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Article ; Online: Aging unconventionally: γδ T cells, iNKT cells, and MAIT cells in aging.

Kurioka, Ayako / Klenerman, Paul

2023 Volume 69, Page(s) 101816

Abstract: Unconventional T cells include γδ T cells, invariant Natural Killer T cells (iNKT) cells and Mucosal Associated Invariant T (MAIT) cells, which are distinguished from conventional T cells by their recognition of non-peptide ligands presented by non- ... ...

Abstract	Unconventional T cells include γδ T cells, invariant Natural Killer T cells (iNKT) cells and Mucosal Associated Invariant T (MAIT) cells, which are distinguished from conventional T cells by their recognition of non-peptide ligands presented by non-polymorphic antigen presenting molecules and rapid effector functions that are pre-programmed during their development. Here we review current knowledge of the effect of age on unconventional T cells, from early life to old age, in both mice and humans. We then discuss the role of unconventional T cells in age-associated diseases and infections, highlighting the similarities between members of the unconventional T cell family in the context of aging.
MeSH term(s)	Humans ; Mice ; Animals ; Mucosal-Associated Invariant T Cells ; Natural Killer T-Cells ; Aging
Language	English
Publishing date	2023-08-01
Publishing country	England
Document type	Journal Article ; Review ; Research Support, Non-U.S. Gov't
ZDB-ID	1018141-6
ISSN	1096-3618 ; 1044-5323
ISSN (online)	1096-3618
ISSN	1044-5323
DOI	10.1016/j.smim.2023.101816
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Article ; Online: Innate-like CD8+ T-cells and NK cells: converging functions and phenotypes.

Kurioka, Ayako / Klenerman, Paul / Willberg, Christian B

Immunology

2018

Abstract: New data in the worlds of both innate-like CD8+ T-cells and natural killer (NK) cells have, in parallel, clarified some of the phenotypes of these cells and also their associated functions. While these cells are typically viewed entirely separately, the ... ...

Abstract	New data in the worlds of both innate-like CD8+ T-cells and natural killer (NK) cells have, in parallel, clarified some of the phenotypes of these cells and also their associated functions. While these cells are typically viewed entirely separately, the emerging innate functions of T-cells and, similarly, the adaptive functions of NK cells suggest that many behaviours can be considered in parallel. In this review we compare the innate functions of CD8+ T-cells (especially mucosal-associated invariant T-cells) and those of NK cells, and how these relate to expression of phenotypic markers, especially CD161 and CD56.
Language	English
Publishing date	2018-03-14
Publishing country	England
Document type	Journal Article ; Review
ZDB-ID	80124-0
ISSN	1365-2567 ; 0019-2805 ; 0953-4954
ISSN (online)	1365-2567
ISSN	0019-2805 ; 0953-4954
DOI	10.1111/imm.12925
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Article: Erratum: MAIT cells: new guardians of the liver.

Kurioka, Ayako / Walker, Lucy J / Klenerman, Paul / Willberg, Christian B

Clinical & translational immunology

2017 Volume 6, Issue 2, Page(s) e132

Abstract: This corrects the article DOI: 10.1038/cti.2016.51.]. ...

Abstract	[This corrects the article DOI: 10.1038/cti.2016.51.].
Language	English
Publishing date	2017-02-24
Publishing country	Australia
Document type	Published Erratum
ZDB-ID	2694482-0
ISSN	2050-0068
ISSN	2050-0068
DOI	10.1038/cti.2017.5
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Article: MAIT cells: new guardians of the liver.

Kurioka, Ayako / Walker, Lucy J / Klenerman, Paul / Willberg, Christian B

Clinical & translational immunology

2016 Volume 5, Issue 8, Page(s) e98

Abstract: The liver is an important immunological organ that remains sterile and tolerogenic in homeostasis, despite continual exposure to non-self food and microbial-derived products from the gut. However, where intestinal mucosal defenses are breached or in the ... ...

Abstract	The liver is an important immunological organ that remains sterile and tolerogenic in homeostasis, despite continual exposure to non-self food and microbial-derived products from the gut. However, where intestinal mucosal defenses are breached or in the presence of a systemic infection, the liver acts as a second 'firewall', because of its enrichment with innate effector cells able to rapidly respond to infections or tissue dysregulation. One of the largest populations of T cells within the human liver are mucosal-associated invariant T (MAIT) cells, a novel innate-like T-cell population that can recognize a highly conserved antigen derived from the microbial riboflavin synthesis pathway. MAIT cells are emerging as significant players in the human immune system, associated with an increasing number of clinical diseases of bacterial, viral, autoimmune and cancerous origin. As reviewed here, we are only beginning to investigate the potential role of this dominant T-cell subset in the liver, but the reactivity of MAIT cells to both inflammatory cytokines and riboflavin derivatives suggests that MAIT cells may have an important role in first line of defense as part of the liver firewall. As such, MAIT cells are promising targets for modulating the host defense and inflammation in both acute and chronic liver diseases.
Language	English
Publishing date	2016-08-19
Publishing country	Australia
Document type	Journal Article ; Review
ZDB-ID	2694482-0
ISSN	2050-0068
ISSN	2050-0068
DOI	10.1038/cti.2016.51
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Article ; Online: Conservation of the OmpC Porin Among Typhoidal and Non-Typhoidal

