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Article ; Online: Seeing through the Smoke: Clearing Up the Link between Donor Smoke Exposure and Lung Transplant Outcomes.

Bermea, Rene S / Keller, Brian C

American journal of respiratory and critical care medicine

2023 Volume 209, Issue 1, Page(s) 12–13

MeSH term(s)	Humans ; Primary Graft Dysfunction ; Lung Transplantation ; Smoking
Language	English
Publishing date	2023-12-10
Publishing country	United States
Document type	Editorial ; Comment
ZDB-ID	1180953-x
ISSN	1535-4970 ; 0003-0805 ; 1073-449X
ISSN (online)	1535-4970
ISSN	0003-0805 ; 1073-449X
DOI	10.1164/rccm.202310-1803ED
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Article: Reduced Community-acquired Respiratory Virus Infection, but Not Non-virus Infection, in Lung Transplant Recipients During Government-mandated Public Health Measures to Reduce COVID-19 Transmission.

Keller, Brian C / Ma, Jianing / Peng, Jing / Ramsammy, Verai

Transplantation direct

2023 Volume 9, Issue 3, Page(s) e1445

Abstract: Community-acquired respiratory viruses (CARVs) are an important cause of morbidity and mortality in lung transplant (LTx) recipients. Despite routine mask-wearing, LTx patients remain at a higher risk of CARV infection than the general population. In ... ...

Abstract	Community-acquired respiratory viruses (CARVs) are an important cause of morbidity and mortality in lung transplant (LTx) recipients. Despite routine mask-wearing, LTx patients remain at a higher risk of CARV infection than the general population. In 2019, severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the causative agent of COVID-19 and a novel CARV, emerged leading federal and state officials to implement public health nonpharmaceutical interventions (NPIs) to curb its spread. We hypothesized that NPI would be associated with the reduced spread of traditional CARVs. Methods: A single-center, retrospective cohort analysis comparing CARV infection before a statewide stay-at-home order, during the stay-at-home order and subsequent statewide mask mandate, and during 5 mo following the elimination of NPI was performed. All LTx recipients followed by and tested at our center were included. Data (multiplex respiratory viral panels; SARS-CoV-2 reverse transcription polymerase chain reaction; blood cytomegalovirus and Epstein Barr virus polymerase chain reaction; blood and bronchoalveolar lavage bacterial and fungal cultures) were collected from the medical record. Chi-square or Fisher exact tests were utilized for categorical variables. A mixed-effect model was used for continuous variables. Results: Incidence of non-COVID CARV infection was significantly lower during the MASK period than during the PRE period. No difference was noted in airway or bloodstream bacterial or fungal infections, but cytomegalovirus bloodborne viral infections increased. Conclusions: Reductions in respiratory viral infections, but not bloodborne viral infections nor nonviral respiratory, bloodborne, or urinary infections, were observed in the setting of public health COVID-19 mitigation strategies, suggesting the effectiveness of NPI in preventing general respiratory virus transmission.
Language	English
Publishing date	2023-02-17
Publishing country	United States
Document type	Journal Article
ISSN	2373-8731
ISSN	2373-8731
DOI	10.1097/TXD.0000000000001445
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Article ; Online: Noncanonical mechanism of Nrf2 activation by diacylglycerol polyethylene glycol adducts in normal human epidermal keratinocytes.

Miyoshi, Tatsuro / Keller, Brian C / Ashino, Takashi / Numazawa, Satoshi

PloS one

2023 Volume 18, Issue 10, Page(s) e0291905

Abstract: Polyethylene glycol-23 glyceryl distearate (GDS-23), a diacylglycerol polyethylene glycol adduct, forms niosomes with a liposome-like structure and functions as an active ingredient in drug delivery systems. In addition, it upregulates antioxidant ... ...

