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Article ; Online: l-Fucose prevention of renal ischaemia/reperfusion injury in Mice.

Howard, Mark C / Nauser, Christopher L / Farrar, Conrad A / Wallis, Russell / Sacks, Steven H

FASEB journal : official publication of the Federation of American Societies for Experimental Biology

2019 Volume 34, Issue 1, Page(s) 822–834

Abstract: ... the local tissue concentration of free l-fucose following systemic administration, in order to block ligand ... in the intrarenal concentration of l-fucose following an IP bolus given before the ischemia induction procedure ... At this l-fucose dose, complement activation and acute post-ischemic kidney injury are prevented ...

Abstract	In a recent study, we identified a fucosylated damage-associated ligand exposed by ischemia on renal tubule epithelial cells, which after recognition by collectin-11 (CL-11 or collectin kidney 1 (CL-K1)), initiates complement activation and acute kidney injury. We exploited the ability to increase the local tissue concentration of free l-fucose following systemic administration, in order to block ligand binding by local CL-11 and prevent complement activation. We achieved a thirty-five-fold increase in the intrarenal concentration of l-fucose following an IP bolus given before the ischemia induction procedure - a concentration found to significantly block in vitro binding of CL-11 on hypoxia-stressed renal tubule cells. At this l-fucose dose, complement activation and acute post-ischemic kidney injury are prevented, with additional protection achieved by a second bolus after the induction procedure. CL-11
MeSH term(s)	Acute Kidney Injury/drug therapy ; Acute Kidney Injury/metabolism ; Animals ; Complement Activation/drug effects ; Complement System Proteins/drug effects ; Complement System Proteins/metabolism ; Fucose/metabolism ; Fucose/pharmacokinetics ; Graft Survival/drug effects ; Ischemia/drug therapy ; Ischemia/metabolism ; Kidney/drug effects ; Kidney/metabolism ; Kidney Transplantation/methods ; Mice, Knockout ; Reperfusion Injury/drug therapy ; Reperfusion Injury/metabolism
Chemical Substances	Fucose (28RYY2IV3F) ; Complement System Proteins (9007-36-7)
Language	English
Publishing date	2019-11-27
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	639186-2
ISSN	1530-6860 ; 0892-6638
ISSN (online)	1530-6860
ISSN	0892-6638
DOI	10.1096/fj.201901582R
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Article ; Online: Investigating the Conformations of a Family of [M 2 L 3 ] 4+ Helicates Using Single Crystal X-ray Diffraction

Matthew J. Wallis / Hyunsung Min / Leonard F. Lindoy / Feng Li

Molecules, Vol 28, Iss 1404, p

2023 Volume 1404

Abstract: We present five new dinuclear triple helicate compounds of types [Mn 2 L 3 ](ClO 4 ) 4 , [Co 2 L 3 ... BF 4 ) 4 , [Ni 2 L 3 ](BF 4 ) 4 , [Cu 2 L 3 ](BF 4 ) 4 , and [Zn 2 L 3 ](BF 4 ) 4 , where L is ...

Abstract	We present five new dinuclear triple helicate compounds of types [Mn 2 L 3 ](ClO 4 ) 4 , [Co 2 L 3 ](BF 4 ) 4 , [Ni 2 L 3 ](BF 4 ) 4 , [Cu 2 L 3 ](BF 4 ) 4 , and [Zn 2 L 3 ](BF 4 ) 4 , where L is a previously reported semi-rigid ligand incorporating two α-diimine primary donor groups and two secondary 4-pyridyl donor groups. All complexes have been characterized in both solution and the solid state. Single crystal X-ray diffraction studies were used to probe the variation in the respective helical structures as the coordinated metal ion was altered, including the effect on the orientations of the secondary binding domains. The influence of the metal ion size, the spin state in the case of Fe(II), and the presence of Jahn-Teller distortions on the overall helical structure has been investigated. These results form a basis for the design and construction of new large metallosupramolecular architectures which manifest properties associated with the constituent helical metalloligand units.
Keywords	metallosupramolecular ; helicate ; transition metal ; metalloligand ; Organic chemistry ; QD241-441
Subject code	290
Language	English
Publishing date	2023-02-01T00:00:00Z
Publisher	MDPI AG
Document type	Article ; Online
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Article ; Online: Persistent deciduous teeth: Association of prevalence with breed, breed size and body weight in pure-bred client-owned dogs in the United States.

