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  1. Article ; Online: Age-related differences in kinetics during double- and single-leg jumps in boys.

    Hioki, Yusuke / Furuhashi, Yuki / Kasuga, Kohsyo / Hayashi, Ryohei

    The Journal of sports medicine and physical fitness

    2023  Volume 63, Issue 4, Page(s) 550–557

    Abstract: Background: Plyometric training, such as single-leg jumps, may be one of the most effective ways to improve a child's jumping and sprinting ability. However, few studies on age-related changes in single-legged jumping ability seem to exist. Therefore, ... ...

    Abstract Background: Plyometric training, such as single-leg jumps, may be one of the most effective ways to improve a child's jumping and sprinting ability. However, few studies on age-related changes in single-legged jumping ability seem to exist. Therefore, the aim of this study was to examine age-related changes in double- and single-leg jump performance.
    Methods: A total of 143 untrained boys aged 7-15 years performed double-leg counter-movement jump (CMJ) and rebound jump (RJ) and single-leg CMJ (SCMJ) and RJ (SRJ). Jump height (JH), peak vertical ground reaction force (PvGRF), and relative vertical ground reaction force (RvGRF) during CMJ and SCMJ, and RJ-Index, JH, ground contact time (CT), PvGRF, and RvGRF during RJ and SRJ were recorded, and one-way analysis of variance was used to examine differences between age group.
    Results: JH, PvGRF, and RvGRF of CMJ and SCMJ increased with age with a similar trend (P<0.001). RJ-Index, JH, and PvGRF of RJ and SRJ also increased with age (P<0.001). CT of RJ did not change with age, but SRJ became longer with age (P<0.001). The RvGRF of RJ increased with age (P<0.001), but the RvGRF of SRJ did not change.
    Conclusions: These results suggest that age-related changes in CMJ among boys aged 7-15 years have similar trends for double- and single-leg jumps. However, age-related changes of RJ differed between double- and single-leg jumps, suggesting that differences in adaptation of relative force exertion may occur.
    MeSH term(s) Male ; Child ; Humans ; Leg ; Plyometric Exercise/methods ; Movement ; Kinetics ; Adaptation, Physiological
    Language English
    Publishing date 2023-01-26
    Publishing country Italy
    Document type Journal Article
    ZDB-ID 410823-1
    ISSN 1827-1928 ; 0022-4707
    ISSN (online) 1827-1928
    ISSN 0022-4707
    DOI 10.23736/S0022-4707.22.14569-X
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Inappropriate timing of salt intake increases the risk of heat-related illness

    Takeyasu Kakamu / Teruna Ito / Shota Endo / Tomoo Hidaka / Yusuke Masuishi / Hideaki Kasuga / Tetsuhito Fukushima

    PLoS ONE, Vol 19, Iss

    An observational study

    2024  Volume 1

    Keywords Medicine ; R ; Science ; Q
    Language English
    Publishing date 2024-01-01T00:00:00Z
    Publisher Public Library of Science (PLoS)
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  3. Article ; Online: Developing a broad perspective of future work and career in medical students through field trips to a disaster area: a qualitative study.

    Hidaka, Tomoo / Endo, Shota / Kasuga, Hideaki / Masuishi, Yusuke / Kakamu, Takeyasu / Fukushima, Tetsuhito

    BMC research notes

    2024  Volume 17, Issue 1, Page(s) 63

    Abstract: Objective: Field trips to disaster-affected areas (FTDAs) without a specific purpose, such as medical cooperation, are widely used in medical education. However, what medical students gain from FTDAs remains unclear. The present study aimed to clarify ... ...

