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  1. Book ; Online: Contribution of Innate Responses to Viral Control in HIV-1 Infection

    Borrow, Persephone / Bhardwaj, Nina

    2020  

    Keywords Medicine ; Immunology ; HIV-1 ; innate response ; dendritic cell ; type 1 interferon ; NK cell
    Size 1 electronic resource (152 pages)
    Publisher Frontiers Media SA
    Document type Book ; Online
    Note English ; Open Access
    HBZ-ID HT021231208
    ISBN 9782889639151 ; 2889639150
    Database ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

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  2. Article ; Online: Human T follicular regulatory cells with helper and regulatory lineage origins.

    Nguyen, Quang / Borrow, Persephone

    Nature reviews. Immunology

    2023  Volume 23, Issue 4, Page(s) 204

    MeSH term(s) Humans ; T-Lymphocytes, Helper-Inducer ; T-Lymphocytes, Regulatory
    Language English
    Publishing date 2023-02-28
    Publishing country England
    Document type Journal Article
    ZDB-ID 2062776-2
    ISSN 1474-1741 ; 1474-1733
    ISSN (online) 1474-1741
    ISSN 1474-1733
    DOI 10.1038/s41577-023-00850-4
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Targeting autoantibodies in COVID-19.

    Pedroza-Pacheco, Isabela / Borrow, Persephone

    Nature reviews. Immunology

    2021  Volume 21, Issue 3, Page(s) 134

    Language English
    Publishing date 2021-02-09
    Publishing country England
    Document type Journal Article
    ZDB-ID 2062776-2
    ISSN 1474-1741 ; 1474-1733
    ISSN (online) 1474-1741
    ISSN 1474-1733
    DOI 10.1038/s41577-021-00513-2
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: The antibodies 3D12 and 4D12 recognise distinct epitopes and conformations of HLA-E.

    Brackenridge, Simon / John, Nessy / Früh, Klaus / Borrow, Persephone / McMichael, Andrew J

    Frontiers in immunology

    2024  Volume 15, Page(s) 1329032

    Abstract: The commonly used antibodies 3D12 and 4D12 recognise the human leukocyte antigen E (HLA-E) protein. These antibodies bind distinct epitopes on HLA-E and differ in their ability to bind alleles of the major histocompatibility complex E (MHC-E) proteins of ...

    Abstract The commonly used antibodies 3D12 and 4D12 recognise the human leukocyte antigen E (HLA-E) protein. These antibodies bind distinct epitopes on HLA-E and differ in their ability to bind alleles of the major histocompatibility complex E (MHC-E) proteins of rhesus and cynomolgus macaques. We confirmed that neither antibody cross-reacts with classical HLA alleles, and used hybrids of different MHC-E alleles to map the regions that are critical for their binding. 3D12 recognises a region on the alpha 3 domain, with its specificity for HLA-E resulting from the amino acids present at three key positions (219, 223 and 224) that are unique to HLA-E, while 4D12 binds to the start of the alpha 2 domain, adjacent to the C terminus of the presented peptide. 3D12 staining is increased by incubation of cells at 27°C, and by addition of the canonical signal sequence peptide presented by HLA-E peptide (VL9, VMAPRTLVL). This suggests that 3D12 may bind peptide-free forms of HLA-E, which would be expected to accumulate at the cell surface when cells are incubated at lower temperatures, as well as HLA-E with peptide. Therefore, additional studies are required to determine exactly what forms of HLA-E can be recognised by 3D12. In contrast, while staining with 4D12 was also increased when cells were incubated at 27°C, it was decreased when the VL9 peptide was added. We conclude that 4D12 preferentially binds to peptide-free HLA-E, and, although not suitable for measuring the total cell surface levels of MHC-E, may putatively identify peptide-receptive forms.
    MeSH term(s) Humans ; Epitopes ; HLA-E Antigens ; Histocompatibility Antigens Class I ; HLA Antigens ; Peptides ; Histocompatibility Antigens Class II ; Antibodies, Monoclonal
    Chemical Substances Epitopes ; HLA-E Antigens ; Histocompatibility Antigens Class I ; HLA Antigens ; Peptides ; Histocompatibility Antigens Class II ; Antibodies, Monoclonal
    Language English
    Publishing date 2024-03-20
    Publishing country Switzerland
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
    ZDB-ID 2606827-8
    ISSN 1664-3224 ; 1664-3224
    ISSN (online) 1664-3224
    ISSN 1664-3224
    DOI 10.3389/fimmu.2024.1329032
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Inhibition of salt inducible kinases reduces rhythmic HIV-1 replication and reactivation from latency.

