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  1. Article ; Online: Additional Conditions Amenable to Observation Care.

    Wheatley, Matthew A

    Emergency medicine clinics of North America

    2017  Volume 35, Issue 3, Page(s) 701–712

    Abstract: ED observation units (EDOUs) are designed for patients who require diagnostics or therapeutics beyond the initial ED visit to determine the need for hospital admission. Best evidence is that this care be delivered via ordersets or protocols. Occasionally, ...

    Abstract ED observation units (EDOUs) are designed for patients who require diagnostics or therapeutics beyond the initial ED visit to determine the need for hospital admission. Best evidence is that this care be delivered via ordersets or protocols. Occasionally, patients present with conditions that are amenable to EDOU care but fall outside the commonly used protocols. This article details a few of these conditions: abnormal uterine bleeding, allergic reaction, alcohol intoxication, acetaminophen overdose and sickle cell vaso-occlusive crisis. It is not meant to be exhaustive as patient care needs can vary hospital to hospital.
    MeSH term(s) Alcoholic Intoxication/therapy ; Anemia, Sickle Cell/therapy ; Drug Overdose/therapy ; Emergencies ; Emergency Service, Hospital/organization & administration ; Female ; Hospital Units ; Humans ; Hypersensitivity/therapy ; Observation ; Uterine Hemorrhage/therapy
    Language English
    Publishing date 2017-08
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 605637-4
    ISSN 1558-0539 ; 0733-8627
    ISSN (online) 1558-0539
    ISSN 0733-8627
    DOI 10.1016/j.emc.2017.03.012
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1919: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  2. Article: Effect of α-Substitution on the Reactivity of C(sp

    Wheatley, Matthew / Zuccarello, Marco / Tsitopoulou, Maria / Macgregor, Stuart A / Baudoin, Olivier

    ACS catalysis

    2023  Volume 13, Issue 19, Page(s) 12563–12570

    Abstract: We report mechanistic studies on the reactivity of different α-substituted C( ... ...

    Abstract We report mechanistic studies on the reactivity of different α-substituted C(sp
    Language English
    Publishing date 2023-09-11
    Publishing country United States
    Document type Journal Article
    ISSN 2155-5435
    ISSN 2155-5435
    DOI 10.1021/acscatal.3c03806
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Opt-Out Syphilis Screening at an Urgent Care Center in Atlanta: Evaluation of a Pilot Program.

    Sweitzer, Stephanie / Sharp, Joseph / Baker, Dylan / Lynch, Alexis / Stauch, Meredith A / Wheatley, Matthew / Lora, Meredith / Cantos, Valeria D / Gruen, Judah

    Sexually transmitted diseases

    2024  

    Abstract: Background: HIV and syphilis disproportionately impact communities with low access to primary care, who often utilize urgent care centers (UCC) for sexual healthcare. UCC visits represent an opportunity for identification and treatment of syphilis and ... ...

    Abstract Background: HIV and syphilis disproportionately impact communities with low access to primary care, who often utilize urgent care centers (UCC) for sexual healthcare. UCC visits represent an opportunity for identification and treatment of syphilis and linkage to HIV testing and prevention services. We describe a universal, opt-out syphilis screening program pilot at an Atlanta UCC.
    Methods: A chart review was performed on patients 18 years and older who were offered opt-out syphilis screening and had a rapid plasma reagin (RPR) test collected from 9/1/21 to 12/31/21. Demographic data, syphilis stage and treatment, and HIV testing and serostatus were abstracted from the electronic health record. Patients with reactive RPRs were contacted by a study physician for syphilis staging and treatment, counseling, and referral for HIV pre-exposure prophylaxis (PrEP) or treatment.
    Results: From 9/1/21 to 12/31/21, 5794 patients were triaged and 1381 underwent RPR screening (23.8%). Eighty (5.8%) had reactive RPRs, and 42 (52.5%) had active syphilis. Of those with active syphilis, 39 (92.9%) received any treatment, and 35 (83.3%) completed treatment. Patients with late syphilis were less likely to complete syphilis treatment (aOR 0.03, p = 0.009, 95% CI 0.002-0.42). Among 955 offered PrEP, 41 (4.3%) expressed interest in PrEP, and 7 (0.7%) completed PrEP clinic intake. Univariate analysis did not identify any factors associated with interest in PrEP.
    Conclusions: In a UCC setting, routine, opt-out syphilis testing resulted in increased syphilis identification and treatment. It also provided an opportunity for PrEP counseling and referral, although few patients completed PrEP clinic intake.
    Language English
    Publishing date 2024-04-19
    Publishing country United States
    Document type Journal Article
    ZDB-ID 435191-5
    ISSN 1537-4521 ; 0148-5717
    ISSN (online) 1537-4521
    ISSN 0148-5717
    DOI 10.1097/OLQ.0000000000001980
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1217: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
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    Jg. 1995 - 2021: Lesesall (1.OG)
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  4. Article ; Online: Predictable NHEJ Insertion and Assessment of HDR Editing Strategies in Plants.

