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Article ; Online: Corrigendum to ..úChallenging molecular dogmas in human sepsis using mathematical reasoning..Ñ [EBioMedicine 80 (2022) 104031].

Ghazal, Peter / Rodrigues, Patricia R S / Chakraborty, Mallinath / Oruganti, Siva / Woolley, Thomas E

2022 Volume 85, Page(s) 104331

Language	English
Publishing date	2022-10-29
Publishing country	Netherlands
Document type	Published Erratum
ZDB-ID	2851331-9
ISSN	2352-3964
ISSN (online)	2352-3964
DOI	10.1016/j.ebiom.2022.104331
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Histological evidence of hypothyroidism in mice chronically exposed to conventional farming.

Coelho, Nádia / Camarinho, Ricardo / Garcia, Patrícia / Rodrigues, Armindo S

Environmental toxicology and pharmacology

2024 Volume 106, Page(s) 104387

Abstract: Worldwide, disorders of the thyroid gland are a growing concern; such can be caused by exposure to contaminants, including agrochemicals used in conventional agriculture, which act as endocrine disruptors. The purpose of this study is to evaluate whether ...

Abstract	Worldwide, disorders of the thyroid gland are a growing concern; such can be caused by exposure to contaminants, including agrochemicals used in conventional agriculture, which act as endocrine disruptors. The purpose of this study is to evaluate whether or not exposure to an environment with conventional agriculture leads to thyroid disruption. Mus musculus were used as bioindicator species, captured in two sites: a farm where conventional agriculture is practiced, and a place without agriculture. Thyroid histomorphometric and morphologic data were analyzed. The impacts of the agricultural environment over the thyroid were revealed, as indications of hypothyroidism were observed in exposed mice: the area and volume of epithelial cells were much lower. Alterations in thyroid histomorphology were also observed: lower follicular sphericity, irregularly delimited epithelium and increased exfoliation into the colloid. These results highlight the need for transition from current conventional agricultural systems towards organic systems.
MeSH term(s)	Animals ; Mice ; Farms ; Agriculture ; Hypothyroidism/chemically induced ; Endocrine Disruptors
Chemical Substances	Endocrine Disruptors
Language	English
Publishing date	2024-02-14
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	1318302-3
ISSN	1872-7077 ; 1382-6689
ISSN (online)	1872-7077
ISSN	1382-6689
DOI	10.1016/j.etap.2024.104387
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Immune-metabolic adaptations in pregnancy: A potential stepping-stone to sepsis.

Sharma, Simran / Rodrigues, Patricia R S / Zaher, Summia / Davies, Luke C / Ghazal, Peter

EBioMedicine

2022 Volume 86, Page(s) 104337

Abstract: Physiological shifts during pregnancy predispose women to a higher risk of developing sepsis resulting from a maladapted host-response to infection. Insightful studies have delineated subtle point-changes to the immune system during pregnancy. Here, we ... ...

Abstract	Physiological shifts during pregnancy predispose women to a higher risk of developing sepsis resulting from a maladapted host-response to infection. Insightful studies have delineated subtle point-changes to the immune system during pregnancy. Here, we present an overlay of these point-changes, asking what changes and when, at a physiological, cellular, and molecular systems-level in the context of sepsis. We identify distinct immune phases in pregnancy delineated by placental hormone-driven changes in homeostasis setpoints of the immune and metabolic systems that subtly mirrors changes observed in sepsis. We propose that pregnancy immune-metabolic setpoint changes impact feedback thresholds that increase risk for a maladapted host-response to infection and thus act as a stepping-stone to sepsis. Defining maternal immune-metabolic setpoint changes is not only vital for tailoring the right diagnostic tools for early management of maternal sepsis but will facilitate an unravelling of the pathophysiological pathways that predispose an individual to sepsis.
MeSH term(s)	Humans ; Pregnancy ; Female ; Placenta/metabolism ; Sepsis/diagnosis ; Sepsis/etiology ; Sepsis/metabolism ; Pregnancy Complications, Infectious ; Adaptation, Physiological ; Homeostasis
Language	English
Publishing date	2022-12-02
Publishing country	Netherlands
Document type	Journal Article ; Review
ZDB-ID	2851331-9
ISSN	2352-3964
ISSN (online)	2352-3964
DOI	10.1016/j.ebiom.2022.104337
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Corrigendum to .úChallenging molecular dogmas in human sepsis using mathematical reasoning.Ñ [EBioMedicine 80 (2022) 104031]