    Borrmann, Helene / Ismed, Dini / Kliszczak, Anna E / Borrow, Persephone / Vasudevan, Sridhar / Jagannath, Aarti / Zhuang, Xiaodong / McKeating, Jane A

    The Journal of general virology

    2023  Volume 104, Issue 8

    Abstract: Human immunodeficiency virus type 1 (HIV-1) causes a major burden on global health, and eradication of latent virus infection is one of the biggest challenges in the field. The circadian clock is an endogenous timing system that oscillates with a ~24 h ... ...

    Abstract Human immunodeficiency virus type 1 (HIV-1) causes a major burden on global health, and eradication of latent virus infection is one of the biggest challenges in the field. The circadian clock is an endogenous timing system that oscillates with a ~24 h period regulating multiple physiological processes and cellular functions, and we recently reported that the cell intrinsic clock regulates rhythmic HIV-1 replication. Salt inducible kinases (SIK) contribute to circadian regulatory networks, however, there is limited evidence for SIKs regulating HIV-1 infection. Here, we show that pharmacological inhibition of SIKs perturbed the cellular clock and reduced rhythmic HIV-1 replication in circadian synchronised cells. Further, SIK inhibitors or genetic silencing of
    MeSH term(s) Humans ; HIV-1/genetics ; HIV Infections ; Virus Latency/genetics ; Virus Replication
    Language English
    Publishing date 2023-08-02
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Research Support, N.I.H., Extramural
    ZDB-ID 219316-4
    ISSN 1465-2099 ; 0022-1317
    ISSN (online) 1465-2099
    ISSN 0022-1317
    DOI 10.1099/jgv.0.001877
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 610: Show issues Location:
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  6. Article ; Online: Corrigendum: Elucidation of the Signatures of Proteasome-Catalysed Peptide Splicing.

    Paes, Wayne / Leonov, German / Partridge, Thomas / Nicastri, Annalisa / Ternette, Nicola / Borrow, Persephone

    Frontiers in immunology

    2021  Volume 12, Page(s) 755002

    Abstract: This corrects the article DOI: 10.3389/fimmu.2020.563800.]. ...

    Abstract [This corrects the article DOI: 10.3389/fimmu.2020.563800.].
    Language English
    Publishing date 2021-09-23
    Publishing country Switzerland
    Document type Published Erratum
    ZDB-ID 2606827-8
    ISSN 1664-3224 ; 1664-3224
    ISSN (online) 1664-3224
    ISSN 1664-3224
    DOI 10.3389/fimmu.2021.755002
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: Intracellular trafficking of HLA-E and its regulation.

    He, Wanlin / Gea-Mallorquí, Ester / Colin-York, Huw / Fritzsche, Marco / Gillespie, Geraldine M / Brackenridge, Simon / Borrow, Persephone / McMichael, Andrew J

    The Journal of experimental medicine

    2023  Volume 220, Issue 8

    Abstract: Interest in MHC-E-restricted CD8+ T cell responses has been aroused by the discovery of their efficacy in controlling simian immunodeficiency virus (SIV) infection in a vaccine model. The development of vaccines and immunotherapies utilizing human MHC-E ( ...

