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  1. Article ; Online: Dynamic tracking of human umbilical cord mesenchymal stem cells (hUC-MSCs) following intravenous administration in mice model.

    Chin, Sze-Piaw / Marzuki, Marini / Tai, Lihui / Mohamed Shahrehan, Nurul Ashikin / Ricky, Christine / Fanty, Audrey / Salleh, Annas / Low, Chui Thean / Then, Kong-Yong / Hoe, Susan Ling Ling / Cheong, Soon Keng

    Regenerative therapy

    2024  Volume 25, Page(s) 273–283

    Abstract: ... the biodistribution, homing and clearance of systemically administered hUC-MSCs in healthy BALB/c mice model ... Upon intravenous infusion of transduced hUC-MSCs into the healthy BALB/c mice, the cells were dynamically monitored ... administration, BLI showed that transduced hUC-MSCs first localised predominantly in the lungs of healthy BALB/c ...

    Abstract Introduction: In the past decades, human umbilical cord-derived mesenchymal stem cells (hUC-MSCs) have sparked interest in cellular therapy due to their immunomodulatory properties. Nevertheless, the fate of hUC-MSCs in the body remains poorly understood. This study aimed to investigate the biodistribution, homing and clearance of systemically administered hUC-MSCs in healthy BALB/c mice model.
    Methods: hUC-MSCs were labelled with GFP-Luc2 protein, followed by characterisation with flow cytometry. Upon intravenous infusion of transduced hUC-MSCs into the healthy BALB/c mice, the cells were dynamically monitored through the bioluminescent imaging (BLI) approach.
    Results: Transduction of hUC-MSCs with GFP-Luc2 not only preserved the characteristics of MSCs, but also allowed live monitoring of transduced cells in the mice model. Upon systemic administration, BLI showed that transduced hUC-MSCs first localised predominantly in the lungs of healthy BALB/c mice and mainly remained in the lungs for up to 3 days before eventually cleared from the body. At terminal sacrifice, plasma chemistry biomarkers remained unchanged except for C-peptide levels, which were significantly reduced in the hUC-MSCs group. Histopathological findings further revealed that hUC-MSCs infusion did not cause any adverse effects and toxicity to lung, liver and heart tissues.
    Conclusions: Collectively, systemically administrated hUC-MSCs was safe and demonstrated dynamic homing capacity before eventually disappearing from the body.
    Language English
    Publishing date 2024-01-24
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 2835333-X
    ISSN 2352-3204 ; 2352-3204
    ISSN (online) 2352-3204
    ISSN 2352-3204
    DOI 10.1016/j.reth.2024.01.003
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Micromagnetic stimulation (

    Saha, Renata / Sanger, Zachary / Bloom, Robert P / Benally, Onri J / Wu, Kai / Tonini, Denis / Low, Walter C / Keirstead, Susan A / Netoff, Theoden I / Wang, Jian-Ping

    Journal of neural engineering

    2023  Volume 20, Issue 3

    Abstract: Objective. ...

    Abstract Objective.
    MeSH term(s) Rats ; Animals ; Sciatic Nerve/physiology ; Muscle, Skeletal/physiology ; Electrodes ; Electric Stimulation/methods
    Language English
    Publishing date 2023-05-31
    Publishing country England
    Document type Journal Article ; Research Support, U.S. Gov't, Non-P.H.S. ; Research Support, Non-U.S. Gov't
    ZDB-ID 2170901-4
    ISSN 1741-2552 ; 1741-2560
    ISSN (online) 1741-2552
    ISSN 1741-2560
    DOI 10.1088/1741-2552/acd582
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article: American Association of Clinical Endocrinology Consensus Statement: Comprehensive Type 2 Diabetes Management Algorithm - 2023 Update.

    Samson, Susan L / Vellanki, Priyathama / Blonde, Lawrence / Christofides, Elena A / Galindo, Rodolfo J / Hirsch, Irl B / Isaacs, Scott D / Izuora, Kenneth E / Low Wang, Cecilia C / Twining, Christine L / Umpierrez, Guillermo E / Valencia, Willy Marcos

    Endocrine practice : official journal of the American College of Endocrinology and the American Association of Clinical Endocrinologists

    2023  Volume 29, Issue 5, Page(s) 305–340

    Abstract: Objective: This consensus statement provides (1) visual guidance in concise graphic algorithms to assist with clinical decision-making of health care professionals in the management of persons with type 2 diabetes mellitus to improve patient care and (2) ...