    Abstract Objective: Field trips to disaster-affected areas (FTDAs) without a specific purpose, such as medical cooperation, are widely used in medical education. However, what medical students gain from FTDAs remains unclear. The present study aimed to clarify what medical students gain from FTDAs. Five medical students who had visited the Fukushima nuclear power plant in Japan participated in a semi-structured group interview to ask what they gained from such a visit. The narratives were analysed using open coding.
    Results: The following four themes emerged: "Spirit of scientific inquiry", "Foundation for lifelong education and personal growth", "Broadened understanding of the medical profession", and "Importance of practicing medicine in the community setting". The ambiguity of medical students' specific roles in the field trip compared to the fieldwork may have encouraged them to make sense of the experience from their perspective. As a result, students may have gained a broader perspective of their future work and career through the FTDA. If medical educators can gain consensus from the residents of a disaster site, different disaster-affected areas can be potential sites for medical education using FTDAs.
    MeSH term(s) Humans ; Students, Medical ; Qualitative Research ; Consensus ; Disasters ; Education, Medical
    Language English
    Publishing date 2024-03-04
    Publishing country England
    Document type Journal Article
    ZDB-ID 2413336-X
    ISSN 1756-0500 ; 1756-0500
    ISSN (online) 1756-0500
    ISSN 1756-0500
    DOI 10.1186/s13104-024-06724-9
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: NLRC5/MHC class I transactivator: A key target for immune escape by SARS-CoV-2.

    Zhu, Baohui / Ouda, Ryota / Kasuga, Yusuke / de Figueiredo, Paul / Kobayashi, Koichi S

    BioEssays : news and reviews in molecular, cellular and developmental biology

    2024  Volume 46, Issue 4, Page(s) e2300109

    Abstract: Antigen presentation to CD8+ T cells by MHC class I molecules is essential for host defense against viral infections. Various mechanisms have evolved in multiple viruses to escape immune surveillance and defense to support viral proliferation in host ... ...

    Abstract Antigen presentation to CD8+ T cells by MHC class I molecules is essential for host defense against viral infections. Various mechanisms have evolved in multiple viruses to escape immune surveillance and defense to support viral proliferation in host cells. Through in vitro SARS-CoV-2 infection studies and analysis of COVID-19 patient samples, we found that SARS-CoV-2 suppresses the induction of the MHC class I pathway by inhibiting the expression and function of NLRC5, a major transcriptional regulator of MHC class I genes. In this review, we discuss the molecular mechanisms for suppression of the MHC class I pathway and clinical implications for COVID-19.
    MeSH term(s) Humans ; Genes, MHC Class I ; Trans-Activators/genetics ; SARS-CoV-2/genetics ; COVID-19/genetics ; Histocompatibility Antigens Class I ; Intracellular Signaling Peptides and Proteins/genetics
    Chemical Substances Trans-Activators ; Histocompatibility Antigens Class I ; NLRC5 protein, human ; Intracellular Signaling Peptides and Proteins
    Language English
    Publishing date 2024-03-10
    Publishing country United States
    Document type Review ; Journal Article
    ZDB-ID 50140-2
    ISSN 1521-1878 ; 0265-9247
    ISSN (online) 1521-1878
    ISSN 0265-9247
    DOI 10.1002/bies.202300109
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Maintaining early diagnosis of pancreatic adenocarcinoma in Japan: Local resilience against COVID-19.

    Kasuga, Noriki / Sekino, Yusuke / Takayanagi, Takuya / Ishii, Ken / Nagase, Hajime / Kurita, Yusuke / Nakajima, Atsushi

    Pancreatology : official journal of the International Association of Pancreatology (IAP) ... [et al.

    2023  Volume 23, Issue 6, Page(s) 607–614

    Abstract: Background and aims: This study evaluated the impact of the coronavirus disease 2019 (COVID-19) pandemic on pancreatic adenocarcinoma (PA) practice in our region and discussed the effects of our institution's regional collaborative system, the "Early ... ...