    Abstract Interest in MHC-E-restricted CD8+ T cell responses has been aroused by the discovery of their efficacy in controlling simian immunodeficiency virus (SIV) infection in a vaccine model. The development of vaccines and immunotherapies utilizing human MHC-E (HLA-E)-restricted CD8+ T cell response requires an understanding of the pathway(s) of HLA-E transport and antigen presentation, which have not been clearly defined previously. We show here that, unlike classical HLA class I, which rapidly exits the endoplasmic reticulum (ER) after synthesis, HLA-E is largely retained because of a limited supply of high-affinity peptides, with further fine-tuning by its cytoplasmic tail. Once at the cell surface, HLA-E is unstable and is rapidly internalized. The cytoplasmic tail plays a crucial role in facilitating HLA-E internalization, which results in its enrichment in late and recycling endosomes. Our data reveal distinctive transport patterns and delicate regulatory mechanisms of HLA-E, which help to explain its unusual immunological functions.
    MeSH term(s) Animals ; Humans ; Histocompatibility Antigens Class I/metabolism ; CD8-Positive T-Lymphocytes ; Antigen Presentation ; Vaccines ; HLA-E Antigens
    Chemical Substances Histocompatibility Antigens Class I ; Vaccines
    Language English
    Publishing date 2023-05-04
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
    ZDB-ID 218343-2
    ISSN 1540-9538 ; 0022-1007
    ISSN (online) 1540-9538
    ISSN 0022-1007
    DOI 10.1084/jem.20221941
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: IL-15 reprogramming compensates for NK cell mitochondrial dysfunction in HIV-1 infection.

    Moreno-Cubero, Elia / Alrubayyi, Aljawharah / Balint, Stefan / Ogbe, Ane / Gill, Upkar S / Matthews, Rebecca / Kinloch, Sabine / Burns, Fiona / Rowland-Jones, Sarah L / Borrow, Persephone / Schurich, Anna / Dustin, Michael / Peppa, Dimitra

    JCI insight

    2024  Volume 9, Issue 4

    Abstract: Dynamic regulation of cellular metabolism is important for maintaining homeostasis and can directly influence immune cell function and differentiation, including NK cell responses. Persistent HIV-1 infection leads to a state of chronic immune activation, ...

    Abstract Dynamic regulation of cellular metabolism is important for maintaining homeostasis and can directly influence immune cell function and differentiation, including NK cell responses. Persistent HIV-1 infection leads to a state of chronic immune activation, NK cell subset redistribution, and progressive NK cell dysregulation. In this study, we examined the metabolic processes that characterize NK cell subsets in HIV-1 infection, including adaptive NK cell subpopulations expressing the activating receptor NKG2C, which expand during chronic infection. These adaptive NK cells exhibit an enhanced metabolic profile in HIV-1- individuals infected with human cytomegalovirus (HCMV). However, the bioenergetic advantage of adaptive CD57+NKG2C+ NK cells is diminished during chronic HIV-1 infection, where NK cells uniformly display reduced oxidative phosphorylation (OXPHOS). Defective OXPHOS was accompanied by increased mitochondrial depolarization, structural alterations, and increased DRP-1 levels promoting fission, suggesting that mitochondrial defects are restricting the metabolic plasticity of NK cell subsets in HIV-1 infection. The metabolic requirement for the NK cell response to receptor stimulation was alleviated upon IL-15 pretreatment, which enhanced mammalian target of rapamycin complex 1 (mTORC1) activity. IL-15 priming enhanced NK cell functionality to anti-CD16 stimulation in HIV-1 infection, representing an effective strategy for pharmacologically boosting NK cell responses.
    MeSH term(s) Humans ; Cytomegalovirus Infections ; HIV-1 ; Interleukin-15 ; HIV Infections ; Killer Cells, Natural ; Mitochondrial Diseases/complications
    Chemical Substances Interleukin-15
    Language English
    Publishing date 2024-01-16
    Publishing country United States
    Document type Journal Article
    ISSN 2379-3708
    ISSN (online) 2379-3708
    DOI 10.1172/jci.insight.173099
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: MARS an improved de novo peptide candidate selection method for non-canonical antigen target discovery in cancer.

    Liao, Hanqing / Barra, Carolina / Zhou, Zhicheng / Peng, Xu / Woodhouse, Isaac / Tailor, Arun / Parker, Robert / Carré, Alexia / Borrow, Persephone / Hogan, Michael J / Paes, Wayne / Eisenlohr, Laurence C / Mallone, Roberto / Nielsen, Morten / Ternette, Nicola

    Nature communications

    2024  Volume 15, Issue 1, Page(s) 661

    Abstract: Understanding the nature and extent of non-canonical human leukocyte antigen (HLA) presentation in tumour cells is a priority for target antigen discovery for the development of next generation immunotherapies in cancer. We here employ a de novo mass ... ...

