LIVIVO - Search results -

Search results

Result 1 - 10 of total 144

Search options

Article ; Online: Meeting report

Rana P. Singh / Raymond B. Birge / Dhyan Chandra

Cell Communication and Signaling, Vol 21, Iss 1, Pp 1-

International Symposium on Mitochondria, Cell Death and Human Diseases: Jawaharlal Nehru University, New Delhi, India, February 18–19, 2023

2023 Volume 3

Abstract: Abstract The School of Life Sciences at the Jawaharlal Nehru University in New Delhi, India held an International Symposium on Mitochondria, Cell Death and Human Diseases on February 18–19, 2023. The meeting provided a highly interactive forum for ... ...

Abstract	Abstract The School of Life Sciences at the Jawaharlal Nehru University in New Delhi, India held an International Symposium on Mitochondria, Cell Death and Human Diseases on February 18–19, 2023. The meeting provided a highly interactive forum for scientific discussion, cultural exchange, and collaborations between international scientists working in diverse areas of mitochondrial biology, cell death, and cancer. The two-day symposium attracted more than 180 delegates that included leading international scientists, early career researchers in India, as well as postdoctoral fellows and students. Several of the students, postdoctoral fellows, and junior faculty presented platform talks and had a chance to showcase the depth and emerging progress in biomedical research in India. The meeting will be instrumental for planning future congresses and symposium throughout India, not only to focus on mitochondrial biology, cell death and cancer but to foster continued ferment and collaborations in the biological sciences throughout India.
Keywords	Medicine ; R ; Cytology ; QH573-671
Subject code	950
Language	English
Publishing date	2023-06-01T00:00:00Z
Publisher	BMC
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

Full text online

Full text

Inter-library loan at ZB MED

Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

Article ; Online: Activation of retinal ganglion cells using a biomimetic artificial retina.

Greco, Jordan A / Wagner, Nicole L / Jensen, Ralph J / Lawrence, Daniel B / Ranaghan, Matthew J / Sandberg, Megan N / Sandberg, Daniel J / Birge, Robert R

Journal of neural engineering

2021 Volume 18, Issue 6

Abstract: Objective. ...

Abstract	Objective.
MeSH term(s)	Animals ; Biomimetics ; Humans ; Light ; Rats ; Retina/physiology ; Retinal Degeneration/therapy ; Retinal Ganglion Cells/physiology ; Retinitis Pigmentosa
Language	English
Publishing date	2021-12-01
Publishing country	England
Document type	Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't ; Research Support, U.S. Gov't, Non-P.H.S.
ZDB-ID	2170901-4
ISSN	1741-2552 ; 1741-2560
ISSN (online)	1741-2552
ISSN	1741-2560
DOI	10.1088/1741-2552/ac395c
Database	MEDical Literature Analysis and Retrieval System OnLINE

In stock of ZB MED Cologne/Königswinter

Zs.A 6071: Show issues

Location:
Je nach Verfügbarkeit (siehe Angabe bei Bestand)
bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
ab Jg. 2022: Lesesaal (EG)

Order via subito

This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

Details ▾
- See ZB MED holdings
- Order with fees

Article ; Online: Modeling of a spatially resolved ion temperature diagnostic for inertial confinement fusion.

Danly, C R / Birge, N / Geppert-Kleinrath, V / Haines, B M / Ivancic, S / Jorgenson, H J / Katz, J / Merrill, F E / Mendoza, E F / Sorce, A / Tafoya, L R / Volegov, P L / Wilde, C H / Wilson, D C

The Review of scientific instruments

2023 Volume 94, Issue 4

Abstract: The performance of modern laser-driven inertial confinement fusion (ICF) experiments is degraded by contamination of the deuterium-tritium (DT) fuel with high-Z material during compression. Simulations suggest that this mix can be described by the ion ... ...

