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Article ; Online: The Netherlands

De Bruin, Yuri Bruinen / Jeddi, Maryam Zare

Information Resources in Toxicology, Volume 2 ; ISBN: 9780128216125

2020

Abstract: Many sources exist that contain valuable information on toxicology testing methods comprising in vivo (use of whole animals) and in vitro (use of artificial environment outside of living organisms) testing methods. The information resources presented ... ...

Abstract	Many sources exist that contain valuable information on toxicology testing methods comprising in vivo (use of whole animals) and in vitro (use of artificial environment outside of living organisms) testing methods. The information resources presented below relate to chemical substances and are collected to pro-vide key guidance on available information on in vivo, in vitro, and other toxicological testing and assessment methods (e.g., in silico toxicological methods performed on computer or via computer simulation), on relevant databases, published literature, books and journals, teaching aids, and finally organizations, foundations, and testing laboratories involved in toxicity assessment. The current information is of relevance for research, applied sciences and policy implementation purposes, such as the implementation of the European Union’s (EU’s) chemicals policy REACH (Registration, Evaluation, Authorisation, and Restriction of CHemicals) or the GPSD (General Product Safety Directive) and many other regulations. The provided information resources are recommended starting points when searching for information on testing methods, alternative testing methods and computational assessment methods. The reader should take note, however, that the information provided is not a comprehensive listing given the ever-expanding number of Internet and Web resources that are becoming available.
Keywords	Toxicity testing methods ; alternative testing methods ; chemical safety assessment ; data repositories ; information resources
Subject code	028
Language	English
Publisher	Elsevier
Publishing country	nl
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: The European exposure science strategy 2020-2030.

Fantke, Peter / Bruinen de Bruin, Yuri / Schlüter, Urs / Connolly, Alison / Bessems, Jos / Kephalopoulos, Stylianos / Zare Jeddi, Maryam / van Nieuwenhuyse, An / Dudzina, Tatsiana / Scheepers, Paul T J / von Goetz, Natalie

Environment international

2022 Volume 170, Page(s) 107555

Abstract: Exposure science is an emerging and rapidly growing field dedicated to all aspects concerning the contact between chemical, biological, physical or psycho-social stressors and human and ecological receptors. With that, exposure science plays a central ... ...

Abstract	Exposure science is an emerging and rapidly growing field dedicated to all aspects concerning the contact between chemical, biological, physical or psycho-social stressors and human and ecological receptors. With that, exposure science plays a central role in protecting human and ecosystem health, and contributes to the global transition towards a green and sustainable society. In Europe, however, exposure science is currently not sufficiently recognised as a scientific field, resulting in inefficient uptake into policies. In response, the wider European exposure science community developed elements and actions under the auspices of the Europe Regional Chapter of the International Society of Exposure Science (ISES Europe), for identified priority areas, namely education, exposure models, exposure data, human biomonitoring, and policy uptake. In the present document, we synthesize these strategic elements into an overarching 'European Exposure Science Strategy 2020-2030', following three strategic objectives that focus on acknowledging exposure science as an independent and interconnected field, harmonizing approaches and tools across regulations, and exploring collaboration, education and funding mechanisms. To operationalise this strategy, we present concrete key actions and propose initiatives and funding options for advancing the underlying science, cultivating broader education and cross-sector exposure knowledge transfer, and fostering effective uptake of exposure information into policy. We aim at anchoring European efforts in the global exposure science context, with a special focus on the interface between scientific advancements, application in decision support, and dissemination and training. This will help to develop exposure science as a strong scientific field with the ultimate goal to successfully assess and manage various stressors across sectors and geographic scales.
MeSH term(s)	Humans ; Ecosystem ; Europe ; European Union
Language	English
Publishing date	2022-09-30
Publishing country	Netherlands
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	554791-x
ISSN	1873-6750 ; 0160-4120
ISSN (online)	1873-6750
ISSN	0160-4120
DOI	10.1016/j.envint.2022.107555
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Article ; Online: Testing methods and toxicity assessment (including alternatives)

Jeddi, Maryam Zare / de Bruin, Yuri Bruinen / Van Der Linden, Sander

Information Resources in Toxicology, Volume 1 ; ISBN: 9780128137253

2020

Abstract	Many sources exist that contain valuable information on toxicology testing methods comprising in vivo (use of whole animals) and in vitro (use of artificial environment outside of living organisms) testing methods. The information resources presented below relate to chemical substances and are collected to provide key guidance on available information on in vivo, in vitro, and other toxicological testing and assessment methods (e.g., in silico toxicological methods performed on computer or via computer simulation), on relevant databases, published literature, books and journals, teaching aids, and finally organizations, foundations, and testing laboratories involved in toxicity assessment.
Keywords	Alternatives to animal methods ; in vitro ; in vivo
Language	English
Publisher	Elsevier
Publishing country	nl
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: One Health security lessons from a year-long webinar series on international COVID-19 response.

