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Article ; Online: Protection by natural IgG: a sweet partnership with soluble lectins does the trick!

Puga, Irene / Cerutti, Andrea

2013 Volume 32, Issue 22, Page(s) 2897–2899

MeSH term(s)	Animals ; Autoantibodies/immunology ; Bacteria/isolation & purification ; Immunity, Innate ; Immunoglobulin G/immunology ; Lectins/immunology ; Opsins/immunology ; Ficolins
Chemical Substances	Autoantibodies ; Immunoglobulin G ; Lectins ; Opsins
Language	English
Publishing date	2013-10-25
Publishing country	England
Document type	Journal Article ; Comment
ZDB-ID	586044-1
ISSN	1460-2075 ; 0261-4189
ISSN (online)	1460-2075
ISSN	0261-4189
DOI	10.1038/emboj.2013.235
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Zs.A 1808: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (1.OG) ab Jg. 2022: Lesesaal (EG)
Zs.MG 100: Show issues

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Article ; Online: The B cell helper side of neutrophils.

Cerutti, Andrea / Puga, Irene / Magri, Giuliana

Journal of leukocyte biology

2013 Volume 94, Issue 4, Page(s) 677–682

Abstract: Neutrophils use opsonizing antibodies to enhance the clearance of intruding microbes. Recent studies indicate that splenic neutrophils also induce antibody production by providing helper signals to B cells lodged in the MZ of the spleen. Here, we discuss ...

Abstract	Neutrophils use opsonizing antibodies to enhance the clearance of intruding microbes. Recent studies indicate that splenic neutrophils also induce antibody production by providing helper signals to B cells lodged in the MZ of the spleen. Here, we discuss the B cell helper function of neutrophils in the context of growing evidence indicating that neutrophils function as sophisticated regulators of innate and adaptive immune responses.
MeSH term(s)	Animals ; B-Lymphocytes/cytology ; B-Lymphocytes/immunology ; Humans ; Immunologic Factors/metabolism ; Models, Immunological ; Neutrophils/cytology ; Neutrophils/immunology
Chemical Substances	Immunologic Factors
Language	English
Publishing date	2013-04-29
Publishing country	United States
Document type	Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't ; Review
ZDB-ID	605722-6
ISSN	1938-3673 ; 0741-5400
ISSN (online)	1938-3673
ISSN	0741-5400
DOI	10.1189/jlb.1112596
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Zs.A 603: Show issues

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Article ; Online: Marginal zone B cells: virtues of innate-like antibody-producing lymphocytes.

Cerutti, Andrea / Cols, Montserrat / Puga, Irene

Nature reviews. Immunology

2013 Volume 13, Issue 2, Page(s) 118–132

Abstract: Protective responses to microorganisms involve the nonspecific but rapid defence mechanisms of the innate immune system, followed by the specific but slow defence mechanisms of the adaptive immune system. Located as sentinels at the interface between the ...

Abstract	Protective responses to microorganisms involve the nonspecific but rapid defence mechanisms of the innate immune system, followed by the specific but slow defence mechanisms of the adaptive immune system. Located as sentinels at the interface between the circulation and lymphoid tissue, splenic marginal zone B cells rapidly respond to blood-borne antigens by adopting 'crossover' defensive strategies that blur the conventional boundaries of innate and adaptive immunity. This Review discusses how marginal zone B cells function as innate-like lymphocytes that mount rapid antibody responses to both T cell-dependent and T cell-independent antigens. These responses require the integration of activation signals from germline-encoded and somatically recombined receptors for microorganisms with helper signals from effector cells of the innate and adaptive immune systems.
MeSH term(s)	Animals ; Antibody Formation ; Antigens/immunology ; Antigens/metabolism ; B-Lymphocytes/immunology ; B-Lymphocytes/metabolism ; Humans ; Immunity, Innate ; Immunoglobulin Class Switching ; Lymphoid Tissue/cytology ; Lymphoid Tissue/immunology ; Mutation ; Protein Binding/immunology ; Signal Transduction
Chemical Substances	Antigens
Language	English
Publishing date	2013-01-24
Publishing country	England
Document type	Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't ; Review
ZDB-ID	2062776-2
ISSN	1474-1741 ; 1474-1733
ISSN (online)	1474-1741
ISSN	1474-1733
DOI	10.1038/nri3383
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Zs.A 5565: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (2.OG) ab Jg. 2022: Lesesaal (EG)
Zs.MG 34: Show issues

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Article ; Online: Correction: Exosomes Derived from Burkitt's Lymphoma Cell Lines Induce Proliferation, Differentiation, and Class-Switch Recombination in B Cells.