    Abstract Objective: This consensus statement provides (1) visual guidance in concise graphic algorithms to assist with clinical decision-making of health care professionals in the management of persons with type 2 diabetes mellitus to improve patient care and (2) a summary of details to support the visual guidance found in each algorithm.
    Methods: The American Association of Clinical Endocrinology (AACE) selected a task force of medical experts who updated the 2020 AACE Comprehensive Type 2 Diabetes Management Algorithm based on the 2022 AACE Clinical Practice Guideline: Developing a Diabetes Mellitus Comprehensive Care Plan and consensus of task force authors.
    Results: This algorithm for management of persons with type 2 diabetes includes 11 distinct sections: (1) Principles for the Management of Type 2 Diabetes; (2) Complications-Centric Model for the Care of Persons with Overweight/Obesity; (3) Prediabetes Algorithm; (4) Atherosclerotic Cardiovascular Disease Risk Reduction Algorithm: Dyslipidemia; (5) Atherosclerotic Cardiovascular Disease Risk Reduction Algorithm: Hypertension; (6) Complications-Centric Algorithm for Glycemic Control; (7) Glucose-Centric Algorithm for Glycemic Control; (8) Algorithm for Adding/Intensifying Insulin; (9) Profiles of Antihyperglycemic Medications; (10) Profiles of Weight-Loss Medications (new); and (11) Vaccine Recommendations for Persons with Diabetes Mellitus (new), which summarizes recommendations from the Advisory Committee on Immunization Practices of the U.S. Centers for Disease Control and Prevention.
    Conclusions: Aligning with the 2022 AACE diabetes guideline update, this 2023 diabetes algorithm update emphasizes lifestyle modification and treatment of overweight/obesity as key pillars in the management of prediabetes and diabetes mellitus and highlights the importance of appropriate management of atherosclerotic risk factors of dyslipidemia and hypertension. One notable new theme is an emphasis on a complication-centric approach, beyond glucose levels, to frame decisions regarding first-line pharmacologic choices for the treatment of persons with diabetes. The algorithm also includes access/cost of medications as factors related to health equity to consider in clinical decision-making.
    MeSH term(s) Humans ; United States ; Diabetes Mellitus, Type 2/drug therapy ; Endocrinologists ; Cardiovascular Diseases ; Overweight ; Prediabetic State/therapy ; Endocrinology ; Obesity/therapy ; Hypertension ; Glucose/therapeutic use ; Dyslipidemias/therapy
    Chemical Substances Glucose (IY9XDZ35W2)
    Language English
    Publishing date 2023-05-06
    Publishing country United States
    Document type Practice Guideline ; Journal Article
    ZDB-ID 1473503-9
    ISSN 1530-891X
    ISSN 1530-891X
    DOI 10.1016/j.eprac.2023.02.001
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: A Real-Time Mobile Intervention to Reduce Sedentary Behavior Before and After Cancer Surgery: Pilot Randomized Controlled Trial.

    Low, Carissa A / Danko, Michaela / Durica, Krina C / Vega, Julio / Li, Meng / Kunta, Abhineeth Reddy / Mulukutla, Raghu / Ren, Yiyi / Sereika, Susan M / Bartlett, David L / Bovbjerg, Dana H / Dey, Anind K / Jakicic, John M

    JMIR perioperative medicine

    2023  Volume 6, Page(s) e41425

    Abstract: Background: Sedentary behavior (SB) is prevalent after abdominal cancer surgery, and interventions targeting perioperative SB could improve postoperative recovery and outcomes. We conducted a pilot study to evaluate the feasibility and preliminary ... ...

