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  1. Article ; Online: CD109 Pumps Up Type Two Dendritic Cells for Allergic Responses in the Airways.

    Nakano, Hideki / Cook, Donald N

    American journal of respiratory cell and molecular biology

    2022  Volume 68, Issue 2, Page(s) 127–128

    MeSH term(s) Humans ; Hypersensitivity ; Transforming Growth Factor beta ; Asthma ; Dendritic Cells ; Inflammation ; Neoplasm Proteins ; Antigens, CD ; GPI-Linked Proteins
    Chemical Substances Transforming Growth Factor beta ; CD109 protein, human ; Neoplasm Proteins ; Antigens, CD ; GPI-Linked Proteins
    Language English
    Publishing date 2022-08-27
    Publishing country United States
    Document type Editorial ; Research Support, N.I.H., Intramural ; Comment
    ZDB-ID 1025960-0
    ISSN 1535-4989 ; 1044-1549
    ISSN (online) 1535-4989
    ISSN 1044-1549
    DOI 10.1165/rcmb.2022-0405ED
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 2851: Show issues Location:
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  2. Article ; Online: Role of Environmental Adjuvants in Asthma Development.

    Cook, Donald N

    Current allergy and asthma reports

    2020  Volume 20, Issue 9, Page(s) 42

    Abstract: Purpose of review: This review summarizes recent progress in our understanding how environmental adjuvants promote the development of asthma.: Recent findings: Asthma is a heterogeneous set of lung pathologies with overlapping features. Human studies ...

    Abstract Purpose of review: This review summarizes recent progress in our understanding how environmental adjuvants promote the development of asthma.
    Recent findings: Asthma is a heterogeneous set of lung pathologies with overlapping features. Human studies and animal models suggest that exposure to different environmental adjuvants activate distinct immune pathways, which in turn give rise to distinct forms, or endotypes, of allergic asthma. Depending on their concentrations, inhaled TLR ligands can activate either type 2 inflammation, or Th17 differentiation, along with regulatory responses that function to attenuate inflammation. By contrast, a different category of environmental adjuvants, proteases, activate distinct immune pathways and prime predominantly type 2 immune responses. Asthma is not a single disease, but rather a group of pathologies with overlapping features. Different endotypes of asthma likely arise from perturbations of distinct immunologic pathways during allergic sensitization.
    MeSH term(s) Animals ; Asthma/diagnosis ; Asthma/etiology ; Asthma/pathology ; Environmental Exposure/adverse effects ; Humans
    Language English
    Publishing date 2020-06-16
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Intramural ; Review
    ZDB-ID 2057370-4
    ISSN 1534-6315 ; 1529-7322
    ISSN (online) 1534-6315
    ISSN 1529-7322
    DOI 10.1007/s11882-020-00935-3
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    Zs.A 5548: Show issues Location:
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  3. Article ; Online: A new wrinkle for skin dendritic cell migration.

    Cook, Donald N / Nakano, Hideki

    Blood

    2021  Volume 137, Issue 20, Page(s) 2716–2717

    MeSH term(s) Langerhans Cells ; Skin ; Skin Aging
    Language English
    Publishing date 2021-05-18
    Publishing country United States
    Document type Editorial ; Comment
    ZDB-ID 80069-7
    ISSN 1528-0020 ; 0006-4971
    ISSN (online) 1528-0020
    ISSN 0006-4971
    DOI 10.1182/blood.2020010619
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  4. Article ; Online: What's the deal with efferocytosis and asthma?

    Martinez, Jennifer / Cook, Donald N

    Trends in immunology

    2021  Volume 42, Issue 10, Page(s) 904–919

    Abstract: Mucosal sites, such as the lung, serve as crucial, yet vulnerable barriers to environmental insults such as pathogens, allergens, and toxins. Often, these exposures induce massive infiltration and death of short-lived immune cells in the lung, and ... ...

