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Article ; Online: Response to Barriere et al.

Seneff, Stephanie / Nigh, Greg / Kyriakopoulos, Anthony M / McCullough, Peter A

Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association

2023 Volume 178, Page(s) 113898

Language	English
Publishing date	2023-06-17
Publishing country	England
Document type	Letter ; Comment
ZDB-ID	782617-5
ISSN	1873-6351 ; 0278-6915
ISSN (online)	1873-6351
ISSN	0278-6915
DOI	10.1016/j.fct.2023.113898
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article: A Potential Role of the Spike Protein in Neurodegenerative Diseases: A Narrative Review.

Seneff, Stephanie / Kyriakopoulos, Anthony M / Nigh, Greg / McCullough, Peter A

Cureus

2023 Volume 15, Issue 2, Page(s) e34872

Abstract: Human prion protein and prion-like protein misfolding are widely recognized as playing a causal role in many neurodegenerative diseases. Based on in vitro and in vivo experimental evidence relating to prion and prion-like disease, we extrapolate from the ...

Abstract	Human prion protein and prion-like protein misfolding are widely recognized as playing a causal role in many neurodegenerative diseases. Based on in vitro and in vivo experimental evidence relating to prion and prion-like disease, we extrapolate from the compelling evidence that the spike glycoprotein of SARS-CoV-2 contains extended amino acid sequences characteristic of a prion-like protein to infer its potential to cause neurodegenerative disease. We propose that vaccine-induced spike protein synthesis can facilitate the accumulation of toxic prion-like fibrils in neurons. We outline various pathways through which these proteins could be expected to distribute throughout the body. We review both cellular pathologies and the expression of disease that could become more frequent in those who have undergone mRNA vaccination. Specifically, we describe the spike protein's contributions, via its prion-like properties, to neuroinflammation and neurodegenerative diseases; to clotting disorders within the vasculature; to further disease risk due to suppressed prion protein regulation in the context of widely prevalent insulin resistance; and to other health complications. We explain why these prion-like characteristics are more relevant to vaccine-related mRNA-induced spike proteins than natural infection with SARS-CoV-2. We note with an optimism an apparent loss of prion-like properties among the current Omicron variants. We acknowledge that the chain of pathological events described throughout this paper is only hypothetical and not yet verified. We also acknowledge that the evidence we usher in, while grounded in the research literature, is currently largely circumstantial, not direct. Finally, we describe the implications of our findings for the general public, and we briefly discuss public health recommendations we feel need urgent consideration. An earlier version of this article was previously posted to the Authorea preprint server on August 16, 2022.
Language	English
Publishing date	2023-02-11
Publishing country	United States
Document type	Journal Article ; Review
ZDB-ID	2747273-5
ISSN	2168-8184
ISSN	2168-8184
DOI	10.7759/cureus.34872
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article: Retraction: COVID-19 mRNA Vaccines: Lessons Learned from the Registrational Trials and Global Vaccination Campaign.

Mead, M Nathaniel / Seneff, Stephanie / Wolfinger, Russ / Rose, Jessica / Denhaerynck, Kris / Kirsch, Steve / McCullough, Peter A

Cureus

2024 Volume 16, Issue 2, Page(s) r137

Abstract: This retracts the article DOI: 10.7759/cureus.52876.]. ...

Abstract	[This retracts the article DOI: 10.7759/cureus.52876.].
Language	English
Publishing date	2024-02-26
Publishing country	United States
Document type	Retraction of Publication
ZDB-ID	2747273-5
ISSN	2168-8184
ISSN	2168-8184
DOI	10.7759/cureus.r137
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article: Bell's palsy or an aggressive infiltrating basaloid carcinoma post-mRNA vaccination for COVID-19? A case report and review of the literature.

Kyriakopoulos, Anthony M / Nigh, Greg / McCullough, Peter A / Olivier, Maria D / Seneff, Stephanie

EXCLI journal

2023 Volume 22, Page(s) 992–1011

Abstract: We report on an aggressive, infiltrating, metastatic, and ultimately lethal basaloid type of carcinoma arising shortly after an mRNA vaccination for COVID-19. The wife of the patient, since deceased, gave the consent for publishing the case. The ... ...

Abstract	We report on an aggressive, infiltrating, metastatic, and ultimately lethal basaloid type of carcinoma arising shortly after an mRNA vaccination for COVID-19. The wife of the patient, since deceased, gave the consent for publishing the case. The malignancy was of cutaneous origin and the case showed symptoms consistent with Bell's palsy and trigeminal neuralgia beginning four days post-vaccination (right side head temporal pain). The temporal pain was suggestive for inflammation and impairment of T cell immune activation. Magnetic Resonance Imaging (MRI) showed a vascular loop on the left lateral aspect of the 5
Language	English
Publishing date	2023-09-11
Publishing country	Germany
Document type	Case Reports
ISSN	1611-2156
ISSN	1611-2156
DOI	10.17179/excli2023-6145
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Article: COVID-19 mRNA Vaccines: Lessons Learned from the Registrational Trials and Global Vaccination Campaign.

