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  1. Article ; Online: NKT cells in the antitumor response: the β version?

    Kronenberg, Mitchell / Engel, Isaac

    The Journal of clinical investigation

    2024  Volume 134, Issue 4

    Abstract: NKT cells recognize glycolipids presented by CD1d-expressing antigen-presenting cells (APCs) and include type I NKT cells with antitumor function and type II NKT cells, which have been reported to suppress the antitumor response. Some type II NKT cells ... ...

    Abstract NKT cells recognize glycolipids presented by CD1d-expressing antigen-presenting cells (APCs) and include type I NKT cells with antitumor function and type II NKT cells, which have been reported to suppress the antitumor response. Some type II NKT cells recognize sulfatide, a glycosphingolipid with a sulfate modification of the sugar. Type I NKT cells recognize different glycosphingolipids. In this issue of the JCI, Nishio and colleagues showed that APCs could process sulfatide antigens, analogous to protein processing for peptide-reactive T cells. Antigen processing in lysosomes removed sulfate to generate a glycosphingolipid that stimulated type I NKT cells and thereby turned an antigen with no antitumor activity into one that not only stimulated type I NKT cells but also stimulated antitumor responses. These findings may extend to the development of glycolipid antigens that could stimulate anticancer responses via antigen processing by APCs.
    MeSH term(s) Natural Killer T-Cells ; Sulfoglycosphingolipids/metabolism ; Antigens, CD1d ; Glycolipids/metabolism ; Glycosphingolipids/metabolism ; Sulfates/metabolism
    Chemical Substances Sulfoglycosphingolipids ; Antigens, CD1d ; Glycolipids ; Glycosphingolipids ; Sulfates
    Language English
    Publishing date 2024-02-15
    Publishing country United States
    Document type Journal Article
    ZDB-ID 3067-3
    ISSN 1558-8238 ; 0021-9738
    ISSN (online) 1558-8238
    ISSN 0021-9738
    DOI 10.1172/JCI177663
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Book: Gamma-delta-T-cells & intraepithelial lymphocytes

    Kronenberg, Mitchell

    (Immunological reviews ; 215)

    2007  

    Title variant Gamma delta T cells & intraepithelial lymphocytes
    Author's details Mitchell Kronenberg ..., guest ed
    Series title Immunological reviews ; 215
    Collection
    Language English
    Size 253 S. : Ill., graph. Darst.
    Publisher Blackwell Munksgaard
    Publishing place Oxford
    Publishing country Great Britain
    Document type Book
    HBZ-ID HT014996769
    Database Catalogue ZB MED Medicine, Health

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    In stock of ZB MED Cologne/Königswinter

    Shelf markLoan statusLocation
    Se 160 -215- verfügbar in Königswinter Königswinter

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  3. Article ; Online: Innate-like T Cells: Connecting the Dots Linking Microscopic Intestinal Inflammation to Spondyloarthritis.

    Zhao, Meng / Kronenberg, Mitchell

    Arthritis & rheumatology (Hoboken, N.J.)

    2023  Volume 75, Issue 11, Page(s) 1907–1909

    MeSH term(s) Humans ; T-Lymphocytes ; Spondylarthritis ; Inflammation ; Immunity, Innate
    Language English
    Publishing date 2023-10-22
    Publishing country United States
    Document type Editorial ; Research Support, N.I.H., Extramural ; Comment
    ZDB-ID 2756371-6
    ISSN 2326-5205 ; 2326-5191
    ISSN (online) 2326-5205
    ISSN 2326-5191
    DOI 10.1002/art.42660
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 24: Show issues Location:
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  4. Article: Metabolic Triggers of Invariant Natural Killer T-Cell Activation during Sterile Autoinflammatory Disease.

    Riffelmacher, Thomas / Kronenberg, Mitchell

    Critical reviews in immunology

    2021  Volume 40, Issue 5, Page(s) 367–378

    Abstract: Ample evidence exists for activation of invariant natural killer T (iNKT) cells in a sterile manner by endogenous ligands or microbial antigens from the commensal flora, indicating that iNKT cells are not truly self-tolerant. Their controlled ... ...

