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  1. Article ; Online: Targeting ADAMTS-7: A Vaccination Against Atherosclerosis-and Its Complications?

    Kessler, Thorsten / Schunkert, Heribert

    Circulation

    2023  Volume 147, Issue 9, Page(s) 743–745

    MeSH term(s) Humans ; Atherosclerosis/prevention & control ; Vaccination ; ADAMTS7 Protein/metabolism
    Chemical Substances ADAMTS7 Protein (EC 3.4.24.-)
    Language English
    Publishing date 2023-02-27
    Publishing country United States
    Document type Editorial ; Research Support, Non-U.S. Gov't ; Comment
    ZDB-ID 80099-5
    ISSN 1524-4539 ; 0009-7322 ; 0069-4193 ; 0065-8499
    ISSN (online) 1524-4539
    ISSN 0009-7322 ; 0069-4193 ; 0065-8499
    DOI 10.1161/CIRCULATIONAHA.122.063495
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Complete revascularisation should be immediate in STEMI: pros and cons.

    Kastrati, Adnan / Kessler, Thorsten / Rinaldi, Riccardo / Brugaletta, Salvatore

    EuroIntervention : journal of EuroPCR in collaboration with the Working Group on Interventional Cardiology of the European Society of Cardiology

    2024  Volume 20, Issue 3, Page(s) e171–e173

    MeSH term(s) Humans ; ST Elevation Myocardial Infarction/surgery ; Coronary Artery Disease ; Myocardial Revascularization ; Vascular Surgical Procedures
    Language English
    Publishing date 2024-02-05
    Publishing country France
    Document type Journal Article
    ZDB-ID 2457174-X
    ISSN 1969-6213 ; 1774-024X
    ISSN (online) 1969-6213
    ISSN 1774-024X
    DOI 10.4244/EIJ-E-23-00045
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Role of the extracellular matrix in cell-cell communication: a new therapeutic target?

    Kessler, Thorsten / Sager, Hendrik B / Mann, Matthias

    European heart journal

    2023  Volume 44, Issue 37, Page(s) 3495–3497

    MeSH term(s) Humans ; Cell Communication ; Extracellular Matrix
    Language English
    Publishing date 2023-02-19
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 603098-1
    ISSN 1522-9645 ; 0195-668X
    ISSN (online) 1522-9645
    ISSN 0195-668X
    DOI 10.1093/eurheartj/ehad061
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Coronary Artery Disease Genetics Enlightened by Genome-Wide Association Studies.

    Kessler, Thorsten / Schunkert, Heribert

    JACC. Basic to translational science

    2021  Volume 6, Issue 7, Page(s) 610–623

    Abstract: Many cardiovascular diseases are facilitated by strong inheritance. For example, large-scale genetic studies identified hundreds of genomic loci that affect the risk of coronary artery disease. At each of these loci, common variants are associated with ... ...

    Abstract Many cardiovascular diseases are facilitated by strong inheritance. For example, large-scale genetic studies identified hundreds of genomic loci that affect the risk of coronary artery disease. At each of these loci, common variants are associated with disease risk with robust statistical evidence but individually small effect sizes. Only a minority of candidate genes found at these loci are involved in the pathophysiology of traditional risk factors, but experimental research is making progress in identifying novel, and, in part, unexpected mechanisms. Targets identified by genome-wide association studies have already led to the development of novel treatments, specifically in lipid metabolism. This review summarizes recent genetic and experimental findings in this field. In addition, the development and possible clinical usefulness of polygenic risk scores in risk prediction and individualization of treatment, particularly in lipid metabolism, are discussed.
    Language English
    Publishing date 2021-07-26
    Publishing country United States
    Document type Journal Article ; Review
    ISSN 2452-302X
    ISSN (online) 2452-302X
    DOI 10.1016/j.jacbts.2021.04.001
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Book ; Online ; Thesis: The role of p22phox in the cardiovascular response to obesity

    Klop, Mathieu Edouard [Verfasser] / Görlach, Agnes [Akademischer Betreuer] / Görlach, Agnes [Gutachter] / Keßler, Thorsten [Gutachter]

    2023  

    Author's details Mathieu Edouard Klop ; Gutachter: Agnes Görlach, Thorsten Keßler ; Betreuer: Agnes Görlach
    Keywords Medizin, Gesundheit ; Medicine, Health
    Subject code sg610
    Language English
    Publisher Universitätsbibliothek der TU München
    Publishing place München
    Document type Book ; Online ; Thesis
    Database Digital theses on the web

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  6. Book ; Online ; Thesis: Apoptosis inducing factor 1 and its role during plaque stabilization in carotid artery disease and ischemic stroke

    Bischoff, Lukas Verfasser] / [Mägdefessel, Lars [Akademischer Betreuer] / Thorsten, Keßler Gutachter] / [Mägdefessel, Lars [Gutachter]

    2023  

    Author's details Lukas Bischoff ; Gutachter: Keßler Thorsten, Lars Mägdefessel ; Betreuer: Lars Mägdefessel
    Keywords Medizin, Gesundheit ; Medicine, Health
    Subject code sg610
    Language English
    Publisher Universitätsbibliothek der TU München
    Publishing place München
    Document type Book ; Online ; Thesis
    Database Digital theses on the web

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  7. Article ; Online: Inhibitors of the renin-angiotensin system and SARS-CoV-2 infection.