Wallis, C / Ivanova, A / Holcombe, L J

Research in veterinary science

2024 Volume 169, Page(s) 105161

Abstract: Dogs use their teeth for a multitude of tasks and, as such, it is vital for their health and wellbeing that their oral health is maintained. Persistent deciduous teeth (PDT), those that fail to fall out at the appropriate time, are associated with ... ...

Abstract	Dogs use their teeth for a multitude of tasks and, as such, it is vital for their health and wellbeing that their oral health is maintained. Persistent deciduous teeth (PDT), those that fail to fall out at the appropriate time, are associated with malocclusion (misaligned bite), soft tissue trauma and increased risk of periodontal disease. The objective of the current study was to perform a retrospective analysis of veterinary medical data to understand the effect of dog breed size, dog breed and body weight on prevalence of PDT. Medical records collected from almost 3 million dogs visiting a chain of veterinary hospitals across the United States over a 5-year period showed an overall prevalence of 7% for PDT, the data represented 60 breeds with extra-small breeds (<6.5 kg) showing significantly higher prevalence (15%) than all other breed sizes (P < 0.001). Statistical modelling of extra-small, small and medium-small breed sizes showed that those on Wellness Plans or that had not received a dental prophylaxis for at least two years had significantly increased odds of PDT being detected (Odds ratio 2.72-3.2 and 2.17-3.36 respectively, P < 0.0001). Dogs with a below ideal body condition score had a decreased odds of PDT (Odds ratio 0.57-0.89, P < 0.0001) whereas those above ideal had an increased odds (Odds ratio 1.11-1.60, P < 0.0001). The findings from this extensive dataset highlight the importance of regular veterinarian examinations to identify and remove PDT, helping to avoid increasing the risk of associated issues such as periodontal disease and malocclusion.
MeSH term(s)	Animals ; Dogs ; United States/epidemiology ; Retrospective Studies ; Prevalence ; Dog Diseases/epidemiology ; Dog Diseases/genetics ; Malocclusion/veterinary ; Periodontal Diseases/epidemiology ; Periodontal Diseases/veterinary ; Body Weight ; Tooth, Deciduous
Language	English
Publishing date	2024-01-23
Publishing country	England
Document type	Journal Article
ZDB-ID	840961-4
ISSN	1532-2661 ; 0034-5288
ISSN (online)	1532-2661
ISSN	0034-5288
DOI	10.1016/j.rvsc.2024.105161
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Article ; Online: No effect of acute L-arginine supplementation on O₂ cost or exercise tolerance.

Vanhatalo, Anni / Bailey, Stephen J / DiMenna, Fred J / Blackwell, Jamie R / Wallis, Gareth A / Jones, Andrew M

European journal of applied physiology

2013 Volume 113, Issue 7, Page(s) 1805–1819

Abstract: The extent to which dietary supplementation with the nitric oxide synthase (NOS) substrate, L ...