Kennedy, Caroline R M / de Bruin, Yuri Bruinen / Lequarré, Anne-Sophie / Ackerman, Rebecca T / Luster, Jill / Tsang, Tiffany M / McInturff, Kari D / Carter, Cassandra P / Pilch, Richard

One health outlook

2022 Volume 4, Issue 1, Page(s) 15

Abstract: Following the principles outlined by the Global Outbreak Alert and Response Network, the Federal Bureau of Investigation's International Biosecurity and Prevention Forum, the European Commission's Joint Research Centre, and the Middlebury Institute of ... ...

Abstract	Following the principles outlined by the Global Outbreak Alert and Response Network, the Federal Bureau of Investigation's International Biosecurity and Prevention Forum, the European Commission's Joint Research Centre, and the Middlebury Institute of International Studies' James Martin Center for Nonproliferation Studies cohosted a webinar series from April 2020 to January 2021 on COVID-19 management across Africa, Europe, and North America. We provide here an overview of the webinar series and discuss how lessons learned during the COVID-19 pandemic and debated during the webinars can be used to bridge One Health with biological threat-driven health security. This report can be used to inform recommendations for future One Health security approaches to strengthen global capacity and multidisciplinary cooperation.
Language	English
Publishing date	2022-10-08
Publishing country	England
Document type	Journal Article
ISSN	2524-4655
ISSN (online)	2524-4655
DOI	10.1186/s42522-022-00071-0
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Advancing exposure data analytics and repositories as part of the European Exposure Science Strategy 2020-2030.

Kosnik, Marissa B / Kephalopoulos, Stylianos / Muñoz, Amalia / Aurisano, Nicolò / Cusinato, Alberto / Dimitroulopoulou, Sani / Slobodnik, Jaroslav / De Mello, Jonathas / Zare Jeddi, Maryam / Cascio, Claudia / Ahrens, Andreas / Bruinen de Bruin, Yuri / Lieck, Lothar / Fantke, Peter

Environment international

2022 Volume 170, Page(s) 107610

Abstract: High-quality and comprehensive exposure-related data are critical for different decision contexts, including environmental and human health monitoring, and chemicals risk assessment and management. However, exposure-related data are currently scattered, ... ...

Abstract	High-quality and comprehensive exposure-related data are critical for different decision contexts, including environmental and human health monitoring, and chemicals risk assessment and management. However, exposure-related data are currently scattered, frequently of unclear quality and structure, not readily accessible, and stored in various-partly overlapping-data repositories, leading to inefficient and ineffective data usage in Europe and globally. We propose strategic guidance for an integrated European exposure data production and management framework for use in science and policy, building on current and future data analysis and digitalization trends. We map the existing exposure data landscape to requirements for data analytics and repositories across European policies and regulations. We further identify needs and ways forward for improving data generation, sharing, and usage, and translate identified needs into an operational action plan for European and global advancement of exposure data for policies and regulations. Identified key areas of action are to develop consistent exposure data standards and terminology for data production and reporting, increase data transparency and availability, enhance data storage and related infrastructure, boost automation in data management, increase data integration, and advance tools for innovative data analysis. Improving and streamlining exposure data generation and uptake into science and policy is crucial for the European Chemicals Strategy for Sustainability and European Digital Strategy, in line with EU Data policies on data management and interoperability.
MeSH term(s)	Humans ; Data Science ; Europe
Language	English
Publishing date	2022-10-30
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	554791-x
ISSN	1873-6750 ; 0160-4120
ISSN (online)	1873-6750
ISSN	0160-4120
DOI	10.1016/j.envint.2022.107610
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Article ; Online: The European exposure science strategy 2020–2030

Peter Fantke / Yuri Bruinen de Bruin / Urs Schlüter / Alison Connolly / Jos Bessems / Stylianos Kephalopoulos / Maryam Zare Jeddi / An van Nieuwenhuyse / Tatsiana Dudzina / Paul T.J. Scheepers / Natalie von Goetz

