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  1. Article ; Online: Waning of SARS-CoV-2 booster viral-load reduction effectiveness.

    Levine-Tiefenbrun, Matan / Yelin, Idan / Alapi, Hillel / Herzel, Esma / Kuint, Jacob / Chodick, Gabriel / Gazit, Sivan / Patalon, Tal / Kishony, Roy

    Nature communications

    2022  Volume 13, Issue 1, Page(s) 1237

    Abstract: The BNT162b2 COVID-19 vaccine has been shown to reduce viral load of breakthrough infections (BTIs), an important factor affecting infectiousness. This viral-load protective effect has been waning with time post the second vaccine and later restored with ...

    Abstract The BNT162b2 COVID-19 vaccine has been shown to reduce viral load of breakthrough infections (BTIs), an important factor affecting infectiousness. This viral-load protective effect has been waning with time post the second vaccine and later restored with a booster shot. It is currently unclear though for how long this regained effectiveness lasts. Analyzing Ct values of SARS-CoV-2 qRT-PCR tests of over 22,000 infections during a Delta-variant-dominant period in Israel, we find that this viral-load reduction effectiveness significantly declines within months post the booster dose. Adjusting for age, sex and calendric date, Ct values of RdRp gene initially increases by 2.7 [CI: 2.3-3.0] relative to unvaccinated in the first month post the booster dose, yet then decays to a difference of 1.3 [CI: 0.7-1.9] in the second month and becomes small and insignificant in the third to fourth months. The rate and magnitude of this post-booster decline in viral-load reduction effectiveness mirror those observed post the second vaccine. These results suggest rapid waning of the booster's effectiveness in reducing infectiousness, possibly affecting community-level spread of the virus.
    MeSH term(s) Adult ; Algorithms ; BNT162 Vaccine/administration & dosage ; BNT162 Vaccine/immunology ; COVID-19/immunology ; COVID-19/prevention & control ; COVID-19/virology ; COVID-19 Vaccines/administration & dosage ; COVID-19 Vaccines/immunology ; Female ; Humans ; Immunization, Secondary/methods ; Immunization, Secondary/statistics & numerical data ; Immunogenicity, Vaccine/immunology ; Linear Models ; Male ; Middle Aged ; SARS-CoV-2/genetics ; SARS-CoV-2/immunology ; SARS-CoV-2/physiology ; Time Factors ; Treatment Outcome ; Vaccination/methods ; Vaccination/statistics & numerical data ; Viral Load/immunology
    Chemical Substances COVID-19 Vaccines ; BNT162 Vaccine (N38TVC63NU)
    Language English
    Publishing date 2022-03-04
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2553671-0
    ISSN 2041-1723 ; 2041-1723
    ISSN (online) 2041-1723
    ISSN 2041-1723
    DOI 10.1038/s41467-022-28936-y
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Waning of SARS-CoV-2 booster viral-load reduction effectiveness

    Matan Levine-Tiefenbrun / Idan Yelin / Hillel Alapi / Esma Herzel / Jacob Kuint / Gabriel Chodick / Sivan Gazit / Tal Patalon / Roy Kishony

    Nature Communications, Vol 13, Iss 1, Pp 1-

    2022  Volume 4

    Abstract: ... Here, analyzing viral loads of BTIs post third vaccine shot, Levine-Tiefenbrun et al. show waning ...

    Abstract The BNT162b2 COVID-19 vaccine has been shown to reduce viral load of breakthrough infections (BTIs). Here, analyzing viral loads of BTIs post third vaccine shot, Levine-Tiefenbrun et al. show waning of the booster’s effectiveness in reducing infectiousness within months, mirroring the rate and magnitude of decline observed post the second shot.
    Keywords Science ; Q
    Language English
    Publishing date 2022-03-01T00:00:00Z
    Publisher Nature Portfolio
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  3. Article ; Online: Initial report of decreased SARS-CoV-2 viral load after inoculation with the BNT162b2 vaccine.

    Levine-Tiefenbrun, Matan / Yelin, Idan / Katz, Rachel / Herzel, Esma / Golan, Ziv / Schreiber, Licita / Wolf, Tamar / Nadler, Varda / Ben-Tov, Amir / Kuint, Jacob / Gazit, Sivan / Patalon, Tal / Chodick, Gabriel / Kishony, Roy

    Nature medicine

    2021  Volume 27, Issue 5, Page(s) 790–792

    Abstract: Beyond their substantial protection of individual vaccinees, coronavirus disease 2019 (COVID-19) vaccines might reduce viral load in breakthrough infection and thereby further suppress onward transmission. In this analysis of a real-world dataset of ... ...

