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  1. Book: Interferon: the 50th anniversary

    Pitha, Paula M.

    with 8 tables

    (Current topics in microbiology and immunology ; 316)

    2007  

    Author's details Paula M. Pitha (ed.)
    Series title Current topics in microbiology and immunology ; 316
    Collection
    Keywords Interferon
    Language English
    Size VI, 391 S. : Ill., graph. Darst.
    Publisher Springer
    Publishing place Berlin u.a.
    Publishing country Germany
    Document type Book
    HBZ-ID HT015291793
    ISBN 978-3-540-71328-9 ; 3-540-71328-X
    Database Catalogue ZB MED Medicine, Health

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    In stock of ZB MED Cologne/Königswinter

    Shelf markLoan statusLocation
    Ud II Zs 24 -316- verfügbar in Königswinter Königswinter

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  2. Article ; Online: Innate antiviral response: role in HIV-1 infection.

    Pitha, Paula M

    Viruses

    2011  Volume 3, Issue 7, Page(s) 1179–1203

    Abstract: As an early response to infection, cells induce a profile of the early inflammatory proteins including antiviral cytokines and chemokines. Two families of transcriptional factors play a major role in the transcriptional activation of the early ... ...

    Abstract As an early response to infection, cells induce a profile of the early inflammatory proteins including antiviral cytokines and chemokines. Two families of transcriptional factors play a major role in the transcriptional activation of the early inflammatory genes: The well-characterized family of NFkB factors and the family of interferon regulatory factors (IRF). The IRFs play a critical role in the induction of type I interferon (IFN) and chemokine genes, as well as genes mediating antiviral, antibacterial, and inflammatory responses. Type I IFNs represent critical components of innate antiviral immunity. These proteins not only exert direct antiviral effects, but also induce maturation of dendritic cells (DC), and enhance functions of NK, T and B cells, and macrophages. This review will summarize the current knowledge of the mechanisms leading to the innate antiviral response with a focus on its role in the regulation of HIV-1 infection and pathogenicity. We would like this review to be both historical and a future perspective.
    MeSH term(s) Animals ; Cytokines/immunology ; HIV Infections/immunology ; HIV Infections/virology ; HIV-1/immunology ; Humans ; Immunity, Innate/immunology
    Chemical Substances Cytokines
    Language English
    Publishing date 2011-07-14
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2516098-9
    ISSN 1999-4915 ; 1999-4915
    ISSN (online) 1999-4915
    ISSN 1999-4915
    DOI 10.3390/v3071179
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: My interferon years.

    Pitha, Paula M

    Journal of interferon & cytokine research : the official journal of the International Society for Interferon and Cytokine Research

    2008  Volume 28, Issue 12, Page(s) 699–702

    MeSH term(s) History, 20th Century ; History, 21st Century ; Interferons/history
    Chemical Substances Interferons (9008-11-1)
    Language English
    Publishing date 2008-12
    Publishing country United States
    Document type Biography ; Historical Article ; Journal Article ; Portraits
    ZDB-ID 1226675-9
    ISSN 1557-7465 ; 1079-9907
    ISSN (online) 1557-7465
    ISSN 1079-9907
    DOI 10.1089/jir.2008.2812.hp
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1748: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  4. Article ; Online: Innate Antiviral Response

    Paula M. Pitha

    Viruses, Vol 3, Iss 7, Pp 1179-

    Role in HIV-1 Infection

    2011  Volume 1203

    Abstract: As an early response to infection, cells induce a profile of the early inflammatory proteins including antiviral cytokines and chemokines. Two families of transcriptional factors play a major role in the transcriptional activation of the early ... ...

    Abstract As an early response to infection, cells induce a profile of the early inflammatory proteins including antiviral cytokines and chemokines. Two families of transcriptional factors play a major role in the transcriptional activation of the early inflammatory genes: The well-characterized family of NFkB factors and the family of interferon regulatory factors (IRF). The IRFs play a critical role in the induction of type I interferon (IFN) and chemokine genes, as well as genes mediating antiviral, antibacterial, and inflammatory responses. Type I IFNs represent critical components of innate antiviral immunity. These proteins not only exert direct antiviral effects, but also induce maturation of dendritic cells (DC), and enhance functions of NK, T and B cells, and macrophages. This review will summarize the current knowledge of the mechanisms leading to the innate antiviral response with a focus on its role in the regulation of HIV-1 infection and pathogenicity. We would like this review to be both historical and a future perspective.
    Keywords virus ; HIV-1 ; interferon ; IRF ; innate immune response ; Microbiology ; QR1-502 ; Science ; Q ; DOAJ:Microbiology ; DOAJ:Biology ; DOAJ:Biology and Life Sciences
    Subject code 570
    Language English
    Publishing date 2011-07-01T00:00:00Z
    Publisher MDPI AG
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  5. Article ; Online: Role of hsp90 in systemic lupus erythematosus and its clinical relevance.