Environment International, Vol 170, Iss , Pp 107555- (2022)

2022

Abstract	Exposure science is an emerging and rapidly growing field dedicated to all aspects concerning the contact between chemical, biological, physical or psycho-social stressors and human and ecological receptors. With that, exposure science plays a central role in protecting human and ecosystem health, and contributes to the global transition towards a green and sustainable society. In Europe, however, exposure science is currently not sufficiently recognised as a scientific field, resulting in inefficient uptake into policies. In response, the wider European exposure science community developed elements and actions under the auspices of the Europe Regional Chapter of the International Society of Exposure Science (ISES Europe), for identified priority areas, namely education, exposure models, exposure data, human biomonitoring, and policy uptake. In the present document, we synthesize these strategic elements into an overarching ‘European Exposure Science Strategy 2020–2030’, following three strategic objectives that focus on acknowledging exposure science as an independent and interconnected field, harmonizing approaches and tools across regulations, and exploring collaboration, education and funding mechanisms. To operationalise this strategy, we present concrete key actions and propose initiatives and funding options for advancing the underlying science, cultivating broader education and cross-sector exposure knowledge transfer, and fostering effective uptake of exposure information into policy. We aim at anchoring European efforts in the global exposure science context, with a special focus on the interface between scientific advancements, application in decision support, and dissemination and training. This will help to develop exposure science as a strong scientific field with the ultimate goal to successfully assess and manage various stressors across sectors and geographic scales.
Keywords	Human exposure ; Ecosystem exposure ; Exposure assessment ; Risk assessment ; Safe and sustainable-by-design (SSbD) ; International Society of Exposure Science ; Environmental sciences ; GE1-350
Subject code	333
Language	English
Publishing date	2022-12-01T00:00:00Z
Publisher	Elsevier
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Towards further harmonization of a glossary for exposure science-an ISES Europe statement.

Heinemeyer, Gerhard / Connolly, Alison / von Goetz, Natalie / Bessems, Jos / Bruinen de Bruin, Yuri / Coggins, Marie A / Fantke, Peter / Galea, Karen S / Gerding, Johannes / Hader, John D / Heussen, Henri / Kephalopoulos, Stylianos / McCourt, Josephine / Scheepers, Paul T J / Schlueter, Urs / van Tongeren, Martie / Viegas, Susana / Zare Jeddi, Maryam / Vermeire, Theo

Journal of exposure science & environmental epidemiology

2021 Volume 32, Issue 4, Page(s) 526–529

MeSH term(s)	Environmental Exposure ; Europe ; Humans
Language	English
Publishing date	2021-11-02
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2218551-3
ISSN	1559-064X ; 1559-0631
ISSN (online)	1559-064X
ISSN	1559-0631
DOI	10.1038/s41370-021-00390-w
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Article: Initial impacts of global risk mitigation measures taken during the combatting of the COVID-19 pandemic.

Bruinen de Bruin, Yuri / Lequarre, Anne-Sophie / McCourt, Josephine / Clevestig, Peter / Pigazzani, Filippo / Zare Jeddi, Maryam / Colosio, Claudio / Goulart, Margarida

Safety science

2020 Volume 128, Page(s) 104773

Abstract: This paper presents an analysis of risk mitigation measures taken by countries around the world facing the current COVID-19 outbreak. In light of the current pandemic the authors collated and clustered (using harmonised terminology) the risk mitigation ... ...

Abstract	This paper presents an analysis of risk mitigation measures taken by countries around the world facing the current COVID-19 outbreak. In light of the current pandemic the authors collated and clustered (using harmonised terminology) the risk mitigation measures taken around the globe in the combat to contain, and since March 11, 2020, to limit the spread of the SARS-CoV-2 virus known to cause the Coronavirus disease 2019 (COVID-19). This overview gathers lessons learnt, providing an update on the current knowledge for authorities, sectors and first responders on the effectiveness of said measures, and may allow enhanced prevention, preparedness and response for future outbreaks. Various measures such as mobility restrictions, physical distancing, hygienic measures, socio-economic restrictions, communication and international support mechanisms have been clustered and are reviewed in terms of the nature of the actions taken and their qualitative early-perceived impact. At the time of writing, it is still too premature to express the quantitative effectiveness of each risk mitigation cluster, but it seems that the best mitigation results are reported when applying a combination of voluntary and enforceable measures.
Keywords	covid19
Language	English
Publishing date	2020-04-15
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	1074634-1
ISSN	1879-1042 ; 0925-7535
ISSN (online)	1879-1042
ISSN	0925-7535
DOI	10.1016/j.ssci.2020.104773
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Article ; Online: The European exposure science strategy 2020–2030

