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  1. Article: Selective adsorption of fluorinated super greenhouse gases within a metal-organic framework with dynamic corrugated ultramicropores.

    Whitehead, Bevan S / Brennessel, William W / Michtavy, Shane S / Silva, Hope A / Kim, Jaehwan / Milner, Phillip J / Porosoff, Marc D / Barnett, Brandon R

    Chemical science

    2024  Volume 15, Issue 16, Page(s) 5964–5972

    Abstract: Perfluorocompound (PFC) gases play vital roles in microelectronics processing. Requirements for ultra-high purities traditionally necessitate use of virgin sources and thereby hinder the capture, purification, and reuse of these costly gases. Most ... ...

    Abstract Perfluorocompound (PFC) gases play vital roles in microelectronics processing. Requirements for ultra-high purities traditionally necessitate use of virgin sources and thereby hinder the capture, purification, and reuse of these costly gases. Most importantly, gaseous PFCs are incredibly potent greenhouse gases with atmospheric lifetimes on the order of 10
    Language English
    Publishing date 2024-03-25
    Publishing country England
    Document type Journal Article
    ZDB-ID 2559110-1
    ISSN 2041-6539 ; 2041-6520
    ISSN (online) 2041-6539
    ISSN 2041-6520
    DOI 10.1039/d3sc07007g
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  2. Article ; Online: miRNA cargo in circulating vesicles from neurons is altered in individuals with schizophrenia and associated with severe disease.

    Barnett, Michelle M / Reay, William R / Geaghan, Michael P / Kiltschewskij, Dylan J / Green, Melissa J / Weidenhofer, Judith / Glatt, Stephen J / Cairns, Murray J

    Science advances

    2023  Volume 9, Issue 48, Page(s) eadi4386

    Abstract: While RNA expression appears to be altered in several brain disorders, the constraints of postmortem analysis make it impractical for well-powered population studies and biomarker development. Given that the unique molecular composition of neurons are ... ...

    Abstract While RNA expression appears to be altered in several brain disorders, the constraints of postmortem analysis make it impractical for well-powered population studies and biomarker development. Given that the unique molecular composition of neurons are reflected in their extracellular vesicles (EVs), we hypothesized that the fractionation of neuron derived EVs provides an opportunity to specifically profile their encapsulated contents noninvasively from blood. To investigate this hypothesis, we determined miRNA expression in microtubule associated protein 1B (MAP1B)-enriched serum EVs derived from neurons from a large cohort of individuals with schizophrenia and nonpsychiatric comparison participants. We observed dysregulation of miRNA in schizophrenia subjects, in particular those with treatment-resistance and severe cognitive deficits. These data support the hypothesis that schizophrenia is associated with alterations in posttranscriptional regulation of synaptic gene expression and provides an example of the potential utility of tissue-specific EV analysis in brain disorders.
    MeSH term(s) Humans ; MicroRNAs/genetics ; MicroRNAs/metabolism ; Schizophrenia/genetics ; Schizophrenia/metabolism ; Neurons/metabolism ; Extracellular Vesicles/metabolism ; Brain Diseases
    Chemical Substances MicroRNAs
    Language English
    Publishing date 2023-11-29
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2810933-8
    ISSN 2375-2548 ; 2375-2548
    ISSN (online) 2375-2548
    ISSN 2375-2548
    DOI 10.1126/sciadv.adi4386
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  3. Article ; Online: Coordinatively Unsaturated Metallates of Cobalt(II), Nickel(II), and Zinc(II) Guarded by a Rigid and Narrow Void.

    Hastings, Christopher D / Huffman, Lucy S X / Tiwari, Chandan Kumar / Betancourth, Jolaine Galindo / Brennessel, William W / Barnett, Brandon R

    Inorganic chemistry

    2023  Volume 62, Issue 30, Page(s) 11920–11931

    Abstract: Both natural enzymatic systems and synthetic porous material catalysts utilize well-defined and uniform channels to dictate reaction selectivities on the basis of size or shape. Mimicry of this design element in homogeneous systems is generally difficult ...

