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Article ; Online: Impact of enhanced recovery after surgery protocols on surgical site wound infection rates in urological procedures.

Cai, Yongjian / Cai, Xianguo / Zhang, Xianjun / Zhu, Jialiang / Chen, Wanbo

2024 Volume 21, Issue 1, Page(s) e14582

Abstract: This meta-analysis assesses the impact of Enhanced Recovery After Surgery (ERAS) protocols on surgical site wound infections (SSWIs) in urological procedures. Analysing data from 10 studies, our focus was on SSWI rates on the third and seventh ... ...

Abstract	This meta-analysis assesses the impact of Enhanced Recovery After Surgery (ERAS) protocols on surgical site wound infections (SSWIs) in urological procedures. Analysing data from 10 studies, our focus was on SSWI rates on the third and seventh postoperative days. The results reveal a significant reduction in SSWI rates for patients managed under ERAS protocols compared with traditional care. Notably, Figure 4 demonstrates a substantial decrease in SSWI on the third day (I
MeSH term(s)	Humans ; Enhanced Recovery After Surgery ; Length of Stay ; Postoperative Complications ; Postoperative Period ; Surgical Wound Infection/prevention & control
Language	English
Publishing date	2024-01-25
Publishing country	England
Document type	Journal Article ; Meta-Analysis
ZDB-ID	2170920-8
ISSN	1742-481X ; 1742-4801
ISSN (online)	1742-481X
ISSN	1742-4801
DOI	10.1111/iwj.14582
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Article: Systematic review and meta-analysis on laparoscopic cystectomy in bladder cancer: reply letter.

Zhu, Jialiang / Lu, Ziwen / Chen, Wanbo / Ke, Mang / Cai, Xianguo

Translational andrology and urology

2022 Volume 11, Issue 5, Page(s) 733–734

Language	English
Publishing date	2022-06-01
Publishing country	China
Document type	Journal Article
ZDB-ID	2851630-8
ISSN	2223-4691 ; 2223-4691 ; 2223-4683
ISSN (online)	2223-4691
ISSN	2223-4691 ; 2223-4683
DOI	10.21037/tau-22-203
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Article ; Online: Impact of open and minimally invasive surgery on postoperative wound complications in patients undergoing prostate surgery: A meta-analysis.

Zhu, Jialiang / Lu, Ziwen / Cai, Xianguo / Chen, Wanbo

International wound journal

2023 Volume 21, Issue 1, Page(s) e14367

Abstract: In this article, we analysed the therapeutic efficacy of open radical prostatectomy (ORP) and minimally invasive surgery (MIS) after operation for the treatment of post-operation complications. In summary, because of the broad methodology of the ... ...

Abstract	In this article, we analysed the therapeutic efficacy of open radical prostatectomy (ORP) and minimally invasive surgery (MIS) after operation for the treatment of post-operation complications. In summary, because of the broad methodology of the available trials and the low number of trials, the data were limited. The investigators combined the results of six of the 211 original studies. We looked up 4 databases: PubMed, EMBASE, Web of Science and the Cochrane Library. A total of six publications were selected. The main result was the rate of post-operation wound complications. Secondary results were the time of operation and the duration of hospitalization. Our findings indicate that the minimal invasive operation can decrease the incidence of wound infections (OR, 0.61; 95% CI: 0.42,0.90, p = 0.01), bleeding (MD, -293.09; 95% CI: -431.48, -154.71, p < 0.0001), and length of stay in the hospital compared with open surgery (MD, -1.85; 95% CI: -3.52, -0.17, p = 0.03), but minimally invasive surgery increased patient operative time (MD, 51.45; 95% CI: 40.99, 61.92, p < 0.0001). Compared with the open operation, the microinvasive operation has the superiority in the treatment of the wound complications following the operation of radical prostatic carcinoma. But the operation time of the microinvasive operation is much longer. Furthermore, there is a certain amount of bias among the various studies, so it is important to be cautious in interpretation of the findings.
MeSH term(s)	Male ; Humans ; Prostate ; Postoperative Complications/etiology ; Postoperative Complications/epidemiology ; Minimally Invasive Surgical Procedures/adverse effects ; Minimally Invasive Surgical Procedures/methods ; Prostatectomy/adverse effects ; Prostatectomy/methods ; Treatment Outcome
Language	English
Publishing date	2023-09-14
Publishing country	England
Document type	Meta-Analysis ; Journal Article
ZDB-ID	2170920-8
ISSN	1742-481X ; 1742-4801
ISSN (online)	1742-481X
ISSN	1742-4801
DOI	10.1111/iwj.14367
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Article ; Online: Adenosine and its derivatives improve exercise performance and exert anti-fatigue effects via AMPK/PGC-1α signaling pathway in mice