Peter Ghazal / Patricia R.S. Rodrigues / Mallinath Chakraborty / Siva Oruganti / Thomas E. Woolley

EBioMedicine, Vol 85, Iss , Pp 104331- (2022)

2022

Keywords	Medicine ; R ; Medicine (General) ; R5-920
Language	English
Publishing date	2022-11-01T00:00:00Z
Publisher	Elsevier
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Challenging molecular dogmas in human sepsis using mathematical reasoning.

Ghazal, Peter / Rodrigues, Patricia R S / Chakraborty, Mallinath / Oruganti, Siva / Woolley, Thomas E

EBioMedicine

2022 Volume 80, Page(s) 104031

Abstract: Sepsis is defined as a dysregulated host-response to infection, across all ages and pathogens. What defines a dysregulated state remains intensively researched but incompletely understood. Here, we dissect the meaning of this definition and its ... ...

Abstract	Sepsis is defined as a dysregulated host-response to infection, across all ages and pathogens. What defines a dysregulated state remains intensively researched but incompletely understood. Here, we dissect the meaning of this definition and its importance for the diagnosis and management of sepsis. We deliberate on pathophysiological features and dogmas that range from cytokine storms and immune paralysis to dormancy and altered homeostasis setpoints. Mathematical reasoning, used to test for plausibility, reveals three interlinked cardinal rules governing host-response trajectories in sepsis. Rule one highlights that the amplitude of the immune response while important is not sufficient and is strictly dependent on rule two, specifying bioenergetic capacity and are together dynamically driven by rule three, delineating stability and alterations in setpoints. We consider these rules and associated pathophysiological parameters for guiding data-science and artificial intelligence mining of multi-omics and big-data for improving the precision of diagnostic and therapeutic approaches to sepsis. FUNDING: PG funded by the European Regional Development Fund and Welsh Government (Ser Cymru programme - Project Sepsis).
MeSH term(s)	Artificial Intelligence ; Cytokine Release Syndrome ; Humans ; Sepsis/diagnosis
Language	English
Publishing date	2022-05-03
Publishing country	Netherlands
Document type	Journal Article ; Review
ZDB-ID	2851331-9
ISSN	2352-3964
ISSN (online)	2352-3964
DOI	10.1016/j.ebiom.2022.104031
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Challenging molecular dogmas in human sepsis using mathematical reasoning

Peter Ghazal / Patricia R.S. Rodrigues / Mallinath Chakraborty / Siva Oruganti / Thomas E. Woolley

EBioMedicine, Vol 80, Iss , Pp 104031- (2022)

2022

Abstract: Summary: Sepsis is defined as a dysregulated host-response to infection, across all ages and pathogens. What defines a dysregulated state remains intensively researched but incompletely understood. Here, we dissect the meaning of this definition and its ... ...

Abstract	Summary: Sepsis is defined as a dysregulated host-response to infection, across all ages and pathogens. What defines a dysregulated state remains intensively researched but incompletely understood. Here, we dissect the meaning of this definition and its importance for the diagnosis and management of sepsis. We deliberate on pathophysiological features and dogmas that range from cytokine storms and immune paralysis to dormancy and altered homeostasis setpoints. Mathematical reasoning, used to test for plausibility, reveals three interlinked cardinal rules governing host-response trajectories in sepsis. Rule one highlights that the amplitude of the immune response while important is not sufficient and is strictly dependent on rule two, specifying bioenergetic capacity and are together dynamically driven by rule three, delineating stability and alterations in setpoints. We consider these rules and associated pathophysiological parameters for guiding data-science and artificial intelligence mining of multi-omics and big-data for improving the precision of diagnostic and therapeutic approaches to sepsis. Funding: PG funded by the European Regional Development Fund and Welsh Government (Ser Cymru programme – Project Sepsis).
Keywords	Sepsis ; Host-response ; Cytokine storm ; Immunosuppression ; Inflammation ; Infection ; Medicine ; R ; Medicine (General) ; R5-920
Language	English
Publishing date	2022-06-01T00:00:00Z
Publisher	Elsevier
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Metformin acts in the gut and induces gut-liver crosstalk.