Gutzeit, Cindy / Nagy, Noemi / Gentile, Maurizio / Lyberg, Katarina / Gumz, Janine / Vallhov, Helen / Puga, Irene / Klein, Eva / Gabrielsson, Susanne / Cerutti, Andrea / Scheynius, Annika

Journal of immunology (Baltimore, Md. : 1950)

2019 Volume 203, Issue 3, Page(s) 769–770

Language	English
Publishing date	2019-06-21
Publishing country	United States
Document type	Journal Article ; Published Erratum
ZDB-ID	3056-9
ISSN	1550-6606 ; 0022-1767 ; 1048-3233 ; 1047-7381
ISSN (online)	1550-6606
ISSN	0022-1767 ; 1048-3233 ; 1047-7381
DOI	10.4049/jimmunol.1900638
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Ud II Zs.37: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular ab Jg. 2022: Lesesaal (EG)
Zs.MG 28: Show issues

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Article ; Online: Regulation of frontline antibody responses by innate immune signals.

Chorny, Alejo / Puga, Irene / Cerutti, Andrea

Immunologic research

2012 Volume 54, Issue 1-3, Page(s) 4–13

Abstract: Mature B cells generate protective immunity by undergoing immunoglobulin (Ig) class switching and somatic hypermutation, two Ig gene-diversifying processes that usually require cognate interactions with T cells that express CD40 ligand. This T-cell- ... ...

Abstract	Mature B cells generate protective immunity by undergoing immunoglobulin (Ig) class switching and somatic hypermutation, two Ig gene-diversifying processes that usually require cognate interactions with T cells that express CD40 ligand. This T-cell-dependent pathway provides immunological memory but is relatively slow to occur. Thus, it must be integrated with a faster, T-cell-independent pathway for B-cell activation through CD40 ligand-like molecules that are released by innate immune cells in response to microbial products. Here, we discuss recent advances in our understanding of the interplay between the innate immune system and B cells, particularly "frontline" B cells located in the marginal zone of the spleen and in the intestine.
MeSH term(s)	Animals ; Antibody Formation ; B-Lymphocytes/immunology ; Humans ; Immunity, Innate ; Intestinal Mucosa/immunology ; Spleen/immunology
Language	English
Publishing date	2012-04-04
Publishing country	United States
Document type	Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't ; Review
ZDB-ID	632857-x
ISSN	1559-0755 ; 0257-277X
ISSN (online)	1559-0755
ISSN	0257-277X
DOI	10.1007/s12026-012-8307-5
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Zs.A 1755: Show issues

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Article ; Online: Activation of B cells by non-canonical helper signals.

Cerutti, Andrea / Cols, Montserrat / Puga, Irene

EMBO reports

2012 Volume 13, Issue 9, Page(s) 798–810

Abstract: Cognate interaction between T and B lymphocytes of the adaptive immune system is essential for the production of high-affinity antibodies against microbes, and for the establishment of long-term immunological memory. Growing evidence shows that--in ... ...

Abstract	Cognate interaction between T and B lymphocytes of the adaptive immune system is essential for the production of high-affinity antibodies against microbes, and for the establishment of long-term immunological memory. Growing evidence shows that--in addition to presenting antigens to T and B cells--macrophages, dendritic cells and other cells of the innate immune system provide activating signals to B cells, as well as survival signals to antibody-secreting plasma cells. Here, we discuss how these innate immune cells contribute to the induction of highly diversified and temporally sustained antibody responses, both systemically and at mucosal sites of antigen entry.
MeSH term(s)	Animals ; Antibodies/immunology ; B-Lymphocytes/immunology ; Dendritic Cells/immunology ; Humans ; Immunity, Innate ; Lymphocyte Activation/immunology ; Macrophages/immunology ; Mucous Membrane/immunology ; Natural Killer T-Cells/immunology ; T-Lymphocytes, Helper-Inducer/immunology
Chemical Substances	Antibodies
Language	English
Publishing date	2012-08-07
Publishing country	England
Document type	Journal Article ; Review
ZDB-ID	2020896-0
ISSN	1469-3178 ; 1469-221X
ISSN (online)	1469-3178
ISSN	1469-221X
DOI	10.1038/embor.2012.111
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Zs.A 5433: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (2.OG) ab Jg. 2022: Lesesaal (EG)
Zs.MG 41: Show issues

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Article ; Online: New helping friends for B cells.