    Molla, Kutubuddin A / Shih, Justin / Wheatley, Matthew S / Yang, Yinong

    Frontiers in genome editing

    2022  Volume 4, Page(s) 825236

    Abstract: Canonical CRISPR-Cas9 genome editing technique has profoundly impacted the fields of plant biology, biotechnology, and crop improvement. Since non-homologous end joining (NHEJ) is usually considered to generate random indels, its high efficiency mutation ...

    Abstract Canonical CRISPR-Cas9 genome editing technique has profoundly impacted the fields of plant biology, biotechnology, and crop improvement. Since non-homologous end joining (NHEJ) is usually considered to generate random indels, its high efficiency mutation is generally not pertinent to precise editing. Homology-directed repair (HDR) can mediate precise editing with supplied donor DNA, but it suffers from extreme low efficiency in higher plants. Therefore, precision editing in plants will be facilitated by the ability to predict NHEJ repair outcome and to improve HDR efficiency. Here, we report that NHEJ-mediated single nucleotide insertion at different rice genes is predictable based on DNA sequences at the target loci. Three mutation prediction tools (inDelphi, FORECasT, and SPROUT) have been validated in the rice plant system. We also evaluated the chimeric guide RNA (cgRNA) and Cas9-Retron precISe Parallel Editing via homologY (CRISPEY) strategies to facilitate donor template supply for improving HDR efficiency in
    Language English
    Publishing date 2022-03-16
    Publishing country Switzerland
    Document type Journal Article
    ISSN 2673-3439
    ISSN (online) 2673-3439
    DOI 10.3389/fgeed.2022.825236
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Using health administrative data to model associations and predict hospital admissions and length of stay for people with eating disorders.

    Kim, Marcellinus / Holton, Matthew / Sweeting, Arianne / Koreshe, Eyza / McGeechan, Kevin / Miskovic-Wheatley, Jane

    BMC psychiatry

    2023  Volume 23, Issue 1, Page(s) 326

    Abstract: Background: Eating disorders are serious mental illnesses requiring a whole of health approach. Routinely collected health administrative data has clinical utility in describing associations and predicting health outcome measures. This study aims to ... ...