    Abstract Background: Sedentary behavior (SB) is prevalent after abdominal cancer surgery, and interventions targeting perioperative SB could improve postoperative recovery and outcomes. We conducted a pilot study to evaluate the feasibility and preliminary effects of a real-time mobile intervention that detects and disrupts prolonged SB before and after cancer surgery, relative to a monitoring-only control condition.
    Objective: Our aim was to evaluate the feasibility and preliminary effects of a perioperative SB intervention on objective activity behavior, patient-reported quality of life and symptoms, and 30-day readmissions.
    Methods: Patients scheduled for surgery for metastatic gastrointestinal cancer (n=26) were enrolled and randomized to receive either the SB intervention or activity monitoring only. Both groups used a Fitbit smartwatch and companion smartphone app to rate daily symptoms and collect continuous objective activity behavior data starting from at least 10 days before surgery through 30 days post discharge. Participants in the intervention group also received prompts to walk after any SB bout that exceeded a prespecified threshold, with less frequent prompts on days that patients reported more severe symptoms. Participants completed end-of-study ratings of acceptability, and we also examined adherence to assessments and to walking prompts. In addition, we examined effects of the intervention on objective SB and step counts, patient-reported quality of life and depressive and physical symptoms, as well as readmissions.
    Results: Accrual (74%), retention (88%), and acceptability ratings (mean overall satisfaction 88.5/100, SD 9.1) were relatively high. However, adherence to assessments and engagement with the SB intervention decreased significantly after surgery and did not recover to preoperative levels after postoperative discharge. All participants exhibited significant increases in SB and symptoms and decreases in steps and quality of life after surgery, and participants randomized to the SB intervention unexpectedly had longer maximum SB bouts relative to the control group. No significant benefits of the intervention with regard to activity, quality of life, symptoms, or readmission were observed.
    Conclusions: Perioperative patients with metastatic gastrointestinal cancer were interested in a real-time SB intervention and rated the intervention as highly acceptable, but engagement with the intervention and with daily symptom and activity monitoring decreased significantly after surgery. There were no significant effects of the intervention on step counts, patient-reported quality of life or symptoms, and postoperative readmissions, and there was an apparent adverse effect on maximum SB. Results highlight the need for additional work to modify the intervention to make reducing SB and engaging with mobile health technology after abdominal cancer surgery more feasible and beneficial.
    Trial registration: ClinicalTrials.gov NCT03211806; https://tinyurl.com/3napwkkt.
    Language English
    Publishing date 2023-01-12
    Publishing country Canada
    Document type Journal Article
    ISSN 2561-9128
    ISSN (online) 2561-9128
    DOI 10.2196/41425
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Strength-frequency curve for micromagnetic neurostimulation through excitatory postsynaptic potentials (EPSPs) on rat hippocampal neurons and numerical modeling of magnetic microcoil (

    Saha, Renata / Faramarzi, Sadegh / Bloom, Robert P / Benally, Onri J / Wu, Kai / di Girolamo, Arturo / Tonini, Denis / Keirstead, Susan A / Low, Walter C / Netoff, Theoden I / Wang, Jian-Ping

    Journal of neural engineering

    2022  Volume 19, Issue 1

    Abstract: Objective. ...

    Abstract Objective.
    MeSH term(s) Animals ; Electric Stimulation ; Excitatory Postsynaptic Potentials ; Hippocampus/physiology ; Magnetic Phenomena ; Neurons ; Rats ; Synapses/physiology ; Synaptic Transmission
    Language English
    Publishing date 2022-02-04
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Research Support, U.S. Gov't, Non-P.H.S.
    ZDB-ID 2170901-4
    ISSN 1741-2552 ; 1741-2560
    ISSN (online) 1741-2552
    ISSN 1741-2560
    DOI 10.1088/1741-2552/ac4baf
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Co-circulation of alpha- and beta-coronaviruses in Pteropus vampyrus flying foxes from Indonesia.

    Ch'ng, Lena / Tsang, Susan M / Ong, Zoe A / Low, Dolyce H W / Wiantoro, Sigit / Smith, Ina L / Simmons, Nancy B / Su, Yvonne C F / Lohman, David J / Smith, Gavin J D / Mendenhall, Ian H

    Transboundary and emerging diseases

    2022  Volume 69, Issue 6, Page(s) 3917–3925

    Abstract: Bats are important reservoirs for alpha- and beta-coronaviruses. Coronaviruses (CoV) have been detected in pteropodid bats from several Southeast Asian countries, but little is known about coronaviruses in the Indonesian archipelago in proportion to its ... ...