    Abstract Both natural enzymatic systems and synthetic porous material catalysts utilize well-defined and uniform channels to dictate reaction selectivities on the basis of size or shape. Mimicry of this design element in homogeneous systems is generally difficult owing to the flexibility inherent in most small molecular species. Herein, we report the synthesis of a tripodal ligand scaffold that orients a narrow and rigid cavity atop accessible metal coordination space. The permanent void is formed through a macrocyclization reaction whereby the 3,5-dihydroxyphenyl arms are covalently linked through methylene bridges. Deprotonative metallation leads to anionic and coordinatively unsaturated complexes of divalent cobalt, nickel, and zinc. An analogous series of trigonal monopyramidal complexes bearing a nonmacrocyclized variant of the tripodal ligand are also reported. Physical characterization of the coordination complexes has been carried out using multiple spectroscopic techniques (NMR, EPR, and UV-vis), cyclic voltammetry, and X-ray diffraction. Complexes of the macrocyclized [L
    Language English
    Publishing date 2023-07-18
    Publishing country United States
    Document type Journal Article
    ZDB-ID 1484438-2
    ISSN 1520-510X ; 0020-1669
    ISSN (online) 1520-510X
    ISSN 0020-1669
    DOI 10.1021/acs.inorgchem.3c01335
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  4. Article ; Online: Nerve Wrap for Local Delivery of FK506/Tacrolimus Accelerates Nerve Regeneration.

    Xiao, Bo / Feturi, Firuz / Su, An-Jey A / Van der Merwe, Yolandi / Barnett, Joshua M / Jabbari, Kayvon / Khatter, Neil J / Li, Bing / Katzel, Evan B / Venkataramanan, Raman / Solari, Mario G / Wagner, William R / Steketee, Michael B / Simons, Daniel J / Washington, Kia M

    International journal of molecular sciences

    2024  Volume 25, Issue 2

    Abstract: Peripheral nerve injuries (PNIs) occur frequently and can lead to devastating and permanent sensory and motor function disabilities. Systemic tacrolimus (FK506) administration has been shown to hasten recovery and improve functional outcomes after PNI ... ...

    Abstract Peripheral nerve injuries (PNIs) occur frequently and can lead to devastating and permanent sensory and motor function disabilities. Systemic tacrolimus (FK506) administration has been shown to hasten recovery and improve functional outcomes after PNI repair. Unfortunately, high systemic levels of FK506 can result in adverse side effects. The localized administration of FK506 could provide the neuroregenerative benefits of FK506 while avoiding systemic, off-target side effects. This study investigates the utility of a novel FK506-impregnated polyester urethane urea (PEUU) nerve wrap to treat PNI in a previously validated rat infraorbital nerve (ION) transection and repair model. ION function was assessed by microelectrode recordings of trigeminal ganglion cells responding to controlled vibrissae deflections in ION-transected and -repaired animals, with and without the nerve wrap. Peristimulus time histograms (PSTHs) having 1 ms bins were constructed from spike times of individual single units. Responses to stimulus onsets (ON responses) were calculated during a 20 ms period beginning 1 ms after deflection onset; this epoch captures the initial, transient phase of the whisker-evoked response. Compared to no-wrap controls, rats with PEUU-FK506 wraps functionally recovered earlier, displaying larger response magnitudes. With nerve wrap treatment, FK506 blood levels up to six weeks were measured nearly at the limit of quantification (LOQ ≥ 2.0 ng/mL); whereas the drug concentrations within the ION and muscle were much higher, demonstrating the local delivery of FK506 to treat PNI. An immunohistological assessment of ION showed increased myelin expression for animals assigned to neurorrhaphy with PEUU-FK506 treatment compared to untreated or systemic-FK506-treated animals, suggesting that improved PNI outcomes using PEUU-FK506 is mediated by the modulation of Schwann cell activity.
    MeSH term(s) Animals ; Rats ; Tacrolimus/pharmacology ; Myelin Sheath ; Neurons ; Urethane ; Nerve Regeneration ; Amides ; Carbamates ; Urea ; Esters
    Chemical Substances Tacrolimus (WM0HAQ4WNM) ; Urethane (3IN71E75Z5) ; Amides ; Carbamates ; Urea (8W8T17847W) ; Esters
    Language English
    Publishing date 2024-01-10
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2019364-6
    ISSN 1422-0067 ; 1422-0067 ; 1661-6596
    ISSN (online) 1422-0067
    ISSN 1422-0067 ; 1661-6596
    DOI 10.3390/ijms25020847
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  5. Article ; Online: Additional tools to boost internal medicine residents' evaluations.