    Abstract Background: Eating disorders are serious mental illnesses requiring a whole of health approach. Routinely collected health administrative data has clinical utility in describing associations and predicting health outcome measures. This study aims to develop models to assess the clinical utility of health administrative data in adult eating disorder emergency presentations and length of stay.
    Methods: Retrospective cohort study on health administrative data in adults with eating disorders from 2014 to 2020 in Sydney Local Health District. Emergency and admitted patient data were collected with all clinically important variables available. Multivariable regression models were analysed to explore associations and to predict admissions and length of stay.
    Results: Emergency department modelling describes some clinically important associations such as decreased odds of admission for patients with Bulimia Nervosa compared to Anorexia Nervosa (Odds Ratio [OR] 0.31, 95% Confidence Interval [95%CI] 0.10 to 0.95; p = 0.04). Admitted data included more predictors and therefore further significant associations including an average of 0.96 days increase in length of stay for each additional count of diagnosis/comorbidities (95% Confidence Interval [95% CI] 0.37 to 1.55; p = 0.001) with a valid prediction model (R
    Conclusions: Health administrative data has clinical utility in adult eating disorders with valid exploratory and predictive models describing associations and predicting admissions and length of stay. Utilising health administrative data this way is an efficient process for assessing impacts of multiple factors on patient care and predicting health care outcomes.
    MeSH term(s) Adult ; Humans ; Length of Stay ; Retrospective Studies ; Routinely Collected Health Data ; Feeding and Eating Disorders/diagnosis ; Feeding and Eating Disorders/epidemiology ; Feeding and Eating Disorders/therapy ; Emergency Service, Hospital ; Hospitals
    Language English
    Publishing date 2023-05-10
    Publishing country England
    Document type Journal Article
    ZDB-ID 2050438-X
    ISSN 1471-244X ; 1471-244X
    ISSN (online) 1471-244X
    ISSN 1471-244X
    DOI 10.1186/s12888-023-04688-x
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Low back pain-related healthcare utilization following intraosseous basivertebral nerve radiofrequency ablation: a pooled analysis from three prospective clinical trials.

    McCormick, Zachary L / Curtis, Timothy / Cooper, Amanda / Wheatley, Margo / Smuck, Matthew

    Pain medicine (Malden, Mass.)

    2023  Volume 25, Issue 1, Page(s) 20–32

    Abstract: Background: The effectiveness and safety of intraosseous basivertebral nerve ablation (BVNA) for treating vertebrogenic pain is established, but low back pain-related healthcare utilization (LBPr-HU) following BVNA continues to be defined.: Methods: ... ...

    Abstract Background: The effectiveness and safety of intraosseous basivertebral nerve ablation (BVNA) for treating vertebrogenic pain is established, but low back pain-related healthcare utilization (LBPr-HU) following BVNA continues to be defined.
    Methods: LBPr-HU data were pooled from 3 prospective studies. LBPr-HU categories of interest included non-invasive conservative care, opioid utilization, lumbosacral spinal injection (LSI), lumbosacral radiofrequency ablation (LRFA), and lumbosacral spinal surgery. Pre- and post-BVNA LBPr-HU were compared at both 1- and 5-years using McNemar's test for proportions and paired t-tests for means.
    Results: Two hundred forty-seven patients received BVNA and had 1-year follow-up; 205 had long-term follow-up (mean of 5.3 ± 1.33 years). Twenty-seven percent fewer participants initiated conservative care in the year post-BVNA compared to the year preceding BVNA (P < .001; 95% CI 19.8-34.5). Of 77/247 participants taking opioids at baseline, 40.3% and 61.7% fewer were taking them at one-year and 5.3 ± 1.33 years post-BVNA, respectively (P < .001). Of participants receiving LSIs in the year preceding BVNA, 81.2% fewer received LSI(s) in the year post-BVNA (P < .001; 95% CI 70.7-90.7); a 76.4% reduction in LSIs was maintained through a mean of 5.3 ± 1.33 years post-BVNA. LRFA rates were 1.6% at 1-year post-BVNA and 8.3% at 5.3 ± 1.33 years post-BVNA. Lumbar fusion surgery was 0.8% at 1-year post-BVNA and 6.5% at 5.3 ± 1.33 years post-BVNA.
    Conclusions: In this aggregate analysis of patients with vertebrogenic pain, utilization of conservative care, opioids, LSIs, and LRFA were substantially reduced through 5 years post-BVNA compared to baseline. Lumbar fusion rates were less than half the published value at 5 years in similar populations.
    MeSH term(s) Humans ; Low Back Pain/surgery ; Low Back Pain/drug therapy ; Prospective Studies ; Lumbosacral Region ; Radiofrequency Ablation ; Patient Acceptance of Health Care ; Treatment Outcome
    Language English
    Publishing date 2023-08-29
    Publishing country England
    Document type Meta-Analysis ; Journal Article
    ZDB-ID 2015903-1
    ISSN 1526-4637 ; 1526-2375
    ISSN (online) 1526-4637
    ISSN 1526-2375
    DOI 10.1093/pm/pnad114
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 6119: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
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  7. Article ; Online: Correspondence.

