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  1. Article ; Online: Long-Acting Injectables Come of Age to Change the HIV Therapeutic Landscape and the Lives of Persons with HIV.

    Smith, Kimberly Y

    AIDS research and human retroviruses

    2021  Volume 37, Issue 3, Page(s) 169–170

    MeSH term(s) Anti-HIV Agents/therapeutic use ; HIV Infections/drug therapy ; Humans ; Injections ; Viral Load
    Chemical Substances Anti-HIV Agents
    Language English
    Publishing date 2021-04-09
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 639130-8
    ISSN 1931-8405 ; 0889-2229
    ISSN (online) 1931-8405
    ISSN 0889-2229
    DOI 10.1089/AID.2021.0037
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  2. Article ; Online: Addressing disparities in HIV mortality: antiretroviral therapy is necessary but not sufficient.

    Smith, Kimberly Y

    Clinical infectious diseases : an official publication of the Infectious Diseases Society of America

    2013  Volume 56, Issue 12, Page(s) 1810–1811

    MeSH term(s) Emigrants and Immigrants/statistics & numerical data ; Female ; HIV Infections/ethnology ; HIV Infections/mortality ; Humans ; Male
    Language English
    Publishing date 2013-06
    Publishing country United States
    Document type Comment ; Editorial
    ZDB-ID 1099781-7
    ISSN 1537-6591 ; 1058-4838
    ISSN (online) 1537-6591
    ISSN 1058-4838
    DOI 10.1093/cid/cit116
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  3. Article ; Online: Durable Efficacy of Switching From a 3- or 4-Drug Tenofovir Alafenamide-Based Regimen to the 2-Drug Regimen Dolutegravir/Lamivudine in the TANGO Study Through Week 196.

    De Wit, Stéphane / Bonnet, Fabrice / Osiyemi, Olayemi / Bisshop, Fiona / Olalla, Julian / Routy, Jean-Pierre / Wyen, Christoph / Moodley, Riya / Pappa, Keith / Wang, Ruolan / Oyee, James / Saggu, Parminder / Letang, Emilio / Wynne, Brian / Jones, Bryn / Smith, Kimberly Y / Ait-Khaled, Mounir

    Journal of acquired immune deficiency syndromes (1999)

    2024  

    Abstract: Background: Switching to the 2-drug regimen dolutegravir/lamivudine demonstrated durable non-inferior efficacy vs continuing 3- or 4-drug tenofovir alafenamide-based regimens for maintaining virologic suppression in people with HIV-1 through Week 144 in ...

    Abstract Background: Switching to the 2-drug regimen dolutegravir/lamivudine demonstrated durable non-inferior efficacy vs continuing 3- or 4-drug tenofovir alafenamide-based regimens for maintaining virologic suppression in people with HIV-1 through Week 144 in TANGO.
    Setting: 134 centers, 10 countries.
    Methods: Adults with HIV-1 RNA <50 copies/mL for >6 months and no history of virologic failure were randomized to switch from stable tenofovir alafenamide-based regimens to dolutegravir/lamivudine on Day 1 (early-switch group) for 196 weeks. Those randomized to continue tenofovir alafenamide-based regimens on Day 1 who maintained virologic suppression at Week 144 switched to dolutegravir/lamivudine at Week 148 (late-switch group). Efficacy, safety, and tolerability (including weight and biomarker changes) of dolutegravir/lamivudine in early-switch and late-switch groups were assessed through Week 196.
    Results: Overall, 369 participants switched to dolutegravir/lamivudine on Day 1 (early-switch) and 298 switched at Week 148 (late-switch). In the early-switch group, 83% (306/369) maintained virologic suppression through Year 4, and 3% (11/369) reported new adverse events between Weeks 144 and 196. The late-switch group at Week 196 and early-switch group at Week 48 had comparable proportions with virologic suppression (93% each) and similar safety profiles. No late-switch participants and 1 early-switch participant met confirmed virologic withdrawal criteria through Week 196, with no resistance-associated mutations observed. Treatment continued to be well tolerated long-term.
    Conclusion: Switching from tenofovir alafenamide-based regimens to dolutegravir/lamivudine showed durable efficacy, high barrier to resistance, and good tolerability through 4 years. These results support dolutegravir/lamivudine as a robust treatment for maintaining virologic suppression.
    Language English
    Publishing date 2024-03-01
    Publishing country United States
    Document type Journal Article
    ZDB-ID 645053-2
    ISSN 1944-7884 ; 1077-9450 ; 0897-5965 ; 0894-9255 ; 1525-4135
    ISSN (online) 1944-7884 ; 1077-9450
    ISSN 0897-5965 ; 0894-9255 ; 1525-4135
    DOI 10.1097/QAI.0000000000003395
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  4. Article ; Online: Paying the price for late starts and early stops: racial and sex disparities in HIV-related mortality.