Valero-Pacheco, Nuriban / Blight, Joshua / Aldapa-Vega, Gustavo / Kemlo, Phillip / Pérez-Toledo, Marisol / Wong-Baeza, Isabel / Kurioka, Ayako / Perez-Shibayama, Christian / Gil-Cruz, Cristina / Sánchez-Torres, Luvia E / Pastelin-Palacios, Rodolfo / Isibasi, Armando / Reyes-Sandoval, Arturo / Klenerman, Paul / López-Macías, Constantino

Frontiers in immunology

2020 Volume 10, Page(s) 2966

Abstract: Salmonella ... ...

Abstract	Salmonella enterica
MeSH term(s)	Amino Acid Sequence ; Bacterial Proteins/chemistry ; Bacterial Proteins/genetics ; Bacterial Proteins/metabolism ; Conserved Sequence ; Humans ; Phylogeny ; Porins/chemistry ; Porins/genetics ; Porins/metabolism ; Protein Conformation, alpha-Helical ; Salmonella/chemistry ; Salmonella/classification ; Salmonella/genetics ; Salmonella/metabolism ; Salmonella Infections/microbiology ; Salmonella typhi/chemistry ; Salmonella typhi/classification ; Salmonella typhi/genetics ; Salmonella typhi/metabolism ; Sequence Alignment ; Typhoid Fever/microbiology
Chemical Substances	Bacterial Proteins ; OmpC protein ; Porins
Language	English
Publishing date	2020-01-09
Publishing country	Switzerland
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2606827-8
ISSN	1664-3224 ; 1664-3224
ISSN (online)	1664-3224
ISSN	1664-3224
DOI	10.3389/fimmu.2019.02966
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Article ; Online: Activation and In Vivo Evolution of the MAIT Cell Transcriptome in Mice and Humans Reveals Tissue Repair Functionality.

Hinks, Timothy S C / Marchi, Emanuele / Jabeen, Maisha / Olshansky, Moshe / Kurioka, Ayako / Pediongco, Troi J / Meehan, Bronwyn S / Kostenko, Lyudmila / Turner, Stephen J / Corbett, Alexandra J / Chen, Zhenjun / Klenerman, Paul / McCluskey, James

Cell reports

2019 Volume 28, Issue 12, Page(s) 3249–3262.e5

Abstract: Mucosal-associated invariant T (MAIT) cells are MR1-restricted innate-like T cells conserved across mammalian species, including mice and humans. By sequencing RNA from sorted MR1-5-OP-RU ... ...

Abstract	Mucosal-associated invariant T (MAIT) cells are MR1-restricted innate-like T cells conserved across mammalian species, including mice and humans. By sequencing RNA from sorted MR1-5-OP-RU tetramer
MeSH term(s)	Animals ; CD8-Positive T-Lymphocytes/cytology ; CD8-Positive T-Lymphocytes/immunology ; Humans ; Lymphocyte Activation ; Mice ; Mucosal-Associated Invariant T Cells/cytology ; Mucosal-Associated Invariant T Cells/immunology ; Natural Killer T-Cells/cytology ; Natural Killer T-Cells/immunology ; Transcriptome/immunology
Language	English
Publishing date	2019-09-13
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2649101-1
ISSN	2211-1247 ; 2211-1247
ISSN (online)	2211-1247
ISSN	2211-1247
DOI	10.1016/j.celrep.2019.07.039
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Article ; Online: Human MAIT cells show metabolic quiescence with rapid glucose-dependent upregulation of granzyme B upon stimulation.

Zinser, Madeleine E / Highton, Andrew J / Kurioka, Ayako / Kronsteiner, Barbara / Hagel, Joachim / Leng, Tianqi / Marchi, Emanuele / Phetsouphanh, Chansavath / Willberg, Chris B / Dunachie, Susanna J / Klenerman, Paul

Immunology and cell biology

2018 Volume 96, Issue 6, Page(s) 666–674

Abstract: Mucosal-associated invariant T (MAIT) cells are a well-characterized innate-like T cell population abundant in the human liver, peripheral tissues and blood. MAIT cells serve in the first line of defense against infections, through engagement of their T ... ...

