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  1. Article: Programmatically Localizing Diabetic Retinopathy Features in 45-Degree Retinal Photographs Using Anatomical Colocation.

    Murphy, Timothy I / Douglass, Amanda G / van Wijngaarden, Peter / Armitage, James A

    Journal of clinical medicine

    2024  Volume 13, Issue 3

    Abstract: ... ...

    Abstract Background
    Language English
    Publishing date 2024-01-30
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2662592-1
    ISSN 2077-0383
    ISSN 2077-0383
    DOI 10.3390/jcm13030807
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  2. Article ; Online: Ophthalmology and the emergence of artificial intelligence.

    Scheetz, Jane / He, Mingguang / van Wijngaarden, Peter

    The Medical journal of Australia

    2021  Volume 214, Issue 4, Page(s) 155–157.e1

    MeSH term(s) Artificial Intelligence/trends ; Diagnostic Techniques, Ophthalmological/trends ; Eye Diseases/diagnosis ; Humans ; Ophthalmology/trends
    Language English
    Publishing date 2021-02-14
    Publishing country Australia
    Document type Journal Article
    ZDB-ID 186082-3
    ISSN 1326-5377 ; 0025-729X
    ISSN (online) 1326-5377
    ISSN 0025-729X
    DOI 10.5694/mja2.50932
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  3. Article ; Online: Metabolic pathways in context: mTOR signalling in the retina and optic nerve - A review.

    Yao, Anthony / van Wijngaarden, Peter

    Clinical & experimental ophthalmology

    2020  Volume 48, Issue 8, Page(s) 1072–1084

    Abstract: The mechanistic target of rapamycin (mTOR) signalling network plays a key role in growth and development, autophagy, metabolism, inflammation as well as ageing, and it is therefore important in ocular health and disease. mTOR dysregulation has been ... ...

    Abstract The mechanistic target of rapamycin (mTOR) signalling network plays a key role in growth and development, autophagy, metabolism, inflammation as well as ageing, and it is therefore important in ocular health and disease. mTOR dysregulation has been identified in a range of conditions, including age-related macular degeneration, diabetic retinopathy, retinitis pigmentosa, traumatic optic neuropathy and glaucoma. Experimental modulation of the pathway has contributed to the understanding of these diseases and offers the potential for new avenues of therapy. This review discusses the mTOR pathway and its role in health and in diseases of the retina and optic nerve.
    MeSH term(s) Diabetic Retinopathy ; Humans ; Metabolic Networks and Pathways ; Optic Nerve ; Retina ; TOR Serine-Threonine Kinases
    Chemical Substances MTOR protein, human (EC 2.7.1.1) ; TOR Serine-Threonine Kinases (EC 2.7.1.1)
    Language English
    Publishing date 2020-08-17
    Publishing country Australia
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Review
    ZDB-ID 2014008-3
    ISSN 1442-9071 ; 1442-6404
    ISSN (online) 1442-9071
    ISSN 1442-6404
    DOI 10.1111/ceo.13819
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  4. Article ; Online: A guide to optometrists for appraising and using artificial intelligence in clinical practice.

    Murphy, Timothy I / Armitage, James A / van Wijngaarden, Peter / Abel, Larry A / Douglass, Amanda G

    Clinical & experimental optometry

    2023  Volume 106, Issue 6, Page(s) 569–579

    Abstract: Artificial intelligence systems are becoming increasingly available as diagnostic aids for optometric practice. These perform well but are often 'black-box' systems offering little or no insight into how a decision was reached. While there is potential ... ...

    Abstract Artificial intelligence systems are becoming increasingly available as diagnostic aids for optometric practice. These perform well but are often 'black-box' systems offering little or no insight into how a decision was reached. While there is potential for artificial intelligence to improve patient outcomes, clinicians without training in computer science may find it difficult to ascertain whether these technologies are suitable for their practice, or how they should be used. This review provides an overview of how artificial intelligence systems work in optometry, their strengths, weaknesses, and regulatory considerations. A checklist is provided for appraising a system, covering regulatory approvals, ascertaining what the system can and cannot do, how it can be used in practice, whether it is suitable for the clinical population, and whether the outputs can be explained. Artificial intelligence has the potential to improve accuracy and efficiency in many areas of optometry if used correctly, and should be embraced by clinicians as an assistive tool.
    MeSH term(s) Humans ; Artificial Intelligence ; Optometrists ; Optometry
    Language English
    Publishing date 2023-04-20
    Publishing country United States
    Document type Review ; Journal Article
    ZDB-ID 639275-1
    ISSN 1444-0938 ; 0816-4622
    ISSN (online) 1444-0938
    ISSN 0816-4622
    DOI 10.1080/08164622.2023.2197578
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  5. Article ; Online: Visual Sensitivity Loss in Geographic Atrophy: Structure-Function Evaluation Using Defect-Mapping Microperimetry.