Huimin Zhu / Tangna Zhao / Wanbo Zeng / Xiao Dong / Yuan Luo / Xiang Li / Aiping Zhang / Weiguo Shi / Liang Xu

Arabian Journal of Chemistry, Vol 17, Iss 1, Pp 105490- (2024)

1481

Abstract: Studies of the AMPK/PGC-1α signaling pathway and exercise-induced metabolism have facilitated the development of anti-fatigue agents and exercise mimetics. In this work, adenosine and its 22 derivatives, typical of substitutions at the hydroxyl group of ... ...

Abstract	Studies of the AMPK/PGC-1α signaling pathway and exercise-induced metabolism have facilitated the development of anti-fatigue agents and exercise mimetics. In this work, adenosine and its 22 derivatives, typical of substitutions at the hydroxyl group of the sugar moiety, were firstly evaluated as anti-fatigue agents. In the running wheel tests, adenosine and most derivatives demonstrated a significant increase in the exhaustion distance when compared to the control group. Particularly, the optimized compound 2 exhibited a 3.1-fold increase in exhaustion distance compared to the positive control group treated with AICAR, and a remarkable 9.8-fold increase compared to the blank control group. Furthermore, improved performances were observed in weight-loaded swimming, high jumping, hanging wire, and tail suspension tests. Compound 2 not only reduced levels of lactic acid (LA) and blood urea nitrogen (BUN), but also preserved hepatic and muscle glycogen content during exercise. Notably, compound 2 activated AMPK/PGC-1α pathway without stimulating the central nervous system. Moreover, compound 2 demonstrated a favorable safety in vivo at a dose of 1.96 × 10-5 mol/kg for 21 days. This study unveils, for the first time, the ability of adenosine and its derivatives to resist exercise-induced fatigue, thereby providing promising lead compounds for the development of drugs aimed to prevent and treat fatigue-related diseases. Moreover, it sheds light on the potential therapeutic approaches utilizing endogenous substance.
Keywords	Adenosine derivative ; Substitution ; Anti-fatigue ; AMPK ; Chemistry ; QD1-999
Subject code	796
Language	English
Publishing date	2024-01-01T00:00:00Z
Publisher	Elsevier
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Arctigenin derivatives improve exercise performance in mice: synthesis and biological evaluation.

Zeng, Wanbo / Wu, Xiaowen / Zhu, Huimin / Shi, Weiguo / Li, Xiang / Tan, Junjie / Xu, Liang

Bioscience, biotechnology, and biochemistry

2023 Volume 87, Issue 8, Page(s) 819–824

Abstract: Arctigenin (ARG) has potent antifatigue activity, but its clinical application has been restricted for its poor water solubility. In this study, seven ARG derivatives containing different amino acids coupled via an ethoxy linker were synthesized, and ... ...

Abstract	Arctigenin (ARG) has potent antifatigue activity, but its clinical application has been restricted for its poor water solubility. In this study, seven ARG derivatives containing different amino acids coupled via an ethoxy linker were synthesized, and tested for their solubility, as well as activities to improve exercise performance in mice. All of the derivatives showed improved solubility compared to that of ARG. Derivative Z-A-6 exhibited the highest activity, showing that the mice ran a 4.88-fold greater distance in the running wheel test and swam a 2.86-fold greater time in the swimming test than those in the blank control group. Z-A-6 treatment increased the plasma superoxide dismutase and catalase concentrations as well as reduced lactic acid and blood urea nitrogen accumulation during exercise. Z-A-6 treatment enhanced the phosphorylation of adenosine monophosphate-activated protein kinase, and no acute toxicity was observed. The results will contribute to the development of potential antifatigue agents.
MeSH term(s)	Mice ; Animals ; Furans/pharmacology ; Furans/chemistry ; Lignans/pharmacology ; Lignans/chemistry ; Superoxide Dismutase/metabolism ; Swimming
Chemical Substances	arctigenin (U76MR9VS6M) ; Furans ; Lignans ; Superoxide Dismutase (EC 1.15.1.1)
Language	English
Publishing date	2023-06-06
Publishing country	England
Document type	Journal Article
ZDB-ID	1106450-x
ISSN	1347-6947 ; 0916-8451
ISSN (online)	1347-6947
ISSN	0916-8451
DOI	10.1093/bbb/zbad063
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Article ; Online: Biofilm Homeostasis Interference Therapy via