Abstract	Mucosal-associated invariant T (MAIT) cells are a well-characterized innate-like T cell population abundant in the human liver, peripheral tissues and blood. MAIT cells serve in the first line of defense against infections, through engagement of their T cell receptor, which recognizes microbial metabolites presented on MR1, and through cytokine-mediated triggering. Typically, they show a quiescent memory phenotype but can undergo rapid upregulation of effector functions including cytolysis upon stimulation. T cells profoundly change their cellular metabolism during their maturation and activation. We sought to determine how MAIT cell metabolism may facilitate both the long-term memory phase in tissue and the transition to rapid effector function. Here, we show, by flow cytometric metabolism assays and extracellular flux analysis that, despite an effector-memory profile, human MAIT cells are metabolically quiescent in a resting state comparable to naïve and central memory T cells. Upon stimulation, they rapidly increase uptake of glucose and show a concomitant upregulation of the effector molecules notably granzyme B, which is impaired by inhibition of glycolysis with 2-deoxyglucose. These findings suggest that MAIT cells share some metabolic characteristics of both resting and effector T cell subsets, with a rapid transition upon triggering. Metabolic programming of this cell type may be of interest in understanding and modulating their function in infectious diseases and cancer.
MeSH term(s)	Glucose/metabolism ; Granzymes/metabolism ; Humans ; Lymphocyte Activation/immunology ; Mucosal-Associated Invariant T Cells/immunology ; Mucosal-Associated Invariant T Cells/metabolism ; Up-Regulation
Chemical Substances	GZMB protein, human (EC 3.4.21.-) ; Granzymes (EC 3.4.21.-) ; Glucose (IY9XDZ35W2)
Language	English
Publishing date	2018-03-09
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	284057-1
ISSN	1440-1711 ; 0818-9641
ISSN (online)	1440-1711
ISSN	0818-9641
DOI	10.1111/imcb.12020
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Article ; Online: Diverse Streptococcus pneumoniae Strains Drive a Mucosal-Associated Invariant T-Cell Response Through Major Histocompatibility Complex class I-Related Molecule-Dependent and Cytokine-Driven Pathways.

Kurioka, Ayako / van Wilgenburg, Bonnie / Javan, Reza Rezaei / Hoyle, Ryan / van Tonder, Andries J / Harrold, Caroline L / Leng, Tianqi / Howson, Lauren J / Shepherd, Dawn / Cerundolo, Vincenzo / Brueggemann, Angela B / Klenerman, Paul

The Journal of infectious diseases

2017 Volume 217, Issue 6, Page(s) 988–999

Abstract: Mucosal-associated invariant T (MAIT) cells represent an innate T-cell population that can recognize ligands generated by the microbial riboflavin synthesis pathway, presented via the major histocompatibility complex class I-related molecule (MR1). ... ...

Abstract	Mucosal-associated invariant T (MAIT) cells represent an innate T-cell population that can recognize ligands generated by the microbial riboflavin synthesis pathway, presented via the major histocompatibility complex class I-related molecule (MR1). Streptococcus pneumoniae is a major human pathogen that is also associated with commensal carriage; thus, host control at the mucosal interface is critical. The recognition of pneumococci by MAIT cells has not been defined nor have the genomics and transcriptomics of the riboflavin operon. We observed robust recognition of pneumococci by MAIT cells, using both MR1-dependent and MR1-independent pathways. The pathway used was dependent on the antigen-presenting cell. The riboflavin operon was highly conserved across a range of 571 pneumococci from 39 countries, dating back to 1916, and different versions of the riboflavin operon were also identified in related Streptococcus species. These data indicate an important functional relationship between MAIT cells and pneumococci.
MeSH term(s)	Cells, Cultured ; Cytokines/genetics ; Cytokines/metabolism ; Genes, MHC Class I/immunology ; Genome, Bacterial ; Humans ; Immunity, Cellular ; Macrophages ; Mucosal-Associated Invariant T Cells/physiology ; Operon ; Riboflavin/biosynthesis ; Streptococcus pneumoniae/classification ; Streptococcus pneumoniae/genetics ; Up-Regulation
Chemical Substances	Cytokines ; Riboflavin (TLM2976OFR)
Language	English
Publishing date	2017-10-12
Publishing country	United States
Document type	Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
ZDB-ID	3019-3
ISSN	1537-6613 ; 0022-1899
ISSN (online)	1537-6613
ISSN	0022-1899
DOI	10.1093/infdis/jix647
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Article: Shared and Distinct Phenotypes and Functions of Human CD161++ Vα7.2+ T Cell Subsets.

