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  1. Article ; Online: Surgical procedures and innovative approaches for vitiligo regenerative treatment and melanocytorrhagy.

    Kawakami, Tamihiro

    The Journal of dermatology

    2022  Volume 49, Issue 4, Page(s) 391–401

    Abstract: Surgical treatments for vitiligo are a safe and effective treatment modality for select patients with vitiligo. Many techniques of vitiligo surgery exist, each with unique advantages and disadvantages. We reviewed the various surgical therapies and ... ...

    Abstract Surgical treatments for vitiligo are a safe and effective treatment modality for select patients with vitiligo. Many techniques of vitiligo surgery exist, each with unique advantages and disadvantages. We reviewed the various surgical therapies and innovative approaches for vitiligo regenerative treatment reported in the literature. Surgical therapies can be subdivided into tissue grafting methods and cellular grafting methods. Tissue grafting methods mainly include mini punch grafts, suction blister roof grafts, and hair follicle grafts. Cellular grafting methods include cultured and non-cultured treatments. The efficacy needs to be improved largely due to the poor proliferation and quality of the autologous melanocytes. Rho-associated protein kinase inhibitor enhances primary melanocyte culture proliferation from vitiligo patients to prevent apoptosis. Innovative approaches using stem cell methods could prove invaluable in developing a novel cell therapy for patients suffering from vitiligo. We succeeded in inducing melanin pigmentation in mice skin in vivo using our human induced pluripotent stem cell-derived melanocytes. In addition, we reviewed melanocytorrhagy, detachment and transepidermal loss of melanocytes, and melanocyte-related adhesion molecules. These adhesion molecules include epithelial cadherin, discoidin domain receptor tyrosine kinase 1, glycoprotein non-metastatic melanoma protein B, macrophage migration inhibiting factor, 17β-hydroxysteroid dehydrogenase 1, and E26 transformation-specific 1.
    MeSH term(s) Animals ; Hair Follicle/pathology ; Humans ; Induced Pluripotent Stem Cells/pathology ; Melanocytes/pathology ; Mice ; Skin Transplantation/methods ; Treatment Outcome ; Vitiligo/pathology ; Vitiligo/surgery
    Language English
    Publishing date 2022-02-17
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 800103-0
    ISSN 1346-8138 ; 0385-2407
    ISSN (online) 1346-8138
    ISSN 0385-2407
    DOI 10.1111/1346-8138.16316
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: μ-opioid receptor overexpression in acquired reactive perforating collagenosis associated with IL-31.

    Kawakami, Tamihiro / Ikeda, Takaharu / Yokoyama, Kae / Dong, Yupeng

    Journal of dermatological science

    2023  Volume 110, Issue 2, Page(s) 69–71

    MeSH term(s) Humans ; Skin Diseases
    Language English
    Publishing date 2023-04-14
    Publishing country Netherlands
    Document type Letter
    ZDB-ID 1024446-3
    ISSN 1873-569X ; 0923-1811
    ISSN (online) 1873-569X
    ISSN 0923-1811
    DOI 10.1016/j.jdermsci.2023.04.003
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article: [Cutaneous Manifestations of Sweet Disease].

    Kawakami, Tamihiro

    Brain and nerve = Shinkei kenkyu no shinpo

    2019  Volume 71, Issue 4, Page(s) 334–338

    Abstract: Sweet disease, also known as acute febrile neutrophilic dermatosis, is a multisystem inflammatory disorder characterized by painful erythematous plaques and aseptic neutrophilic infiltration of various organs. It is also characterized by fever, ... ...

    Abstract Sweet disease, also known as acute febrile neutrophilic dermatosis, is a multisystem inflammatory disorder characterized by painful erythematous plaques and aseptic neutrophilic infiltration of various organs. It is also characterized by fever, polymorphonuclear leukocytosis, and painful erythematous cutaneous plaques. Cutaneous manifestations of Sweet disease are typically painful plaque-forming erythematous papules. Skin biopsies typically demonstrate dermal infiltration with neutrophils in the absence of vasculitis. Sweet disease is often associated with a hematological malignancy, especially acute myeloid leukemia or myeloid dysplasia syndrome. Sweet disease has clinical and laboratory features similar to those of Behçet's disease. Overlap exists between the clinical manifestations of Sweet disease and Behçet's disease. The neuro-Sweet disease is similar to the neuro-Behçet's disease. This article presents information on the pathogenesis, clinical approach, treatment, and expected evolution of these manifestations including the defference between neuro-Sweet disease and neuro-Behçet's disease. The possible role in this interesting association of Behçet's disease and Sweet disease is discussed and a review of the literature is presented.
    MeSH term(s) Behcet Syndrome ; Fever ; Humans ; Inflammation ; Leukocytosis ; Skin/pathology ; Sweet Syndrome/pathology
    Language Japanese
    Publishing date 2019-05-24
    Publishing country Japan
    Document type Journal Article ; Review
    ZDB-ID 390389-8
    ISSN 1344-8129 ; 1881-6096 ; 0006-8969
    ISSN (online) 1344-8129
    ISSN 1881-6096 ; 0006-8969
    DOI 10.11477/mf.1416201271
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Regulation of adhesion molecules and basic fibroblast growth factor 2 in non-segmental vitiligo-derived primary melanocytes.