    Abstract Mucosal sites, such as the lung, serve as crucial, yet vulnerable barriers to environmental insults such as pathogens, allergens, and toxins. Often, these exposures induce massive infiltration and death of short-lived immune cells in the lung, and efficient clearance of these cells is important for preventing hyperinflammation and resolving immunopathology. Herein, we review recent advances in our understanding of efferocytosis, a process whereby phagocytes clear dead cells in a noninflammatory manner. We further discuss how efferocytosis impacts the onset and severity of asthma in humans and mammalian animal models of disease. Finally, we explore how recently identified genetic perturbations or biological pathway modulations affect pathogenesis and shed light on novel therapies aimed at treating or preventing asthma.
    MeSH term(s) Animals ; Apoptosis ; Asthma ; Humans ; Inflammation ; Phagocytes ; Phagocytosis
    Language English
    Publishing date 2021-09-06
    Publishing country England
    Document type Journal Article ; Research Support, N.I.H., Intramural ; Review
    ZDB-ID 2036831-8
    ISSN 1471-4981 ; 1471-4906
    ISSN (online) 1471-4981
    ISSN 1471-4906
    DOI 10.1016/j.it.2021.08.004
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  5. Article ; Online: Regulation of Immune Responses by Nonhematopoietic Cells in Asthma.

    Royer, Derek J / Cook, Donald N

    Journal of immunology (Baltimore, Md. : 1950)

    2021  Volume 206, Issue 2, Page(s) 292–301

    Abstract: Nonhematopoietic cells are emerging as important contributors to many inflammatory diseases, including allergic asthma. Recent advances have led to a deeper understanding of how these cells interact with traditional immune cells, thereby modulating their ...

    Abstract Nonhematopoietic cells are emerging as important contributors to many inflammatory diseases, including allergic asthma. Recent advances have led to a deeper understanding of how these cells interact with traditional immune cells, thereby modulating their activities in both homeostasis and disease. In addition to their well-established roles in gas exchange and barrier function, lung epithelial cells express an armament of innate sensors that can be triggered by various inhaled environmental agents, leading to the production of proinflammatory molecules. Advances in cell lineage tracing and single-cell RNA sequencing have expanded our knowledge of rare, but immunologically important nonhematopoietic cell populations. In parallel with these advances, novel reverse genetic approaches are revealing how individual genes in different lung-resident nonhematopoietic cell populations contribute to the initiation and maintenance of asthma. This knowledge is already revealing new pathways that can be selectively targeted to treat distinct forms of asthma.
    MeSH term(s) Animals ; Asthma/immunology ; Cell Communication ; Epithelial Cells/immunology ; Fibroblasts/immunology ; Humans ; Immunity, Innate ; Lung/immunology ; Th2 Cells/immunology
    Language English
    Publishing date 2021-01-04
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Intramural ; Review
    ZDB-ID 3056-9
    ISSN 1550-6606 ; 0022-1767 ; 1048-3233 ; 1047-7381
    ISSN (online) 1550-6606
    ISSN 0022-1767 ; 1048-3233 ; 1047-7381
    DOI 10.4049/jimmunol.2000885
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    Ud II Zs.37: Show issues Location:
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    Zs.MG 28: Show issues

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  6. Article ; Online: (Inverse) Agonists of Retinoic Acid-Related Orphan Receptor γ: Regulation of Immune Responses, Inflammation, and Autoimmune Disease.

    Jetten, Anton M / Cook, Donald N

    Annual review of pharmacology and toxicology

    2019  Volume 60, Page(s) 371–390

    Abstract: Retinoic acid-related orphan receptor γt (RORγt) functions as a ligand-dependent transcription factor that regulates multiple proinflammatory genes and plays a critical role in several inflammatory and autoimmune diseases. Various endogenous and ... ...