    Smith, Kimberly Y

    Clinical infectious diseases : an official publication of the Infectious Diseases Society of America

    2009  Volume 49, Issue 10, Page(s) 1579–1581

    MeSH term(s) Adolescent ; Adult ; Anti-HIV Agents/therapeutic use ; Continental Population Groups ; Female ; HIV Infections/drug therapy ; HIV Infections/epidemiology ; HIV Infections/mortality ; Humans ; Life Expectancy/trends ; Male ; Middle Aged ; Patient Compliance/statistics & numerical data ; Risk-Taking ; Sex Factors ; Survival Analysis ; United States/epidemiology ; Young Adult
    Chemical Substances Anti-HIV Agents
    Language English
    Publishing date 2009-11-15
    Publishing country United States
    Document type Comment ; Editorial
    ZDB-ID 1099781-7
    ISSN 1537-6591 ; 1058-4838
    ISSN (online) 1537-6591
    ISSN 1058-4838
    DOI 10.1086/644773
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  5. Article ; Online: Second Nationwide Tuberculosis Outbreak Caused by Bone Allografts Containing Live Cells - United States, 2023.

    Wortham, Jonathan M / Haddad, Maryam B / Stewart, Rebekah J / Annambhotla, Pallavi / Basavaraju, Sridhar V / Nabity, Scott A / Griffin, Isabel S / McDonald, Emily / Beshearse, Elizabeth M / Grossman, Marissa K / Schildknecht, Kimberly R / Calvet, Helene M / Keh, Chris E / Percak, Jeffrey M / Coloma, Myron / Shaw, Tambi / Davidson, Peter J / Smith, Shona R / Dickson, Robert P /
    Kaul, Daniel R / Gonzalez, Annett R / Rai, Saroj / Rodriguez, Gretchen / Morris, Sandra / Armitige, Lisa Y / Stapleton, Jessica / Lacassagne, Michael / Young, Laura R / Ariail, Kiley / Behm, Heidi / Jordan, Hannah T / Spencer, Magdalene / Nilsen, Diana M / Denison, Brenda Montoya / Burgos, Marcos / Leonard, Juliet M / Cortes, Erick / Thacker, Tyler C / Lehman, Kimberly A / Langer, Adam J / Cowan, Lauren S / Starks, Angela M / LoBue, Philip A

    MMWR. Morbidity and mortality weekly report

    2024  Volume 72, Issue 5253, Page(s) 1385–1389

    Abstract: During July 7-11, 2023, CDC received reports of two patients in different states with a tuberculosis (TB) diagnosis following spinal surgical procedures that used bone allografts containing live cells from the same deceased donor. An outbreak associated ... ...

    Abstract During July 7-11, 2023, CDC received reports of two patients in different states with a tuberculosis (TB) diagnosis following spinal surgical procedures that used bone allografts containing live cells from the same deceased donor. An outbreak associated with a similar product manufactured by the same tissue establishment (i.e., manufacturer) occurred in 2021. Because of concern that these cases represented a second outbreak, CDC and the Food and Drug Administration worked with the tissue establishment to determine that this product was obtained from a donor different from the one implicated in the 2021 outbreak and learned that the bone allograft product was distributed to 13 health care facilities in seven states. Notifications to all seven states occurred on July 12. As of December 20, 2023, five of 36 surgical bone allograft recipients received laboratory-confirmed TB disease diagnoses; two patients died of TB. Whole-genome sequencing demonstrated close genetic relatedness between positive Mycobacterium tuberculosis cultures from surgical recipients and unused product. Although the bone product had tested negative by nucleic acid amplification testing before distribution, M. tuberculosis culture of unused product was not performed until after the outbreak was recognized. The public health response prevented up to 53 additional surgical procedures using allografts from that donor; additional measures to protect patients from tissue-transmitted M. tuberculosis are urgently needed.
    MeSH term(s) Humans ; United States/epidemiology ; Tuberculosis/epidemiology ; Tuberculosis/diagnosis ; Mycobacterium tuberculosis/genetics ; Tissue Donors ; Disease Outbreaks ; Allografts
    Language English
    Publishing date 2024-01-05
    Publishing country United States
    Document type Journal Article
    ZDB-ID 412775-4
    ISSN 1545-861X ; 0149-2195
    ISSN (online) 1545-861X
    ISSN 0149-2195
    DOI 10.15585/mmwr.mm725253a1
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  6. Article ; Online: Listeria monocytogenes GlmR Is an Accessory Uridyltransferase Essential for Cytosolic Survival and Virulence.