    Dong, Yupeng / Kawakami, Tamihiro / Komatsu, Toshiro

    Journal of dermatological science

    2022  Volume 108, Issue 2, Page(s) 109–111

    MeSH term(s) Humans ; Fibroblast Growth Factor 2/metabolism ; Vitiligo/metabolism ; Melanocytes/metabolism ; Cell Adhesion Molecules/genetics ; Cell Adhesion Molecules/metabolism
    Chemical Substances Fibroblast Growth Factor 2 (103107-01-3) ; Cell Adhesion Molecules
    Language English
    Publishing date 2022-11-04
    Publishing country Netherlands
    Document type Letter
    ZDB-ID 1024446-3
    ISSN 1873-569X ; 0923-1811
    ISSN (online) 1873-569X
    ISSN 0923-1811
    DOI 10.1016/j.jdermsci.2022.10.005
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  5. Article ; Online: Overlapping acute generalized exanthematous pustulosis drug reaction with eosinophilia and systemic symptoms induced by a second dose of the Moderna COVID-19 vaccine.

    Ikeda, Takaharu / Yokoyama, Kae / Kawakami, Tamihiro

    The Journal of dermatology

    2022  Volume 49, Issue 12, Page(s) e446–e447

    MeSH term(s) Humans ; Acute Generalized Exanthematous Pustulosis/diagnosis ; Acute Generalized Exanthematous Pustulosis/etiology ; 2019-nCoV Vaccine mRNA-1273 ; Drug Hypersensitivity Syndrome/diagnosis ; Drug Hypersensitivity Syndrome/etiology ; COVID-19/prevention & control ; Eosinophilia/chemically induced ; Eosinophilia/diagnosis
    Chemical Substances 2019-nCoV Vaccine mRNA-1273 (EPK39PL4R4)
    Language English
    Publishing date 2022-07-29
    Publishing country England
    Document type Letter ; Comment
    ZDB-ID 800103-0
    ISSN 1346-8138 ; 0385-2407
    ISSN (online) 1346-8138
    ISSN 0385-2407
    DOI 10.1111/1346-8138.16541
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  6. Article ; Online: Heliotrope-like manifestation of adult-onset Still disease with macrophage activation syndrome: A case-based review.

    Ikeda, Takaharu / Yokoyama, Kae / Kawakami, Tamihiro

    The Journal of dermatology

    2022  Volume 49, Issue 7, Page(s) 736–740

    Abstract: Adult-onset Still disease (AOSD) has been typically associated with an evanescent skin rash that appears during febrile episodes. Subsequently, reports of a more persistent rash have appeared in the literature, referred to as the atypical rash of AOSD. ... ...

    Abstract Adult-onset Still disease (AOSD) has been typically associated with an evanescent skin rash that appears during febrile episodes. Subsequently, reports of a more persistent rash have appeared in the literature, referred to as the atypical rash of AOSD. The atypical nonevanescent rash can be usually divided into dermographism-like, lichenoid, and dermatomyositis-like lesions. Some authors have suggested that AOSD with the atypical rash could be severe, with a poor prognosis. We describe the case of a Japanese woman with AOSD characterized by persistent pruritic lesions resembling those observed in heliotrope manifestation of dermatomyositis. We conducted a literature review of clinical cases of AOSD on MEDLINE and the Web of Science. We identified nine cases of atypical rash of the eyelids, heliotrope-like manifestation of AOSD in addition to our case. All nine patients were female and they had a mean age of 39.3 ± 2.8 years. Four (44.4%) patients had macrophage activation syndrome (MAS) or disseminated intravascular coagulation (DIC) as complications and our case was the only one associated with both MAS and DIC. When a clinician encounters a female patient with heliotrope-like rash resembling those observed in dermatomyositis, the underrecognition of the skin manifestations may result in delayed diagnosis of AOSD. We believe that physicians should identify this type of cutaneous lesion to diagnose AOSD earlier and administer adequate treatment. Although the contribution of tocilizumab to the occurrence of MAS has not been determined, careful observation should be considered during tocilizumab therapy in patients with active AOSD.
    MeSH term(s) Adult ; Dermatomyositis/complications ; Dermatomyositis/diagnosis ; Dermatomyositis/pathology ; Disseminated Intravascular Coagulation ; Exanthema/complications ; Exanthema/etiology ; Female ; Humans ; Macrophage Activation Syndrome/complications ; Macrophage Activation Syndrome/etiology ; Male ; Still's Disease, Adult-Onset/complications ; Still's Disease, Adult-Onset/diagnosis ; Still's Disease, Adult-Onset/drug therapy
    Language English
    Publishing date 2022-04-19
    Publishing country England
    Document type Case Reports ; Journal Article ; Review
    ZDB-ID 800103-0
    ISSN 1346-8138 ; 0385-2407
    ISSN (online) 1346-8138
    ISSN 0385-2407
    DOI 10.1111/1346-8138.16373
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  7. Article ; Online: Presence of eosinophil extracellular trap cell death in the affected skin of eosinophilic granulomatosis with polyangiitis.