Abstract	Polyethylene glycol-23 glyceryl distearate (GDS-23), a diacylglycerol polyethylene glycol adduct, forms niosomes with a liposome-like structure and functions as an active ingredient in drug delivery systems. In addition, it upregulates antioxidant proteins such as heme oxygenase 1 and NAD(P)H-quinone dehydrogenase 1 in cells. However, the activation of nuclear factor E2-related factor-2 (Nrf2), which plays a role in inducing the expression of antioxidant proteins, and its protective effects induced by GDS-23 treatment against oxidative stress have not been elucidated. This study aimed at verifying the activation of Nrf2 by GDS-23 and clarifying its underlying mechanisms, and investigated whether GDS-23 protects against hydroquinone-induced cytotoxicity. Normal human epidermal keratinocytes were treated with GDS-23. Real-time reverse transcription-polymerase chain reaction, western blotting, and immunostaining were used to investigate the mechanism of Nrf2 activation, and neutral red assay was performed to evaluate cytotoxicity. GDS-23-treated cells showed an increase in antioxidant protein levels and stabilization of Nrf2 in the nucleus. During Nrf2 activation, p62, an autophagy-related adaptor protein, was phosphorylated at Ser349. Inhibition of the interaction between the phosphorylated p62 and Kelch-like ECH-associated protein 1 significantly suppressed the GDS-23-mediated induction of antioxidant protein expression. In addition, hydroquinone-induced cell toxicity was significantly attenuated by GDS-23. GDS-23 induced the intracellular antioxidant system by activating Nrf2 in a p62 phosphorylation-dependent manner without generating oxidative stress in the cells. GDS-23 may be applied as a multifunctional material for drug delivery system that enhances internal antioxidant systems.
MeSH term(s)	Humans ; Antioxidants/metabolism ; Diglycerides/pharmacology ; Heme Oxygenase-1/genetics ; Heme Oxygenase-1/metabolism ; Hydroquinones/toxicity ; Kelch-Like ECH-Associated Protein 1/metabolism ; Keratinocytes/metabolism ; NF-E2-Related Factor 2/metabolism ; Oxidative Stress ; Polyethylene Glycols/pharmacology ; Polyethylene Glycols/metabolism
Chemical Substances	Antioxidants ; Diglycerides ; Heme Oxygenase-1 (EC 1.14.14.18) ; hydroquinone (XV74C1N1AE) ; Hydroquinones ; Kelch-Like ECH-Associated Protein 1 ; NF-E2-Related Factor 2 ; Polyethylene Glycols (3WJQ0SDW1A)
Language	English
Publishing date	2023-10-11
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2267670-3
ISSN	1932-6203 ; 1932-6203
ISSN (online)	1932-6203
ISSN	1932-6203
DOI	10.1371/journal.pone.0291905
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Article ; Online: Noncanonical mechanism of Nrf2 activation by diacylglycerol polyethylene glycol adducts in normal human epidermal keratinocytes.

Tatsuro Miyoshi / Brian C Keller / Takashi Ashino / Satoshi Numazawa

PLoS ONE, Vol 18, Iss 10, p e

2023 Volume 0291905

Abstract	Polyethylene glycol-23 glyceryl distearate (GDS-23), a diacylglycerol polyethylene glycol adduct, forms niosomes with a liposome-like structure and functions as an active ingredient in drug delivery systems. In addition, it upregulates antioxidant proteins such as heme oxygenase 1 and NAD(P)H-quinone dehydrogenase 1 in cells. However, the activation of nuclear factor E2-related factor-2 (Nrf2), which plays a role in inducing the expression of antioxidant proteins, and its protective effects induced by GDS-23 treatment against oxidative stress have not been elucidated. This study aimed at verifying the activation of Nrf2 by GDS-23 and clarifying its underlying mechanisms, and investigated whether GDS-23 protects against hydroquinone-induced cytotoxicity. Normal human epidermal keratinocytes were treated with GDS-23. Real-time reverse transcription-polymerase chain reaction, western blotting, and immunostaining were used to investigate the mechanism of Nrf2 activation, and neutral red assay was performed to evaluate cytotoxicity. GDS-23-treated cells showed an increase in antioxidant protein levels and stabilization of Nrf2 in the nucleus. During Nrf2 activation, p62, an autophagy-related adaptor protein, was phosphorylated at Ser349. Inhibition of the interaction between the phosphorylated p62 and Kelch-like ECH-associated protein 1 significantly suppressed the GDS-23-mediated induction of antioxidant protein expression. In addition, hydroquinone-induced cell toxicity was significantly attenuated by GDS-23. GDS-23 induced the intracellular antioxidant system by activating Nrf2 in a p62 phosphorylation-dependent manner without generating oxidative stress in the cells. GDS-23 may be applied as a multifunctional material for drug delivery system that enhances internal antioxidant systems.
Keywords	Medicine ; R ; Science ; Q
Subject code	500
Language	English
Publishing date	2023-01-01T00:00:00Z
Publisher	Public Library of Science (PLoS)
Document type	Article ; Online
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Article ; Online: Concerns About a Dog Model of Dry Eye Disease.