    Pensinger, Daniel A / Gutierrez, Kimberly V / Smith, Hans B / Vincent, William J B / Stevenson, David S / Black, Katherine A / Perez-Medina, Krizia M / Dillard, Joseph P / Rhee, Kyu Y / Amador-Noguez, Daniel / Huynh, TuAnh N / Sauer, John-Demian

    mBio

    2023  Volume 14, Issue 2, Page(s) e0007323

    Abstract: The cytosol of eukaryotic host cells is an intrinsically hostile environment for bacteria. Understanding how cytosolic pathogens adapt to and survive in the cytosol is critical to developing novel therapeutic interventions against these pathogens. The ... ...

    Abstract The cytosol of eukaryotic host cells is an intrinsically hostile environment for bacteria. Understanding how cytosolic pathogens adapt to and survive in the cytosol is critical to developing novel therapeutic interventions against these pathogens. The cytosolic pathogen Listeria monocytogenes requires
    MeSH term(s) Listeria monocytogenes ; Virulence ; Cytosol/metabolism ; UDPglucose-Hexose-1-Phosphate Uridylyltransferase/metabolism ; Cell Wall/metabolism ; Uridine Diphosphate/metabolism ; Bacterial Proteins/genetics ; Bacterial Proteins/metabolism
    Chemical Substances UDPglucose-Hexose-1-Phosphate Uridylyltransferase (EC 2.7.7.12) ; Uridine Diphosphate (58-98-0) ; Bacterial Proteins
    Language English
    Publishing date 2023-03-20
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural
    ZDB-ID 2557172-2
    ISSN 2150-7511 ; 2161-2129
    ISSN (online) 2150-7511
    ISSN 2161-2129
    DOI 10.1128/mbio.00073-23
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  7. Article ; Online: ahctf1

    Morgan, Kimberly J / Doggett, Karen / Geng, Fansuo / Mieruszynski, Stephen / Whitehead, Lachlan / Smith, Kelly A / Hogan, Benjamin M / Simons, Cas / Baillie, Gregory J / Molania, Ramyar / Papenfuss, Anthony T / Hall, Thomas E / Ober, Elke A / Stainier, Didier Y R / Gong, Zhiyuan / Heath, Joan K

    eLife

    2023  Volume 12

    Abstract: The nucleoporin (NUP) ELYS, encoded ... ...

    Abstract The nucleoporin (NUP) ELYS, encoded by
    MeSH term(s) Animals ; Carcinoma, Hepatocellular/genetics ; Carcinoma, Hepatocellular/pathology ; Zebrafish/genetics ; Zebrafish/metabolism ; Nuclear Pore Complex Proteins/genetics ; Nuclear Pore Complex Proteins/metabolism ; Hyperplasia ; Liver Neoplasms/genetics ; Liver Neoplasms/pathology ; Mutation ; Proto-Oncogene Proteins p21(ras)/genetics ; Proto-Oncogene Proteins p21(ras)/metabolism ; Zebrafish Proteins/genetics ; Zebrafish Proteins/metabolism
    Chemical Substances Nuclear Pore Complex Proteins ; Kras protein, zebrafish (EC 3.6.5.2) ; Proto-Oncogene Proteins p21(ras) (EC 3.6.5.2) ; Zebrafish Proteins
    Language English
    Publishing date 2023-01-17
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2687154-3
    ISSN 2050-084X ; 2050-084X
    ISSN (online) 2050-084X
    ISSN 2050-084X
    DOI 10.7554/eLife.73407
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  8. Article ; Online: Relationships among biochemical measures in children with diabetic ketoacidosis.

    Glaser, Nicole S / Stoner, Michael J / Kwok, Maria Y / Quayle, Kimberly S / Brown, Kathleen M / Schunk, Jeff E / Trainor, Jennifer L / McManemy, Julie K / Tzimenatos, Leah / Rewers, Arleta / Nigrovic, Lise E / Bennett, Jonathan E / Myers, Sage R / Smith, McKenna / Casper, T Charles / Kuppermann, Nathan

    Journal of pediatric endocrinology & metabolism : JPEM

    2023  Volume 36, Issue 3, Page(s) 313–318

    Abstract: Objectives: Investigating empirical relationships among laboratory measures in children with diabetic ketoacidosis (DKA) can provide insights into physiological alterations occurring during DKA. We determined whether alterations in laboratory measures ... ...