Kurioka, Ayako / Jahun, Aminu S / Hannaway, Rachel F / Walker, Lucy J / Fergusson, Joannah R / Sverremark-Ekström, Eva / Corbett, Alexandra J / Ussher, James E / Willberg, Christian B / Klenerman, Paul

Frontiers in immunology

2017 Volume 8, Page(s) 1031

Abstract: Human mucosal-associated invariant T (MAIT) cells are an important T cell subset that are enriched in tissues and possess potent effector functions. Typically such cells are marked by their expression of Vα7.2-Jα33/Jα20/Jα12 T cell receptors, and ... ...

Abstract	Human mucosal-associated invariant T (MAIT) cells are an important T cell subset that are enriched in tissues and possess potent effector functions. Typically such cells are marked by their expression of Vα7.2-Jα33/Jα20/Jα12 T cell receptors, and functionally they are major histocompatibility complex class I-related protein 1 (MR1)-restricted, responding to bacterially derived riboflavin synthesis intermediates. MAIT cells are contained within the CD161++ Vα7.2+ T cell population, the majority of which express the CD8 receptor (CD8+), while a smaller fraction expresses neither CD8 or CD4 coreceptor (double negative; DN) and a further minority are CD4+. Whether these cells have distinct homing patterns, phenotype and functions have not been examined in detail. We used a combination of phenotypic staining and functional assays to address the similarities and differences between these CD161++ Vα7.2+ T cell subsets. We find that most features are shared between CD8+ and DN CD161++ Vα7.2+ T cells, with a small but detectable role evident for CD8 binding in tuning functional responsiveness. By contrast, the CD4+ CD161++ Vα7.2+ T cell population, although showing MR1-dependent responsiveness to bacterial stimuli, display reduced T helper 1 effector functions, including cytolytic machinery, while retaining the capacity to secrete interleukin-4 (IL-4) and IL-13. This was consistent with underlying changes in transcription factor (TF) expression. Although we found that only a proportion of CD4+ CD161++ Vα7.2+ T cells stained for the MR1-tetramer, explaining some of the heterogeneity of CD4+ CD161++ Vα7.2+ T cells, these differences in TF expression were shared with CD4+ CD161++ MR1-tetramer+ cells. These data reveal the functional diversity of human CD161++ Vα7.2+ T cells and indicate potentially distinct roles for the different subsets
Language	English
Publishing date	2017
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2606827-8
ISSN	1664-3224
ISSN	1664-3224
DOI	10.3389/fimmu.2017.01031
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Article: CD161 Defines a Functionally Distinct Subset of Pro-Inflammatory Natural Killer Cells.

Kurioka, Ayako / Cosgrove, Cormac / Simoni, Yannick / van Wilgenburg, Bonnie / Geremia, Alessandra / Björkander, Sophia / Sverremark-Ekström, Eva / Thurnheer, Christine / Günthard, Huldrych F / Khanna, Nina / Walker, Lucy Jane / Arancibia-Cárcamo, Carolina V / Newell, Evan W / Willberg, Christian B / Klenerman, Paul

Frontiers in immunology

2018 Volume 9, Page(s) 486

Abstract: CD161 is a C-type lectin-like receptor expressed on the majority of natural killer (NK) cells; however, the significance of CD161 expression on NK cells has not been comprehensively investigated. Recently, we found that CD161 expression identifies a ... ...

Abstract	CD161 is a C-type lectin-like receptor expressed on the majority of natural killer (NK) cells; however, the significance of CD161 expression on NK cells has not been comprehensively investigated. Recently, we found that CD161 expression identifies a transcriptional and innate functional phenotype that is shared across various T cell populations. Using mass cytometry and microarray experiments, we demonstrate that this functional phenotype extends to NK cells. CD161 marks NK cells that have retained the ability to respond to innate cytokines during their differentiation, and is lost upon cytomegalovirus-induced maturation in both healthy and human immunodeficiency virus (HIV)-infected patients. These pro-inflammatory NK cells are present in the inflamed lamina propria where they are enriched for integrin CD103 expression. Thus, CD161 expression identifies NK cells that may contribute to inflammatory disease pathogenesis and correlates with an innate responsiveness to cytokines in both T and NK cells.
MeSH term(s)	Antigens, CD/immunology ; Female ; Gene Expression Regulation/immunology ; HIV Infections/immunology ; HIV Infections/pathology ; HIV-1/immunology ; Humans ; Immunity, Innate ; Integrin alpha Chains/immunology ; Killer Cells, Natural/immunology ; Killer Cells, Natural/pathology ; Male ; NK Cell Lectin-Like Receptor Subfamily B/immunology
Chemical Substances	Antigens, CD ; Integrin alpha Chains ; KLRB1 protein, human ; NK Cell Lectin-Like Receptor Subfamily B ; alpha E integrins
Language	English
Publishing date	2018-04-09
Publishing country	Switzerland
Document type	Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
ZDB-ID	2606827-8
ISSN	1664-3224
ISSN	1664-3224
DOI	10.3389/fimmu.2018.00486
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