Li, Qianming / Liu, Quan / Wang, Zhengxi / Zhang, Xianzuo / Ma, Ruixiang / Hu, Xianli / Mei, Jiawei / Su, Zheng / Zhu, Wanbo / Zhu, Chen

Small (Weinheim an der Bergstrasse, Germany)

2023 Volume 19, Issue 22, Page(s) e2300592

Abstract: The recurrence of biofilm-associated infections (BAIs) remains high after implant-associated surgery. Biofilms on the implant surface reportedly shelter bacteria from antibiotics and evade innate immune defenses. Moreover, little is currently known about ...

Abstract	The recurrence of biofilm-associated infections (BAIs) remains high after implant-associated surgery. Biofilms on the implant surface reportedly shelter bacteria from antibiotics and evade innate immune defenses. Moreover, little is currently known about eliminating residual bacteria that can induce biofilm reinfection. Herein, novel "interference-regulation strategy" based on bovine serum albumin-iridium oxide nanoparticles (BIONPs) as biofilm homeostasis interrupter and immunomodulator via singlet oxygen (
MeSH term(s)	Biofilms ; Anti-Bacterial Agents/pharmacology ; Anti-Bacterial Agents/therapeutic use ; Phototherapy ; Prostheses and Implants ; Hyperthermia, Induced/methods
Chemical Substances	Anti-Bacterial Agents
Language	English
Publishing date	2023-02-27
Publishing country	Germany
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2168935-0
ISSN	1613-6829 ; 1613-6810
ISSN (online)	1613-6829
ISSN	1613-6810
DOI	10.1002/smll.202300592
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Article: Systematic review and meta-analysis on laparoscopic cystectomy in bladder cancer.

Zhu, Jialiang / Lu, Ziwen / Chen, Wanbo / Ke, Mang / Cai, Xianguo

Translational andrology and urology

2022 Volume 11, Issue 1, Page(s) 67–78

Abstract: Background: This study aimed to systematically evaluate the efficacy of laparoscopic radical cystectomy (LRC) surgical therapy in patients with bladder cancer (BC), and to provide evidence for the clinical treatment of BC.: Methods: The Embase, Ovid, ...

Abstract	Background: This study aimed to systematically evaluate the efficacy of laparoscopic radical cystectomy (LRC) surgical therapy in patients with bladder cancer (BC), and to provide evidence for the clinical treatment of BC. Methods: The Embase, Ovid, PubMed, Medline, Springer, and Web of Sciences database were searched to screen articles with clinical controlled trials on LRC treatment of BC. The Cochrane Handbook 5.0.2 software and Review Manager 5.3 software were adopted to evaluate the risk of bias and to perform a meta-analysis of the included articles in this study. Results: A total of 12 articles were obtained, including 1,283 research cases. The meta-analysis results showed that relative to the control group (Ctrl), the observation group (Observ group) had significantly lower intraoperative blood loss (IBL) after LRC [mean difference (MD) =-458.75; 95% confidential interval (CI): -505.75 to -411.76; Z=19.13; P<0.00001], blood transfusion rate (BTR) (odds ratio =0.36; 95% CI: 0.13-0.94; Z=2.08; and P=0.04), use of analgesics (MD =-24.53; 95% CI: -39.04 to -10.01; Z=3.31; and P=0.0009), and incidence of postoperative complications (Risk ratio =0.58; 95% CI: 0.39-0.85; Z=2.77; and P=0.006). However, and the length of hospital stay could not be shortened (MD =-2.43; 95% CI: -4.83 to -0.02; Z=1.98; and P=0.05). Discussion: LRC treatment of BC could effectively reduce the amount of IBS, and lower the intraoperative BTR, use of analgesics, and incidence of postoperative complications. Therefore, it could be used in the clinical surgical treatment of BC patients.
Language	English
Publishing date	2022-03-03
Publishing country	China
Document type	Journal Article
ZDB-ID	2851630-8
ISSN	2223-4691 ; 2223-4691 ; 2223-4683
ISSN (online)	2223-4691
ISSN	2223-4691 ; 2223-4683
DOI	10.21037/tau-21-1076
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Icaridin-Loading Nitrocellulose As a New Repellent Against Aquatic Leech with Waterproof and Long-Acting Properties.

Zeng, Wanbo / Ren, Hongqian / Zhu, Huimin / Shi, Weiguo / Xu, Liang

Vector borne and zoonotic diseases (Larchmont, N.Y.)