Abstract	The performance of modern laser-driven inertial confinement fusion (ICF) experiments is degraded by contamination of the deuterium-tritium (DT) fuel with high-Z material during compression. Simulations suggest that this mix can be described by the ion temperature distribution of the implosion, given that such contaminants deviate in temperature from the surrounding DT plasma. However, existing neutron time-of-flight (nTOF) diagnostics only measure the spatially integrated ion temperature. This paper describes the techniques and forward modeling used to develop a novel diagnostic imaging system to measure the spatially resolved ion temperature of an ICF implosion for the first time. The technique combines methods in neutron imaging and nTOF diagnostics to measure the ion temperature along one spatial dimension at yields currently achievable on the OMEGA laser. A detailed forward model of the source and imaging system was developed to guide instrument design. The model leverages neutron imaging reconstruction algorithms, radiation hydrodynamics and Monte Carlo simulations, optical ray tracing, and more. The results of the forward model agree with the data collected on OMEGA using the completed diagnostic. The analysis of the experimental data is still ongoing and will be discussed in a separate publication.
Language	English
Publishing date	2023-12-12
Publishing country	United States
Document type	Journal Article
ZDB-ID	209865-9
ISSN	1089-7623 ; 0034-6748
ISSN (online)	1089-7623
ISSN	0034-6748
DOI	10.1063/5.0101892
Database	MEDical Literature Analysis and Retrieval System OnLINE

In stock of ZB MED Bonn / Germany

Z 4' 46/112: Show issues

Order via subito

Inter-library loan at ZB MED

Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

Details ▾
- See ZB MED holdings
- Order with fees

Article ; Online: Dual Axl/MerTK inhibitor INCB081776 creates a proinflammatory tumor immune microenvironment and enhances anti-PDL1 efficacy in head and neck cancer.

Kostecki, Kourtney L / Iida, Mari / Wiley, Anne L / Kimani, Stanley / Mehall, Bridget / Tetreault, Kaitlin / Alexandridis, Roxana / Yu, Menggang / Hong, Seungpyo / Salgia, Ravi / Bruce, Justine Y / Birge, Raymond B / Harari, Paul M / Wheeler, Deric L

Head & neck

2023 Volume 45, Issue 5, Page(s) 1255–1271

Abstract: Background: The tyrosine kinase receptors Axl and MerTK are highly overexpressed in head and neck cancer (HNC) cells, where they are critical drivers of survival, proliferation, metastasis, and therapeutic resistance.: Methods: We investigated the ... ...

Abstract	Background: The tyrosine kinase receptors Axl and MerTK are highly overexpressed in head and neck cancer (HNC) cells, where they are critical drivers of survival, proliferation, metastasis, and therapeutic resistance. Methods: We investigated the role of Axl and MerTK in creating an immunologically "cold" tumor immune microenvironment (TIME) by targeting both receptors simultaneously with a small molecule inhibitor of Axl and MerTK (INCB081776). Effects of INCB081776 and/or anti-PDL1 on mouse oral cancer (MOC) cell growth and on the TIME were evaluated. Results: Targeting Axl and MerTK can reduce M Conclusions: This data indicates that simultaneous targeting of Axl and MerTK with INCB081776, either alone or in combination with anti-PDL1, slows tumor growth and creates a proinflammatory TIME in mouse models of HNC.
MeSH term(s)	Animals ; Mice ; c-Mer Tyrosine Kinase ; Cell Line, Tumor ; Head and Neck Neoplasms ; Protein Kinase Inhibitors/pharmacology ; Proto-Oncogene Proteins ; Tumor Microenvironment
Chemical Substances	atezolizumab (52CMI0WC3Y) ; c-Mer Tyrosine Kinase (EC 2.7.10.1) ; Mertk protein, mouse (EC 2.7.10.1) ; Protein Kinase Inhibitors ; Proto-Oncogene Proteins ; AXL receptor tyrosine kinase, mouse
Language	English
Publishing date	2023-03-20
Publishing country	United States
Document type	Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
ZDB-ID	645165-2
ISSN	1097-0347 ; 0148-6403 ; 1043-3074
ISSN (online)	1097-0347
ISSN	0148-6403 ; 1043-3074
DOI	10.1002/hed.27340
Database	MEDical Literature Analysis and Retrieval System OnLINE

In stock of ZB MED Cologne/Königswinter

Zs.A 1493: Show issues

Location:
Je nach Verfügbarkeit (siehe Angabe bei Bestand)
bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
Jg. 1995 - 2021: Lesesall (1.OG)
ab Jg. 2022: Lesesaal (EG)

Order via subito

Details ▾
- See ZB MED holdings
- Order with fees

Article ; Online: Biology of phosphatidylserine (PS)

David C. Calianese / Raymond B. Birge

Cell Communication and Signaling, Vol 18, Iss 1, Pp 1-

basic physiology and implications in immunology, infectious disease, and cancer

2020 Volume 5

Abstract: Abstract Phosphatidylserine (PS) is an anionic phospholipid found on the membranes of a variety of organelles throughout the cell, most notably the plasma membrane. Under homeostatic conditions, PS is typically restricted to the inner leaflet of the ... ...