    Wheatley, H Matthew / Mantopoulos, Dimosthenis / Prenner, Jonathan

    Retinal cases & brief reports

    2023  Volume 18, Issue 2, Page(s) e3

    Language English
    Publishing date 2023-10-02
    Publishing country United States
    Document type Journal Article
    ISSN 1937-1578
    ISSN (online) 1937-1578
    DOI 10.1097/ICB.0000000000001502
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  8. Article ; Online: Ruthenium-Catalyzed Monoselective C-H Methylation and

    Hogg, Ashley / Wheatley, Matthew / Domingo-Legarda, Pablo / Carral-Menoyo, Asier / Cottam, Naomi / Larrosa, Igor

    JACS Au

    2022  Volume 2, Issue 11, Page(s) 2529–2538

    Abstract: Site-selective installation of C-Me bonds remains a powerful and sought-after tool to alter the chemical and pharmacological properties of a molecule. Direct C-H functionalization provides an attractive means of achieving this transformation. Such ... ...

    Abstract Site-selective installation of C-Me bonds remains a powerful and sought-after tool to alter the chemical and pharmacological properties of a molecule. Direct C-H functionalization provides an attractive means of achieving this transformation. Such protocols, however, typically utilize harsh conditions and hazardous methylating agents with poor applicability toward late-stage functionalization. Furthermore, highly monoselective methylation protocols remain scarce. Herein, we report an efficient monoselective, directed
    Language English
    Publishing date 2022-10-21
    Publishing country United States
    Document type Journal Article
    ISSN 2691-3704
    ISSN (online) 2691-3704
    DOI 10.1021/jacsau.2c00399
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: Intrahepatic Cholangiocarcinoma With Extrahepatic Metastasis and High Tumor Mutation Burden: Case of Complete Pathological Response to Cisplatin/Gemcitabine/Pembrolizumab.

    Robinson, Matthew D / Wheatley, Roseanna / Foster, Lucy / Jamdar, Saurabh / Siriwardena, Ajith K / Lamarca, Angela / Hubner, Richard / Valle, Juan W / McNamara, Mairéad G

    JCO precision oncology

    2024  Volume 8, Page(s) e2300572

    MeSH term(s) Humans ; Cholangiocarcinoma/genetics ; Cholangiocarcinoma/drug therapy ; Cholangiocarcinoma/pathology ; Gemcitabine ; Deoxycytidine/analogs & derivatives ; Deoxycytidine/therapeutic use ; Deoxycytidine/administration & dosage ; Cisplatin/therapeutic use ; Cisplatin/administration & dosage ; Bile Duct Neoplasms/genetics ; Bile Duct Neoplasms/drug therapy ; Bile Duct Neoplasms/pathology ; Antineoplastic Combined Chemotherapy Protocols/therapeutic use ; Antibodies, Monoclonal, Humanized/therapeutic use ; Mutation ; Male ; Neoplasm Metastasis ; Middle Aged
    Chemical Substances Gemcitabine ; Deoxycytidine (0W860991D6) ; Cisplatin (Q20Q21Q62J) ; pembrolizumab (DPT0O3T46P) ; Antibodies, Monoclonal, Humanized
    Language English
    Publishing date 2024-04-25
    Publishing country United States
    Document type Case Reports ; Journal Article
    ISSN 2473-4284
    ISSN (online) 2473-4284
    DOI 10.1200/PO.23.00572
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: New Clarification About Observation Billing May Improve Care for Behavioral Health Patients.

    Osborne, Anwar D / Wheatley, Matthew A / Baugh, Christopher W / Granovsky, Michael

    The western journal of emergency medicine

    2020  Volume 21, Issue 2, Page(s) 411

    Language English
    Publishing date 2020-01-27
    Publishing country United States
    Document type Letter
    ZDB-ID 2375700-0
    ISSN 1936-9018 ; 1936-900X
    ISSN (online) 1936-9018
    ISSN 1936-900X
    DOI 10.5811/westjem.2019.11.45703
    Database MEDical Literature Analysis and Retrieval System OnLINE

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