    Abstract Retinoic acid-related orphan receptor γt (RORγt) functions as a ligand-dependent transcription factor that regulates multiple proinflammatory genes and plays a critical role in several inflammatory and autoimmune diseases. Various endogenous and synthetic RORγ (inverse) agonists have been identified that regulate RORγ transcriptional activity, including many cholesterol intermediates and oxysterols. Changes in cholesterol biosynthesis and metabolism can therefore have a significant impact on the generation of oxysterol RORγ ligands and, consequently, can control RORγt activity and inflammation. These observations contribute to a growing literature that connects cholesterol metabolism to the regulation of immune responses and autoimmune disease. Loss of RORγ function in knockout mice and in mice treated with RORγ inverse agonists results in reduced production of proinflammatory cytokines, such as IL-17A/F, and increased resistance to autoimmune disease in several experimental rodent models. Thus, RORγt inverse agonists might provide an attractive therapeutic approach to treat a variety of autoimmune diseases.
    MeSH term(s) Animals ; Autoimmune Diseases/drug therapy ; Autoimmune Diseases/immunology ; Cytokines/immunology ; Disease Models, Animal ; Drug Inverse Agonism ; Humans ; Inflammation/drug therapy ; Inflammation/immunology ; Ligands ; Mice ; Mice, Knockout ; Nuclear Receptor Subfamily 1, Group F, Member 3/agonists
    Chemical Substances Cytokines ; Ligands ; Nuclear Receptor Subfamily 1, Group F, Member 3
    Language English
    Publishing date 2019-08-06
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Intramural ; Review
    ZDB-ID 196587-6
    ISSN 1545-4304 ; 0362-1642
    ISSN (online) 1545-4304
    ISSN 0362-1642
    DOI 10.1146/annurev-pharmtox-010919-023711
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  7. Article ; Online: Breathing can be dangerous: Opportunistic fungal pathogens and the diverse community of the small mammal lung mycobiome.

    Salazar-Hamm, Paris S / Montoya, Kyana N / Montoya, Liliam / Cook, Kel / Liphardt, Schuyler / Taylor, John W / Cook, Joseph A / Natvig, Donald O

    Frontiers in fungal biology

    2022  Volume 3, Page(s) 996574

    Abstract: Human lung mycobiome studies typically sample bronchoalveolar lavage or sputum, potentially overlooking fungi embedded in tissues. Employing ultra-frozen lung tissues from biorepositories, we obtained fungal ribosomal RNA ITS2 sequences from 199 small ... ...

    Abstract Human lung mycobiome studies typically sample bronchoalveolar lavage or sputum, potentially overlooking fungi embedded in tissues. Employing ultra-frozen lung tissues from biorepositories, we obtained fungal ribosomal RNA ITS2 sequences from 199 small mammals across 39 species. We documented diverse fungi, including common environmental fungi such as
    Language English
    Publishing date 2022-09-26
    Publishing country Switzerland
    Document type Journal Article
    ISSN 2673-6128
    ISSN (online) 2673-6128
    DOI 10.3389/ffunb.2022.996574
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  8. Article ; Online: Grassroots and Digital Outreach Strategies Raise Awareness of COVID-19 Information and Research in Baltimore City.

    Miller, Hailey N / Stevens, Sarah C / Young, Donald / Lacanienta, Cyd T / Tomiwa, Tosin / Vazquez, Monica Guerrero / Olawole, Wura / Zhu, Trinity / Lewis-Land, Cassie / Clark, Roger / Peeler, Anna / Byiringiro, Samuel / Cook, Brittany / Weston, Christine / Bronner, Yvonne / Rich, Tim / Himmelfarb, Cheryl R

    American journal of public health

    2024  Volume 114, Issue S1, Page(s) S69–S73

    Abstract: We aimed to disseminate reliable COVID-19 information to the Black and Latino communities of Baltimore City, Maryland, between July 2020 and December 2022. With community partners, we disseminated evidence-based COVID-19 information via grassroots and ... ...

    Abstract We aimed to disseminate reliable COVID-19 information to the Black and Latino communities of Baltimore City, Maryland, between July 2020 and December 2022. With community partners, we disseminated evidence-based COVID-19 information via grassroots and digital strategies, including Hopkins Opportunity for Participant Engagement, and connected volunteers to COVID-19 research. Using a multimodal approach facilitated dissemination of reliable information and raised awareness of research; evaluation of trust is ongoing. Robust, multimodal strategies are needed to foster trust and equity among diverse communities. (
    MeSH term(s) Humans ; Baltimore ; COVID-19 ; Hispanic or Latino ; Trust ; Black or African American ; Information Dissemination
    Language English
    Publishing date 2024-01-11
    Publishing country United States
    Document type Journal Article
    ZDB-ID 121100-6
    ISSN 1541-0048 ; 0090-0036 ; 0002-9572
    ISSN (online) 1541-0048
    ISSN 0090-0036 ; 0002-9572
    DOI 10.2105/AJPH.2023.307492
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  9. Article ; Online: Chemokine CCL19 promotes type 2 T-cell differentiation and allergic airway inflammation.