Ofri, Ron / Millichamp, Nicholas J / Keller, Charlotte / McLellan, Gillian J / Komáromy, András M / Morton, David / Matas, Màrian / Michau, Tammy M / Coall, Sarah / Sansom, Jane / Leonard, Brian C

Translational vision science & technology

2024 Volume 13, Issue 3, Page(s) 28

MeSH term(s)	Animals ; Dogs ; Dry Eye Syndromes/diagnosis ; Tears
Language	English
Publishing date	2024-03-28
Publishing country	United States
Document type	Letter
ZDB-ID	2674602-5
ISSN	2164-2591 ; 2164-2591
ISSN (online)	2164-2591
ISSN	2164-2591
DOI	10.1167/tvst.13.3.28
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Article ; Online: Experimental determination of magnetic field quality conversion factors for eleven ionization chambers in 1.5 T and 0.35 T MR-linac systems.

Orlando, Nathan / Crosby, Jennie / Glide-Hurst, Carri / Culberson, Wesley / Keller, Brian / Sarfehnia, Arman

Medical physics

2023 Volume 51, Issue 4, Page(s) 2998–3009

Abstract: ... A26, PTW T31010, T31021, and T31022, and IBA FC23-C, CC25, CC13, and CC08. The experimental method ...

Abstract	Background: The static magnetic field present in magnetic resonance (MR)-guided radiotherapy systems can influence dose deposition and charged particle collection in air-filled ionization chambers. Thus, accurately quantifying the effect of the magnetic field on ionization chamber response is critical for output calibration. Formalisms for reference dosimetry in a magnetic field have been proposed, whereby a magnetic field quality conversion factor k Purpose: The purpose of this study is to experimentally measure k Methods: Eleven ionization chamber models were characterized in this study: Exradin A12, A12S, A28, and A26, PTW T31010, T31021, and T31022, and IBA FC23-C, CC25, CC13, and CC08. The experimental method to measure k Results: Measured k Conclusions: For a high-field MR-linac, the characterization of ionization chamber performance as angular orientation varied relative to the magnetic field confirmed that the ideal orientation for output calibration is parallel. For most of these chamber models, this study represents the first experimental characterization of chamber performance in clinical MR-linac beams. This is a critical step toward accurate output calibration for MR-guided radiotherapy systems and the measured k
MeSH term(s)	Radiometry ; Radiotherapy, Image-Guided ; Relative Biological Effectiveness ; Magnetic Fields ; Monte Carlo Method ; Water
Chemical Substances	Water (059QF0KO0R)
Language	English
Publishing date	2023-12-07
Publishing country	United States
Document type	Journal Article
ZDB-ID	188780-4
ISSN	2473-4209 ; 0094-2405
ISSN (online)	2473-4209
ISSN	0094-2405
DOI	10.1002/mp.16858
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Article ; Online: Characterization of the

Keller, Matthew J / Zhang, Qiu / Qian, Shuo / Sanders, Brian C / O'Neill, Hugh M / Hettich, Robert L

Analytical chemistry

2023 Volume 96, Issue 1, Page(s) 212–219

Abstract: Customization of deuterated biomolecules is vital for many advanced biological experiments including neutron scattering. However, because it is challenging to control the proportion and regiospecificity of deuterium incorporation in live systems, often ... ...

Abstract	Customization of deuterated biomolecules is vital for many advanced biological experiments including neutron scattering. However, because it is challenging to control the proportion and regiospecificity of deuterium incorporation in live systems, often only two or three synthetic lipids are mixed together to form simplistic model membranes. This limits the applicability and biological accuracy of the results generated with these synthetic membranes. Despite some limited prior examination of deuterating
MeSH term(s)	Phospholipids ; Deuterium/chemistry ; Neutron Diffraction/methods ; Escherichia coli/metabolism ; Tandem Mass Spectrometry
Chemical Substances	Phospholipids ; Deuterium (AR09D82C7G)
Language	English
Publishing date	2023-12-27
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't ; Research Support, U.S. Gov't, Non-P.H.S.
ZDB-ID	1508-8
ISSN	1520-6882 ; 0003-2700
ISSN (online)	1520-6882
ISSN	0003-2700
DOI	10.1021/acs.analchem.3c03750
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Article ; Online: Comparing DIC and WAIC for multilevel models with missing data.