Mead, M Nathaniel / Seneff, Stephanie / Wolfinger, Russ / Rose, Jessica / Denhaerynck, Kris / Kirsch, Steve / McCullough, Peter A

publication RETRACTED

Cureus

2024 Volume 16, Issue 1, Page(s) e52876

Abstract: Our understanding of COVID-19 vaccinations and their impact on health and mortality has evolved substantially since the first vaccine rollouts. Published reports from the original randomized phase 3 trials concluded that the COVID-19 mRNA vaccines could ... ...

Abstract	Our understanding of COVID-19 vaccinations and their impact on health and mortality has evolved substantially since the first vaccine rollouts. Published reports from the original randomized phase 3 trials concluded that the COVID-19 mRNA vaccines could greatly reduce COVID-19 symptoms. In the interim, problems with the methods, execution, and reporting of these pivotal trials have emerged. Re-analysis of the Pfizer trial data identified statistically significant increases in serious adverse events (SAEs) in the vaccine group. Numerous SAEs were identified following the Emergency Use Authorization (EUA), including death, cancer, cardiac events, and various autoimmune, hematological, reproductive, and neurological disorders. Furthermore, these products never underwent adequate safety and toxicological testing in accordance with previously established scientific standards. Among the other major topics addressed in this narrative review are the published analyses of serious harms to humans, quality control issues and process-related impurities, mechanisms underlying adverse events (AEs), the immunologic basis for vaccine inefficacy, and concerning mortality trends based on the registrational trial data. The risk-benefit imbalance substantiated by the evidence to date contraindicates further booster injections and suggests that, at a minimum, the mRNA injections should be removed from the childhood immunization program until proper safety and toxicological studies are conducted. Federal agency approval of the COVID-19 mRNA vaccines on a blanket-coverage population-wide basis had no support from an honest assessment of all relevant registrational data and commensurate consideration of risks versus benefits. Given the extensive, well-documented SAEs and unacceptably high harm-to-reward ratio, we urge governments to endorse a global moratorium on the modified mRNA products until all relevant questions pertaining to causality, residual DNA, and aberrant protein production are answered.
Language	English
Publishing date	2024-01-24
Publishing country	United States
Document type	Journal Article ; Review ; Retracted Publication
ZDB-ID	2747273-5
ISSN	2168-8184
ISSN	2168-8184
DOI	10.7759/cureus.52876
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article: Mitogen Activated Protein Kinase (MAPK) Activation, p53, and Autophagy Inhibition Characterize the Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) Spike Protein Induced Neurotoxicity.

Kyriakopoulos, Anthony M / Nigh, Greg / McCullough, Peter A / Seneff, Stephanie

Cureus

2022 Volume 14, Issue 12, Page(s) e32361

Abstract: The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) spike protein and prions use common pathogenic pathways to induce toxicity in neurons. Infectious prions rapidly activate the p38 mitogen activated protein kinase (MAPK) pathway, and SARS- ... ...

Abstract	The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) spike protein and prions use common pathogenic pathways to induce toxicity in neurons. Infectious prions rapidly activate the p38 mitogen activated protein kinase (MAPK) pathway, and SARS-CoV-2 spike proteins rapidly activate both the p38 MAPK and c-Jun NH2-terminal kinase (JNK) pathways through toll-like receptor signaling, indicating the potential for similar neurotoxicity, causing prion and prion-like disease. In this review, we analyze the roles of autophagy inhibition, molecular mimicry, elevated intracellular p53 levels and reduced Wild-type p53-induced phosphatase 1 (Wip1) and dual-specificity phosphatase (DUSP) expression in neurons in the disease process. The pathways induced by the spike protein via toll-like receptor activation induce both the upregulation of PrP
Language	English
Publishing date	2022-12-09
Publishing country	United States
Document type	Journal Article ; Review
ZDB-ID	2747273-5
ISSN	2168-8184
ISSN	2168-8184
DOI	10.7759/cureus.32361
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Innate immune suppression by SARS-CoV-2 mRNA vaccinations: The role of G-quadruplexes, exosomes, and MicroRNAs.

Seneff, Stephanie / Nigh, Greg / Kyriakopoulos, Anthony M / McCullough, Peter A

Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association

2022 Volume 164, Page(s) 113008

Abstract: The mRNA SARS-CoV-2 vaccines were brought to market in response to the public health crises of Covid-19. The utilization of mRNA vaccines in the context of infectious disease has no precedent. The many alterations in the vaccine mRNA hide the mRNA from ... ...

