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  1. Book ; Online ; E-Book: Biomarkers of human aging

    Moskalev, Alexey

    (Healthy ageing and longevity ; 10)

    2019  

    Author's details Alexey Moskalev editor
    Series title Healthy ageing and longevity ; 10
    Collection
    Keywords Electronic books
    Language English
    Size 1 Online-Ressource (vii, 421 Seiten), Illustrationen
    Publisher Springer
    Publishing place Cham
    Publishing country Switzerland
    Document type Book ; Online ; E-Book
    Remark Zugriff für angemeldete ZB MED-Nutzerinnen und -Nutzer
    HBZ-ID HT020231561
    ISBN 978-3-030-24970-0 ; 9783030249694 ; 3-030-24970-0 ; 3030249697
    DOI 10.1007/978-3-030-24970-0
    Database ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

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  2. Article ; Online: "Development of gerontology would be more effective under governmental support": an interview with Vladimir N. Anisimov.

    Moskalev, Alexey

    Biogerontology

    2023  Volume 24, Issue 3, Page(s) 421–442

    MeSH term(s) Geriatrics
    Language English
    Publishing date 2023-04-19
    Publishing country Netherlands
    Document type Interview ; Review
    ZDB-ID 2047160-9
    ISSN 1573-6768 ; 1389-5729
    ISSN (online) 1573-6768
    ISSN 1389-5729
    DOI 10.1007/s10522-023-10025-2
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 5706: Show issues Location:
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  3. Article ; Online: Potential Geroprotectors - From Bench to Clinic.

    Moskalev, Alexey A

    Biochemistry. Biokhimiia

    2023  Volume 88, Issue 11, Page(s) 1732–1738

    Abstract: Geroprotectors are substances that slow down aging process and can be used for prevention of age-related diseases. Geroprotectors can improve functioning of various organ systems and enhance their homeostatic capabilities. We have developed a system of ... ...

    Abstract Geroprotectors are substances that slow down aging process and can be used for prevention of age-related diseases. Geroprotectors can improve functioning of various organ systems and enhance their homeostatic capabilities. We have developed a system of criteria for geroprotectors and proposed their classification based on the mechanisms of their action on the aging processes. Geroprotectors are required to reduce mortality, improve human aging biomarkers, have minimal side effects, and enhance quality of life. Additionally, there are approaches based on combining geroprotectors targeted to different targets and mechanisms of aging to achieve maximum effectiveness. Currently, numerous preclinical studies are being conducted to identify new molecular targets and develop new approaches to extend healthy aging, although the number of clinical trials is limited. Geroprotectors have the potential to become a new class of preventive medicines as they prevent onset of certain diseases or slow down their progression.
    MeSH term(s) Humans ; Senotherapeutics ; Quality of Life ; Aging
    Chemical Substances Senotherapeutics
    Language English
    Publishing date 2023-12-17
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 1109-5
    ISSN 1608-3040 ; 0006-2979 ; 0320-9717
    ISSN (online) 1608-3040
    ISSN 0006-2979 ; 0320-9717
    DOI 10.1134/S0006297923110056
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Book ; Online ; Conference proceedings: Proceedings of the 3rd International Conference on Genetics of Aging and Longevity

    Moskalev, Alexey / Pasyukova, Elena G.

    2016  

    Abstract: In this book, we present a collection of articles covering a wide range of current aging research and highlighting its prospects and future directions. These articles are based on or related to the topics of the 3rd International Conference «Genetics of ... ...

    Abstract In this book, we present a collection of articles covering a wide range of current aging research and highlighting its prospects and future directions. These articles are based on or related to the topics of the 3rd International Conference «Genetics of aging and longevity». The Conference took place 6-10 April, 2014 in Sochi, the city located on the Black Sea coast near the Caucasian mountains, in Russia. Top gerontologists and geneticists from 31 countries around the world came together to discuss current problems in many areas related to the genetics of longevity and mechanisms of aging. We would like to thank those of them who contributed to this e-Book by sharing latest achievements, ideas and hypotheses. We hope that this e-Book will come to notice of scientists interested in the development of genetics of aging and longevity and in the search for life-beneficial environments and life-prolonging interventions
    Keywords Science (General) ; Genetics
    Size 1 electronic resource (88 p.)
    Publisher Frontiers Media SA
    Document type Book ; Online ; Conference proceedings
    Note English ; Open Access
    HBZ-ID HT020090646
    ISBN 9782889199266 ; 2889199266
    Database ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

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  5. Book: Life extension

    Vaiserman, Alexander / Moskalev, Alexey / Pasyukova, Elena

    lessons from Drosophila

    (Healthy ageing and longevity ; 3)

    2015  

    Author's details Alexander M. Vaiserman ; Alexey A. Moskalev ; Elena G. Pasyukova ed
    Series title Healthy ageing and longevity ; 3
    Collection
    Keywords Drosophila ; Aging ; Healthspan ; Longevity-associated genes ; Life extension
    Language English
    Size VIII, 353 S. : Ill., graph. Darst., 235 mm x 155 mm
    Publisher Springer
    Publishing place Cham u.a.
    Publishing country Switzerland
    Document type Book
    HBZ-ID HT018707932
    ISBN 978-3-319-18325-1 ; 3-319-18325-7 ; 9783319183268 ; 3319183265
    Database Catalogue ZB MED Medicine, Health

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    Shelf markLoan statusLocation
    2015 A 2618 available for loan (reading room) Lesesaal EG

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  6. Article ; Online: The challenges of estimating biological age.