Du, Han / Keller, Brian / Alacam, Egamaria / Enders, Craig

Behavior research methods

2023

Abstract: In Bayesian statistics, the most widely used criteria of Bayesian model assessment and comparison are Deviance Information Criterion (DIC) and Watanabe-Akaike Information Criterion (WAIC). We use a multilevel mediation model as an illustrative example to ...

Abstract	In Bayesian statistics, the most widely used criteria of Bayesian model assessment and comparison are Deviance Information Criterion (DIC) and Watanabe-Akaike Information Criterion (WAIC). We use a multilevel mediation model as an illustrative example to compare different types of DIC and WAIC. More specifically, we aim to compare the performance of conditional and marginal DICs and WAICs, and investigate their performance with missing data. We focus on two versions of DIC ([Formula: see text] and [Formula: see text]) and one version of WAIC. In addition, we explore whether it is necessary to include the nuisance models of incomplete exogenous variables in likelihood. Based on the simulation results, whether [Formula: see text] is better than [Formula: see text] and WAIC and whether we should include the nuisance models of exogenous variables in likelihood functions depend on whether we use marginal or conditional likelihoods. Overall, we find that the marginal likelihood based-[Formula: see text] that excludes the likelihood of covariate models generally had the highest true model selection rates.
Language	English
Publishing date	2023-10-20
Publishing country	United States
Document type	Journal Article
ZDB-ID	231560-9
ISSN	1554-3528 ; 0743-3808 ; 1554-351X
ISSN (online)	1554-3528
ISSN	0743-3808 ; 1554-351X
DOI	10.3758/s13428-023-02231-0
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Article ; Online: Trends in Donation After Circulatory Death in Lung Transplantation in the United States: Impact Of Era.

Bobba, Christopher M / Whitson, Bryan A / Henn, Matthew C / Mokadam, Nahush A / Keller, Brian C / Rosenheck, Justin / Ganapathi, Asvin M

Transplant international : official journal of the European Society for Organ Transplantation

2022 Volume 35, Page(s) 10172

Abstract: Background: ...

Abstract	Background:
MeSH term(s)	Brain Death ; Death ; Graft Survival ; Humans ; Lung Transplantation ; Retrospective Studies ; Tissue Donors ; Tissue and Organ Procurement ; United States
Language	English
Publishing date	2022-04-04
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	639435-8
ISSN	1432-2277 ; 0934-0874
ISSN (online)	1432-2277
ISSN	0934-0874
DOI	10.3389/ti.2022.10172
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Article ; Online: Looking Beyond the Allograft Survival: Long-Term, 5-Year Renal Outcome in Lung Transplant Recipients.

Doraiswamy, Mohankumar / Obole, Eshetu / Botros, Mena / Keller, Brian C / Pesavento, Todd / Singh, Priyamvada

Transplantation proceedings

2021 Volume 53, Issue 10, Page(s) 3065–3068

Abstract: With the increased incidence and survival of lung transplant (LTx) recipients, the risk for chronic sequelae such as chronic kidney disease (CKD) is on the rise. Data on the long-term renal outcome are scarce. We performed a retrospective chart review of ...

Abstract	With the increased incidence and survival of lung transplant (LTx) recipients, the risk for chronic sequelae such as chronic kidney disease (CKD) is on the rise. Data on the long-term renal outcome are scarce. We performed a retrospective chart review of 171 adults with LTx from January 1, 2014, to January 1, 2019. Primary outcomes were prevalence of CKD/end-stage renal disease, acute kidney injury (AKI) as a risk factor for future CKD, and all-cause mortality in recipients with CKD compared with the non-CKD group. Secondary outcomes were frequency of utilization of modalities for CKD (urinalysis, imaging, biopsy, nephrology consultations). Baseline median creatinine and estimated glomerular filtration rate (eGFR) were 0.8 mg/dL and 90 mL/min/1.73 m
MeSH term(s)	Acute Kidney Injury ; Allografts ; Glomerular Filtration Rate ; Humans ; Lung ; Renal Dialysis ; Renal Insufficiency, Chronic ; Retrospective Studies ; Risk Factors ; Transplant Recipients
Language	English
Publishing date	2021-10-30
Publishing country	United States
Document type	Journal Article
ZDB-ID	82046-5
ISSN	1873-2623 ; 0041-1345
ISSN (online)	1873-2623
ISSN	0041-1345
DOI	10.1016/j.transproceed.2021.09.037
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