LIVIVO - Search results -

Search results

Result 1 - 10 of total 3715

Search options

Article ; Online: Introduction. Mémoire(s), politique et sociétés dans les Amériques

Diana Burgos-Vigna / Julien Zarifian

Cahiers du MIMMOC, Vol

2023 Volume 30

Keywords	politiques mémorielles ; mémoires ; traumatismes ; violence ; réparation ; Social Sciences ; H ; Social sciences (General) ; H1-99
Language	English
Publishing date	2023-12-01T00:00:00Z
Publisher	Université de Poitiers
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

Full text online

Full text

Inter-library loan at ZB MED

Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

Article ; Online: Mining the bacterial genome to discover new antimicrobial molecules

Wenjie Liang / Julien Diana

EMBO Molecular Medicine, Vol 14, Iss 2, Pp n/a-n/a (2022)

2022

Abstract: Multidrug resistance is one of the major public health issues the world is facing today. However, the World Health Organization (WHO) revealed recently that there has been little progress in the development of new antibiotics to tackle drug‐resistant ... ...

Abstract	Multidrug resistance is one of the major public health issues the world is facing today. However, the World Health Organization (WHO) revealed recently that there has been little progress in the development of new antibiotics to tackle drug‐resistant infections. By mining the bacterial genome database, Zhu et al, in the last issue of EMBO Molecular Medicine, report a defensin expressed by human oral actinomyces, actinomycesin, and characterize its anti‐infectious capacity (Zhu et al, 2021). They demonstrate the safety and efficacy of this bacterial antimicrobial peptide (AMP) against various bacterial strains, describe its mode of action, and validate its use as systemic drug therapy against bacterial infections in mice. This study highlights human oral bacteria as a source of antimicrobial agents that need to be considered in the future to fight multidrug‐resistant bacteria.
Keywords	Medicine (General) ; R5-920 ; Genetics ; QH426-470
Language	English
Publishing date	2022-02-01T00:00:00Z
Publisher	Wiley
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

Full text online

Full text

Inter-library loan at ZB MED

Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

Article ; Online: Mining the bacterial genome to discover new antimicrobial molecules.

Liang, Wenjie / Diana, Julien

EMBO molecular medicine

2021 Volume 14, Issue 2, Page(s) e15409

Abstract	Multidrug resistance is one of the major public health issues the world is facing today. However, the World Health Organization (WHO) revealed recently that there has been little progress in the development of new antibiotics to tackle drug-resistant infections. By mining the bacterial genome database, Zhu et al, in the last issue of EMBO Molecular Medicine, report a defensin expressed by human oral actinomyces, actinomycesin, and characterize its anti-infectious capacity (Zhu et al, 2021). They demonstrate the safety and efficacy of this bacterial antimicrobial peptide (AMP) against various bacterial strains, describe its mode of action, and validate its use as systemic drug therapy against bacterial infections in mice. This study highlights human oral bacteria as a source of antimicrobial agents that need to be considered in the future to fight multidrug-resistant bacteria.
MeSH term(s)	Animals ; Anti-Bacterial Agents/chemistry ; Anti-Infective Agents/pharmacology ; Drug Resistance, Multiple, Bacterial/drug effects ; Genome, Bacterial/drug effects ; Mice ; Microbial Sensitivity Tests
Chemical Substances	Anti-Bacterial Agents ; Anti-Infective Agents
Language	English
Publishing date	2021-12-15
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't ; Comment
ZDB-ID	2467145-9
ISSN	1757-4684 ; 1757-4676
ISSN (online)	1757-4684
ISSN	1757-4676
DOI	10.15252/emmm.202115409
Database	MEDical Literature Analysis and Retrieval System OnLINE

In stock of ZB MED Cologne/Königswinter

Zs.A 6784: Show issues

Location:
Je nach Verfügbarkeit (siehe Angabe bei Bestand)
bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
ab Jg. 2022: Lesesaal (EG)

Order via subito

This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

Details ▾
- See ZB MED holdings
- Order with fees

Article ; Online: The Dual Role of Antimicrobial Peptides in Autoimmunity.