Abstract	Abstract Phosphatidylserine (PS) is an anionic phospholipid found on the membranes of a variety of organelles throughout the cell, most notably the plasma membrane. Under homeostatic conditions, PS is typically restricted to the inner leaflet of the plasma membrane. However, during cellular activation and/or induction of cell death, PS is externalized on the outer surface via the activation of phospholipid scramblases. Externalized PS not only changes the biochemical and biophysical properties of the plasma membrane but also initiates a series of interactions between endogenous extracellular proteins as well as receptors on neighboring cells to stimulate engulfment (efferocytosis) that influence the surrounding immune milieu. In this thematic series published in Cell Communication and Signaling, we feature review articles that highlight recent work in the field of PS biology, including the biochemistry and physiological significance of PS externalization, therapeutic applications and efforts to target PS, as well as posit open questions that remain in the field.
Keywords	Medicine ; R ; Cytology ; QH573-671
Subject code	571
Language	English
Publishing date	2020-03-01T00:00:00Z
Publisher	BMC
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

Full text online

Full text

Inter-library loan at ZB MED

Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

Article ; Online: International conference on Cell Death in Cancer and Toxicology 2018 (CDCT-2018).

Ansari, Kausar M / Arany, Praveen R / Arama, Eli / Larisch, Sarit / Birge, Raymond B / Chandra, Dhyan

Cell communication and signaling : CCS

2018 Volume 16, Issue 1, Page(s) 34

Abstract: The International Conference on Cell Death in Cancer and Toxicology 2018 (February 20-22, 2018) provided an international forum for scientific collaborations across multiple disciplines in cancer, cell death, and toxicology. During the three-day ... ...

Abstract	The International Conference on Cell Death in Cancer and Toxicology 2018 (February 20-22, 2018) provided an international forum for scientific collaborations across multiple disciplines in cancer, cell death, and toxicology. During the three-day symposium, researchers and clinicians shared recent advances in basic, clinical, and translational research in cancer. Several student poster abstracts were selected for platform talks and many young investigators participated in the meeting. Together, this highly interactive meeting showcased the rapid expansion in biomedical research in India and paved the way for future meetings on cell death and cancer throughout India.
MeSH term(s)	Cell Death ; Internationality ; Neoplasms/pathology ; Toxicology ; Translational Medical Research
Language	English
Publishing date	2018-06-28
Publishing country	England
Document type	Congress
ISSN	1478-811X
ISSN (online)	1478-811X
DOI	10.1186/s12964-018-0238-x
Database	MEDical Literature Analysis and Retrieval System OnLINE

Order via subito

Inter-library loan at ZB MED

Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

Article ; Online: Bootstrap estimation of the effect of instrument response function uncertainty on the reconstruction of fusion neutron sources.

Lamb, Kevin M / Geppert-Kleinrath, Verena / Birge, Noah W / Danly, Christopher R / Divol, Laurent / Fittinghoff, David N / Freeman, Matthew S / Pak, Arthur E / Wilde, Carl H / Zylstra, Alex B / Volegov, Petr L

The Review of scientific instruments

2021 Volume 93, Issue 4, Page(s) 43508

Abstract: Neutron imagers are important diagnostics for the inertial confinement fusion implosions at the National Ignition Facility. They provide two- and three-dimensional reconstructions of the neutron source shape that are key indicators of the overall ... ...

Abstract	Neutron imagers are important diagnostics for the inertial confinement fusion implosions at the National Ignition Facility. They provide two- and three-dimensional reconstructions of the neutron source shape that are key indicators of the overall performance. To interpret the shape results properly, it is critical to estimate the uncertainty in those reconstructions. There are two main sources of uncertainties: limited neutron statistics, leading to random errors in the reconstructed images, and incomplete knowledge of the instrument response function (the pinhole-dependent point spread function). While the statistical errors dominate the uncertainty for lower yield deuterium-tritium (DT) shots, errors due to the instrument response function dominate the uncertainty for DT yields on the order of 10
Language	English
Publishing date	2021-04-05
Publishing country	United States
Document type	Journal Article
ZDB-ID	209865-9
ISSN	1089-7623 ; 0034-6748
ISSN (online)	1089-7623
ISSN	0034-6748
DOI	10.1063/5.0086450
Database	MEDical Literature Analysis and Retrieval System OnLINE

In stock of ZB MED Bonn / Germany

Z 4' 46/112: Show issues

Order via subito

Inter-library loan at ZB MED

Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

Details ▾
- See ZB MED holdings
- Order with fees

Article: Mertk: An emerging target in cancer biology and immuno-oncology.