    Shukla, Hem D / Pitha, Paula M

    Autoimmune diseases

    2012  Volume 2012, Page(s) 728605

    Abstract: Heat shock proteins (HSP) are a family of ubiquitous and phylogenically highly conserved proteins which play an essential role as molecular chaperones in protein folding and transport. Heat Shock Protein 90 (Hsp90) is not mandatory for the biogenesis of ... ...

    Abstract Heat shock proteins (HSP) are a family of ubiquitous and phylogenically highly conserved proteins which play an essential role as molecular chaperones in protein folding and transport. Heat Shock Protein 90 (Hsp90) is not mandatory for the biogenesis of most proteins, rather it participate in structural maturation and conformational regulation of a number of signaling molecules and transcription factors. Hsp90 has been shown to play an important role in antigen presentation, activation of lymphocytes, macrophages, maturation of dendritic cells, and in the enhanceosome mediated induction of inflammation. Systemic lupus erythematosus (SLE) is a chronic autoimmune inflammatory disease with complex immunological and clinical manifestations. Dysregulated expression of Type I interferon α, activation of B cells and production of autoantibodies are hallmarks of SLE. The enhanced levels of Hsp90 were detected in the serum of SLE patients. The elevated level of Hsp90 in SLE has also been correlated with increased levels of IL-6 and presence of autoantibodies to Hsp90. This suggests that Hsp90 may contribute to the inflammation and disease progression and that targeting of Hsp 90 expression may be a potential treatment of SLE. The pharmacologic inhibition of Hsp90 was successfully applied in mouse models of autoimmune encephalomyelitis and SLE-like autoimmune diseases. Thus targeting Hsp90 may be an effective treatment for SLE, especially if combined with other targeted therapeutic approaches.
    Language English
    Publishing date 2012-10-04
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2573894-X
    ISSN 2090-0430 ; 2090-0430
    ISSN (online) 2090-0430
    ISSN 2090-0430
    DOI 10.1155/2012/728605
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article: Unexpected similarities in cellular responses to bacterial and viral invasion.

    Pitha, Paula M

    Proceedings of the National Academy of Sciences of the United States of America

    2004  Volume 101, Issue 3, Page(s) 695–696

    MeSH term(s) Animals ; Bacterial Infections/immunology ; Bacterial Infections/metabolism ; DNA-Binding Proteins/metabolism ; Humans ; I-kappa B Kinase ; Immunity, Cellular ; Immunity, Innate ; Interferon Regulatory Factor-3 ; Membrane Glycoproteins/metabolism ; Models, Immunological ; Protein-Serine-Threonine Kinases/metabolism ; Receptors, Cell Surface/metabolism ; Signal Transduction ; Toll-Like Receptors ; Transcription Factors/metabolism ; Virus Diseases/immunology ; Virus Diseases/metabolism
    Chemical Substances DNA-Binding Proteins ; IRF3 protein, human ; Interferon Regulatory Factor-3 ; Membrane Glycoproteins ; Receptors, Cell Surface ; Toll-Like Receptors ; Transcription Factors ; Protein-Serine-Threonine Kinases (EC 2.7.11.1) ; TBK1 protein, human (EC 2.7.11.1) ; CHUK protein, human (EC 2.7.11.10) ; I-kappa B Kinase (EC 2.7.11.10) ; IKBKB protein, human (EC 2.7.11.10) ; IKBKE protein, human (EC 2.7.11.10)
    Language English
    Publishing date 2004-01-20
    Publishing country United States
    Document type Journal Article ; Comment
    ZDB-ID 209104-5
    ISSN 1091-6490 ; 0027-8424
    ISSN (online) 1091-6490
    ISSN 0027-8424
    DOI 10.1073/pnas.0307303101
    Database MEDical Literature Analysis and Retrieval System OnLINE

    Full text online

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1148: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  7. Article ; Online: Life devoted to viruses and interferon: Charles Chany (1920-2013).