Abstract	The extent to which dietary supplementation with the nitric oxide synthase (NOS) substrate, L-arginine (ARG), impacts on NO production and NO-mediated physiological responses is controversial. This randomised, double blinded, cross-over study investigated the effects of acute ARG supplementation on NO biomarkers, O₂ cost of exercise and exercise tolerance in humans. In one experiment, 15 subjects completed moderate- and severe-intensity running bouts after acute supplementation with 6 g ARG or placebo (PLA). In another experiment, eight subjects completed moderate- and severe-intensity cycling bouts after acute supplementation with 6 g ARG plus 25 g of carbohydrate (ARG + CHO) or an energy-matched dose of carbohydrate alone (CHO). The plasma nitrite concentration was not different after ARG (Pre: 204 ± 79; Post: 241 ± 114 nM; P > 0.05) or ARG + CHO consumption (Pre: 304 ± 57; Post: 335 ± 116 nM; P > 0.05). During moderate-intensity exercise, the steady-state pulmonary VO₂ was not different, relative to the respective placebo conditions, after ARG (PLA: 2,407 ± 318, ARG: 2,422 ± 333 mL min(-1)) or ARG + CHO (CHO: 1,695 ± 304, ARG + CHO: 1,712 ± 312 mL min(-1)) ingestion (P > 0.05). The tolerable duration of severe exercise was also not significantly different (P > 0.05) after ingesting ARG (PLA: 551 ± 140, ARG: 552 ± 150 s) or ARG + CHO (CHO: 457 ± 182, ARG + CHO: 441 ± 221 s). In conclusion, acute dietary supplementation with ARG or ARG + CHO did not alter biomarkers of NO synthesis, O₂ cost of exercise or exercise tolerance in healthy subjects.
MeSH term(s)	Adult ; Arginine/pharmacology ; Carbohydrates/pharmacology ; Dietary Supplements ; Double-Blind Method ; Exercise Tolerance/drug effects ; Humans ; Male ; Nitrites/blood ; Oxygen Consumption/drug effects ; Running
Chemical Substances	Carbohydrates ; Nitrites ; Arginine (94ZLA3W45F)
Language	English
Publishing date	2013-02-20
Publishing country	Germany
Document type	Journal Article ; Randomized Controlled Trial ; Research Support, Non-U.S. Gov't
ZDB-ID	124793-1
ISSN	1439-6327 ; 1432-1025 ; 0301-5548 ; 1439-6319
ISSN (online)	1439-6327 ; 1432-1025
ISSN	0301-5548 ; 1439-6319
DOI	10.1007/s00421-013-2593-z
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Article ; Online: Death-seq and ye shall find: A novel screening strategy for dying cells.

Wallis, Ryan / Bishop, Cleo L

Cell metabolism

2023 Volume 35, Issue 10, Page(s) 1675–1676

Abstract: Killing senescent cells to improve health-span holds great promise. However, screening for senescence-regulating genes and molecules is challenging because these cells do not proliferate. In this issue, Colville and Liu et al. develop Death-seq, a ... ...

Abstract	Killing senescent cells to improve health-span holds great promise. However, screening for senescence-regulating genes and molecules is challenging because these cells do not proliferate. In this issue, Colville and Liu et al. develop Death-seq, a positive selection screening tool that overcomes this hurdle to offer broad genetic and pharmacological utility.
MeSH term(s)	Apoptosis ; Cellular Senescence/genetics
Language	English
Publishing date	2023-10-04
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't ; Comment
ZDB-ID	2176834-1
ISSN	1932-7420 ; 1550-4131
ISSN (online)	1932-7420
ISSN	1550-4131
DOI	10.1016/j.cmet.2023.09.003
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Article: Lower Extremity Nodules After Spelunking in Mexico.

Sulejmani, Pranvera / Wallis, Luke / Alabkaa, Anas / Ahmed, Aadil

Cureus

2023 Volume 15, Issue 6, Page(s) e39908

Abstract: Mycobacterium ... ...

Abstract	Mycobacterium marinum
Language	English
Publishing date	2023-06-03
Publishing country	United States
Document type	Case Reports
ZDB-ID	2747273-5
ISSN	2168-8184
ISSN	2168-8184
DOI	10.7759/cureus.39908
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Article ; Online: 3-Domains screening toolkit for medical assessment of older drivers: Feasibility study in Australian general practice.

Wallis, Katharine A / Scott, Theresa L / Mendis, Marini / Spurling, Geoffrey

Australian journal of general practice

2023 Volume 52, Issue 6, Page(s) 401–407

Abstract: Background and objectives: Some general practitioners (GPs) find the older driver medical assessment challenging, citing clinical uncertainty and concerns about communicating the need for further testing or driving cessation while maintaining a trusting ...