    Abstract Bats are important reservoirs for alpha- and beta-coronaviruses. Coronaviruses (CoV) have been detected in pteropodid bats from several Southeast Asian countries, but little is known about coronaviruses in the Indonesian archipelago in proportion to its mammalian biodiversity. In this study, we screened pooled faecal samples from the Indonesian colonies of Pteropus vampyrus with unbiased next-generation sequencing. Bat CoVs related to Rousettus leschenaultii CoV HKU9 and Eidolon helvum CoV were detected. The 121 faecal samples were further screened using a conventional hemi-nested pan-coronavirus PCR assay. Three positive samples were successfully sequenced, and phylogenetic reconstruction revealed the presence of alpha- and beta-coronaviruses. CoVs belonging to the subgenera Nobecovirus, Decacovirus and Pedacovirus were detected in a single P. vampyrus roost. This study expands current knowledge of coronavirus diversity in Indonesian flying foxes, highlighting the need for longitudinal surveillance of colonies as continuing urbanization and deforestation heighten the risk of spillover events.
    MeSH term(s) Animals ; Coronavirus/genetics ; Chiroptera ; Indonesia/epidemiology ; Phylogeny ; Coronavirus Infections/veterinary
    Language English
    Publishing date 2022-12-02
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 2414822-2
    ISSN 1865-1682 ; 1865-1674
    ISSN (online) 1865-1682
    ISSN 1865-1674
    DOI 10.1111/tbed.14762
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: Characterising Australian memory clinics: current practice and service needs informing national service guidelines.

    Naismith, Sharon L / Michaelian, Johannes C / Low, Lee-Fay / Arsenova, Valerie / Mehrani, Inga / Fyfe, Katrina / Kochan, Nicole A / Kurrle, Susan E / Rowe, Christopher / Sachdev, Perminder S

    BMC geriatrics

    2022  Volume 22, Issue 1, Page(s) 578

    Abstract: Background: Memory clinics (MCs) play a key role in accurate and timely diagnoses and treatment of dementia and mild cognitive impairment. However, within Australia, there are little data available on current practices in MCs, which hinder international ...

    Abstract Background: Memory clinics (MCs) play a key role in accurate and timely diagnoses and treatment of dementia and mild cognitive impairment. However, within Australia, there are little data available on current practices in MCs, which hinder international comparisons for best practice, harmonisation efforts and national coordination. Here, we aimed to characterise current service profiles of Australian MCs.
    Methods: The 'Australian Dementia Network Survey of Expert Opinion on Best Practice and the Current Clinical Landscape' was conducted between August-September 2020 as part of a larger-scale Delphi process deployed to develop national MC guidelines. In this study, we report on the subset of questions pertaining to current practice including wait-times and post-diagnostic care.
    Results: Responses were received from 100 health professionals representing 60 separate clinics (45 public, 11 private, and 4 university/research clinics). The majority of participants were from clinics in metropolitan areas (79%) and in general were from high socioeconomic areas. While wait-times varied, only 28.3% of clinics were able to offer an appointment within 1-2 weeks for urgent referrals, with significantly more private clinics (58.3%) compared to public clinics (19.5%) being able to do so. Wait-times were less than 8 weeks for 34.5% of non-urgent referrals. Only 20.0 and 30.9% of clinics provided cognitive interventions or post-diagnostic support respectively, with 7.3% offering home-based reablement programs, and only 12.7% offering access to group-based education. Metropolitan clinics utilised neuropsychological assessments for a broader range of cases and were more likely to offer clinical trials and access to research opportunities.
    Conclusions: In comparison to similar countries with comprehensive government-funded public healthcare systems (i.e., United Kingdom, Ireland and Canada), wait-times for Australian MCs are long, and post-diagnostic support or evidence-based strategies targeting cognition are not common practice. The timely and important results of this study highlight a need for Australian MCs to adopt a more holistic service of multidisciplinary assessment and post-diagnostic support, as well as the need for the number of Australian MCs to be increased to match the rising number of dementia cases.
    MeSH term(s) Appointments and Schedules ; Australia/epidemiology ; Dementia/diagnosis ; Dementia/epidemiology ; Dementia/therapy ; Humans ; Referral and Consultation ; Surveys and Questionnaires
    Language English
    Publishing date 2022-07-14
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2059865-8
    ISSN 1471-2318 ; 1471-2318
    ISSN (online) 1471-2318
    ISSN 1471-2318
    DOI 10.1186/s12877-022-03253-7
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: Can we really make catheter-associated urinary tract infections a never event? A level 1 trauma center's experience with prophylactic antibiotic bladder irrigation.