Liang, Wenjie / Diana, Julien

Frontiers in immunology

2020 Volume 11, Page(s) 2077

Abstract: Autoimmune diseases (AiDs) are characterized by the destruction of host tissues by the host immune system. The etiology of AiDs is complex, with the implication of multiple genetic defects and various environmental factors (pathogens, antibiotic use, ... ...

Abstract	Autoimmune diseases (AiDs) are characterized by the destruction of host tissues by the host immune system. The etiology of AiDs is complex, with the implication of multiple genetic defects and various environmental factors (pathogens, antibiotic use, pollutants, stress, and diet). The interaction between these two compartments results in the rupture of tolerance against self-antigens and the unwanted activation of the immune system. Thanks to animal models, the immunopathology of many AiDs is well described, with the implication of both the innate and adaptive immune systems. This progress toward the understanding of AiDs led to several therapies tested in patients. However, the results from these clinical trials have not been satisfactory, from reversing the course of AiDs to preventing them. The need for a cure has prompted many investigators to explore alternative aspects in the immunopathology of these diseases. Among these new aspects, the role of antimicrobial host defense peptides (AMPs) is growing. Indeed, beyond their antimicrobial activity, AMPs are potent immunomodulatory molecules and consequently are implicated in the development of numerous AiDs. Importantly, according to the disease considered, AMPs appear to play a dual role in autoimmunity with either anti- or pro-inflammatory abilities. Here, we aimed to summarize the current knowledge about the role of AMPs in the development of AiDs and attempt to provide some hypotheses explaining their dual role. Definitely, a complete understanding of this aspect is mandatory before the design of AMP-based therapies against AiDs.
MeSH term(s)	Animals ; Antimicrobial Cationic Peptides/metabolism ; Autoimmune Diseases/diagnosis ; Autoimmune Diseases/etiology ; Autoimmune Diseases/metabolism ; Autoimmunity ; Biomarkers ; Defensins/metabolism ; Disease Susceptibility ; Host-Pathogen Interactions/immunology ; Humans ; Immunity, Innate ; Immunomodulation ; Pore Forming Cytotoxic Proteins/metabolism
Chemical Substances	Antimicrobial Cationic Peptides ; Biomarkers ; Defensins ; Pore Forming Cytotoxic Proteins ; ropocamptide (3DD771JO2H)
Language	English
Publishing date	2020-09-02
Publishing country	Switzerland
Document type	Journal Article ; Research Support, Non-U.S. Gov't ; Review
ZDB-ID	2606827-8
ISSN	1664-3224 ; 1664-3224
ISSN (online)	1664-3224
ISSN	1664-3224
DOI	10.3389/fimmu.2020.02077
Database	MEDical Literature Analysis and Retrieval System OnLINE

Order via subito

Article ; Online: Awakening adult neural stem cells: NOX signalling as a positive regulator of the quiescence-to-proliferation transition in the Xenopus retina.

Donval, Alicia / Hernandez Puente, Cinthia Violeta / Lainé, Anaïs / Roman, Diana / Vessely, Romain / Leclercq, Julien / Perron, Muriel / Locker, Morgane

Development (Cambridge, England)

2024 Volume 151, Issue 2

Abstract: A growing wealth of data suggest that reactive oxygen species (ROS) signalling might be crucial in conferring embryonic or adult stem cells their specific properties. However, how stem cells control ROS production and scavenging, and how ROS in turn ... ...