    Abstract Background and aims: This study evaluated the impact of the coronavirus disease 2019 (COVID-19) pandemic on pancreatic adenocarcinoma (PA) practice in our region and discussed the effects of our institution's regional collaborative system, the "Early Stage Pancreatic Cancer Diagnosis Project," which was originally unrelated to this study's purpose.
    Methods: We retrospectively investigated 150 patients with PA at Yokohama Rosai Hospital by defining three time periods: before (C0), during the first year (C1), and during the second year (C2) of the COVID-19 pandemic.
    Results: Among the three periods (C0, C1, and C2), there were significantly less patients with stage I PA (14.0%, 0%, and 7.4%, p = 0.032) in C1, and significantly more patients with stage III PA (10.0%, 28.3%, and 9.3%, p = 0.014) in C1. The pandemic significantly prolonged the median durations from disease onset to patients' first visits (28, 49, and 14 days, p = 0.012). In contrast, there was no significant difference in the median durations from referral to first visit to our institution (4, 4, and 6 days, p = 0.391).
    Conclusions: The pandemic advanced the stage of PA in our region. Although the pancreatic referral network remained functional during the pandemic, there were delays from disease onset to patients' first visit to healthcare providers, including clinics. While the pandemic caused temporary damage to PA practice, the routine regional collaboration provided by our institution's project allowed for early resilience. A notable limitation is that the impact of the pandemic on PA prognosis was not evaluated.
    MeSH term(s) Humans ; COVID-19 ; Adenocarcinoma/diagnosis ; Adenocarcinoma/epidemiology ; Adenocarcinoma/pathology ; Retrospective Studies ; Pancreatic Neoplasms/diagnosis ; Pancreatic Neoplasms/epidemiology ; Pandemics ; Japan/epidemiology ; Early Detection of Cancer ; COVID-19 Testing ; Pancreatic Neoplasms
    Language English
    Publishing date 2023-06-02
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2056680-3
    ISSN 1424-3911 ; 1424-3903
    ISSN (online) 1424-3911
    ISSN 1424-3903
    DOI 10.1016/j.pan.2023.06.002
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Inappropriate timing of salt intake increases the risk of heat-related illness: An observational study.

    Kakamu, Takeyasu / Ito, Teruna / Endo, Shota / Hidaka, Tomoo / Masuishi, Yusuke / Kasuga, Hideaki / Fukushima, Tetsuhito

    PloS one

    2024  Volume 19, Issue 1, Page(s) e0296388

    Abstract: The importance of salt intake in preventing heat-related illness (HRI) is well established, however, the specific method of ingestion has not been sufficiently studied. This study, therefore, aimed to investigate the optimal timing of salt intake to ... ...

    Abstract The importance of salt intake in preventing heat-related illness (HRI) is well established, however, the specific method of ingestion has not been sufficiently studied. This study, therefore, aimed to investigate the optimal timing of salt intake to prevent HRI during hot outdoor work. We recruited 28 healthy male firefighters working at a fire department in Japan. They were provided a questionnaire to complete before and after receiving training in the summer season. We assessed their salt intake as before, during, and after training or none. In addition, they completed a brief self-administered diet history questionnaire to evaluate their daily salt and alcohol intake. HRI was determined through subjective and objective symptoms listed in the questionnaire, and environmental data were obtained from a national database. Subsequently, factors related to HRI were determined using a logistic regression model. The mean age of the participants was 31.0 ± 7.7 years. The study was performed within 250 working days, and we detected 28 HRI symptoms (11.2%). The median alcohol intake was 25.6 g/day when calculated according to the actual work system. Logistic mixed effect model analysis revealed that salt intake before training (OR: 5.893, 95% CI: 1.407-24.675), and salt intake before and during training (OR: 22.889, 95% CI: 4.276-122.516) were positively associated with HRI symptoms. The results indicate that inappropriate timing of salt intake increases the risks of HRI. Thus, a timely intake of salt in adequate amounts may be important in preventing these risks.
    MeSH term(s) Humans ; Male ; Young Adult ; Adult ; Sodium Chloride, Dietary/adverse effects ; Hot Temperature ; Heat Stress Disorders/prevention & control ; Logistic Models ; Firefighters
    Chemical Substances Sodium Chloride, Dietary
    Language English
    Publishing date 2024-01-02
    Publishing country United States
    Document type Observational Study ; Journal Article
    ZDB-ID 2267670-3
    ISSN 1932-6203 ; 1932-6203
    ISSN (online) 1932-6203
    ISSN 1932-6203
    DOI 10.1371/journal.pone.0296388
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: Association between home meal preparers and salt intake in haemodialysis patients: a cross-sectional study.

    Uchida, Haruna / Hidaka, Tomoo / Endo, Shota / Kasuga, Hideaki / Masuishi, Yusuke / Kakamu, Takeyasu / Fukushima, Tetsuhito

    BMJ open

    2024  Volume 14, Issue 2, Page(s) e075214

    Abstract: Objectives: This study aimed to examine the association between home meal preparer and salt intake among haemodialysis patients, including daily dietary status. We hypothesised that salt intake is higher among individuals who rely on meal preparation ... ...

    Abstract Objectives: This study aimed to examine the association between home meal preparer and salt intake among haemodialysis patients, including daily dietary status. We hypothesised that salt intake is higher among individuals who rely on meal preparation from others than those who prepare meals by themselves.
    Design: Cross-sectional study.
    Setting: Two medical facilities in Fukushima Prefecture, Japan.
    Participants: 237 haemodialysis outpatients who visited one of the medical facilities between February 2020 and August 2021 and were diagnosed with anuria, defined as urination of <100 mL/day, were the potential participants of the present study. Finally, 181 participants (131 male and 50 female) were included in the analysis.
    Outcome measure: Salt intake amount was calculated from the results of predialysis and postdialysis blood draws, using Watson's formula based on predialysis weight, predialysis serum sodium level, postdialysis weight and serum sodium level at the end of dialysis.
    Results: Salt intake was significantly higher in participants who relied on meal preparation from others ('relying on others') than those who prepared meals by themselves ('self-prepared') (B=1.359; 95% CI: 0.495 to 2.222). No statistical difference was found between individuals who ate out or ate takeout ('outsourcing') and those who prepared their own meals ('self-prepared'). These results were robust after adjustment for confounding factors.
    Conclusions: The present study revealed an association between self-preparation of meals at home and reduced salt intake among dialysis patients. Our findings suggest that whoever is the home meal preparer is possibly a social determinant of salt intake. To improve the prognosis of haemodialysis patients, actively reaching out to the family and assessing their social environment, such as identifying the home meal preparer and, if the patient relies on others for meal preparation, conducting nutritional/dietary guidance for that person, are effective in enhancing salt reduction.
    MeSH term(s) Humans ; Male ; Female ; Sodium Chloride, Dietary ; Cross-Sectional Studies ; Renal Dialysis ; Meals ; Sodium
    Chemical Substances Sodium Chloride, Dietary ; Sodium (9NEZ333N27)
    Language English
    Publishing date 2024-02-07
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2599832-8
    ISSN 2044-6055 ; 2044-6055
    ISSN (online) 2044-6055
    ISSN 2044-6055
    DOI 10.1136/bmjopen-2023-075214
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: Returning to a Once Highly Contaminated Homeland in Fukushima in 2023: Resident Concerns of Agricultural Accident and Public Safety.

    Hidaka, Tomoo / Kakamu, Takeyasu / Endo, Shota / Kasuga, Hideaki / Masuishi, Yusuke / Fukushima, Tetsuhito

    Disaster medicine and public health preparedness

    2023  Volume 17, Page(s) e449

    MeSH term(s) Humans ; Radiation Injuries ; Radiation Exposure ; Accidents ; Fukushima Nuclear Accident ; Japan
    Language English
    Publishing date 2023-08-11
    Publishing country United States
    Document type Letter ; Research Support, Non-U.S. Gov't
    ZDB-ID 2375268-3
    ISSN 1938-744X ; 1935-7893
    ISSN (online) 1938-744X
    ISSN 1935-7893
    DOI 10.1017/dmp.2023.113
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article: Clinical Features and Prognostic Impact of Pancreatic Ductal Adenocarcinoma without Dilatation of the Main Pancreatic Duct: A Single-Center Retrospective Analysis.