    Abstract Understanding the nature and extent of non-canonical human leukocyte antigen (HLA) presentation in tumour cells is a priority for target antigen discovery for the development of next generation immunotherapies in cancer. We here employ a de novo mass spectrometric sequencing approach with a refined, MHC-centric analysis strategy to detect non-canonical MHC-associated peptides specific to cancer without any prior knowledge of the target sequence from genomic or RNA sequencing data. Our strategy integrates MHC binding rank, Average local confidence scores, and peptide Retention time prediction for improved de novo candidate Selection; culminating in the machine learning model MARS. We benchmark our model on a large synthetic peptide library dataset and reanalysis of a published dataset of high-quality non-canonical MHC-associated peptide identifications in human cancer. We achieve almost 2-fold improvement for high quality spectral assignments in comparison to de novo sequencing alone with an estimated accuracy of above 85.7% when integrated with a stepwise peptide sequence mapping strategy. Finally, we utilize MARS to detect and validate lncRNA-derived peptides in human cervical tumour resections, demonstrating its suitability to discover novel, immunogenic, non-canonical peptide sequences in primary tumour tissue.
    MeSH term(s) Humans ; Female ; Peptides/genetics ; Uterine Cervical Neoplasms/genetics ; Amino Acid Sequence ; Peptide Library ; Benchmarking
    Chemical Substances Peptides ; Peptide Library
    Language English
    Publishing date 2024-01-22
    Publishing country England
    Document type Journal Article
    ZDB-ID 2553671-0
    ISSN 2041-1723 ; 2041-1723
    ISSN (online) 2041-1723
    ISSN 2041-1723
    DOI 10.1038/s41467-023-44460-z
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: Innate immunity in acute HIV-1 infection.

    Borrow, Persephone

    Current opinion in HIV and AIDS

    2011  Volume 6, Issue 5, Page(s) 353–363

    Abstract: Purpose of review: Acute HIV-1 infection (AHI) is composed of the eclipse phase, during which the transmitted virus struggles to avoid eradication and achieve amplification/spread; the expansion phase when virus disseminates and undergoes exponential ... ...

    Abstract Purpose of review: Acute HIV-1 infection (AHI) is composed of the eclipse phase, during which the transmitted virus struggles to avoid eradication and achieve amplification/spread; the expansion phase when virus disseminates and undergoes exponential replication associated with extensive CD4⁺ T-cell destruction; and the containment phase when set-point levels of viremia and immune activation are established. The importance of interactions between HIV-1 and innate responses in determining events throughout AHI is increasingly recognized, and is reviewed here.
    Recent findings: During the eclipse phase, HIV-1 subverts dendritic cell functions to promote its replication at mucosal sites and employs multiple strategies to minimize control by type 1 interferons. Systemic virus dissemination is associated with widespread activation of innate responses which fuels HIV-1 replication. To minimize the protective effects of innate responses, HIV-1 resists control by natural killer cells and may impair innate regulation of adaptive responses. Innate responses remain chronically activated after HIV-1 containment which is thought to drive HIV-1 pathogenesis.
    Summary: Innate responses are pivotal determinants of events at all stages of AHI. Increased understanding of mechanisms involved in innate control of HIV-1 and pathways regulating innate activation during HIV-1 infection could facilitate development of novel approaches to combating this infection.
    MeSH term(s) HIV Infections/immunology ; HIV Infections/virology ; HIV-1/immunology ; HIV-1/pathogenicity ; Humans ; Immunity, Innate
    Language English
    Publishing date 2011-07-07
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't ; Review
    ZDB-ID 2502511-9
    ISSN 1746-6318 ; 1746-630X
    ISSN (online) 1746-6318
    ISSN 1746-630X
    DOI 10.1097/COH.0b013e3283495996
    Database MEDical Literature Analysis and Retrieval System OnLINE

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