    Rieger, Rebecca M / Bonnin, Sophia S / Hopp, Morgan J / Low, Trevor M / Villa, David C / Coates, Susan L / Chapple, Kristina M / Soe-Lin, Hahn / Weinberg, Jordan A

    The journal of trauma and acute care surgery

    2022  Volume 93, Issue 5, Page(s) 627–631

    Abstract: Background: Hospital-acquired catheter-associated urinary tract infections (CAUTIs) are considered "never events" and are reportable to Centers for Medicare and Medicaid Services as a quality indicator. Despite protocols to determine appropriate removal ...

    Abstract Background: Hospital-acquired catheter-associated urinary tract infections (CAUTIs) are considered "never events" and are reportable to Centers for Medicare and Medicaid Services as a quality indicator. Despite protocols to determine appropriate removal of urinary catheters as soon as possible, severely injured trauma patients often require prolonged catheterization during ongoing resuscitation or develop retention requiring catheter replacement, exposing them to risk for CAUTI. We evaluated whether prophylactic antibiotic bladder irrigation reduces the incidence of CAUTI in critically ill trauma patients.
    Methods: As a quality initiative, gentamicin bladder catheter irrigation (GBCI) was performed on a level 1 trauma center's patients at risk for CAUTI in 2021, defined by indwelling Foley catheterization for a minimum of 3 days. We then conducted a retrospective study using a comparison cohort of 2020 admissions as the control group. Catheter-associated urinary tract infection rates per 1,000 catheterized days were compared between these two groups. Patients with traumatic bladder injuries were excluded.
    Results: Our cohort included 342 patients with a median hospitalization of 11 (7-17) days, Injury Severity Score of 17 (10-26), and 6 (4-11) days of catheterization. Eighty-six patients, catheterized for 939 at-risk days, received twice-daily GBCI compared with 256, catheterized for 2,114 at-risk days, who did not. Zero patients in the GBCI group versus nine patients in the control group developed CAUTI. The incidence of CAUTI in the GBCI group was significantly less than in the control group (0/1,000 vs. 4.3/1,000 catheterized days, p = 0.018).
    Conclusion: Prophylactic antibiotic bladder irrigation was associated with a zero incidence of CAUTI among trauma patients at risk for CAUTI. This practice holds promise as effective infection prophylaxis for such patients. The optimal duration and frequency of irrigation remain to be determined.
    Level of evidence: Therapeutic/care management, Level III.
    MeSH term(s) Aged ; Humans ; United States/epidemiology ; Urinary Catheterization/adverse effects ; Urinary Catheterization/methods ; Catheter-Related Infections/epidemiology ; Catheter-Related Infections/prevention & control ; Catheter-Related Infections/etiology ; Urinary Bladder ; Trauma Centers ; Retrospective Studies ; Medicare ; Urinary Tract Infections/epidemiology ; Urinary Tract Infections/etiology ; Urinary Tract Infections/prevention & control ; Urinary Catheters/adverse effects ; Medical Errors ; Anti-Bacterial Agents ; Cross Infection/epidemiology ; Cross Infection/etiology ; Cross Infection/prevention & control
    Chemical Substances Anti-Bacterial Agents
    Language English
    Publishing date 2022-05-12
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2651070-4
    ISSN 2163-0763 ; 2163-0755
    ISSN (online) 2163-0763
    ISSN 2163-0755
    DOI 10.1097/TA.0000000000003671
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: Sex Differences Across the Life Course: A Focus On Unique Nutritional and Health Considerations among Women.

    Bailey, Regan L / Dog, Tieraona Low / Smith-Ryan, Abbie E / Das, Sai Krupa / Baker, Fiona C / Madak-Erdogan, Zeynep / Hammond, Billy R / Sesso, Howard D / Eapen, Alex / Mitmesser, Susan H / Wong, Andrea / Nguyen, Haiuyen

    The Journal of nutrition

    2022  Volume 152, Issue 7, Page(s) 1597–1610

    Abstract: In the United States, women, while having a longer life expectancy than men, experience a differential risk for chronic diseases and have unique nutritional needs based on physiological and hormonal changes across the life span. However, much of what is ... ...