    Abstract Ample evidence exists for activation of invariant natural killer T (iNKT) cells in a sterile manner by endogenous ligands or microbial antigens from the commensal flora, indicating that iNKT cells are not truly self-tolerant. Their controlled autoreactivity state is disturbed in many types of sterile inflammatory disease, resulting in their central role in modulating autoimmune responses. This review focuses on sterile iNKT-cell responses that are initiated by metabolic triggers, such as obesity-associated inflammation and fatty liver disease, as a manifestation of metabolic disease and dyslipidemia, as well as ischemia reperfusion injuries and sickle cell disease, characterized by acute lack of oxygen and oxidative stress response on reperfusion. In the intestine, inflammation and iNKT-cell response type are shaped by the microbiome as an extended "self". Disease- and organ-specific differences in iNKT-cell response type are summarized and help to define common pathways that shape iNKT-cell responses in the absence of exogenous antigen.
    MeSH term(s) Antigens ; Autoimmunity ; Hereditary Autoinflammatory Diseases ; Humans ; Lymphocyte Activation ; Natural Killer T-Cells
    Chemical Substances Antigens
    Language English
    Publishing date 2021-02-18
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't ; Review
    ZDB-ID 1353116-5
    ISSN 1040-8401
    ISSN 1040-8401
    DOI 10.1615/CritRevImmunol.2020035158
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 1699: Show issues Location:
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  5. Article ; Online: Intravital Imaging of Intestinal Intraepithelial Lymphocytes.

    McArdle, Sara / Seo, Goo-Young / Kronenberg, Mitchell / Mikulski, Zbigniew

    Bio-protocol

    2023  Volume 13, Issue 14, Page(s) e4720

    Abstract: Intestinal intraepithelial lymphocytes (IEL) are a numerous population of T cells located within the epithelium of the small and large intestines, being more numerous in the small intestine (SI). They surveil this tissue by interacting with epithelial ... ...

    Abstract Intestinal intraepithelial lymphocytes (IEL) are a numerous population of T cells located within the epithelium of the small and large intestines, being more numerous in the small intestine (SI). They surveil this tissue by interacting with epithelial cells. Intravital microscopy is an important tool for visualizing the patrolling activity of IEL in the SI of live mice. Most IEL express CD8α; therefore, here we describe an established protocol of intravital imaging that tracks lymphocytes labeled with a CD8α-specific monoclonal antibody in the SI epithelium of live mice. We also describe data acquisition and quantification of the movement metrics, including mean speed, track length, displacement length, and paths for each CD8α
    Language English
    Publishing date 2023-07-20
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2833269-6
    ISSN 2331-8325 ; 2331-8325
    ISSN (online) 2331-8325
    ISSN 2331-8325
    DOI 10.21769/BioProtoc.4720
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: The ImmGen consortium OpenSource T cell project.

    Zemmour, David / Goldrath, Ananda / Kronenberg, Mitchell / Kang, Joonsoo / Benoist, Christophe

    Nature immunology

    2022  Volume 23, Issue 5, Page(s) 643–644

    MeSH term(s) Gene Regulatory Networks ; T-Lymphocytes
    Language English
    Publishing date 2022-04-25
    Publishing country United States
    Document type Letter
    ZDB-ID 2016987-5
    ISSN 1529-2916 ; 1529-2908
    ISSN (online) 1529-2916
    ISSN 1529-2908
    DOI 10.1038/s41590-022-01197-z
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 5294: Show issues Location:
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    Zs.MG 42: Show issues

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  7. Article ; Online: When less is more: T lymphocyte populations with restricted antigen receptor diversity.