Abstract	A growing wealth of data suggest that reactive oxygen species (ROS) signalling might be crucial in conferring embryonic or adult stem cells their specific properties. However, how stem cells control ROS production and scavenging, and how ROS in turn contribute to stemness, remain poorly understood. Using the Xenopus retina as a model system, we first investigated the redox status of retinal stem cells (RSCs). We discovered that they exhibit higher ROS levels compared with progenitors and retinal neurons, and express a set of specific redox genes. We next addressed the question of ROS functional involvement in these cells. Using pharmacological or genetic tools, we demonstrate that inhibition of NADPH oxidase-dependent ROS production increases the proportion of quiescent RSCs. Surprisingly, this is accompanied by an apparent acceleration of the mean division speed within the remaining proliferating pool. Our data further unveil that such impact on RSC cell cycling is achieved by modulation of the Wnt/Hedgehog signalling balance. Altogether, we highlight that RSCs exhibit distinctive redox characteristics and exploit NADPH oxidase signalling to limit quiescence and fine-tune their proliferation rate.
MeSH term(s)	Animals ; Xenopus laevis/metabolism ; Reactive Oxygen Species ; Cell Proliferation ; Hedgehog Proteins ; Retina/metabolism ; Neural Stem Cells ; Adult Stem Cells/metabolism ; NADPH Oxidases/genetics ; Wnt Signaling Pathway
Chemical Substances	Reactive Oxygen Species ; Hedgehog Proteins ; NADPH Oxidases (EC 1.6.3.-)
Language	English
Publishing date	2024-01-18
Publishing country	England
Document type	Journal Article
ZDB-ID	90607-4
ISSN	1477-9129 ; 0950-1991
ISSN (online)	1477-9129
ISSN	0950-1991
DOI	10.1242/dev.201463
Database	MEDical Literature Analysis and Retrieval System OnLINE

In stock of ZB MED Cologne/Königswinter

Ub I Zs.183: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular ab Jg. 2022: Lesesaal (EG)
Zs.MG 91: Show issues

Order via subito

Details ▾
- See ZB MED holdings
- Order with fees

Article: The Relevance of Human Whistled Languages for the Analysis and Decoding of Dolphin Communication.

Meyer, Julien / Magnasco, Marcelo O / Reiss, Diana

Frontiers in psychology

2021 Volume 12, Page(s) 689501

Abstract: Humans use whistled communications, the most elaborate of which are commonly called "whistled languages" or "whistled speech" because they consist of a natural type of speech. The principle of whistled speech is straightforward: people articulate words ... ...

Abstract	Humans use whistled communications, the most elaborate of which are commonly called "whistled languages" or "whistled speech" because they consist of a natural type of speech. The principle of whistled speech is straightforward: people articulate words while whistling and thereby transform spoken utterances by simplifying them, syllable by syllable, into whistled melodies. One of the most striking aspects of this whistled transformation of words is that it remains intelligible to trained speakers, despite a reduced acoustic channel to convey meaning. It constitutes a natural traditional means of telecommunication that permits spoken communication at long distances in a large diversity of languages of the world. Historically, birdsong has been used as a model for vocal learning and language. But conversely, human whistled languages can serve as a model for elucidating how information may be encoded in dolphin whistle communication. In this paper, we elucidate the reasons why human whistled speech and dolphin whistles are interesting to compare. Both are characterized by similar acoustic parameters and serve a common purpose of long distance communication in natural surroundings in two large brained social species. Moreover, their differences - e.g., how they are produced, the dynamics of the whistles, and the types of information they convey - are not barriers to such a comparison. On the contrary, by exploring the structure and attributes found across human whistle languages, we highlight that they can provide an important model as to how complex information is and can be encoded in what appears at first sight to be simple whistled modulated signals. Observing details, such as processes of segmentation and coarticulation, in whistled speech can serve to advance and inform the development of new approaches for the analysis of whistle repertoires of dolphins, and eventually other species. Human whistled languages and dolphin whistles could serve as complementary test benches for the development of new methodologies and algorithms for decoding whistled communication signals by providing new perspectives on how information may be encoded structurally and organizationally.
Language	English
Publishing date	2021-09-21
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2563826-9
ISSN	1664-1078
ISSN	1664-1078
DOI	10.3389/fpsyg.2021.689501
Database	MEDical Literature Analysis and Retrieval System OnLINE

Order via subito

Article ; Online: High-Throughput Time-Lapse Fluorescence Microscopy Screening for Heterogeneously Expressed Genes in Bacillus subtilis.

Mortier, Julien / Van Riet, Stefanie / Senovilla Herrero, Diana / Vanoirbeek, Kristof / Aertsen, Abram

Microbiology spectrum

2022 Volume 10, Issue 1, Page(s) e0204521

Abstract: Elucidating phenotypic heterogeneity in clonal bacterial populations is important for both the fundamental understanding of bacterial behavior and the synthetic engineering of bacteria in biotechnology. In this study, we present and validate a high- ... ...

