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  1. Book: Antifungal immunity

    Drummond, Rebecca A.

    methods and protocols

    (Methods in molecular biology ; 2667 ; Springer protocols)

    2023  

    Author's details edited by Rebecca A. Drummond
    Series title Methods in molecular biology ; 2667
    Springer protocols
    Collection
    Keywords Mycoses/Immunological aspects ; Immunity ; Antifungal agents
    Subject code 616.969079
    Language English
    Size xi, 226 Seiten, Illustrationen, 26 cm
    Publisher Humana Press
    Publishing place New York, NY
    Publishing country United States
    Document type Book
    HBZ-ID HT030013811
    ISBN 978-1-071-63198-0 ; 9781071631997 ; 1-071-63198-5 ; 1071631993
    Database Catalogue ZB MED Medicine, Health

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    Shelf markLoan statusLocation
    Zs A 7042 -2667- not available for loan Lesesaal EG

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  2. Article ; Online: One in, one out: Commensal fungus protects against infection.

    Drummond, Rebecca A

    The Journal of experimental medicine

    2024  Volume 221, Issue 5

    Abstract: Gut-resident fungi have a broad influence over health and disease. In this issue of JEM, Sekeresova Kralova et al. (https://doi.org/10.1084/jem.20231686) identify a commensal yeast that displaced fungal pathogen Candida albicans and protected against ... ...

    Abstract Gut-resident fungi have a broad influence over health and disease. In this issue of JEM, Sekeresova Kralova et al. (https://doi.org/10.1084/jem.20231686) identify a commensal yeast that displaced fungal pathogen Candida albicans and protected against subsequent invasive infections that originate from the gut.
    MeSH term(s) Fungi
    Language English
    Publishing date 2024-03-18
    Publishing country United States
    Document type Journal Article
    ZDB-ID 218343-2
    ISSN 1540-9538 ; 0022-1007
    ISSN (online) 1540-9538
    ISSN 0022-1007
    DOI 10.1084/jem.20240220
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: What fungal CNS infections can teach us about neuroimmunology and CNS-specific immunity.

    Drummond, Rebecca A

    Seminars in immunology

    2023  Volume 67, Page(s) 101751

    Abstract: Immunity to fungal infections of the central nervous system (CNS) is one of the most poorly understood subjects within the field of medical mycology. Yet, the majority of deaths from invasive fungal infections are caused by brain-tropic fungi. In recent ... ...

    Abstract Immunity to fungal infections of the central nervous system (CNS) is one of the most poorly understood subjects within the field of medical mycology. Yet, the majority of deaths from invasive fungal infections are caused by brain-tropic fungi. In recent years, there have been several significant discoveries in the regulation of neuroinflammation and the role of the immune system in tissue homeostasis within the CNS. In this review, I highlight five important advances in the neuroimmunology field over the last decade and discuss how we should capitalise on these discoveries to better understand the pathogenesis of fungal CNS infections. In addition, the latest insights into fungal invasion tactics, microglia-astrocyte crosstalk and regulation of antifungal adaptive immune responses are summarised in the context of our contemporary understanding of CNS-specific immunity.
    MeSH term(s) Humans ; Central Nervous System ; Microglia ; Mycoses ; Immunity ; Central Nervous System Infections
    Language English
    Publishing date 2023-03-27
    Publishing country England
    Document type Journal Article ; Review ; Research Support, Non-U.S. Gov't
    ZDB-ID 1018141-6
    ISSN 1096-3618 ; 1044-5323
    ISSN (online) 1096-3618
    ISSN 1044-5323
    DOI 10.1016/j.smim.2023.101751
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: mSphere of Influence: Discovering New Layers of Complexity in the Immune System.

    Drummond, Rebecca A

    mSphere

    2021  Volume 6, Issue 3

    Abstract: Rebecca Drummond works in the field of antifungal immunity. In this mSphere of Influence article ...

    Abstract Rebecca Drummond works in the field of antifungal immunity. In this mSphere of Influence article, she reflects on how papers by Amit et al. (H. Keren-Shaul, A. Spinrad, A. Weiner, O. Matcovitch-Natan, et al., Cell 169:1276-1290, 2017) and Ayres et al. (K. K. Sanchez, G. Y. Chen, A. M. P. Schieber, S. E. Redford, et al., Cell 175:146-158, 2018) made an impact on her by introducing her to new concepts in immune system complexity.
    MeSH term(s) Central Nervous System Infections/immunology ; Humans ; Immune System ; Single-Cell Analysis
    Language English
    Publishing date 2021-05-05
    Publishing country United States
    Document type Journal Article
    ISSN 2379-5042
    ISSN (online) 2379-5042
    DOI 10.1128/mSphere.00359-21
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: How metals fuel fungal virulence, yet promote anti-fungal immunity.

    Alselami, Alanoud / Drummond, Rebecca A

    Disease models & mechanisms

    2023  Volume 16, Issue 10

    Abstract: Invasive fungal infections represent a significant global health problem, and present several clinical challenges, including limited treatment options, increasing rates of antifungal drug resistance and compounding comorbidities in affected patients. ... ...