    Kronenberg, Mitchell

    Journal of immunology (Baltimore, Md. : 1950)

    2014  Volume 193, Issue 3, Page(s) 975–976

    MeSH term(s) Animals ; Lung/cytology ; Lung/immunology ; Lung/metabolism ; Mice ; Natural Killer T-Cells/immunology ; Natural Killer T-Cells/metabolism ; Receptors, Antigen, T-Cell, alpha-beta/metabolism ; Receptors, Antigen, T-Cell, gamma-delta/metabolism ; Spleen/cytology ; Spleen/immunology ; Spleen/metabolism ; T-Cell Antigen Receptor Specificity/immunology ; T-Lymphocyte Subsets/immunology ; T-Lymphocyte Subsets/metabolism ; Thymus Gland/cytology ; Thymus Gland/immunology ; Thymus Gland/metabolism
    Chemical Substances Receptors, Antigen, T-Cell, alpha-beta ; Receptors, Antigen, T-Cell, gamma-delta
    Language English
    Publishing date 2014-08-01
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 3056-9
    ISSN 1550-6606 ; 0022-1767 ; 1048-3233 ; 1047-7381
    ISSN (online) 1550-6606
    ISSN 0022-1767 ; 1048-3233 ; 1047-7381
    DOI 10.4049/jimmunol.1401491
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Ud II Zs.37: Show issues Location:
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  8. Article ; Online: Cancer immunity thwarted by the microbiome.

    Hartmann, Nadine / Kronenberg, Mitchell

    Science (New York, N.Y.)

    2018  Volume 360, Issue 6391, Page(s) 858–859

    MeSH term(s) Immunity ; Microbiota ; Neoplasms
    Language English
    Publishing date 2018-06-28
    Publishing country United States
    Document type Journal Article ; Comment
    ZDB-ID 128410-1
    ISSN 1095-9203 ; 0036-8075
    ISSN (online) 1095-9203
    ISSN 0036-8075
    DOI 10.1126/science.aat8289
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.MG 77: Show issues

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  9. Article ; Online: Engineered Stem Cells Provide Cancer-Killing iNKT Cells.

    Murray, Mallory Paynich / Kronenberg, Mitchell

    Cell stem cell

    2019  Volume 25, Issue 4, Page(s) 454–455

    Abstract: Invariant natural killer T (iNKT) cells have been tested for their potential use in cancer immune therapy, but their low frequency has limited their use. In this issue, Zhu and colleagues propose to overcome this by engineering hematopoietic stem cells ( ... ...

    Abstract Invariant natural killer T (iNKT) cells have been tested for their potential use in cancer immune therapy, but their low frequency has limited their use. In this issue, Zhu and colleagues propose to overcome this by engineering hematopoietic stem cells (HSCs) to provide a continual source of iNKT cells. (Zhu et al., 2019).
    MeSH term(s) Hematopoietic Stem Cells ; Humans ; Natural Killer T-Cells ; Neoplasms ; Stem Cell Transplantation
    Language English
    Publishing date 2019-10-25
    Publishing country United States
    Document type Journal Article ; Comment
    ZDB-ID 2375354-7
    ISSN 1875-9777 ; 1934-5909
    ISSN (online) 1875-9777
    ISSN 1934-5909
    DOI 10.1016/j.stem.2019.09.005
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: Editorial introduction.

    Gumperz, Jenny / Kronenberg, Mitchell / Teyton, Luc

    Molecular immunology

    2019  Volume 114, Page(s) 269

    MeSH term(s) Adaptive Immunity/immunology ; Animals ; Humans ; Immunity, Innate/immunology ; Mammals/immunology ; Natural Killer T-Cells/immunology
    Language English
    Publishing date 2019-08-06
    Publishing country England
    Document type Editorial
    ZDB-ID 424427-8
    ISSN 1872-9142 ; 0161-5890
    ISSN (online) 1872-9142
    ISSN 0161-5890
    DOI 10.1016/j.molimm.2019.08.001
    Database MEDical Literature Analysis and Retrieval System OnLINE

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