Lahey, Kevin C / Gadiyar, Varsha / Hill, Amanda / Desind, Samuel / Wang, Ziren / Davra, Viralkumar / Patel, Radhey / Zaman, Ahnaf / Calianese, David / Birge, Raymond B

International review of cell and molecular biology

2022 Volume 368, Page(s) 35–59

Abstract: Mertk, a type I Receptor Tyrosine Kinase (RTK) and member of the TAM (Tyro3, Axl, and Mertk) family of homologous tyrosine kinases, has important roles in signal transduction both homeostatically on normal cells as well as patho-physiologically on both ... ...

Abstract	Mertk, a type I Receptor Tyrosine Kinase (RTK) and member of the TAM (Tyro3, Axl, and Mertk) family of homologous tyrosine kinases, has important roles in signal transduction both homeostatically on normal cells as well as patho-physiologically on both tumor-associated macrophages and malignant cells by its overexpression in a wide array of cancers. The main ligands of Mertk are Vitamin K-modified endogenous proteins Gas6 and Protein S (ProS1), heterobifunctional modular proteins that bind Mertk via two carboxyl-terminal laminin-like globular (LG) domains, and an N-terminal Gla domain that binds anionic phospholipids, whereby externalized phosphatidylserine (PS) on stressed viable and caspase-activated apoptotic cells is most emblematic. Recent studies indicate that Vitamin K-dependent γ-carboxylation on the N-terminal Gla domain of Gas6 and Protein S is necessary for PS binding and Mertk activation, implying that Mertk is preferentially active in tissues where there is high externalized PS, such as the tumor microenvironment (TME) and acute virally infected tissues. Once stimulated, activated Mertk can provide a survival advantage for cancer cells as well as drive compensatory proliferation. On monocytes and tumor-associated macrophages, Mertk promotes efferocytosis and acts as an inhibitory receptor that impairs host anti-tumor immunity, functioning akin to a myeloid checkpoint inhibitor. In recent years, inhibition of Mertk has been implicated in a dual role to enhance the sensitivity of cancer cells to cytotoxic agents along with improving host anti-tumor immunity with anti-PD-1/PD-L1 immunotherapy. Here, we examine the rationale of Mertk-targeted immunotherapies, the current and potential therapeutic strategies, the clinical status of Mertk-specific therapies, and potential challenges and obstacles for Mertk-focused therapies.
MeSH term(s)	Biology ; Humans ; Neoplasms/therapy ; Protein S ; Proto-Oncogene Proteins/metabolism ; Tumor Microenvironment ; Vitamin K ; c-Mer Tyrosine Kinase/metabolism
Chemical Substances	Protein S ; Proto-Oncogene Proteins ; Vitamin K (12001-79-5) ; MERTK protein, human (EC 2.7.10.1) ; c-Mer Tyrosine Kinase (EC 2.7.10.1)
Language	English
Publishing date	2022-05-05
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	2427220-6
ISSN	1937-6448 ; 0074-7696
ISSN	1937-6448 ; 0074-7696
DOI	10.1016/bs.ircmb.2022.04.004
Database	MEDical Literature Analysis and Retrieval System OnLINE

Full text online

Accessible to users with ZB MED library card

In stock of ZB MED Cologne/Königswinter

Uc I Zs.317: Show issues

Location:
Je nach Verfügbarkeit (siehe Angabe bei Bestand)
bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
ab Jg. 2022: Lesesaal (EG)

Order via subito

Details ▾

Article ; Online: Uterine cervical involvement of non‐Hodgkin lymphoma

Özer Birge / Mehmet Sait Bakır / Can Dinc / Ceyda Karadag / Ahmet Boduroglu / Tayup Simsek

Clinical Case Reports, Vol 9, Iss 6, Pp n/a-n/a (2021)

Rare cause of postcoital bleeding

2021

Abstract: Abstract It should be kept in mind that non‐Hodgkin lymphoma may involve uterine cervix and a multidisciplinary approach should be adopted. ...

Abstract	Abstract It should be kept in mind that non‐Hodgkin lymphoma may involve uterine cervix and a multidisciplinary approach should be adopted.
Keywords	B‐cell lymphoma ; cervix uteri cancer ; non‐Hodgkin lymphoma ; Medicine ; R ; Medicine (General) ; R5-920
Language	English
Publishing date	2021-06-01T00:00:00Z
Publisher	Wiley
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

Full text online

Full text

Inter-library loan at ZB MED

Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

Article ; Online: MerTK signaling in macrophages promotes the synthesis of inflammation resolution mediators by suppressing CaMKII activity.