Cerutti, Andrea / Puga, Irene / Cols, Montserrat

European journal of immunology

2012 Volume 42, Issue 8, Page(s) 1956–1968

Abstract: Over the past decade, a growing recognition of the importance of neutralizing antibodies in host defense combined with the success of B-cell depletion therapies in treating auto-immune disorders has led to an increased focus on better understanding the ... ...

Abstract	Over the past decade, a growing recognition of the importance of neutralizing antibodies in host defense combined with the success of B-cell depletion therapies in treating auto-immune disorders has led to an increased focus on better understanding the pathways underpinning B-cell antibody production. In general, B cells require cognate interaction with T helper cells in the germinal center of lymphoid follicles to generate protective antibodies. However, recent evidence shows that B cells receive additional help from invariant natural killer T cells, dendritic cells, and various granulocytes, including neutrophils, eosinophils, and basophils. These innate immune cells enhance T-cell-dependent antibody responses by delivering B-cell helper signals both in the germinal center and at postgerminal center lymphoid sites such as the bone marrow. In addition to enhancing and complementing the B-cell helper activity of canonical T cells, invariant natural killer T cells, dendritic cells, and granulocytes can deliver T cell-independent B-cell helper signals at the mucosal interface and in the marginal zone of the spleen to initiate rapid innate-like antibody responses. Here, we discuss recent advances in the role of adaptive and innate B-cell helper signals in antibody diversification and production.
MeSH term(s)	Adaptive Immunity ; Antibody Formation ; B-Lymphocytes/immunology ; Bone Marrow/immunology ; Cell Communication ; Dendritic Cells/immunology ; Germinal Center/immunology ; Granulocytes/immunology ; Humans ; Immunity, Innate ; Lymphocyte Activation ; Lymphoid Tissue/immunology ; Natural Killer T-Cells/immunology ; Signal Transduction ; Spleen/immunology ; T-Lymphocytes, Helper-Inducer/immunology
Language	English
Publishing date	2012-08-03
Publishing country	Germany
Document type	Journal Article ; Review
ZDB-ID	120108-6
ISSN	1521-4141 ; 0014-2980
ISSN (online)	1521-4141
ISSN	0014-2980
DOI	10.1002/eji.201242594
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Zs.A 489: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (1.OG) ab Jg. 2022: Lesesaal (EG)
Zs.MG 85: Show issues

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Article ; Online: Innate control of B cell responses.

Cerutti, Andrea / Puga, Irene / Cols, Montserrat

Trends in immunology

2011 Volume 32, Issue 5, Page(s) 202–211

Abstract	Mature B cells generate protective immunity by undergoing immunoglobulin (Ig) class switching and somatic hypermutation, two Ig gene-diversifying processes that usually require cognate interactions with T cells that express CD40 ligand. This T cell-dependent pathway provides immunological memory but is relatively slow to occur. Thus, it must be integrated with a faster, T cell-independent pathway for B cell activation through CD40 ligand-like molecules that are released by innate immune cells in response to microbial products. Here, we discuss recent advances in our understanding of the interplay between the innate immune system and B cells, particularly at the mucosal interface. We also review the role of innate signals in the regulation of Ig diversification and production.
MeSH term(s)	B-Cell Activating Factor/metabolism ; B-Lymphocytes/cytology ; B-Lymphocytes/immunology ; B-Lymphocytes/metabolism ; Gene Expression Regulation/immunology ; Genes, Immunoglobulin/physiology ; Immunity, Innate ; Ligands ; T-Lymphocytes/immunology ; T-Lymphocytes/metabolism ; Toll-Like Receptors/metabolism ; Tumor Necrosis Factor Ligand Superfamily Member 13/metabolism
Chemical Substances	B-Cell Activating Factor ; Ligands ; TNFSF13B protein, human ; Toll-Like Receptors ; Tumor Necrosis Factor Ligand Superfamily Member 13
Language	English
Publishing date	2011-03-16
Publishing country	England
Document type	Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't ; Review
ZDB-ID	2036831-8
ISSN	1471-4981 ; 1471-4906
ISSN (online)	1471-4981
ISSN	1471-4906
DOI	10.1016/j.it.2011.02.004
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Zs.A 1601: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (1.OG) ab Jg. 2022: Lesesaal (EG)
Zs.MG 2: Show issues

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Article ; Online: Innate signals in mucosal immunoglobulin class switching.

