance of recognition of methylated histones by reader domains in the cell nucleus is well established, the processes associated ... ...

    Abstract Methylation of lysine residues plays crucial roles in a wide variety of cell signaling processes. While the biological importance of recognition of methylated histones by reader domains in the cell nucleus is well established, the processes associated with methylation of non-histone proteins, particularly in the cytoplasm of the cell, are not well understood. Here, we describe a search for potential methyllysine readers using a rapid structural motif-mining algorithm Erebus, the PDB database, and knowledge of the methyllysine binding mechanisms.
    MeSH term(s) Algorithms ; Cytosol/metabolism ; Databases, Protein ; Epigenesis, Genetic ; Histones/chemistry ; Histones/metabolism ; Humans ; Lysine/metabolism ; Methylation ; Models, Molecular ; Protein Binding ; Protein Domains ; Protein Processing, Post-Translational
    Chemical Substances Histones ; Lysine (K3Z4F929H6)
    Language English
    Publishing date 2021-10-07
    Publishing country England
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
    ZDB-ID 2969-5
    ISSN 1470-8728 ; 0006-2936 ; 0306-3275 ; 0264-6021
    ISSN (online) 1470-8728
    ISSN 0006-2936 ; 0306-3275 ; 0264-6021
    DOI 10.1042/BCJ20210106
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    Uc I Zs.110: Show issues Location:
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  7. Article ; Online: Histone H3 Dual Ubiquitylation Mediates Maintenance DNA Methylation.

    Vann, Kendra R / Kutateladze, Tatiana G

    Molecular cell

    2017  Volume 68, Issue 2, Page(s) 261–262

    Abstract: Epigenetic marks, including DNA methylation and posttranslational modifications (PTMs) in histones, are important factors in determining the fate of replicating cells. In this issue of Molecular Cell, Ishiyama et al. (2017) reveal yet another layer in a ... ...

    Abstract Epigenetic marks, including DNA methylation and posttranslational modifications (PTMs) in histones, are important factors in determining the fate of replicating cells. In this issue of Molecular Cell, Ishiyama et al. (2017) reveal yet another layer in a remarkably complex mechanism of maintenance DNA methylation.
    MeSH term(s) DNA Methylation ; Histones/genetics ; Protein Processing, Post-Translational ; Ubiquitin ; Ubiquitination
    Chemical Substances Histones ; Ubiquitin
    Language English
    Publishing date 2017-10-20
    Publishing country United States
    Document type Journal Article ; Comment
    ZDB-ID 1415236-8
    ISSN 1097-4164 ; 1097-2765
    ISSN (online) 1097-4164
    ISSN 1097-2765
    DOI 10.1016/j.molcel.2017.10.007
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    Zs.A 5055: Show issues Location:
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  8. Article ; Online: Inhibition of translation and immune responses by the virulence factor Nsp1 of SARS-CoV-2

    Kendra R. Vann / Adam H. Tencer / Tatiana G. Kutateladze

    Signal Transduction and Targeted Therapy, Vol 5, Iss 1, Pp 1-

    2020  Volume 4

    Keywords Medicine ; R ; Biology (General) ; QH301-705.5 ; covid19
    Language English
    Publishing date 2020-10-01T00:00:00Z
    Publisher Nature Publishing Group
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  9. Article ; Online: Combinatorial inhibition of BTK, PI3K-AKT and BRD4-MYC as a strategy for treatment of mantle cell lymphoma.

    Vann, Kendra R / Pal, Dhananjaya / Smith, Audrey L / Sahar, Namood-E / Krishnaiah, Maddeboina / El-Gamal, Dalia / Kutateladze, Tatiana G

    Molecular biomedicine

    2022  Volume 3, Issue 1, Page(s) 2

    Abstract: Mantle cell lymphoma (MCL) is a subtype of non-Hodgkin's lymphoma characterized by poor prognosis. The complexity of MCL pathogenesis arises from aberrant activities of diverse signaling pathways, including BTK, PI3K-AKT-mTOR and MYC-BRD4. Here, we ... ...

    Abstract Mantle cell lymphoma (MCL) is a subtype of non-Hodgkin's lymphoma characterized by poor prognosis. The complexity of MCL pathogenesis arises from aberrant activities of diverse signaling pathways, including BTK, PI3K-AKT-mTOR and MYC-BRD4. Here, we report that MCL-related signaling pathways can be altered by a single small molecule inhibitor, SRX3305. Binding and kinase activities along with resonance changes in NMR experiments reveal that SRX3305 targets both bromodomains of BRD4 and is highly potent in inhibition of the PI3K isoforms α, γ and δ, as well as BTK and the drug-resistant BTK mutant. Preclinical investigations herein reveal that SRX3305 perturbs the cell cycle, promotes apoptosis in MCL cell lines and shows dose dependent anti-proliferative activity in both MCL and drug-resistant MCL cells. Our findings underscore the effectiveness of novel multi-action small molecule inhibitors for potential treatment of MCL.
    Language English
    Publishing date 2022-01-15
    Publishing country Singapore
    Document type Journal Article
    ISSN 2662-8651
    ISSN (online) 2662-8651
    DOI 10.1186/s43556-021-00066-9
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  10. Article: Architecture of PRC2 Holo Complexes

    Vann, Kendra R / Kutateladze, Tatiana G

    Trends in biochemical sciences. 2018 July, v. 43, no. 7

    2018  

    Abstract: Polycomb repressive complex 2 (PRC2) is a chief epigenetic regulator. In a new article, Chen et al. describe the crystal structure of the heterotetrameric PRC2 holo complex, which provides important mechanistic insights into the organization of its ... ...

    Abstract Polycomb repressive complex 2 (PRC2) is a chief epigenetic regulator. In a new article, Chen et al. describe the crystal structure of the heterotetrameric PRC2 holo complex, which provides important mechanistic insights into the organization of its subunits and the association of PRC2 with chromatin.
    Keywords chromatin ; crystal structure ; epigenetics
    Language English
    Dates of publication 2018-07
    Size p. 487-489.
    Publishing place Elsevier Ltd
    Document type Article
    ZDB-ID 194220-7
    ISSN 0968-0004 ; 0376-5067
    ISSN 0968-0004 ; 0376-5067
    DOI 10.1016/j.tibs.2018.04.009
    Database NAL-Catalogue (AGRICOLA)

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