Abstract	Background and objectives: Some general practitioners (GPs) find the older driver medical assessment challenging, citing clinical uncertainty and concerns about communicating the need for further testing or driving cessation while maintaining a trusting therapeutic relationship. A screening toolkit could help support GP decision making and communication about fitness to drive. The aim of this study was to investigate the feasibility, acceptability and utility of the 3-Domains screening toolkit for the medical assessment of older drivers in Australian general practice. Method: A prospective mixed-methods study was conducted in nine general practices in south-east Queensland. Participants were older drivers (age ≥75 years) attending annual driving licence medical assessment, GPs and practice nurses. The 3-Domains toolkit comprises three screening tests (Snellen chart visual acuity, functional reach, road signs recognition). We evaluated the feasibility, acceptability and utility of the toolkit. Results: Practices used the toolkit in 43 older driver medical assessments (age 75-93 years; combined predictive score 13-96%). Twenty-two semistructured interviews were conducted. Older drivers felt reassured by the thorough assessment. GPs said the toolkit fitted into practice workflows, informed clinical judgement and supported conversations about fitness to drive while preserving therapeutic relationships. Discussion: The 3-Domains screening toolkit is feasible, acceptable and useful for the medical assessment of older drivers in Australian general practice.
MeSH term(s)	Humans ; Aged ; Aged, 80 and over ; Automobile Driving ; Accidents, Traffic/prevention & control ; Feasibility Studies ; Australia ; Prospective Studies ; Clinical Decision-Making ; Uncertainty ; Family Practice
Language	English
Publishing date	2023-06-01
Publishing country	Australia
Document type	Journal Article
ZDB-ID	2924889-9
ISSN	2208-7958 ; 2208-794X
ISSN (online)	2208-7958
ISSN	2208-794X
DOI	10.31128/AJGP-08-22-6528
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Article ; Online: Evaluation of a Teledermatology Postoperative Follow-up Model After Mohs Micrographic Surgery.

Rezac, Laura / Wallis, Luke / Black, William H / Pearlman, Ross L

Dermatologic surgery : official publication for American Society for Dermatologic Surgery [et al.

2024

Language	English
Publishing date	2024-02-28
Publishing country	United States
Document type	Journal Article
ZDB-ID	1227586-4
ISSN	1524-4725 ; 1076-0512
ISSN (online)	1524-4725
ISSN	1076-0512
DOI	10.1097/DSS.0000000000004126
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Article ; Online: TRAF3 enhances type I interferon receptor signaling in T cells by modulating the phosphatase PTPN22.

Hornick, Emma L / Wallis, Alicia M / Bishop, Gail A

Science signaling

2022 Volume 15, Issue 753, Page(s) eabn5507

Abstract: Type I interferons (IFNs) are among the most powerful tools that host cells deploy against intracellular pathogens. Their effectiveness is due both to the rapid, directly antiviral effects of IFN-stimulated gene products and to the effects of type I IFN ... ...