    Lebon, Pierre / Pitha-Rowe, Paula M

    Journal of interferon & cytokine research : the official journal of the International Society for Interferon and Cytokine Research

    2013  Volume 33, Issue 10, Page(s) 549–550

    MeSH term(s) France ; History, 20th Century ; History, 21st Century ; Interferons/history ; United States ; Viruses
    Chemical Substances Interferons (9008-11-1)
    Language English
    Publishing date 2013-10-01
    Publishing country United States
    Document type Biography ; Historical Article ; Journal Article ; Portrait
    ZDB-ID 1226675-9
    ISSN 1557-7465 ; 1079-9907
    ISSN (online) 1557-7465
    ISSN 1079-9907
    DOI 10.1089/jir.2013.1502
    Database MEDical Literature Analysis and Retrieval System OnLINE

    Full text online

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1748: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  8. Article ; Online: Distinct roles of Kaposi's sarcoma-associated herpesvirus-encoded viral interferon regulatory factors in inflammatory response and cancer.

    Baresova, Petra / Pitha, Paula M / Lubyova, Barbora

    Journal of virology

    2013  Volume 87, Issue 17, Page(s) 9398–9410

    Abstract: Kaposi's sarcoma-associated herpesvirus (KSHV) is the etiologic agent associated with Kaposi's sarcoma (KS), primary effusion lymphoma (PEL), and multicentric Castleman disease (MCD). Similar to other herpesviruses, KSHV has two life cycles, latency and ... ...

    Abstract Kaposi's sarcoma-associated herpesvirus (KSHV) is the etiologic agent associated with Kaposi's sarcoma (KS), primary effusion lymphoma (PEL), and multicentric Castleman disease (MCD). Similar to other herpesviruses, KSHV has two life cycles, latency and lytic replication. In latency, the KSHV genome persists as a circular episome in the nucleus of the host cell and only a few viral genes are expressed. In this review, we focus on oncogenic, antiapoptotic, and immunomodulating properties of KSHV-encoded homologues of cellular interferon regulatory factors (IRFs)--viral IRF1 (vIRF1) to vIRF4--and their possible role in the KSHV-mediated antiviral response, apoptosis, and oncogenicity.
    MeSH term(s) Apoptosis ; Carcinogenesis ; Genes, Viral ; Herpesvirus 8, Human/genetics ; Herpesvirus 8, Human/immunology ; Herpesvirus 8, Human/pathogenicity ; Humans ; Inflammation/etiology ; Interferon Regulatory Factors/genetics ; Interferon Regulatory Factors/immunology ; Interferons/metabolism ; Models, Biological ; Multigene Family ; Signal Transduction ; Viral Proteins/genetics ; Viral Proteins/immunology
    Chemical Substances Interferon Regulatory Factors ; Viral Proteins ; viral interferon regulatory factors ; Interferons (9008-11-1)
    Language English
    Publishing date 2013-06-19
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Review
    ZDB-ID 80174-4
    ISSN 1098-5514 ; 0022-538X
    ISSN (online) 1098-5514
    ISSN 0022-538X
    DOI 10.1128/JVI.03315-12
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 609: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

    Order via subito

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  9. Book: Interferon

    Pitha, Paula M

    the 50th anniversary

    (Current topics in microbiology and immunology, ; 316)

    2007  

    Author's details Paula M. Pitha, ed
    Series title Current topics in microbiology and immunology, ; 316
    Keywords Interferon.
    Language English
    Size vi, 391 p. :, ill. ;, 24 cm.
    Publisher Springer
    Publishing place Berlin ; New York
    Document type Book
    ISBN 9783540713289 ; 354071328X
    Database NAL-Catalogue (AGRICOLA)

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    Inter-library loan at ZB MED

    Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

  10. Book: Interferon

    Pitha, Paula M

    the 50th anniversary

    (Current topics in microbiology and immunology, ; 316)

    2007  

    Author's details Paula M. Pitha, ed
    Series title Current topics in microbiology and immunology, ; 316
    MeSH term(s) Interferon Type I
    Language English
    Size vi, 391 p. :, ill.
    Publisher Springer
    Publishing place Berlin ; New York
    Document type Book
    ISBN 9783540713289 ; 354071328X
    Database Catalogue of the US National Library of Medicine (NLM)

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    Kategorien

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

    Inter-library loan at ZB MED

    Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

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