    Abdel-Aziz, Yousef / Barnett, William R / Altorok, Nezam / Assaly, Ragheb

    International journal of medical education

    2019  Volume 10, Page(s) 43–44

    MeSH term(s) Accreditation ; Clinical Competence ; Humans ; Internal Medicine/education ; Internship and Residency/standards
    Language English
    Publishing date 2019-02-28
    Publishing country England
    Document type Letter
    ISSN 2042-6372
    ISSN (online) 2042-6372
    DOI 10.5116/ijme.5c6c.358f
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  6. Article ; Online: Understanding ethanol's acute effects on medial prefrontal cortex neural activity using state-space approaches.

    Morningstar, Mitchell D / Barnett, William H / Goodlett, Charles R / Kuznetsov, Alexey / Lapish, Christopher C

    Neuropharmacology

    2021  Volume 198, Page(s) 108780

    Abstract: Acute ethanol (EtOH) intoxication results in several maladaptive behaviors that may be attributable, in part, to the effects of EtOH on neural activity in medial prefrontal cortex (mPFC). The acute effects of EtOH on mPFC function have been largely ... ...

    Abstract Acute ethanol (EtOH) intoxication results in several maladaptive behaviors that may be attributable, in part, to the effects of EtOH on neural activity in medial prefrontal cortex (mPFC). The acute effects of EtOH on mPFC function have been largely described as inhibitory. However, translating these observations on function into a mechanism capable of delineating acute EtOH's effects on behavior has proven difficult. This review highlights the role of acute EtOH on electrophysiological measurements of mPFC function and proposes that interpreting these changes through the lens of dynamical systems theory is critical to understand the mechanisms that mediate the effects of EtOH intoxication on behavior. Specifically, the present review posits that the effects of EtOH on mPFC N-methyl-d-aspartate (NMDA) receptors are critical for the expression of impaired behavior following EtOH consumption. This hypothesis is based on the observation that recurrent activity in cortical networks is supported by NMDA receptors, and, when disrupted, may lead to impairments in cognitive function. To evaluate this hypothesis, we discuss the representation of mPFC neural activity in low-dimensional, dynamic state spaces. This approach has proven useful for identifying the underlying computations necessary for the production of behavior. Ultimately, we hypothesize that EtOH-related alterations to NMDA receptor function produces alterations that can be effectively conceptualized as impairments in attractor dynamics and provides insight into how acute EtOH disrupts forms of cognition that rely on mPFC function. This article is part of the special Issue on 'Neurocircuitry Modulating Drug and Alcohol Abuse'.
    MeSH term(s) Alcohol Drinking ; Alcoholic Intoxication/psychology ; Alcoholism ; Animals ; Central Nervous System Depressants/pharmacology ; Ethanol/pharmacology ; Humans ; Nerve Net/drug effects ; Prefrontal Cortex/drug effects
    Chemical Substances Central Nervous System Depressants ; Ethanol (3K9958V90M)
    Language English
    Publishing date 2021-09-01
    Publishing country England
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Review
    ZDB-ID 218272-5
    ISSN 1873-7064 ; 0028-3908
    ISSN (online) 1873-7064
    ISSN 0028-3908
    DOI 10.1016/j.neuropharm.2021.108780
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  7. Article ; Online: Corrigendum: Research IT maturity models for academic health centers: Early development and initial evaluation.

    Knosp, Boyd M / Barnett, William K / Anderson, Nicholas R / Embi, Peter J

    Journal of clinical and translational science

    2019  Volume 3, Issue 1, Page(s) 45

    Abstract: This corrects the article DOI: 10.1017/cts.2018.339.]. ...

    Abstract [This corrects the article DOI: 10.1017/cts.2018.339.].
    Language English
    Publishing date 2019-05-28
    Publishing country England
    Document type Published Erratum
    ISSN 2059-8661
    ISSN (online) 2059-8661
    DOI 10.1017/cts.2019.374
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  8. Article: Does a Starting Positive End-Expiratory Pressure of 8 cmH

    Barnett, William R / Maqsood, Aadil / Kesireddy, Nithin / Khokher, Waleed / Holtzapple, Zachary / Safi, Fadi A / Assaly, Ragheb

    Frontiers in medicine

    2021  Volume 8, Page(s) 744651

    Abstract: Introduction: ...