Puga, Irene / Cols, Montserrat / Cerutti, Andrea

The Journal of allergy and clinical immunology

2010 Volume 126, Issue 5, Page(s) 889–95; quiz 896–7

Abstract: The intestinal mucosa contains large communities of commensal bacteria that process otherwise indigestible food components, synthesize essential vitamins, stimulate the maturation of the immune system, and form an ecologic niche that prevents the growth ... ...

Abstract	The intestinal mucosa contains large communities of commensal bacteria that process otherwise indigestible food components, synthesize essential vitamins, stimulate the maturation of the immune system, and form an ecologic niche that prevents the growth of pathogenic species. Conversely, the intestine provides the commensals with a stable habitat rich in energy derived from the ingested food. A delicate homeostatic balance maintains this mutualistic relationship without triggering a destructive inflammatory response. Commensals orchestrate intestinal homeostasis by entertaining an intimate dialogue with epithelial cells and immune cells lodged in the mucosa. Such a dialogue generates finely tuned signaling programs that ensure a state of hyporesponsiveness against noninvasive commensals and a state of active readiness against invasive pathogens. In this dialogue epithelial cells function as "interpreters" that continuously translate microbial messages to "instruct" immune cells as to the antigenic composition of the intestinal lumen. This education process initiates sophisticated defensive strategies that comprise massive production of IgA, a noninflammatory mucosal antibody class that generates immunity while preserving homeostasis.
MeSH term(s)	Animals ; Homeostasis/immunology ; Humans ; Immunity, Mucosal/immunology ; Immunoglobulin Class Switching/immunology ; Intestinal Mucosa/immunology ; Signal Transduction/immunology
Language	English
Publishing date	2010-11-02
Publishing country	United States
Document type	Journal Article ; Review
ZDB-ID	121011-7
ISSN	1097-6825 ; 1085-8725 ; 0091-6749
ISSN (online)	1097-6825 ; 1085-8725
ISSN	0091-6749
DOI	10.1016/j.jaci.2010.09.026
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Article ; Online: Innate signaling networks in mucosal IgA class switching.

Chorny, Alejo / Puga, Irene / Cerutti, Andrea

Advances in immunology

2010 Volume 107, Page(s) 31–69

Abstract: The past 20 years have seen a growing interest over the control of adaptive immune responses by the innate immune system. In particular, considerable attention has been paid to the mechanisms by which antigen-primed dendritic cells orchestrate the ... ...

Abstract	The past 20 years have seen a growing interest over the control of adaptive immune responses by the innate immune system. In particular, considerable attention has been paid to the mechanisms by which antigen-primed dendritic cells orchestrate the differentiation of T cells. Additional studies have elucidated the pathways followed by T cells to initiate immunoglobulin responses in B cells. In this review, we discuss recent advances on the mechanisms by which intestinal bacteria, epithelial cells, dendritic cells, and macrophages cross talk with intestinal T cells and B cells to induce frontline immunoglobulin A class switching and production.
MeSH term(s)	Animals ; Humans ; Immunity, Innate ; Immunity, Mucosal/genetics ; Immunity, Mucosal/immunology ; Immunoglobulin A, Secretory/genetics ; Immunoglobulin A, Secretory/immunology ; Immunoglobulin Class Switching/genetics ; Immunoglobulin Class Switching/immunology ; Intestinal Mucosa/immunology ; Signal Transduction/genetics ; Signal Transduction/immunology
Chemical Substances	Immunoglobulin A, Secretory
Language	English
Publishing date	2010-10-27
Publishing country	United States
Document type	Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't ; Review
ZDB-ID	80226-8
ISSN	1557-8445 ; 0065-2776
ISSN (online)	1557-8445
ISSN	0065-2776
DOI	10.1016/B978-0-12-381300-8.00002-2
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