    Abstract Objectives: Investigating empirical relationships among laboratory measures in children with diabetic ketoacidosis (DKA) can provide insights into physiological alterations occurring during DKA. We determined whether alterations in laboratory measures during DKA conform to theoretical predictions.
    Methods: We used Pearson correlation statistics and linear regression to investigate correlations between blood glucose, electrolytes, pH and PCO
    Results: pH and bicarbonate levels were strongly correlated (r=0.64), however, pH and PCO
    Conclusions: Elevated glucose levels at DKA presentation largely reflect alterations in glomerular filtration rate. pH and PCO
    MeSH term(s) Humans ; Child ; Diabetic Ketoacidosis ; Blood Glucose ; Glucose ; Glomerular Filtration Rate ; Diabetes Mellitus
    Chemical Substances Blood Glucose ; Glucose (IY9XDZ35W2)
    Language English
    Publishing date 2023-01-16
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 1231070-0
    ISSN 2191-0251 ; 0334-018X
    ISSN (online) 2191-0251
    ISSN 0334-018X
    DOI 10.1515/jpem-2022-0570
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  9. Article ; Online: Updates on LI-RADS Treatment Response Criteria for Hepatocellular Carcinoma: Focusing on MRI.

    Patel, Richa / Aslam, Anum / Parikh, Neehar D / Mervak, Benjamin / Mubarak, Eman / Higgins, Lily / Lala, Kayli / Conner, Jack F / Khaykin, Valerie / Bashir, Mustafa / Do, Richard Kinh Gian / Burke, Lauren M B / Smith, Elainea N / Kim, Charles Y / Shampain, Kimberly L / Owen, Dawn / Mendiratta-Lala, Mishal

    Journal of magnetic resonance imaging : JMRI

    2023  Volume 57, Issue 6, Page(s) 1641–1654

    Abstract: As the incidence of hepatocellular carcinoma (HCC) and subsequent treatments with liver-directed therapies rise, the complexity of assessing lesion response has also increased. The Liver Imaging Reporting and Data Systems (LI-RADS) treatment response ... ...

    Abstract As the incidence of hepatocellular carcinoma (HCC) and subsequent treatments with liver-directed therapies rise, the complexity of assessing lesion response has also increased. The Liver Imaging Reporting and Data Systems (LI-RADS) treatment response algorithm (LI-RADS TRA) was created to standardize the assessment of response after locoregional therapy (LRT) on contrast-enhanced CT or MRI. Originally created based on expert opinion, these guidelines are currently undergoing revision based on emerging evidence. While many studies support the use of LR-TRA for evaluation of HCC response after thermal ablation and intra-arterial embolic therapy, data suggest a need for refinements to improve assessment after radiation therapy. In this manuscript, we review expected MR imaging findings after different forms of LRT, clarify how to apply the current LI-RADS TRA by type of LRT, explore emerging literature on LI-RADS TRA, and highlight future updates to the algorithm. EVIDENCE LEVEL: 3. TECHNICAL EFFICACY: Stage 2.
    MeSH term(s) Humans ; Carcinoma, Hepatocellular/diagnostic imaging ; Carcinoma, Hepatocellular/radiotherapy ; Liver Neoplasms/diagnostic imaging ; Liver Neoplasms/radiotherapy ; Data Systems ; Magnetic Resonance Imaging/methods ; Retrospective Studies ; Contrast Media ; Sensitivity and Specificity
    Chemical Substances Contrast Media
    Language English
    Publishing date 2023-03-05
    Publishing country United States
    Document type Journal Article ; Review ; Research Support, N.I.H., Extramural
    ZDB-ID 1146614-5
    ISSN 1522-2586 ; 1053-1807
    ISSN (online) 1522-2586
    ISSN 1053-1807
    DOI 10.1002/jmri.28659
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    Zs.MO 236: Show issues

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  10. Article ; Online: Sexual and reproductive health in Ethiopia: gains and reflections over the past two decades.

    DeMaria, Lisa M / Smith, Kimberly V / Berhane, Yemane

    Reproductive health

    2022  Volume 19, Issue Suppl 1, Page(s) 175

    MeSH term(s) Ethiopia ; Humans ; Reproductive Health ; Sexual Behavior ; Sexual Health
    Language English
    Publishing date 2022-08-09
    Publishing country England
    Document type Editorial
    ZDB-ID 2149029-6
    ISSN 1742-4755 ; 1742-4755
    ISSN (online) 1742-4755
    ISSN 1742-4755
    DOI 10.1186/s12978-022-01464-0
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