Tobar, Natália / Rocha, Guilherme Z / Santos, Andrey / Guadagnini, Dioze / Assalin, Heloísa B / Camargo, Juliana A / Gonçalves, Any E S S / Pallis, Flavia R / Oliveira, Alexandre G / Rocco, Silvana A / Neto, Raphael M / de Sousa, Irene Layane / Alborghetti, Marcos R / Sforça, Maurício L / Rodrigues, Patrícia B / Ludwig, Raissa G / Vanzela, Emerielle C / Brunetto, Sergio Q / Boer, Patrícia A /

Gontijo, José A R / Geloneze, Bruno / Carvalho, Carla R O / Prada, Patricia O / Folli, Franco / Curi, Rui / Mori, Marcelo A / Vinolo, Marco A R / Ramos, Celso D / Franchini, Kleber G / Tormena, Claudio F / Saad, Mario J A

Proceedings of the National Academy of Sciences of the United States of America

2023 Volume 120, Issue 4, Page(s) e2211933120

Abstract: Metformin is the most prescribed drug for DM2, but its site and mechanism of action are still not well established. Here, we investigated the effects of metformin on basolateral intestinal glucose uptake (BIGU), and its consequences on hepatic glucose ... ...

Abstract	Metformin is the most prescribed drug for DM2, but its site and mechanism of action are still not well established. Here, we investigated the effects of metformin on basolateral intestinal glucose uptake (BIGU), and its consequences on hepatic glucose production (HGP). In diabetic patients and mice, the primary site of metformin action was the gut, increasing BIGU, evaluated through PET-CT. In mice and CaCo2 cells, this increase in BIGU resulted from an increase in GLUT1 and GLUT2, secondary to ATF4 and AMPK. In hyperglycemia, metformin increased the lactate (reducing pH and bicarbonate in portal vein) and acetate production in the gut, modulating liver pyruvate carboxylase, MPC1/2, and FBP1, establishing a gut-liver crosstalk that reduces HGP. In normoglycemia, metformin-induced increases in BIGU is accompanied by hypoglycemia in the portal vein, generating a counter-regulatory mechanism that avoids reductions or even increases HGP. In summary, metformin increases BIGU and through gut-liver crosstalk influences HGP.
MeSH term(s)	Animals ; Humans ; Mice ; Caco-2 Cells ; Diabetes Mellitus, Type 2 ; Glucose/metabolism ; Hypoglycemic Agents/pharmacology ; Liver/metabolism ; Metformin/pharmacology ; Positron Emission Tomography Computed Tomography ; Gastrointestinal Tract/metabolism
Chemical Substances	Glucose (IY9XDZ35W2) ; Hypoglycemic Agents ; Metformin (9100L32L2N)
Language	English
Publishing date	2023-01-19
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	209104-5
ISSN	1091-6490 ; 0027-8424
ISSN (online)	1091-6490
ISSN	0027-8424
DOI	10.1073/pnas.2211933120
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article: A Thorny Tale of Parasites: Screening for Enteric Protozoan Parasites in Hedgehogs from Portugal.

Gomes-Gonçalves, Sara / Santos-Silva, Sérgio / Cruz, Andreia V S / Rodrigues, Clarisse / Soeiro, Vanessa / Barradas, Patrícia / Mesquita, João R

Animals : an open access journal from MDPI

2024 Volume 14, Issue 2

Abstract: Enteric protozoan parasites, such ... ...

Abstract	Enteric protozoan parasites, such as
Language	English
Publishing date	2024-01-21
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2606558-7
ISSN	2076-2615
ISSN	2076-2615
DOI	10.3390/ani14020326
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article: Acute Rupture of the Plantar Fascia in a Soccer Player.