    Moskalev, Alexey

    eLife

    2020  Volume 9

    Abstract: A comparison of nine different approaches over a period of 20 years reveals the most promising indicators for biological age. ...

    Abstract A comparison of nine different approaches over a period of 20 years reveals the most promising indicators for biological age.
    MeSH term(s) Follow-Up Studies
    Language English
    Publishing date 2020-02-11
    Publishing country England
    Document type Journal Article ; Comment
    ZDB-ID 2687154-3
    ISSN 2050-084X ; 2050-084X
    ISSN (online) 2050-084X
    ISSN 2050-084X
    DOI 10.7554/eLife.54969
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  7. Article ; Online: Kinetics of Chemisorption on the Surface of Nanodispersed SnO

    Vasiliev, Alexey / Shaposhnik, Alexey / Moskalev, Pavel / Kul, Oleg

    Sensors (Basel, Switzerland)

    2023  Volume 23, Issue 7

    Abstract: In this work, the kinetics and mechanisms of the interaction of carbon monoxide and hydrogen with the surface of a nanosized ... ...

    Abstract In this work, the kinetics and mechanisms of the interaction of carbon monoxide and hydrogen with the surface of a nanosized SnO
    Language English
    Publishing date 2023-04-04
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2052857-7
    ISSN 1424-8220 ; 1424-8220
    ISSN (online) 1424-8220
    ISSN 1424-8220
    DOI 10.3390/s23073730
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: Is anti-ageing drug discovery becoming a reality?

    Moskalev, Alexey

    Expert opinion on drug discovery

    2019  Volume 15, Issue 2, Page(s) 135–138

    MeSH term(s) Aging/drug effects ; Animals ; Drug Discovery ; Humans ; Longevity/drug effects
    Language English
    Publishing date 2019-12-10
    Publishing country England
    Document type Editorial ; Research Support, Non-U.S. Gov't
    ZDB-ID 2259618-5
    ISSN 1746-045X ; 1746-0441
    ISSN (online) 1746-045X
    ISSN 1746-0441
    DOI 10.1080/17460441.2020.1702965
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 6388: Show issues Location:
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  9. Article ; Online: The challenges of estimating biological age

    Alexey Moskalev

    eLife, Vol

    2020  Volume 9

    Abstract: A comparison of nine different approaches over a period of 20 years reveals the most promising indicators for biological age. ...

    Abstract A comparison of nine different approaches over a period of 20 years reveals the most promising indicators for biological age.
    Keywords biological age ; longitudinal trajectory ; mortality ; aging ; correlation ; Medicine ; R ; Science ; Q ; Biology (General) ; QH301-705.5
    Language English
    Publishing date 2020-02-01T00:00:00Z
    Publisher eLife Sciences Publications Ltd
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  10. Article ; Online: Transposable elements and their role in aging.

    Yushkova, Elena / Moskalev, Alexey

    Ageing research reviews

    2023  Volume 86, Page(s) 101881

    Abstract: Transposable elements (TEs) are an important part of eukaryotic genomes. The role of somatic transposition in aging, carcinogenesis, and other age-related diseases has been determined. This review discusses the fundamental properties of TEs and their ... ...

    Abstract Transposable elements (TEs) are an important part of eukaryotic genomes. The role of somatic transposition in aging, carcinogenesis, and other age-related diseases has been determined. This review discusses the fundamental properties of TEs and their complex interactions with cellular processes, which are crucial for understanding the diverse effects of their activity on the genetics and epigenetics of the organism. The interactions of TEs with recombination, replication, repair, and chromosomal regulation; the ability of TEs to maintain a balance between their own activity and repression, the involvement of TEs in the creation of new or alternative genes, the expression of coding/non-coding RNA, and the role in DNA damage and modification of regulatory networks are reviewed. The contribution of the derepressed TEs to age-dependent effects in individual cells/tissues in different organisms was assessed. Conflicting information about TE activity under stress as well as theories of aging mechanisms related to TEs is discussed. On the one hand, transposition activity in response to stressors can lead to organisms acquiring adaptive innovations of great importance for evolution at the population level. On the other hand, the TE expression can cause decreased longevity and stress tolerance at the individual level. The specific features of TE effects on aging processes in germline and soma and the ways of their regulation in cells are highlighted. Recent results considering somatic mutations in normal human and animal tissues are indicated, with the emphasis on their possible functional consequences. In the context of aging, the correlation between somatic TE activation and age-related changes in the number of proteins required for heterochromatin maintenance and longevity regulation was analyzed. One of the original features of this review is a discussion of not only effects based on the TEs insertions and the associated consequences for the germline cell dynamics and somatic genome, but also the differences between transposon- and retrotransposon-mediated structural genome changes and possible phenotypic characteristics associated with aging and various age-related pathologies. Based on the analysis of published data, a hypothesis about the influence of the species-specific features of number, composition, and distribution of TEs on aging dynamics of different animal genomes was formulated.
    MeSH term(s) Animals ; Humans ; DNA Transposable Elements/genetics ; Aging/genetics ; Longevity/genetics
    Chemical Substances DNA Transposable Elements
    Language English
    Publishing date 2023-02-10
    Publishing country England
    Document type Journal Article ; Review ; Research Support, Non-U.S. Gov't
    ZDB-ID 2075672-0
    ISSN 1872-9649 ; 1568-1637
    ISSN (online) 1872-9649
    ISSN 1568-1637
    DOI 10.1016/j.arr.2023.101881
    Database MEDical Literature Analysis and Retrieval System OnLINE

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