    Kawakami, Tamihiro / Yokoyama, Kae / Ikeda, Takaharu / Tomizawa, Hiroki / Ueki, Shigeharu

    The Journal of dermatology

    2022  Volume 50, Issue 4, Page(s) 551–555

    Abstract: Eosinophil activation in tissue might be associated with disease severity. Eosinophil cytolysis, a process of active cell death, has been referred to as eosinophil extracellular trap cell death (EETosis). In the present study, the authors investigated ... ...

    Abstract Eosinophil activation in tissue might be associated with disease severity. Eosinophil cytolysis, a process of active cell death, has been referred to as eosinophil extracellular trap cell death (EETosis). In the present study, the authors investigated EETosis in the affected skin of four patients with eosinophilic granulomatosis with polyangiitis (EGPA) using an immunofluorescence staining method. Immunofluorescence staining for myelin basic protein, galectin-10, and DNA revealed various degrees of EETosis and Charcot-Leyden crystals in skin tissue, suggesting the different degree of eosinophil activation status. The histopathological characteristic features may help physicians establish an earlier diagnosis of intractable eosinophilic-related disease including EGPA. Furthermore, ETotic eosinophil infiltration in perineurium of skin tissue might play a primary role in peripheral neuropathy of this disorder.
    MeSH term(s) Humans ; Granulomatosis with Polyangiitis/complications ; Churg-Strauss Syndrome/complications ; Extracellular Traps/metabolism ; Eosinophils ; Cell Death
    Language English
    Publishing date 2022-12-13
    Publishing country England
    Document type Journal Article
    ZDB-ID 800103-0
    ISSN 1346-8138 ; 0385-2407
    ISSN (online) 1346-8138
    ISSN 0385-2407
    DOI 10.1111/1346-8138.16656
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: Similar deposition of neutrophil extracellular traps in the dermis among COVID-19-associated IgA vasculitis, post-COVID-19 vaccination IgA vasculitis, and COVID-19-unrelated IgA vasculitis.

    Kawakami, Tamihiro / Yokoyama, Kae / Ikeda, Takaharu / Nishibata, Yuka / Masuda, Sakiko / Tomaru, Utano / Ishizu, Akihiro

    The Journal of dermatology

    2022  Volume 50, Issue 5, Page(s) e151–e152

    MeSH term(s) Humans ; IgA Vasculitis ; Extracellular Traps ; COVID-19 Vaccines ; COVID-19/complications ; Dermis ; Immunoglobulin A
    Chemical Substances COVID-19 Vaccines ; Immunoglobulin A
    Language English
    Publishing date 2022-12-15
    Publishing country England
    Document type Letter
    ZDB-ID 800103-0
    ISSN 1346-8138 ; 0385-2407
    ISSN (online) 1346-8138
    ISSN 0385-2407
    DOI 10.1111/1346-8138.16673
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: The relationship between anti-phosphatidylserine/prothrombin complex IgM antibodies and cutaneous ulcers in patients with cutaneous vasculitis.

    Kawakami, Tamihiro / Okiyama, Naoko / Kodera, Masanari / Seishima, Mariko / Yamaguchi, Yukie

    The Journal of dermatology

    2021  Volume 48, Issue 9, Page(s) 1457–1458

    MeSH term(s) Antibodies, Antiphospholipid ; Humans ; Immunoglobulin M ; Phosphatidylserines ; Prothrombin ; Skin Ulcer/immunology ; Skin Ulcer/pathology ; Vasculitis/immunology ; Vasculitis/pathology
    Chemical Substances Antibodies, Antiphospholipid ; Immunoglobulin M ; Phosphatidylserines ; Prothrombin (9001-26-7)
    Language English
    Publishing date 2021-06-25
    Publishing country England
    Document type Journal Article
    ZDB-ID 800103-0
    ISSN 1346-8138 ; 0385-2407
    ISSN (online) 1346-8138
    ISSN 0385-2407
    DOI 10.1111/1346-8138.16014
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  10. Article ; Online: Skin biopsies using dermoscopy for earlier diagnosis of intravascular large B-cell lymphoma.

    Miyabe, Chie / Nomura, Jun / Ikeda, Takaharu / Takahashi, Kazuo / Kawakami, Tamihiro

    The Journal of dermatology

    2020  Volume 47, Issue 7, Page(s) e276–e278

    MeSH term(s) Biopsy ; Dermoscopy ; Humans ; Lymphoma, Large B-Cell, Diffuse/diagnostic imaging ; Skin ; Vascular Neoplasms/diagnostic imaging
    Language English
    Publishing date 2020-04-10
    Publishing country England
    Document type Letter
    ZDB-ID 800103-0
    ISSN 1346-8138 ; 0385-2407
    ISSN (online) 1346-8138
    ISSN 0385-2407
    DOI 10.1111/1346-8138.15350
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