2022 Volume 22, Issue 2, Page(s) 114–119

Abstract: Leech attachment is a common nuisance to outdoor recreationists and farmers in aquatic environments. Consequences include bleeding, infection, and, rarely, death. Methods to prevent leech attachment are anecdotal and individual; effective repellent ... ...

Abstract	Leech attachment is a common nuisance to outdoor recreationists and farmers in aquatic environments. Consequences include bleeding, infection, and, rarely, death. Methods to prevent leech attachment are anecdotal and individual; effective repellent formulations with universal applicability are needed. In this study, icaridin is demonstrated to be repellent and toxic to aquatic leech, and formulation of icaridin loading nitrocellulose (Icar-Nitr) is proposed as a new leech repellent. The nitrocellulose provided sustained drug release and waterproof properties. One optimal formulation, 10-Icar-Nitr, proved effective for leech repelling in aquatic environment. Using a rat model, the same formulation also showed removal and killing after leech attachment. The nitrocellulose reduced percutaneous absorption of icaridin, and 10-Icar-Nitr showed good biocompatibility. This study provides a potential new and practicable strategy for prevention and removal against leech attachment and bites.
MeSH term(s)	Animals ; Bites and Stings/veterinary ; Collodion ; Insect Repellents ; Piperidines ; Rats
Chemical Substances	Insect Repellents ; Piperidines ; Collodion (9004-70-0) ; picaridin (N51GQX0837)
Language	English
Publishing date	2022-01-28
Publishing country	United States
Document type	Journal Article
ZDB-ID	2047199-3
ISSN	1557-7759 ; 1530-3667
ISSN (online)	1557-7759
ISSN	1530-3667
DOI	10.1089/vbz.2021.0070
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Article ; Online: Physically cross-linked organo-hydrogels for friction interfaces in joint replacements: design, evaluation and potential clinical applications.

Li, Zheng / Liang, Yongzhi / Wan, Jia / Zhu, Wanbo / Wang, Yingjie / Chen, Yuan / Lu, Baoliang / Zhu, Junchen / Zhu, Chen / Zhang, Xianzuo

Journal of materials chemistry. B

2023 Volume 11, Issue 46, Page(s) 11150–11163

Abstract: This paper investigates physically crosslinked organo-hydrogels for total hip replacement surgery. Current materials in artificial joints have limitations in mechanical performance and biocompatibility. To overcome these issues, a new approach based on ... ...

Abstract	This paper investigates physically crosslinked organo-hydrogels for total hip replacement surgery. Current materials in artificial joints have limitations in mechanical performance and biocompatibility. To overcome these issues, a new approach based on hydrogen bonds between polyvinyl alcohol, poly(2-hydroxyethyl methacrylate), and glycerin is proposed to develop bioactive organo-hydrogels with improved mechanical properties and biocompatibility. This study analyzes local pathological characteristics, systemic toxicity, and mechanical properties of the gels. The results show that the gels possess excellent biocompatibility and mechanical strength, suggesting their potential as an alternative material for total hip replacement surgery. These findings contribute to improving patient outcomes in joint replacement procedures.
MeSH term(s)	Humans ; Hydrogels/chemistry ; Friction ; Polyvinyl Alcohol/chemistry ; Arthroplasty, Replacement
Chemical Substances	Hydrogels ; Polyvinyl Alcohol (9002-89-5)
Language	English
Publishing date	2023-11-29
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2702241-9
ISSN	2050-7518 ; 2050-750X
ISSN (online)	2050-7518
ISSN	2050-750X
DOI	10.1039/d3tb01830j
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: A plunge in the number of traumatic traffic injuries in an emergency center in Anhui province, China.

Zhu, Wanbo / Yang, Jiazhao / Xu, Lei / Fang, Shiyuan

The American journal of emergency medicine

2020 Volume 38, Issue 10, Page(s) 2230–2231

MeSH term(s)	Accidents, Traffic/mortality ; Accidents, Traffic/statistics & numerical data ; China ; Humans ; Retrospective Studies ; Time Factors ; Trauma Centers/organization & administration ; Trauma Centers/statistics & numerical data ; Wounds and Injuries/epidemiology ; Wounds and Injuries/etiology
Keywords	covid19
Language	English
Publishing date	2020-03-20
Publishing country	United States
Document type	Letter
ZDB-ID	605890-5
ISSN	1532-8171 ; 0735-6757
ISSN (online)	1532-8171
ISSN	0735-6757
DOI	10.1016/j.ajem.2020.03.027
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