    Abstract In the United States, women, while having a longer life expectancy than men, experience a differential risk for chronic diseases and have unique nutritional needs based on physiological and hormonal changes across the life span. However, much of what is known about health is based on research conducted in men. Additional complexity in assessing nutritional needs within gender include the variations in genetics, body compositions, hormonal milieus, underlying chronic diseases, and medication usage, with this list expanding as we consider these variables across the life course. It is clear women experience nutrient shortfalls during key periods of their lives, which may differentially impact their health. Consequently, as we move into the era of precision nutrition, understanding these sex- and gender-based differences may help optimize recommendations and interventions chosen to support health and weight management. Recently, a scientific conference was convened with content experts to explore these topics from a life-course perspective at biological, physiological, and behavioral levels. This publication summarizes the presentations and discussions from the workshop and provides an overview of important nutrition and related lifestyle considerations across the life course. The landscape of addressing female-specific nutritional needs continues to grow; now more than ever, it is essential to increase our understanding of the physiological differences between men and women, and determine how these physiological considerations may aid in optimizing nutritional strategies to support certain personal goals related to health, quality of life, sleep, and exercise performance among women.
    MeSH term(s) Female ; Humans ; Life Style ; Male ; Nutritional Status ; Quality of Life ; Sex Characteristics ; Sex Factors ; United States
    Language English
    Publishing date 2022-03-16
    Publishing country United States
    Document type Journal Article
    ZDB-ID 218373-0
    ISSN 1541-6100 ; 0022-3166
    ISSN (online) 1541-6100
    ISSN 0022-3166
    DOI 10.1093/jn/nxac059
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: Co‐circulation of alpha‐ and beta‐coronaviruses in Pteropus vampyrus flying foxes from Indonesia

    Ch'ng, Lena / Tsang, Susan M. / Ong, Zoe A. / Low, Dolyce H. W. / Wiantoro, Sigit / Smith, Ina L. / Simmons, Nancy B. / Su, Yvonne C. F. / Lohman, David J. / Smith, Gavin J. D. / Mendenhall, Ian H.

    Transboundary and Emerging Diseases. 2022 Nov., v. 69, no. 6 p.3917-3925

    2022  

    Abstract: Bats are important reservoirs for alpha‐ and beta‐coronaviruses. Coronaviruses (CoV) have been detected in pteropodid bats from several Southeast Asian countries, but little is known about coronaviruses in the Indonesian archipelago in proportion to its ... ...

    Abstract Bats are important reservoirs for alpha‐ and beta‐coronaviruses. Coronaviruses (CoV) have been detected in pteropodid bats from several Southeast Asian countries, but little is known about coronaviruses in the Indonesian archipelago in proportion to its mammalian biodiversity. In this study, we screened pooled faecal samples from the Indonesian colonies of Pteropus vampyrus with unbiased next‐generation sequencing. Bat CoVs related to Rousettus leschenaultii CoV HKU9 and Eidolon helvum CoV were detected. The 121 faecal samples were further screened using a conventional hemi‐nested pan‐coronavirus PCR assay. Three positive samples were successfully sequenced, and phylogenetic reconstruction revealed the presence of alpha‐ and beta‐coronaviruses. CoVs belonging to the subgenera Nobecovirus, Decacovirus and Pedacovirus were detected in a single P. vampyrus roost. This study expands current knowledge of coronavirus diversity in Indonesian flying foxes, highlighting the need for longitudinal surveillance of colonies as continuing urbanization and deforestation heighten the risk of spillover events.
    Keywords Pedacovirus ; Pteropus ; Rousettus ; biodiversity ; deforestation ; mammals ; monitoring ; phylogeny ; risk ; urbanization ; Indonesia
    Language English
    Dates of publication 2022-11
    Size p. 3917-3925.
    Publishing place John Wiley & Sons, Ltd
    Document type Article ; Online
    Note JOURNAL ARTICLE
    ZDB-ID 2414822-2
    ISSN 1865-1682 ; 1865-1674
    ISSN (online) 1865-1682
    ISSN 1865-1674
    DOI 10.1111/tbed.14762
    Database NAL-Catalogue (AGRICOLA)

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