Abstract	The mRNA SARS-CoV-2 vaccines were brought to market in response to the public health crises of Covid-19. The utilization of mRNA vaccines in the context of infectious disease has no precedent. The many alterations in the vaccine mRNA hide the mRNA from cellular defenses and promote a longer biological half-life and high production of spike protein. However, the immune response to the vaccine is very different from that to a SARS-CoV-2 infection. In this paper, we present evidence that vaccination induces a profound impairment in type I interferon signaling, which has diverse adverse consequences to human health. Immune cells that have taken up the vaccine nanoparticles release into circulation large numbers of exosomes containing spike protein along with critical microRNAs that induce a signaling response in recipient cells at distant sites. We also identify potential profound disturbances in regulatory control of protein synthesis and cancer surveillance. These disturbances potentially have a causal link to neurodegenerative disease, myocarditis, immune thrombocytopenia, Bell's palsy, liver disease, impaired adaptive immunity, impaired DNA damage response and tumorigenesis. We show evidence from the VAERS database supporting our hypothesis. We believe a comprehensive risk/benefit assessment of the mRNA vaccines questions them as positive contributors to public health.
MeSH term(s)	COVID-19/prevention & control ; COVID-19 Vaccines/adverse effects ; Exosomes/metabolism ; G-Quadruplexes ; Humans ; Immunity, Innate ; MicroRNAs/genetics ; MicroRNAs/metabolism ; Neurodegenerative Diseases/metabolism ; RNA, Messenger/genetics ; RNA, Messenger/metabolism ; SARS-CoV-2 ; Spike Glycoprotein, Coronavirus ; Vaccination/adverse effects ; Vaccines, Synthetic/adverse effects ; mRNA Vaccines/adverse effects
Chemical Substances	COVID-19 Vaccines ; MicroRNAs ; RNA, Messenger ; Spike Glycoprotein, Coronavirus ; Vaccines, Synthetic ; mRNA Vaccines ; spike protein, SARS-CoV-2
Language	English
Publishing date	2022-04-15
Publishing country	England
Document type	Journal Article
ZDB-ID	782617-5
ISSN	1873-6351 ; 0278-6915
ISSN (online)	1873-6351
ISSN	0278-6915
DOI	10.1016/j.fct.2022.113008
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Jg. 1995 - 2021: Lesesall (1.OG)
ab Jg. 2022: Lesesaal (EG)

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Article: Innate immune suppression by SARS-CoV-2 mRNA vaccinations: The role of G-quadruplexes, exosomes, and MicroRNAs

Seneff, Stephanie / Nigh, Greg / Kyriakopoulos, Anthony M. / McCullough, Peter A.

Food and chemical toxicology. 2022 June, v. 164

2022

Abstract	The mRNA SARS-CoV-2 vaccines were brought to market in response to the public health crises of Covid-19. The utilization of mRNA vaccines in the context of infectious disease has no precedent. The many alterations in the vaccine mRNA hide the mRNA from cellular defenses and promote a longer biological half-life and high production of spike protein. However, the immune response to the vaccine is very different from that to a SARS-CoV-2 infection. In this paper, we present evidence that vaccination induces a profound impairment in type I interferon signaling, which has diverse adverse consequences to human health. Immune cells that have taken up the vaccine nanoparticles release into circulation large numbers of exosomes containing spike protein along with critical microRNAs that induce a signaling response in recipient cells at distant sites. We also identify potential profound disturbances in regulatory control of protein synthesis and cancer surveillance. These disturbances potentially have a causal link to neurodegenerative disease, myocarditis, immune thrombocytopenia, Bell's palsy, liver disease, impaired adaptive immunity, impaired DNA damage response and tumorigenesis. We show evidence from the VAERS database supporting our hypothesis. We believe a comprehensive risk/benefit assessment of the mRNA vaccines questions them as positive contributors to public health.
Keywords	COVID-19 infection ; DNA damage ; Severe acute respiratory syndrome coronavirus 2 ; adaptive immunity ; biological half-life ; carcinogenesis ; databases ; exosomes ; human health ; immune response ; interferons ; liver diseases ; markets ; microRNA ; monitoring ; myocarditis ; neurodegenerative diseases ; protein synthesis ; public health ; risk ; thrombocytopenia ; toxicology ; vaccination ; vaccines
Language	English
Dates of publication	2022-06
Publishing place	Elsevier Ltd
Document type	Article
ZDB-ID	782617-5
ISSN	1873-6351 ; 0278-6915
ISSN (online)	1873-6351
ISSN	0278-6915
DOI	10.1016/j.fct.2022.113008
Database	NAL-Catalogue (AGRICOLA)

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Z 4035: Show issues

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Article ; Online: Glyphosate's Synergistic Toxicity in Combination with Other Factors as a Cause of Chronic Kidney Disease of Unknown Origin.