Abstract	Type I interferons (IFNs) are among the most powerful tools that host cells deploy against intracellular pathogens. Their effectiveness is due both to the rapid, directly antiviral effects of IFN-stimulated gene products and to the effects of type I IFN on responding immune cells. Type I IFN signaling through its receptor, IFNAR, is tightly regulated at multiple steps in the signaling cascade, including at the level of IFNAR downstream effectors, which include the kinase JAK1 and the transcriptional regulator STAT1. Here, we found that tumor necrosis factor receptor (TNFR)-associated factor 3 (TRAF3) enhanced the activation of JAK1 and STAT1 specifically in CD4
MeSH term(s)	Antiviral Agents/metabolism ; Interferon Type I/genetics ; Interferon Type I/metabolism ; Phosphoric Monoester Hydrolases/metabolism ; Receptor, Interferon alpha-beta/genetics ; Receptors, Tumor Necrosis Factor/metabolism ; T-Lymphocytes/metabolism ; TNF Receptor-Associated Factor 3/genetics ; TNF Receptor-Associated Factor 3/metabolism
Chemical Substances	Antiviral Agents ; Interferon Type I ; Receptors, Tumor Necrosis Factor ; TNF Receptor-Associated Factor 3 ; Receptor, Interferon alpha-beta (156986-95-7) ; Phosphoric Monoester Hydrolases (EC 3.1.3.2)
Language	English
Publishing date	2022-09-27
Publishing country	United States
Document type	Journal Article ; Research Support, U.S. Gov't, Non-P.H.S. ; Research Support, N.I.H., Extramural
ZDB-ID	2417226-1
ISSN	1937-9145 ; 1945-0877
ISSN (online)	1937-9145
ISSN	1945-0877
DOI	10.1126/scisignal.abn5507
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Article: Nutritional niche overlap analysis as a method to identify potential biocontrol fungi against trunk pathogens

Wallis, C. M.

BioControl. 2021 Aug., v. 66, no. 4

2021

Abstract: ... nitrogen resource use than E. lata and P. chlamydospora. However, only T. harzianum and L. lecanii were ... T. harzianum and L. lecanii would be advanced to additional biological control agent screening ... of all pathogens except P. minimum, and L. lecanii significant reduced growth of D. seriata, E. lata, and N. parvum ...

Abstract	Biological control agents possess various mechanisms to limit pathogens including ability to outcompete pathogens for resources and occupy shared niches. However, measuring this competition between putative biocontrol agents and pathogens for the same resources remains difficult. To evaluate carbon and nitrogen source utilization as a measure of competitiveness, we used phenotype microarrays on three endophytes (Trichoderma atroviridae, Trichoderma harzianum and Lecanicillium lecanii) with reported biological control activity and five stem-infecting fungal pathogens (Diplodia seriata, Eutypa lata, Neofusicoccum parvum, Phaeomoniella chlamydospora, and Phaeoacremonium minimum) that infect grapevine and other important woody plant hosts. The faster growing N. parvum and D. seriata utilized a greater number of the 190 assessed carbon and 380 assessed nitrogen sources than the relatively slower growing pathogens E. lata, P. chlamydospora, and P. minimum. All three endophytes had a greater niche overlap of carbon and nitrogen resource use than E. lata and P. chlamydospora. However, only T. harzianum and L. lecanii were determined to be able to equally compete or slightly outcompete N. parvum and D. seriata over carbon or nitrogen sources. Therefore, based on these results involving carbon and nitrogen source niche utilization, T. harzianum and L. lecanii would be advanced to additional biological control agent screening. Furthermore, according to plate bioassays, both Trichoderma spp. exhibited significant growth reduction of all pathogens except P. minimum, and L. lecanii significant reduced growth of D. seriata, E. lata, and N. parvum. Therefore, a combination of direct antagonism and ability to outcompete over resources is important in selecting biocontrols. Regardless, these results demonstrated the capacity of phenotype microarrays to assess the ability of endophytes to outcompete pathogens over shared resources in in vitro conditions as a complement to traditional plate assays.
Keywords	Diplodia seriata ; Eutypa lata ; Lecanicillium lecanii ; Neofusicoccum parvum ; Phaeoacremonium aleophilum ; Phaeoacremonium chlamydospora ; Trichoderma harzianum ; Vitis ; antagonism ; biological control ; biological control agents ; carbon ; endophytes ; fungi ; growth retardation ; microarray technology ; nitrogen ; phenotype ; woody plants
Language	English
Dates of publication	2021-08
Size	p. 559-571.
Publishing place	Springer Netherlands
Document type	Article
ZDB-ID	1452737-6
ISSN	1573-8248 ; 1386-6141
ISSN (online)	1573-8248
ISSN	1386-6141
DOI	10.1007/s10526-021-10091-w
Database	NAL-Catalogue (AGRICOLA)

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