    Nakano, Keiko / Whitehead, Gregory S / Lyons-Cohen, Miranda R / Grimm, Sara A / Wilkinson, Christina L / Izumi, Gentaro / Livraghi-Butrico, Alessandra / Cook, Donald N / Nakano, Hideki

    The Journal of allergy and clinical immunology

    2023  Volume 153, Issue 2, Page(s) 487–502.e9

    Abstract: Background: Allergic asthma is driven largely by allergen-specific T: Objective: This study sought to define the role of CCL19 in T: Methods: Ccl19-deficient mice were studied in an animal model of allergic asthma. Dendritic cells or fibroblastic ... ...

    Abstract Background: Allergic asthma is driven largely by allergen-specific T
    Objective: This study sought to define the role of CCL19 in T
    Methods: Ccl19-deficient mice were studied in an animal model of allergic asthma. Dendritic cells or fibroblastic reticular cells from wild-type and Ccl19-deficient mice were cultured with naive CD4
    Results: Lungs of Ccl19-deficient mice had less allergic airway inflammation, reduced airway hyperresponsiveness, and less IL-4 and IL-13 production compared with lungs of Ccl19-sufficient animals. Naive CD4
    Conclusions: These results reveal a novel, T
    MeSH term(s) Animals ; Mice ; Chemokine CCL19/genetics ; Receptors, CCR7 ; Ligands ; Asthma/genetics ; Inflammation/pathology ; Lung ; Hypersensitivity/metabolism ; Allergens/metabolism ; Cell Differentiation ; Th2 Cells ; Dendritic Cells
    Chemical Substances Chemokine CCL19 ; Receptors, CCR7 ; Ligands ; Allergens
    Language English
    Publishing date 2023-11-11
    Publishing country United States
    Document type Journal Article
    ZDB-ID 121011-7
    ISSN 1097-6825 ; 1085-8725 ; 0091-6749
    ISSN (online) 1097-6825 ; 1085-8725
    ISSN 0091-6749
    DOI 10.1016/j.jaci.2023.10.024
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  10. Article ; Online: Alicyclic Ring Size Variation of 4-Phenyl-2-naphthoic Acid Derivatives as P2Y

    Wen, Zhiwei / Pramanik, Asmita / Lewicki, Sarah A / Jung, Young-Hwan / Gao, Zhan-Guo / Randle, John C R / Cronin, Chunxia / Chen, Zhoumou / Giancotti, Luigino A / Whitehead, Gregory S / Liang, Bruce T / Breton, Sylvie / Salvemini, Daniela / Cook, Donald N / Jacobson, Kenneth A

    Journal of medicinal chemistry

    2023  Volume 66, Issue 13, Page(s) 9076–9094

    Abstract: ... ...

    Abstract P2Y
    MeSH term(s) Mice ; Animals ; Receptors, Purinergic P2/metabolism ; Naphthalenes/pharmacology ; Naphthalenes/therapeutic use ; Uridine Diphosphate Glucose/metabolism
    Chemical Substances 2-naphthoic acid (QLG01V0W2L) ; Receptors, Purinergic P2 ; Naphthalenes ; Uridine Diphosphate Glucose (V50K1D7P4Y)
    Language English
    Publishing date 2023-06-29
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, N.I.H., Intramural ; Research Support, Non-U.S. Gov't
    ZDB-ID 218133-2
    ISSN 1520-4804 ; 0022-2623
    ISSN (online) 1520-4804
    ISSN 0022-2623
    DOI 10.1021/acs.jmedchem.3c00664
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