Cai, Bishuang / Kasikara, Canan / Doran, Amanda C / Ramakrishnan, Rajasekhar / Birge, Raymond B / Tabas, Ira

Science signaling

2018 Volume 11, Issue 549

Abstract: Inflammation resolution counterbalances excessive inflammation and restores tissue homeostasis after injury. Failure of resolution contributes to the pathology of numerous chronic inflammatory diseases. Resolution is mediated by endogenous specialized ... ...

Abstract	Inflammation resolution counterbalances excessive inflammation and restores tissue homeostasis after injury. Failure of resolution contributes to the pathology of numerous chronic inflammatory diseases. Resolution is mediated by endogenous specialized proresolving mediators (SPMs), which are derived from long-chain fatty acids by lipoxygenase (LOX) enzymes. 5-LOX plays a critical role in the biosynthesis of two classes of SPMs: lipoxins and resolvins. Cytoplasmic localization of the nonphosphorylated form of 5-LOX is essential for SPM biosynthesis, whereas nuclear localization of phosphorylated 5-LOX promotes proinflammatory leukotriene production. We previously showed that MerTK, an efferocytosis receptor on macrophages, promotes SPM biosynthesis by increasing the abundance of nonphosphorylated, cytoplasmic 5-LOX. We now show that activation of MerTK in human macrophages led to ERK-mediated expression of the gene encoding sarcoplasmic/endoplasmic reticulum calcium ATPase 2 (SERCA2), which decreased the cytosolic Ca
MeSH term(s)	Animals ; Arachidonate 5-Lipoxygenase/metabolism ; Calcium/metabolism ; Calcium-Calmodulin-Dependent Protein Kinase Type 2/metabolism ; Cytoplasm/metabolism ; Cytosol/metabolism ; Enzyme Activation ; Extracellular Signal-Regulated MAP Kinases/metabolism ; Gene Expression Regulation, Enzymologic ; HEK293 Cells ; Humans ; Inflammation ; Inflammation Mediators/metabolism ; Intercellular Signaling Peptides and Proteins/metabolism ; Jurkat Cells ; Macrophages/cytology ; Macrophages/metabolism ; Mice ; Mice, Inbred C57BL ; Monocytes/cytology ; Neutrophils/metabolism ; Peritonitis/metabolism ; Phosphorylation ; Sarcoplasmic Reticulum Calcium-Transporting ATPases/metabolism ; Signal Transduction ; c-Mer Tyrosine Kinase/metabolism
Chemical Substances	Inflammation Mediators ; Intercellular Signaling Peptides and Proteins ; growth arrest-specific protein 6 ; Arachidonate 5-Lipoxygenase (EC 1.13.11.34) ; MERTK protein, human (EC 2.7.10.1) ; c-Mer Tyrosine Kinase (EC 2.7.10.1) ; Calcium-Calmodulin-Dependent Protein Kinase Type 2 (EC 2.7.11.17) ; Extracellular Signal-Regulated MAP Kinases (EC 2.7.11.24) ; Sarcoplasmic Reticulum Calcium-Transporting ATPases (EC 3.6.3.8) ; ATP2A2 protein, human (EC 7.2.2.10) ; Calcium (SY7Q814VUP)
Language	English
Publishing date	2018-09-25
Publishing country	United States
Document type	Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
ZDB-ID	2417226-1
ISSN	1937-9145 ; 1945-0877
ISSN (online)	1937-9145
ISSN	1945-0877
DOI	10.1126/scisignal.aar3721
Database	MEDical Literature Analysis and Retrieval System OnLINE

Order via subito

To top

Full text online

More links

Kategorien

Inter-library loan at ZB MED

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

More links

Kategorien

In stock of ZB MED Bonn / Germany

Order via subito

Inter-library loan at ZB MED

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

Full text online

More links

Kategorien

Inter-library loan at ZB MED

More links

Kategorien

Order via subito

Inter-library loan at ZB MED

More links

Kategorien

In stock of ZB MED Bonn / Germany

Order via subito

Inter-library loan at ZB MED

Full text online

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

Full text online

More links

Kategorien

Inter-library loan at ZB MED

More links

Kategorien

Order via subito