Costa, Diogo / Cruz, Patrícia / Brito, Rui / Cantista, Pedro / Rodrigues-Gomes, Sérgio

Cureus

2023 Volume 15, Issue 5, Page(s) e38527

Abstract: Acute rupture of the plantar fascia is a rare but potentially debilitating injury in athletes, particularly those involved in running and jumping sports. Early recognition and prompt treatment are crucial for a successful recovery and return to play. ... ...

Abstract	Acute rupture of the plantar fascia is a rare but potentially debilitating injury in athletes, particularly those involved in running and jumping sports. Early recognition and prompt treatment are crucial for a successful recovery and return to play. Conservative treatment, including rest, immobilization, and physical therapy, may be effective in most cases, while surgical intervention may be required in those that are nonresponsive to conservative treatment. We report a case of plantar fascia rupture in a 22-year-old male semi-professional football player who presented with sudden severe pain in the sole of his right foot during a match, followed by a popping sensation and inability to weight bear. The athlete was healthy and had no history of previous injury in the right foot. MRI confirmed a complete rupture of the plantar fascia. The player was treated conservatively and underwent a rehabilitation program. The player returned to full competition after nine weeks, with no limitations.
Language	English
Publishing date	2023-05-04
Publishing country	United States
Document type	Case Reports
ZDB-ID	2747273-5
ISSN	2168-8184
ISSN	2168-8184
DOI	10.7759/cureus.38527
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article: Natural habitat connectivity and organic management modulate pest dispersal, gene flow, and natural enemy communities.

Novaes, Danyelle R / Sujii, Patricia S / Rodrigues, Camila A / Silva, Karen M N B / Machado, Amanda F P / Inoue-Nagata, Alice K / Nakasu, Erich Y T / Togni, Pedro H B

Ecological applications : a publication of the Ecological Society of America

2023 Volume 34, Issue 2, Page(s) e2938

Abstract: The simplification and fragmentation of agricultural landscapes generate effects on insects at multiple spatial scales. As each functional group perceives and uses the habitat differently, the response of pest insects and their associated natural enemies ...

Abstract	The simplification and fragmentation of agricultural landscapes generate effects on insects at multiple spatial scales. As each functional group perceives and uses the habitat differently, the response of pest insects and their associated natural enemies to environmental changes varies. Therefore, landscape structure may have consequences on gene flow among pest populations in space. This study aimed to evaluate the effects of local and landscape factors, at multiple scales, on the local infestation, gene flow and broad dispersion dynamics of the pest insect Bemisia tabaci (Genn.) Middle East-Asia Minor 1 (MEAM-1, former biotype B) (Hemiptera: Aleyrodidae) and its associated natural enemies in a tropical agroecosystem. We evaluated the abundance of B. tabaci populations and their natural enemy community in 20 tomato farms in Brazil and the gene flow between farms from 2019 to 2021. Landscapes dominated by agriculture resulted in larger B. tabaci populations and higher gene flow, especially in conventional farms. A higher density of native vegetation patches disfavored pest populations, regardless of the management system. The results revealed that whitefly responds to intermediate spatial scales and that landscape factors interact with management systems to modulate whitefly populations on focal farms. Conversely, whitefly natural enemies benefited from higher amounts of natural vegetation at small spatial scales, while the connectivity between natural habitat patches was beneficial for natural enemies regardless of the distance from the focal farm. The resulting dispersion model predicts that the movement of whiteflies between farms increases as the amount of natural vegetation decreases. Our findings demonstrate that landscape features, notably landscape configuration, can mediate infestation episodes, as they affect pest insects and natural enemies in opposite ways. We also showed that landscape features interact with farm traits, which highlights the need for management strategies at multiple spatial scales. In conclusion, we demonstrated the importance of the conservation of natural areas as a key strategy for area-wide ecological pest management and the relevance of organic farming to benefit natural enemy communities in tropical agroecosystems.
MeSH term(s)	Gene Flow ; Agriculture ; Farms ; Brazil ; Movement
Language	English
Publishing date	2023-12-22
Publishing country	United States
Document type	Journal Article
ZDB-ID	1074505-1
ISSN	1939-5582 ; 1051-0761
ISSN (online)	1939-5582
ISSN	1051-0761
DOI	10.1002/eap.2938
Database	MEDical Literature Analysis and Retrieval System OnLINE

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