    Abstract Beyond their substantial protection of individual vaccinees, coronavirus disease 2019 (COVID-19) vaccines might reduce viral load in breakthrough infection and thereby further suppress onward transmission. In this analysis of a real-world dataset of positive severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) test results after inoculation with the BNT162b2 messenger RNA vaccine, we found that the viral load was substantially reduced for infections occurring 12-37 d after the first dose of vaccine. These reduced viral loads hint at a potentially lower infectiousness, further contributing to vaccine effect on virus spread.
    MeSH term(s) Adolescent ; Adult ; Aged ; Aged, 80 and over ; COVID-19/prevention & control ; COVID-19/virology ; COVID-19 Vaccines/immunology ; Female ; Humans ; Male ; Middle Aged ; SARS-CoV-2/immunology ; SARS-CoV-2/isolation & purification ; Vaccination ; Viral Load ; Young Adult
    Chemical Substances COVID-19 Vaccines ; BNT162 vaccine (N38TVC63NU)
    Language English
    Publishing date 2021-03-29
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 1220066-9
    ISSN 1546-170X ; 1078-8956
    ISSN (online) 1546-170X
    ISSN 1078-8956
    DOI 10.1038/s41591-021-01316-7
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 4212: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)
    Zs.MG 39: Show issues

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  4. Article ; Online: Viral loads of Delta-variant SARS-CoV-2 breakthrough infections after vaccination and booster with BNT162b2.

    Levine-Tiefenbrun, Matan / Yelin, Idan / Alapi, Hillel / Katz, Rachel / Herzel, Esma / Kuint, Jacob / Chodick, Gabriel / Gazit, Sivan / Patalon, Tal / Kishony, Roy

    Nature medicine

    2021  Volume 27, Issue 12, Page(s) 2108–2110

    Abstract: The effectiveness of the coronavirus disease 2019 (COVID-19) BNT162b2 vaccine in preventing disease and reducing viral loads of breakthrough infections (BTIs) has been decreasing, concomitantly with the rise of the Delta variant of severe acute ... ...

    Abstract The effectiveness of the coronavirus disease 2019 (COVID-19) BNT162b2 vaccine in preventing disease and reducing viral loads of breakthrough infections (BTIs) has been decreasing, concomitantly with the rise of the Delta variant of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). However, it is unclear whether the observed decreased effectiveness of the vaccine in reducing viral loads is inherent to the Delta variant or is dependent on time from immunization. By analyzing viral loads of over 16,000 infections during the current, Delta-variant-dominated pandemic wave in Israel, we found that BTIs in recently fully vaccinated individuals have lower viral loads than infections in unvaccinated individuals. However, this effect starts to decline 2 months after vaccination and ultimately vanishes 6 months or longer after vaccination. Notably, we found that the effect of BNT162b2 on reducing BTI viral loads is restored after a booster dose. These results suggest that BNT162b2 might decrease the infectiousness of BTIs even with the Delta variant, and that, although this protective effect declines with time, it can be restored, at least temporarily, with a third, booster, vaccine dose.
    MeSH term(s) Antibodies, Neutralizing/blood ; Antibodies, Viral/blood ; BNT162 Vaccine/administration & dosage ; BNT162 Vaccine/immunology ; COVID-19/epidemiology ; COVID-19/immunology ; COVID-19/prevention & control ; COVID-19 Vaccines ; Humans ; Immunization, Secondary ; Israel/epidemiology ; SARS-CoV-2/immunology ; SARS-CoV-2/isolation & purification ; Time Factors ; Vaccination/methods ; Viral Load
    Chemical Substances Antibodies, Neutralizing ; Antibodies, Viral ; COVID-19 Vaccines ; BNT162 Vaccine (N38TVC63NU)
    Language English
    Publishing date 2021-11-02
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 1220066-9
    ISSN 1546-170X ; 1078-8956
    ISSN (online) 1546-170X
    ISSN 1078-8956
    DOI 10.1038/s41591-021-01575-4
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 4212: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)
    Zs.MG 39: Show issues

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  5. Article ; Online: SARS-CoV-2 RT-qPCR Test Detection Rates Are Associated with Patient Age, Sex, and Time since Diagnosis.

    Levine-Tiefenbrun, Matan / Yelin, Idan / Uriel, Hedva / Kuint, Jacob / Schreiber, Licita / Herzel, Esma / Katz, Rachel / Ben-Tov, Amir / Gazit, Sivan / Patalon, Tal / Chodick, Gabriel / Kishony, Roy

    The Journal of molecular diagnostics : JMD

    2021  Volume 24, Issue 2, Page(s) 112–119

    Abstract: Quantifying the detection rate of the widely used quantitative RT-PCR (RT-qPCR) test for severe acute respiratory syndrome coronavirus 2 and its dependence on patient demographic characteristics and disease progression is key in designing epidemiologic ... ...

    Abstract Quantifying the detection rate of the widely used quantitative RT-PCR (RT-qPCR) test for severe acute respiratory syndrome coronavirus 2 and its dependence on patient demographic characteristics and disease progression is key in designing epidemiologic strategies. Analyzing 843,917 test results of 521,696 patients, a "positive period" was defined for each patient between diagnosis of coronavirus disease 2019 and the last positive test result. The fraction of positive test results within this period was then used to estimate detection rate. Regression analyses were used to determine associations of detection with time of sampling after diagnosis, patient demographic characteristics, and viral RNA copy number based on RT-qPCR cycle threshold values of the next positive test result. The overall detection rate in tests performed within 14 days after diagnosis was 83.1%. This rate was higher at days 0 to 5 after diagnosis (89.3%). Furthermore, detection rate was strongly associated with age and sex. Finally, the detection rate with the Allplex 2019-nCoV RT-qPCR kit was associated, at the single-patient level, with viral RNA copy number (P < 10
    MeSH term(s) Adult ; Age Factors ; COVID-19/diagnosis ; COVID-19/epidemiology ; COVID-19/virology ; COVID-19 Testing/methods ; Female ; Humans ; Male ; Middle Aged ; Odds Ratio ; RNA, Viral ; Real-Time Polymerase Chain Reaction/methods ; SARS-CoV-2/genetics ; Sensitivity and Specificity ; Sex Factors ; Time Factors ; Viral Load ; Young Adult
    Chemical Substances RNA, Viral
    Language English
    Publishing date 2021-11-23
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2000060-1
    ISSN 1943-7811 ; 1525-1578
    ISSN (online) 1943-7811
    ISSN 1525-1578
    DOI 10.1016/j.jmoldx.2021.10.010
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 5146: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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  6. Article ; Online: Decreased SARS-CoV-2 viral load following vaccination

    Levine-Tiefenbrun, Matan / Yelin, Idan / Katz, Rachel / Herzel, Esma / Golan, Ziv / Schreiber, Licita / Wolf, Tamar / Nadler, Varda / Ben-Tov, Amir / Kuint, Jacob / Gazit, Sivan / Patalon, Tal / Chodick, Gabriel / Kishony, Roy

    medRxiv

    Abstract: Beyond their substantial protection of individual vaccinees, it is hoped that the COVID-19 vaccines would reduce viral load in breakthrough infections thereby further suppress onward transmission. Here, analyzing positive SARS-CoV-2 test results ... ...

    Abstract Beyond their substantial protection of individual vaccinees, it is hoped that the COVID-19 vaccines would reduce viral load in breakthrough infections thereby further suppress onward transmission. Here, analyzing positive SARS-CoV-2 test results following inoculation with the BNT162b2 mRNA vaccine, we find that the viral load is reduced 4-fold for infections occurring 12-28 days after the first dose of vaccine. These reduced viral loads hint to lower infectiousness, further contributing to vaccine impact on virus spread.
    Keywords covid19
    Language English
    Publishing date 2021-02-08
    Publisher Cold Spring Harbor Laboratory Press
    Document type Article ; Online
    DOI 10.1101/2021.02.06.21251283
    Database COVID19

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  7. Article ; Online: Viral loads of Delta-variant SARS-CoV2 breakthrough infections following vaccination and booster with the BNT162b2 vaccine

    Levine-Tiefenbrun, Matan / Yelin, Idan / Alapi, Hillel / Katz, Rachel / Herzel, Esma / Kuint, Jacob / Chodick, Gabriel / Gazit, Sivan / Patalon, Tal / Kishony, Roy

    medRxiv

    Abstract: The BNT162b2 vaccine showed high real-life effectiveness both at preventing disease and in reducing viral loads of breakthrough infections, but coincidental with the rise of the Delta-variant SARS-CoV2, these protective effects have been decreasing, ... ...

    Abstract The BNT162b2 vaccine showed high real-life effectiveness both at preventing disease and in reducing viral loads of breakthrough infections, but coincidental with the rise of the Delta-variant SARS-CoV2, these protective effects have been decreasing, prompting a third, booster, vaccine inoculation. Here, analyzing viral loads of over 11,000 infections during the current wave in Israel, we find that even though this wave is dominated by the Delta-variant, breakthrough infections in recently vaccinated patients, still within 2 months post their second vaccine inoculation, do have lower viral loads compared to unvaccinated patients, with the extent of viral load reduction similar to pre-Delta breakthrough observations. Yet, this infectiousness protection starts diminishing for patients two months post vaccination and ultimately vanishes for patients 6 months or longer post vaccination. Encouragingly, we find that this diminishing vaccine effectiveness on breakthrough infection viral loads is restored following the booster vaccine. These results suggest that the vaccine is initially effective in reducing infectiousness of breakthrough infections even with the Delta variant, and that while this protectiveness effect declines with time it can be restored, at least temporarily, with a booster vaccine.
    Keywords covid19
    Language English
    Publishing date 2021-09-01
    Publisher Cold Spring Harbor Laboratory Press
    Document type Article ; Online
    DOI 10.1101/2021.08.29.21262798
    Database COVID19

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  8. Article ; Online: Association of COVID-19 RT-qPCR test false-negative rate with patient age, sex and time since diagnosis

    Levine-Tiefenbrun, Matan / Yelin, Idan / Uriel, Hedva / Kuint, Jacob / Schreiber, Licita / Herzel, Esma / Katz, Rachel / Ben-Tov, Amir / Patalon, Tal / Chodick, Gabriel / Kishony, Roy

    medRxiv

    Keywords covid19
    Language English
    Publishing date 2020-11-03
    Publisher Cold Spring Harbor Laboratory Press
    Document type Article ; Online
    DOI 10.1101/2020.10.30.20222935
    Database COVID19

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