    Abstract Introduction:
    Language English
    Publishing date 2021-11-04
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2775999-4
    ISSN 2296-858X
    ISSN 2296-858X
    DOI 10.3389/fmed.2021.744651
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  9. Article ; Online: Initial MEWS score to predict ICU admission or transfer of hospitalized patients with COVID-19: A retrospective study.

    Barnett, William R / Radhakrishnan, Muthukumar / Macko, John / Hinch, Bryan T / Altorok, Nezam / Assaly, Ragheb

    The Journal of infection

    2020  Volume 82, Issue 2, Page(s) 282–327

    MeSH term(s) Aged ; COVID-19/diagnosis ; Female ; Hospitalization ; Humans ; Intensive Care Units ; Male ; Middle Aged ; Retrospective Studies ; Risk Assessment
    Keywords covid19
    Language English
    Publishing date 2020-09-02
    Publishing country England
    Document type Letter
    ZDB-ID 424417-5
    ISSN 1532-2742 ; 0163-4453
    ISSN (online) 1532-2742
    ISSN 0163-4453
    DOI 10.1016/j.jinf.2020.08.047
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  10. Article ; Online: Sociodemographic disparities as a determinant of fetal versus postnatal surgical myelomeningocele repair.

    Harbert, Allie L / Barnett, Randaline R / Abumoussa, Andrew L / Goodnight, William H / Tolleson-Rinehart, Sue / Quinsey, Carolyn S

    Journal of neurosurgery. Pediatrics

    2022  Volume 29, Issue 6, Page(s) 643–649

    Abstract: Objective: Relatively few women undergo open maternal-fetal surgery (OMFS) for myelomeningocele (MMC) despite the potential to reverse hindbrain herniation, reduce the rate of infant shunt-dependent hydrocephalus, and improve ambulation. These benefits ... ...

    Abstract Objective: Relatively few women undergo open maternal-fetal surgery (OMFS) for myelomeningocele (MMC) despite the potential to reverse hindbrain herniation, reduce the rate of infant shunt-dependent hydrocephalus, and improve ambulation. These benefits have the potential to significantly reduce morbidity and lifetime medical care. In this study, the authors examined demographics and socioeconomic variables of women who were offered and opted for OMFS for MMC versus postnatal MMC surgery, with the purpose of identifying variables driving the disparity between these two patient populations.
    Methods: This was a retrospective case-control study of patients who underwent evaluation for OMFS for MMC at a single academic hospital from 2015 to 2020. Race/ethnicity, primary insurance type, zip code, and BMI were collected and compared by treatment received and eligibility status for OMFS. Prevalence odds ratios were used to test for associations between each independent variable and the two outcomes. Logistical regression models were utilized to determine significant predictors of undergoing OMFS and being eligible for OMFS.
    Results: Of 96 women, 36 underwent OMFS for MMC, 40 received postnatal repair, and 20 either terminated the pregnancy or received care at another institution. Overall, 66 (68.8%) women were White, 14 (14.6%) were Black, 13 (13.5%) were Hispanic/Latinx, 1 (1.0%) was Asian, and 2 (2.1%) identified as other or multiple races. Among women who underwent OMFS for MMC, 27 (75.0%) were White, 2 (5.6%) were Black, 4 (11.1%) were Hispanic/Latinx, 1 (2.8%) was Asian, and 2 (5.6%) identified as other or multiple races. Having private insurance or TRICARE was associated with higher odds of being eligible for OMFS compared with women who were uninsured or had Medicaid when accounting for race and income (OR 3.87, 95% CI 1.51-9.59).
    Conclusions: The population evaluated and treated for MMC was homogeneous and insufficiently representative of the population affected by the disease. This finding raises concern, as it suggests underlying barriers to formal evaluation for OMFS for MMC. Insurance status and BMI have a significant association between the access to and election of OMFS, revealing socioeconomic disparities. This was the first study to explore sociodemographic characteristics of patient populations who may be at risk for limited access to highly specialized fetal surgical care.
    MeSH term(s) Pregnancy ; Infant ; Humans ; Female ; Male ; Meningomyelocele/surgery ; Retrospective Studies ; Case-Control Studies ; Fetus/surgery ; Hydrocephalus/surgery
    Language English
    Publishing date 2022-03-04
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2403985-8
    ISSN 1933-0715 ; 1933-0707
    ISSN (online) 1933-0715
    ISSN 1933-0707
    DOI 10.3171/2022.1.PEDS21425
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