Abstract	Elucidating phenotypic heterogeneity in clonal bacterial populations is important for both the fundamental understanding of bacterial behavior and the synthetic engineering of bacteria in biotechnology. In this study, we present and validate a high-throughput and high-resolution time-lapse fluorescence microscopy-based strategy to easily and systematically screen for heterogeneously expressed genes in the Bacillus subtilis model bacterium. This screen allows detection of expression patterns at high spatial and temporal resolution, which often escape detection by other approaches, and can readily be extrapolated to other bacteria. A proof-of-concept screening in B. subtilis revealed both recognized and yet unrecognized heterogeneously expressed genes, thereby validating the approach.
MeSH term(s)	Bacillus subtilis/genetics ; Bacterial Proteins/genetics ; Gene Expression Regulation, Bacterial ; High-Throughput Screening Assays/methods ; Microscopy, Fluorescence/methods ; Time-Lapse Imaging/methods
Chemical Substances	Bacterial Proteins
Language	English
Publishing date	2022-02-16
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2807133-5
ISSN	2165-0497 ; 2165-0497
ISSN (online)	2165-0497
ISSN	2165-0497
DOI	10.1128/spectrum.02045-21
Database	MEDical Literature Analysis and Retrieval System OnLINE

Order via subito

Article ; Online: Transforming a volcanic rock powder waste into an efficient adsorbent to remove dyes (acid green 16 and acid red 97) and metals (Ag

Rossatto, Diovani L / de Lima, Rachel / Netto, Matias S / Vieillard, Julien / Silva, Luis F O / Pinto, Diana / Dotto, Guilherme L

Environmental science and pollution research international

2023 Volume 30, Issue 59, Page(s) 124041–124052

Abstract: This study searched for the best synthesis route for producing an adsorbent from the alkaline fusion of volcanic rock powder waste. The samples synthesized under different conditions of temperature and alkalizing ratio/precursor material, nine in total ( ... ...

Abstract	This study searched for the best synthesis route for producing an adsorbent from the alkaline fusion of volcanic rock powder waste. The samples synthesized under different conditions of temperature and alkalizing ratio/precursor material, nine in total (NP.F, NP.F1, NP.F2, ...NP.F8 ), were used in the adsorption of acid green 16 (AG 16) and acid red 97 (AR 97) dyes and Ag
MeSH term(s)	Coloring Agents ; Powders ; Water ; Sodium Hydroxide ; Indicators and Reagents ; Metals ; Adsorption ; Kinetics ; Water Pollutants, Chemical ; Hydrogen-Ion Concentration
Chemical Substances	Coloring Agents ; Acid Green 16 (12768-78-4) ; acid red 97 (8UJ772G61O) ; Powders ; Water (059QF0KO0R) ; Sodium Hydroxide (55X04QC32I) ; Indicators and Reagents ; Metals ; Water Pollutants, Chemical
Language	English
Publishing date	2023-11-23
Publishing country	Germany
Document type	Journal Article
ZDB-ID	1178791-0
ISSN	1614-7499 ; 0944-1344
ISSN (online)	1614-7499
ISSN	0944-1344
DOI	10.1007/s11356-023-31074-7
Database	MEDical Literature Analysis and Retrieval System OnLINE

In stock of ZB MED Bonn / Germany

Z 5915: Show issues

Order via subito

Inter-library loan at ZB MED

Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

Details ▾
- See ZB MED holdings
- Order with fees

Article: CooperationSplenic CD169+ marginal zone macrophages directly cross-prime CD8+ T cells in vivo using a vacuolar processing pathway

van Endert, Peter / Mauvais, François-Xavier / Hamel, Yamina / Diana, Julien / Garfa, Meriem

Molecular immunology. 2022 Oct., v. 150

2022

Abstract: Cross-priming of CD8+ T cells is of critical importance in triggering CD8+ T cell responses against pathogens and tumors. It is commonly thought that conventional type 1 dendritic cells (cDC1) cross-prime with unequalled efficacy, conferred to them by a ... ...