Gunatilake, Sarath / Seneff, Stephanie / Orlando, Laura

International journal of environmental research and public health

2019 Volume 16, Issue 15

Abstract: Chronic kidney disease of unknown etiology (CKDu) is a global epidemic. Sri Lanka has experienced a doubling of the disease every 4 or 5 years since it was first identified in the North Central province in the mid-1990s. The disease primarily affects ... ...

Abstract	Chronic kidney disease of unknown etiology (CKDu) is a global epidemic. Sri Lanka has experienced a doubling of the disease every 4 or 5 years since it was first identified in the North Central province in the mid-1990s. The disease primarily affects people in agricultural regions who are missing the commonly known risk factors for CKD. Sri Lanka is not alone: health workers have reported prevalence of CKDu in Mexico, Nicaragua, El Salvador, and the state of Andhra Pradesh in India. A global search for the cause of CKDu has not identified a single factor, but rather many factors that may contribute to the etiology of the disease. Some of these factors include heat stroke leading to dehydration, toxic metals such as cadmium and arsenic, fluoride, low selenium, toxigenic cyanobacteria, nutritionally deficient diet and mycotoxins from mold exposure. Furthermore, exposure to agrichemicals, particularly glyphosate and paraquat, are likely compounding factors, and may be the primary factors. Here, we argue that glyphosate in particular is working synergistically with most of the other factors to increase toxic effects. We propose, further, that glyphosate causes insidious harm through its action as an amino acid analogue of glycine, and that this interferes with natural protective mechanisms against other exposures. Glyphosate's synergistic health effects in combination with exposure to other pollutants, in particular paraquat, and physical labor in the ubiquitous high temperatures of lowland tropical regions, could result in renal damage consistent with CKDu in Sri Lanka.
MeSH term(s)	Agricultural Workers' Diseases/epidemiology ; Agricultural Workers' Diseases/etiology ; Dehydration/complications ; Glycine/analogs & derivatives ; Glycine/toxicity ; Heat Stress Disorders/complications ; Herbicides/toxicity ; Humans ; Occupational Exposure/adverse effects ; Paraquat/toxicity ; Prevalence ; Renal Insufficiency, Chronic/epidemiology ; Renal Insufficiency, Chronic/etiology ; Risk Factors ; Sri Lanka/epidemiology ; Glyphosate
Chemical Substances	Herbicides ; Paraquat (PLG39H7695) ; Glycine (TE7660XO1C)
Language	English
Publishing date	2019-07-31
Publishing country	Switzerland
Document type	Journal Article ; Research Support, Non-U.S. Gov't ; Review
ZDB-ID	2175195-X
ISSN	1660-4601 ; 1661-7827
ISSN (online)	1660-4601
ISSN	1661-7827
DOI	10.3390/ijerph16152734
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Article ; Online: Autoimmune inflammatory reactions triggered by the COVID-19 genetic vaccines in terminally differentiated tissues.

Polykretis, Panagis / Donzelli, Alberto / Lindsay, Janci C / Wiseman, David / Kyriakopoulos, Anthony M / Mörz, Michael / Bellavite, Paolo / Fukushima, Masanori / Seneff, Stephanie / McCullough, Peter A

Autoimmunity

2023 Volume 56, Issue 1, Page(s) 2259123

Abstract: As a result of the spread of SARS-CoV-2, a global pandemic was declared. Indiscriminate COVID-19 vaccination has been extended to include age groups and naturally immune people with minimal danger of suffering serious complications due to COVID-19. Solid ...

Abstract	As a result of the spread of SARS-CoV-2, a global pandemic was declared. Indiscriminate COVID-19 vaccination has been extended to include age groups and naturally immune people with minimal danger of suffering serious complications due to COVID-19. Solid immuno-histopathological evidence demonstrates that the COVID-19 genetic vaccines can display a wide distribution within the body, affecting tissues that are terminally differentiated and far away from the injection site. These include the heart and brain, which may incur
MeSH term(s)	Humans ; COVID-19 Vaccines/adverse effects ; COVID-19/prevention & control ; Tissue Distribution ; SARS-CoV-2 ; Brain
Chemical Substances	COVID-19 Vaccines
Language	English
Publishing date	2023-09-15
Publishing country	England
Document type	Journal Article ; Review
ZDB-ID	1025450-x
ISSN	1607-842X ; 0891-6934
ISSN (online)	1607-842X
ISSN	0891-6934
DOI	10.1080/08916934.2023.2259123
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