    Kessler, Thorsten / Schunkert, Heribert

    Herz

    2020  Volume 45, Issue 4, Page(s) 323–324

    Title translation Inhibitoren des Renin-Angiotensin-Systems und SARS-CoV-2-Infektion.
    MeSH term(s) Betacoronavirus ; COVID-19 ; Coronavirus Infections/metabolism ; Humans ; Pandemics ; Pneumonia, Viral/metabolism ; Renin-Angiotensin System/drug effects ; SARS-CoV-2
    Keywords covid19
    Language English
    Publishing date 2020-04-08
    Publishing country Germany
    Document type Letter
    ZDB-ID 8262-4
    ISSN 1615-6692 ; 0340-9937 ; 0946-1299
    ISSN (online) 1615-6692
    ISSN 0340-9937 ; 0946-1299
    DOI 10.1007/s00059-020-04920-4
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article: Genomic Strategies Toward Identification of Novel Therapeutic Targets.

    Kessler, Thorsten / Schunkert, Heribert

    Handbook of experimental pharmacology

    2020  Volume 270, Page(s) 429–462

    Abstract: Coronary artery disease, myocardial infarction, and secondary damages of the myocardium in the form of ischemic heart disease remain major causes of death in Western countries. Beyond traditional risk factors such as smoking, hypertension, dyslipidemia, ... ...

    Abstract Coronary artery disease, myocardial infarction, and secondary damages of the myocardium in the form of ischemic heart disease remain major causes of death in Western countries. Beyond traditional risk factors such as smoking, hypertension, dyslipidemia, or diabetes, a positive family history is known to increase risk. The genetic factors underlying this observation remained unknown for decades until genetic studies were able to identify multiple genomic loci contributing to the heritability of the trait. Knowledge of the affected genes and the resulting molecular and cellular mechanisms leads to improved understanding of the pathophysiology leading to coronary atherosclerosis. Major goals are also to improve prevention and therapy of coronary artery disease and its sequelae via improved risk prediction tools and pharmacological targets. In this chapter, we recapitulate recent major findings. We focus on established novel targets and discuss possible further targets which are currently explored in translational studies.
    MeSH term(s) Coronary Artery Disease/drug therapy ; Coronary Artery Disease/genetics ; Genetic Predisposition to Disease ; Genome-Wide Association Study ; Genomics ; Humans ; Myocardial Infarction
    Language English
    Publishing date 2020-05-13
    Publishing country Germany
    Document type Journal Article
    ISSN 0171-2004
    ISSN 0171-2004
    DOI 10.1007/164_2020_360
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: Genetics of Recovery After Stroke.

    Kessler, Thorsten / Schunkert, Heribert

    Circulation research

    2019  Volume 124, Issue 1, Page(s) 18–20

    MeSH term(s) Brain Ischemia ; Genetic Predisposition to Disease ; Genome-Wide Association Study ; Humans ; Stroke
    Language English
    Publishing date 2019-02-22
    Publishing country United States
    Document type Editorial ; Research Support, Non-U.S. Gov't ; Comment
    ZDB-ID 80100-8
    ISSN 1524-4571 ; 0009-7330 ; 0931-6876
    ISSN (online) 1524-4571
    ISSN 0009-7330 ; 0931-6876
    DOI 10.1161/CIRCRESAHA.118.314269
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: Letter by Kessler et al Regarding Article, "Comparative Efficacy and Safety of Oral P2Y12 Inhibitors in Acute Coronary Syndrome: Network Meta-Analysis of 52 816 Patients From 12 Randomized Trials".

    Kessler, Thorsten / Cassese, Salvatore / Kastrati, Adnan

    Circulation

    2021  Volume 143, Issue 6, Page(s) e230–e231

    MeSH term(s) Acute Coronary Syndrome/diagnosis ; Acute Coronary Syndrome/drug therapy ; Humans ; Network Meta-Analysis ; Purinergic P2Y Receptor Antagonists/adverse effects ; Randomized Controlled Trials as Topic ; Ticlopidine
    Chemical Substances Purinergic P2Y Receptor Antagonists ; Ticlopidine (OM90ZUW7M1)
    Language English
    Publishing date 2021-02-08
    Publishing country United States
    Document type Letter ; Comment
    ZDB-ID 80099-5
    ISSN 1524-4539 ; 0009-7322 ; 0069-4193 ; 0065-8499
    ISSN (online) 1524-4539
    ISSN 0009-7322 ; 0069-4193 ; 0065-8499
    DOI 10.1161/CIRCULATIONAHA.120.049650
    Database MEDical Literature Analysis and Retrieval System OnLINE

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