Abstract	Cross-priming of CD8+ T cells is of critical importance in triggering CD8+ T cell responses against pathogens and tumors. It is commonly thought that conventional type 1 dendritic cells (cDC1) cross-prime with unequalled efficacy, conferred to them by a proteasome and TAP-dependent pathway. Here we present data challenging the unique cross-priming efficacy of both the cDC1 subset and the proteasome/TAP-dependent pathway. Splenic CD169 macrophages are strategically placed in the marginal zone for capture of blood-borne pathogens. However, they are considered unable to directly cross-present and to depend on antigen transfer to cDC1 for cross-priming. We have developed a protocol for purification of CD169 macrophages. Extensive characterization shows that these cells display morphology, phenotype and gene expression distinguishing them clearly from cDC1, cDC2, plasmacytoid DC and red pulp macrophages. In vitro, CD169 cells cross-present soluble, receptor-targeted and phagocytosed antigen with equal or better efficiency than cDC1. Remarkably, this is achieved through a vacuolar, BFA and epoxomicin-independent pathway. Using intravital biphoton microscopy, 3D light sheet imaging and antigen targeting to CD169, we show that CD169 macrophages establish long-lasting antigen-dependent contacts with cognate CD8+ T cells that result in T cell activation in situ and generation of triple-positive effector as well as memory cells. Therefore, splenic CD169 macrophages represent a second set of myeloid cells equipped for highly efficient cross-priming. The biological role of cross-priming by these cells as well as their cooperation with cDC1 cells are under investigation.
Keywords	CD8-positive T-lymphocytes ; antigens ; gene expression ; macrophages ; memory ; microscopy ; phenotype ; proteasome endopeptidase complex ; pulp ; vacuoles
Language	English
Dates of publication	2022-10
Publishing place	Elsevier Ltd
Document type	Article
ZDB-ID	424427-8
ISSN	1872-9142 ; 0161-5890
ISSN (online)	1872-9142
ISSN	0161-5890
DOI	10.1016/j.molimm.2022.05.112
Database	NAL-Catalogue (AGRICOLA)

In stock of ZB MED Cologne/Königswinter

Zs.A 166: Show issues

Location:
Je nach Verfügbarkeit (siehe Angabe bei Bestand)
bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
Jg. 1995 - 2021: Lesesall (1.OG)
ab Jg. 2022: Lesesaal (EG)

Order via subito

Details ▾
- See ZB MED holdings
- Order with fees

Book ; Conference proceedings: Proceedings of the SSIB 2016 Annual Meeting

Williams, Diana L.

(Physiology & behavior ; volume 176 (July 1, 2017))

2017

Title variant	Special issue: Proceedings of the SSIB 2016 Annual Meeting
Event/congress	Society for the Study of Ingestive Behavior (24., 2016, PortoPortugal, Annual Meeting)
Author's details	guest editors: Diana L. Williams and Laurence J. Nolan
Series title	Physiology & behavior ; volume 176 (July 1, 2017)
Collection
Language	English
Publisher	Elsevier
Publishing place	Amsterdam
Publishing country	Netherlands
Document type	Book ; Conference proceedings
Note	Tagungsdaten: Porto, Portugal, from July 12 to 16, 2016
HBZ-ID	HT019362987
Database	Catalogue ZB MED Medicine, Health

In stock of ZB MED Cologne/Königswinter

Shelf mark	Loan status	Location
Zs A 747 -176-	not available for loan	Zeitschriften-Lesesaal

Order via subito

Details ▾
- See ZB MED holdings
- Order with fees

To top

Full text online

More links

Kategorien

Inter-library loan at ZB MED

Full text online

More links

Kategorien

Inter-library loan at ZB MED

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

More links

Kategorien

Order via subito

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

More links

Kategorien

Order via subito

More links

Kategorien

Order via subito

More links

Kategorien

In stock of ZB MED Bonn / Germany

Order via subito

Inter-library loan at ZB MED

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito