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  1. Book ; Thesis: Pathogenerkennung durch das Immunsystem

    Opitz, Bastian

    Toll-like-Rezeptoren und NF-KappaB-Aktivierung

    2001  

    Author's details von Bastian Opitz
    Language German
    Size XI, 76 Bl. : Ill.
    Publishing country Germany
    Document type Book ; Thesis
    Thesis / German Habilitation thesis Berlin, Humboldt-Univ., Diss., 2001
    HBZ-ID HT013463439
    Database Catalogue ZB MED Medicine, Health

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    Shelf markLoan statusLocation
    2002 E 3956 order for loan Magazin

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  2. Article ; Online: TBK1's Role in Bacterial Pneumonia: Perhaps More than Macrophages and IFNs.

    Fiocca Vernengo, Facundo / Opitz, Bastian

    American journal of respiratory cell and molecular biology

    2022  Volume 66, Issue 6, Page(s) 596–597

    MeSH term(s) Animals ; Macrophages/microbiology ; Mice ; Pneumonia, Bacterial ; Pneumonia, Pneumococcal ; Protein Serine-Threonine Kinases ; Streptococcus pneumoniae
    Chemical Substances Tbk1 protein, mouse (EC 2.7.1.-) ; Protein Serine-Threonine Kinases (EC 2.7.11.1)
    Language English
    Publishing date 2022-04-01
    Publishing country United States
    Document type Editorial ; Research Support, Non-U.S. Gov't ; Comment
    ZDB-ID 1025960-0
    ISSN 1535-4989 ; 1044-1549
    ISSN (online) 1535-4989
    ISSN 1044-1549
    DOI 10.1165/rcmb.2022-0040ED
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 2851: Show issues Location:
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  3. Article ; Online: Inflammasome Deficiency Makes Pro-resolving Lipid Mediators Great Again.

    Opitz, Bastian

    American journal of respiratory and critical care medicine

    2017  Volume 196, Issue 6, Page(s) 668–669

    Language English
    Publishing date 2017-09-15
    Publishing country United States
    Document type Journal Article
    ZDB-ID 1180953-x
    ISSN 1535-4970 ; 0003-0805 ; 1073-449X
    ISSN (online) 1535-4970
    ISSN 0003-0805 ; 1073-449X
    DOI 10.1164/rccm.201702-0402ED
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Pseudomonas aeruginosa

    Aljohmani, Ahmad / Opitz, Bastian / Bischoff, Markus / Yildiz, Daniela

    International journal of molecular sciences

    2022  Volume 23, Issue 3

    Abstract: Pneumonia is a life-threatening disease often caused by infection ... ...

    Abstract Pneumonia is a life-threatening disease often caused by infection with
    MeSH term(s) A549 Cells ; ADAM10 Protein/metabolism ; Amyloid Precursor Protein Secretases/metabolism ; Antigens, CD/metabolism ; Cadherins/metabolism ; Epithelium/metabolism ; Exosomes/metabolism ; Exosomes/physiology ; Humans ; Inflammation/microbiology ; Membrane Proteins/metabolism ; Proteolysis ; Pseudomonas aeruginosa/metabolism ; Pseudomonas aeruginosa/pathogenicity ; THP-1 Cells
    Chemical Substances Antigens, CD ; CDH1 protein, human ; Cadherins ; Membrane Proteins ; Amyloid Precursor Protein Secretases (EC 3.4.-) ; ADAM10 Protein (EC 3.4.24.81) ; ADAM10 protein, human (EC 3.4.24.81)
    Language English
    Publishing date 2022-01-23
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2019364-6
    ISSN 1422-0067 ; 1422-0067 ; 1661-6596
    ISSN (online) 1422-0067
    ISSN 1422-0067 ; 1661-6596
    DOI 10.3390/ijms23031259
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Pseudomonas aeruginosa Triggered Exosomal Release of ADAM10 Mediates Proteolytic Cleavage in Trans

    Ahmad Aljohmani / Bastian Opitz / Markus Bischoff / Daniela Yildiz

    International Journal of Molecular Sciences, Vol 23, Iss 1259, p

    2022  Volume 1259

    Abstract: Pneumonia is a life-threatening disease often caused by infection with Streptococcus pneumoniae and Pseudomonas aeruginosa . Many of the mediators (e.g., TNF, IL-6R) and junction molecules (e.g., E-cadherin) orchestrating inflammatory cell recruitment ... ...

    Abstract Pneumonia is a life-threatening disease often caused by infection with Streptococcus pneumoniae and Pseudomonas aeruginosa . Many of the mediators (e.g., TNF, IL-6R) and junction molecules (e.g., E-cadherin) orchestrating inflammatory cell recruitment and loss of barrier integrity are proteolytically cleaved through a disintegrin and metalloproteinases (ADAMs). We could show by Western blot, surface expression analysis and measurement of proteolytic activity in cell-based assays, that ADAM10 in epithelial cells is upregulated and activated upon infection with Pseudomonas aeruginosa and Exotoxin A (ExoA), but not upon infection with Streptococcus pneumoniae . Targeting ADAM10 by pharmacological inhibition or gene silencing, we demonstrated that this activation was critical for cleavage of E-cadherin and modulated permeability and epithelial integrity. Stimulation with heat-inactivated bacteria revealed that the activation was based on the toxin repertoire rather than the interaction with the bacterial particle itself. Furthermore, calcium imaging experiments showed that the ExoA action was based on the induction of calcium influx. Investigating the extracellular vesicles and their proteolytic activity, we could show that Pseudomonas aeruginosa triggered exosomal release of ADAM10 and proteolytic cleavage in trans. This newly described mechanism could constitute an essential mechanism causing systemic inflammation in patients suffering from Pseudomonas aeruginosa -induced pneumonia stimulating future translational studies.
    Keywords proteolysis ; metalloproteinase ; infection ; exosomes ; cell-cell-communication ; Biology (General) ; QH301-705.5 ; Chemistry ; QD1-999
    Subject code 572
    Language English
    Publishing date 2022-01-01T00:00:00Z
    Publisher MDPI AG
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  6. Article ; Online: The microbiota in pneumonia: From protection to predisposition.

    Thibeault, Charlotte / Suttorp, Norbert / Opitz, Bastian

    Science translational medicine

    2021  Volume 13, Issue 576

    Abstract: Mucosal surfaces of the upper respiratory tract and gut are physiologically colonized with their own collection of microbes, the microbiota. The normal upper respiratory tract and gut microbiota protects against pneumonia by impeding colonization by ... ...

    Abstract Mucosal surfaces of the upper respiratory tract and gut are physiologically colonized with their own collection of microbes, the microbiota. The normal upper respiratory tract and gut microbiota protects against pneumonia by impeding colonization by potentially pathogenic bacteria and by regulating immune responses. However, antimicrobial therapy and critical care procedures perturb the microbiota, thus compromising its function and predisposing to lung infections (pneumonia). Interindividual variations and age-related alterations in the microbiota also affect vulnerability to pneumonia. We discuss how the healthy microbiota protects against pneumonia and how host factors and medical interventions alter the microbiota, thus influencing susceptibility to pneumonia.
    Language English
    Publishing date 2021-03-19
    Publishing country United States
    Document type Journal Article ; Review ; Research Support, Non-U.S. Gov't
    ZDB-ID 2518854-9
    ISSN 1946-6242 ; 1946-6234
    ISSN (online) 1946-6242
    ISSN 1946-6234
    DOI 10.1126/scitranslmed.aba0501
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 6941: Show issues Location:
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  7. Article: Perioperative Anaesthesiological Management of Malignant Pleural Mesothelioma Patients Undergoing Extrapleural Pneumonectomy (EPP) and Extended Pleurectomy/Decortication ((E)PD).

    Lauk, Olivia / Deschwanden, Corinna Von / Inci, Ilhan / Caviezel, Claudio / Opitz, Isabelle / Grande, Bastian

    Turkish journal of anaesthesiology and reanimation

    2022  Volume 49, Issue 6, Page(s) 494–499

    Abstract: Introduction: Macroscopic complete resection (MCR) within a multimodality treatment concept offers currently the best survival for malignant pleural mesothelioma patients. The current standardised therapy is within a multimodality approach including ( ... ...

    Abstract Introduction: Macroscopic complete resection (MCR) within a multimodality treatment concept offers currently the best survival for malignant pleural mesothelioma patients. The current standardised therapy is within a multimodality approach including (neo-)adjuvant chemotherapy followed by macroscopic complete resection (MCR). However, MCR in form of extrapleural pneumonectomy (EPP) or extended pleurectomy/decortication ((E)PD) is correlated with significant morbidity and mortality if not performed in high volume centres as described previously according to the literature. In addition, there exist no standardised anaesthesiological protocol for this surgical approach according to the literature.
    Methods: At our institution, diagnosed mesothelioma patients up to an International Mesothelioma Interest Group (IMIG) stage III receive induction chemotherapy followed by either EPP or (E)PD and in certain cases additional adjuvant therapy. In the period 1999-end 2019, 362 patients were intended to be treated and 303 underwent induction chemotherapy followed by MCR. MCR can be achieved either by EPP or (E)PD. Both procedures request a good teamwork between the surgeon and the anaesthesiologist.
    Conclusion: Although, there has been a shift lately from EPP towards lung sparing procedure (E)PD, both surgical approaches are still performed to date and is a challenging procedure for both, the surgeon as well as the anaesthesiologist. Herewith, we present our institutional perioperative standard operating procedures for the surgical and anaesthesiological management of EPP or (E)PD according to international terms of reference.
    Language English
    Publishing date 2022-02-03
    Publishing country Turkey
    Document type Journal Article
    ISSN 2667-677X
    ISSN 2667-677X
    DOI 10.5152/TJAR.2021.1108
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: Microbiota-Dependent Regulation of Antimicrobial Immunity in the Lung.

    Maschirow, Laura / Suttorp, Norbert / Opitz, Bastian

    American journal of respiratory cell and molecular biology

    2019  Volume 61, Issue 3, Page(s) 284–289

    Abstract: Several body sites, including the intestinal and respiratory tracts, are colonized with a myriad of bacteria, archaea, fungi, and viruses, which are collectively referred to as the "microbiota." The bacterial component of the microbiota in particular has ...

    Abstract Several body sites, including the intestinal and respiratory tracts, are colonized with a myriad of bacteria, archaea, fungi, and viruses, which are collectively referred to as the "microbiota." The bacterial component of the microbiota in particular has been recognized to influence a multitude of physiological functions, including innate and adaptive immune responses. Germ-free and microbiota-depleted animals display an impaired antimicrobial defense and are therefore highly susceptible to various infections, including those affecting the lung. In this review, we summarize current understanding of how the microbiota affects antimicrobial immunity and disease tolerance during viral and bacterial pulmonary infections. A better understanding of these mechanisms could help to refine clinical approaches to preserve or rescue the microbiota-immune system interplay and protect patients against lung infections.
    MeSH term(s) Adaptive Immunity/drug effects ; Adaptive Immunity/immunology ; Animals ; Anti-Infective Agents/pharmacology ; Gastrointestinal Microbiome/drug effects ; Gastrointestinal Microbiome/immunology ; Humans ; Immunity, Innate/drug effects ; Immunity, Innate/immunology ; Lung/drug effects ; Lung/immunology ; Microbiota/drug effects
    Chemical Substances Anti-Infective Agents
    Language English
    Publishing date 2019-05-14
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Review
    ZDB-ID 1025960-0
    ISSN 1535-4989 ; 1044-1549
    ISSN (online) 1535-4989
    ISSN 1044-1549
    DOI 10.1165/rcmb.2019-0101TR
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 2851: Show issues Location:
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  9. Article ; Online: CLEC12A Binds to

    Klatt, Ann-Brit / Diersing, Christina / Lippmann, Juliane / Mayer-Lambertz, Sabine / Stegmann, Felix / Fischer, Swantje / Caesar, Sandra / Fiocca Vernengo, Facundo / Hönzke, Katja / Hocke, Andreas C / Ruland, Jürgen / Witzenrath, Martin / Lepenies, Bernd / Opitz, Bastian

    International journal of molecular sciences

    2023  Volume 24, Issue 4

    Abstract: Legionella ... ...

    Abstract Legionella pneumophila
    MeSH term(s) Animals ; Humans ; Mice ; Immunity, Innate ; Lectins, C-Type/metabolism ; Legionella pneumophila/immunology ; Legionnaires' Disease/immunology ; Legionnaires' Disease/microbiology ; Macrophages/metabolism ; Macrophages, Alveolar/metabolism ; Receptors, Mitogen/immunology ; Host-Pathogen Interactions
    Chemical Substances CLEC12A protein, human ; Lectins, C-Type ; Receptors, Mitogen
    Language English
    Publishing date 2023-02-15
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2019364-6
    ISSN 1422-0067 ; 1422-0067 ; 1661-6596
    ISSN (online) 1422-0067
    ISSN 1422-0067 ; 1661-6596
    DOI 10.3390/ijms24043891
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Book ; Thesis: Searches for dark matter self-annihilation signals from dwarf spheroidal galaxies and the Fornax galaxy cluster with imaging air Cherenkov telescopes

    Opitz, Björn Helmut Bastian

    (DESY thesis ; 2014,28)

    2014  

    Author's details by B. H. B. Opitz
    Series title DESY thesis ; 2014,28
    Language English ; German
    Size 160 S., Ill., graph. Darst.
    Publisher DESY
    Publishing place Hamburg
    Document type Book ; Thesis
    Thesis / German Habilitation thesis Univ., FB Physik, Diss.--Hamburg, 2014
    Note Zsfassungen in dt. und engl. Sprache
    Database Former special subject collection: coastal and deep sea fishing

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