    Takayanagi, Takuya / Sekino, Yusuke / Kasuga, Noriki / Ishii, Ken / Nagase, Hajime / Nakajima, Atsushi

    Diagnostics (Basel, Switzerland)

    2023  Volume 13, Issue 5

    Abstract: The presence of main pancreatic duct (MPD) dilatation is important for diagnosing pancreatic ductal adenocarcinomas (PDACs). However, we occasionally encounter PDAC cases without MPD dilatation. The objectives of this study were to compare the clinical ... ...

    Abstract The presence of main pancreatic duct (MPD) dilatation is important for diagnosing pancreatic ductal adenocarcinomas (PDACs). However, we occasionally encounter PDAC cases without MPD dilatation. The objectives of this study were to compare the clinical findings and prognosis of pathologically diagnosed PDAC cases with and without MPD dilatation and to extract factors related to the prognosis of PDAC. The 281 patients pathologically diagnosed with PDAC were divided into two groups: the dilatation group (
    Language English
    Publishing date 2023-03-03
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2662336-5
    ISSN 2075-4418
    ISSN 2075-4418
    DOI 10.3390/diagnostics13050963
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: Reliability and validity of the Japanese version of the weight bias internalization scale.

    Endo, Shota / Kasuga, Hideaki / Yusuke, Masuishi / Hidaka, Tomoo / Kakamu, Takeyasu / Fukushima, Tetsuhito

    BMC research notes

    2022  Volume 15, Issue 1, Page(s) 333

    Abstract: Objective: The weight bias internalization scale (WBIS) is widely used in several languages. However, there is no Japanese version of the WBIS. The purpose of this study is to develop a Japanese version of the WBIS and to verify its reliability and ... ...

    Abstract Objective: The weight bias internalization scale (WBIS) is widely used in several languages. However, there is no Japanese version of the WBIS. The purpose of this study is to develop a Japanese version of the WBIS and to verify its reliability and validity. We translated the original version of the WBIS and had approval from the scale developer. Adults who perceived themselves to be obese completed online baseline survey (N = 285) and two-week follow-up survey (N = 100). We used the Japanese WBIS and scales for obesity-related quality of life, self-esteem, self-efficacy, and depression. We calculated Cronbach's alpha and intra-class correlation coefficient (ICC) to assess reliability of the WBIS and conducted confirmatory factor analysis (CFA) and correlation analysis to assess its validity.
    Results: Cronbach's alpha was 0.91 at baseline and 0.92 at follow-up, and the ICC was 0.87. CFA showed that a one-factor model demonstrated an acceptable fit (χ2 (44) = 158.6, CFI = 0.93, RMSEA = 0.096, SRMR = 0.051), similar to the original version. As we had hypothesized, overall, the Japanese version of the WBIS was significantly correlated with obesity-related quality of life, self-esteem, self-efficacy, and depression. These results confirmed its adequate reliability and validity.
    MeSH term(s) Adult ; Humans ; Reproducibility of Results ; Quality of Life ; Weight Prejudice ; Surveys and Questionnaires ; Obesity ; Psychometrics
    Language English
    Publishing date 2022-10-22
    Publishing country England
    Document type Journal Article
    ZDB-ID 2413336-X
    ISSN 1756-0500 ; 1756-0500
    ISSN (online) 1756-0500
    ISSN 1756-0500
    DOI 10.1186/s13104-022-06221-x
    Database MEDical Literature Analysis and Retrieval System OnLINE

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