    Abstract Invasive fungal infections represent a significant global health problem, and present several clinical challenges, including limited treatment options, increasing rates of antifungal drug resistance and compounding comorbidities in affected patients. Metals, such as copper, iron and zinc, are critical for various biological and cellular processes across phyla. In mammals, these metals are important determinants of immune responses, but pathogenic microbes, including fungi, also require access to these metals to fuel their own growth and drive expression of major virulence traits. Therefore, host immune cells have developed strategies to either restrict access to metals to induce starvation of invading pathogens or deploy toxic concentrations within phagosomes to cause metal poisoning. In this Review, we describe the mechanisms regulating fungal scavenging and detoxification of copper, iron and zinc and the importance of these mechanisms for virulence and infection. We also outline how these metals are involved in host immune responses and the consequences of metal deficiencies or overloads on how the host controls invasive fungal infections.
    MeSH term(s) Animals ; Humans ; Copper/metabolism ; Virulence ; Metals/metabolism ; Iron/metabolism ; Zinc/metabolism ; Invasive Fungal Infections ; Mammals/metabolism
    Chemical Substances Copper (789U1901C5) ; Metals ; Iron (E1UOL152H7) ; Zinc (J41CSQ7QDS)
    Language English
    Publishing date 2023-10-31
    Publishing country England
    Document type Review ; Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2451104-3
    ISSN 1754-8411 ; 1754-8403
    ISSN (online) 1754-8411
    ISSN 1754-8403
    DOI 10.1242/dmm.050393
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Meningeal Whole Mounts for Imaging CNS Fungal Infection.

    Hain, Sofia / Drummond, Rebecca A

    Methods in molecular biology (Clifton, N.J.)

    2023  Volume 2667, Page(s) 113–121

    Abstract: Invasive fungal infections may involve the brain and central nervous system (CNS), leading to often fatal meningitis in immunocompromised individuals. Recent technological advances have allowed us to move beyond studying the brain parenchyma to ... ...

    Abstract Invasive fungal infections may involve the brain and central nervous system (CNS), leading to often fatal meningitis in immunocompromised individuals. Recent technological advances have allowed us to move beyond studying the brain parenchyma to understanding the immune mechanisms of the meninges, the protective layer that surrounds the brain and spinal cord. Specifically, advanced microscopy techniques have enabled researchers to begin to visualize the anatomy of the meninges and the cellular mediators of meningeal inflammation. In this chapter, we describe how to make meningeal tissue mounts for imaging by confocal microscopy.
    MeSH term(s) Humans ; Meninges ; Central Nervous System ; Brain ; Spinal Cord ; Central Nervous System Fungal Infections
    Language English
    Publishing date 2023-05-01
    Publishing country United States
    Document type Journal Article
    ISSN 1940-6029
    ISSN (online) 1940-6029
    DOI 10.1007/978-1-0716-3199-7_8
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: Fungal pathogens: The underappreciated parasites that are now in the spotlight.

    Cook, Peter C / Drummond, Rebecca A

    Parasite immunology

    2023  Volume 45, Issue 2, Page(s) e12968

    Language English
    Publishing date 2023-07-03
    Publishing country England
    Document type Editorial
    ZDB-ID 424444-8
    ISSN 1365-3024 ; 0141-9838
    ISSN (online) 1365-3024
    ISSN 0141-9838
    DOI 10.1111/pim.12968
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: How metals fuel fungal virulence, yet promote anti-fungal immunity

    Alanoud Alselami / Rebecca A. Drummond

    Disease Models & Mechanisms, Vol 16, Iss

    2023  Volume 10

    Keywords copper ; fungal immunology ; iron ; macrophage ; nutritional immunity ; Medicine ; R ; Pathology ; RB1-214
    Language English
    Publishing date 2023-10-01T00:00:00Z
    Publisher The Company of Biologists
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  9. Article ; Online: Sowing the seeds of infection.

    Ballou, Elizabeth R / Drummond, Rebecca A

    Cell host & microbe

    2022  Volume 30, Issue 10, Page(s) 1341–1342

    Abstract: Pathogenic fungi have the remarkable ability to undergo morphological changes that can determine their virulence potential. In this issue of Cell Host & Microbe, Denham et al. identify a fungal morphotype that is uniquely adapted for extrapulmonary ... ...

    Abstract Pathogenic fungi have the remarkable ability to undergo morphological changes that can determine their virulence potential. In this issue of Cell Host & Microbe, Denham et al. identify a fungal morphotype that is uniquely adapted for extrapulmonary dissemination, contributing toward invasive infection and escaping host immune responses.
    MeSH term(s) Adaptation, Physiological ; Fungi ; Seeds ; Virulence
    Language English
    Publishing date 2022-10-12
    Publishing country United States
    Document type Journal Article ; Comment
    ZDB-ID 2278004-X
    ISSN 1934-6069 ; 1931-3128
    ISSN (online) 1934-6069
    ISSN 1931-3128
    DOI 10.1016/j.chom.2022.09.008
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: Modeling Podocyte Ontogeny and Podocytopathies with the Zebrafish.

    Drummond, Bridgette E / Ercanbrack, Wesley S / Wingert, Rebecca A

    Journal of developmental biology

    2023  Volume 11, Issue 1

    Abstract: Podocytes are exquisitely fashioned kidney cells that serve an essential role in the process of blood filtration. Congenital malformation or damage to podocytes has dire consequences and initiates a cascade of pathological changes leading to renal ... ...

    Abstract Podocytes are exquisitely fashioned kidney cells that serve an essential role in the process of blood filtration. Congenital malformation or damage to podocytes has dire consequences and initiates a cascade of pathological changes leading to renal disease states known as podocytopathies. In addition, animal models have been integral to discovering the molecular pathways that direct the development of podocytes. In this review, we explore how researchers have used the zebrafish to illuminate new insights about the processes of podocyte ontogeny, model podocytopathies, and create opportunities to discover future therapies.
    Language English
    Publishing date 2023-02-20
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2720870-9
    ISSN 2221-3759 ; 2221-3759
    ISSN (online) 2221-3759
    ISSN 2221-3759
    DOI 10.3390/jdb11010009
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