Fantke, Peter / Bruinen De Bruin, Yuri / Schlüter, Urs / Connolly, Alison / Bessems, Jos / Kephalopoulos, Stylianos / Zare Jeddi, Maryam / van Nieuwenhuyse, An / Dudzina, Tatsiana / Scheepers, Paul T.J. / von Götz, Natalie

Environment International, 170

2022

Abstract	Exposure science is an emerging and rapidly growing field dedicated to all aspects concerning the contact between chemical, biological, physical or psycho-social stressors and human and ecological receptors. With that, exposure science plays a central role in protecting human and ecosystem health, and contributes to the global transition towards a green and sustainable society. In Europe, however, exposure science is currently not sufficiently recognised as a scientific field, resulting in inefficient uptake into policies. In response, the wider European exposure science community developed elements and actions under the auspices of the Europe Regional Chapter of the International Society of Exposure Science (ISES Europe), for identified priority areas, namely education, exposure models, exposure data, human biomonitoring, and policy uptake. In the present document, we synthesize these strategic elements into an overarching ‘European Exposure Science Strategy 2020–2030’, following three strategic objectives that focus on acknowledging exposure science as an independent and interconnected field, harmonizing approaches and tools across regulations, and exploring collaboration, education and funding mechanisms. To operationalise this strategy, we present concrete key actions and propose initiatives and funding options for advancing the underlying science, cultivating broader education and cross-sector exposure knowledge transfer, and fostering effective uptake of exposure information into policy. We aim at anchoring European efforts in the global exposure science context, with a special focus on the interface between scientific advancements, application in decision support, and dissemination and training. This will help to develop exposure science as a strong scientific field with the ultimate goal to successfully assess and manage various stressors across sectors and geographic scales. ISSN:0160-4120 ISSN:1873-6750
Keywords	Human exposure ; Ecosystem exposure ; Exposure assessment ; Risk assessment ; Safe and sustainable-by-design (SSbD) ; International Society of Exposure Science
Subject code	333
Language	English
Publisher	Elsevier
Publishing country	ch
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Biomonitoring and Subsequent Risk Assessment of Combined Exposure to Phthalates in Iranian Children and Adolescents.

Zare Jeddi, Maryam / Eshaghi Gorji, Mohamad / Rietjens, Ivonne M C M / Louisse, Jochem / Bruinen de Bruin, Yuri / Liska, Roman

International journal of environmental research and public health

2018 Volume 15, Issue 11

Abstract: This study aimed to estimate the exposure and related health risks of phthalates, and to assess the health risks from combined exposure to three of the phthalates sharing the same mode of action (anti-androgenicity) in children. We determined the ... ...

Abstract	This study aimed to estimate the exposure and related health risks of phthalates, and to assess the health risks from combined exposure to three of the phthalates sharing the same mode of action (anti-androgenicity) in children. We determined the internal exposure of 56 Iranian children and adolescents aged 6 to 18 years by analyzing seven urinary metabolites of five phthalates. The estimated daily intake values derived from the biomonitoring data ranged from 0.01 µg/kg bw/day for butyl benzyl phthalate (BBP), to 17.85 µg/kg bw/day for di(2-ethylhexyl) phthalate (DEHP). The risk assessment revealed that not only the exposure to the individual phthalates, but also the combined exposure to the three anti-androgenic phthalates (DEHP, DBP, BBP) did not raise a safety concern (hazard index values averaged 0.2). The range of maximum cumulative ratio values varied from around 1 for most individuals to around 2 in some individuals, indicating that the combined exposures were dominated by one and in some cases by two of the three anti-androgenic phthalates, especially dibutyl phthalate (DBP) and/or DEHP. Based on biomonitoring data, the overall combined exposure of Iranian children to phthalates does not raise a concern, while reduction of exposure is best focused on DEHP and DBP that showed the highest hazard quotient.
MeSH term(s)	Adolescent ; Child ; Environmental Exposure/analysis ; Environmental Monitoring ; Female ; Humans ; Iran ; Male ; Phthalic Acids/analysis ; Risk Assessment
Chemical Substances	Phthalic Acids
Language	English
Publishing date	2018-10-23
Publishing country	Switzerland
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ISSN	1660-4601
ISSN (online)	1660-4601
DOI	10.3390/ijerph15112336
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