    Wu, Zhichao / Hadoux, Xavier / Jannaud, Maxime / Glover, Emily K / Gee, Erin E / Hodgson, Lauren A B / van Wijngaarden, Peter / Guymer, Robyn H

    Investigative ophthalmology & visual science

    2024  Volume 65, Issue 1, Page(s) 36

    Abstract: Purpose: To examine the structure-function relationship in eyes with geographic atrophy (GA) using defect-mapping microperimetry, a testing strategy optimized to quantify the spatial extent of deep visual sensitivity losses.: Methods: Fifty ... ...

    Abstract Purpose: To examine the structure-function relationship in eyes with geographic atrophy (GA) using defect-mapping microperimetry, a testing strategy optimized to quantify the spatial extent of deep visual sensitivity losses.
    Methods: Fifty participants with GA underwent defect-mapping microperimetry testing of the central 8°-radius region (208 locations tested once with a 10-decibel stimuli) and fundus autofluorescence imaging in one eye. The GA extent in the corresponding central 8°-radius was derived by manual annotations and image co-registration to examine the global structure-function relationship. The distance of each test location from the GA margin was also derived, and regions defined, to examine the local structure-function relationship.
    Results: GA extent in the central 8° explained a substantial proportion of variance in the percentage of locations missed (nonresponse) on microperimetry at the global level (R2 = 0.90). At a local level, the probability of missing stimuli at the outer junctional zone (0-500 µm outside the GA margin) and GA margin (probability = 7% and 34%, respectively) was higher than at the outer nonlesional zone (>500 µm outside the GA margin; probability = 2%; P < 0.001 for both). The probability of missing stimuli at the inner junctional zone (0-250 µm inside the GA margin) was also lower than at the inner lesional zone (>250 µm inside the GA margin; probability = 64% and 88%; P < 0.001).
    Conclusions: This study confirms the expected functional relevance of the region with GA on fundus autofluorescence imaging and underscores the potential effectiveness of defect-mapping microperimetry testing for capturing visual function changes when evaluating new GA treatments.
    MeSH term(s) Humans ; Geographic Atrophy/diagnosis ; Macular Degeneration ; Visual Field Tests/methods ; Tomography, Optical Coherence/methods ; Retinal Pigment Epithelium ; Vision Disorders/diagnosis ; Fluorescein Angiography/methods
    Language English
    Publishing date 2024-01-19
    Publishing country United States
    Document type Journal Article
    ZDB-ID 391794-0
    ISSN 1552-5783 ; 0146-0404
    ISSN (online) 1552-5783
    ISSN 0146-0404
    DOI 10.1167/iovs.65.1.36
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  6. Article ; Online: The eye in AI: artificial intelligence in ophthalmology.

    Keel, Stuart / van Wijngaarden, Peter

    Clinical & experimental ophthalmology

    2018  Volume 47, Issue 1, Page(s) 5–6

    MeSH term(s) Artificial Intelligence ; Ophthalmology
    Language English
    Publishing date 2018-11-28
    Publishing country Australia
    Document type Editorial ; Comment
    ZDB-ID 2014008-3
    ISSN 1442-9071 ; 1442-6404
    ISSN (online) 1442-9071
    ISSN 1442-6404
    DOI 10.1111/ceo.13435
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  7. Article ; Online: OCT biomarkers of neurodegenerative diseases - reading the tea leaves or seeing the truth?

    van Wijngaarden, Peter / Hadoux, Xavier / Christinaki, Eirini / De Groef, Lies / Stalmans, Ingeborg

    Clinical & experimental optometry

    2022  Volume 106, Issue 1, Page(s) 102–103

    MeSH term(s) Humans ; Neurodegenerative Diseases/diagnosis ; Tomography, Optical Coherence ; Tea ; Biomarkers ; Plant Leaves
    Chemical Substances Tea ; Biomarkers
    Language English
    Publishing date 2022-06-02
    Publishing country United States
    Document type Letter ; Comment
    ZDB-ID 639275-1
    ISSN 1444-0938 ; 0816-4622
    ISSN (online) 1444-0938
    ISSN 0816-4622
    DOI 10.1080/08164622.2022.2081068
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  8. Article ; Online: Systematic Underestimation of Visual Sensitivity Loss on Microperimetry: Implications for Testing Protocols in Clinical Trials.

    Wu, Zhichao / Hadoux, Xavier / Jannaud, Maxime / Martin, Keith R / van Wijngaarden, Peter / Guymer, Robyn H

    Translational vision science & technology

    2023  Volume 12, Issue 7, Page(s) 11

    Abstract: Purpose: To examine whether systematic changes in visual sensitivity measurements on microperimetry occur over tests within the same session and whether these changes vary according to the level of visual sensitivity loss.: Methods: Eighty ... ...

    Abstract Purpose: To examine whether systematic changes in visual sensitivity measurements on microperimetry occur over tests within the same session and whether these changes vary according to the level of visual sensitivity loss.
    Methods: Eighty individuals with glaucoma or atrophic age-related macular degeneration underwent three microperimetry tests in one eye during one session using the 4-2 staircase strategy. Changes in mean sensitivity (MS) and pointwise sensitivity (PWS) between the first and second test pairs were examined, with PWS was examined separately based on its average value across the three tests in 6-dB bins. The coefficient of repeatability (CoR) for MS between each sequential test pair was also calculated.
    Results: There was a significant decline in MS from the first to second test (P = 0.001), but no significant difference in MS was seen between the second and third tests (P = 0.562). This significant decline in the first test pair was observed in locations with an average PWS of <6 dB or between 6 to 12 dB and between 12 to 18 dB (P < 0.001), but not for all other average PWS bins (P ≥ 0.337). The CoR of MS was significantly lower in the second compared to the first test pair (1.4 dB and 2.5 dB, respectively; P < 0.001).
    Conclusions: The 4-2 staircase strategy conventionally used on microperimetry testing systematically underestimates visual sensitivity loss on the first test.
    Translational relevance: The consistency and accuracy of visual sensitivity measurements on microperimetry in clinical trials could be markedly improved by using estimates from an initial test to seed subsequent tests and excluding this first test from analyses.
    MeSH term(s) Humans ; Reproducibility of Results ; Vision Disorders ; Visual Acuity ; Visual Field Tests/methods ; Visual Fields ; Clinical Trial Protocols as Topic
    Language English
    Publishing date 2023-07-10
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2674602-5
    ISSN 2164-2591 ; 2164-2591
    ISSN (online) 2164-2591
    ISSN 2164-2591
    DOI 10.1167/tvst.12.7.11
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  9. Article ; Online: More than meets the eye: an association between diet soft drink consumption and proliferative diabetic retinopathy.

    van Wijngaarden, Peter / Keel, Stuart

    Clinical & experimental ophthalmology

    2018  Volume 46, Issue 7, Page(s) 719–720

    MeSH term(s) Carbonated Beverages ; Diabetic Retinopathy ; Diet ; Humans
    Language English
    Publishing date 2018-10-05
    Publishing country Australia
    Document type Editorial ; Comment
    ZDB-ID 2014008-3
    ISSN 1442-9071 ; 1442-6404
    ISSN (online) 1442-9071
    ISSN 1442-6404
    DOI 10.1111/ceo.13377
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  10. Article ; Online: The Case for Extended Screening Intervals for People With Diabetes and No or Minimal Retinopathy at Baseline.

    van Wijngaarden, Peter / Keel, Stuart / Scanlon, Peter H

    JAMA ophthalmology

    2019  Volume 137, Issue 4, Page(s) 449–450

    MeSH term(s) Diabetes Mellitus ; Diabetic Retinopathy ; Humans ; Incidence ; Mass Screening ; Retinal Diseases ; Telemedicine
    Language English
    Publishing date 2019-02-07
    Publishing country United States
    Document type Journal Article ; Comment
    ZDB-ID 2701705-9
    ISSN 2168-6173 ; 2168-6165
    ISSN (online) 2168-6173
    ISSN 2168-6165
    DOI 10.1001/jamaophthalmol.2018.6901
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