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  1. Article ; Online: Environmental stimuli and gut inflammation via dysbiosis in mouse and man.

    Lees, Charlie W

    Nature reviews. Gastroenterology & hepatology

    2020  Volume 17, Issue 12, Page(s) 715–716

    MeSH term(s) Anti-Bacterial Agents ; Diet, High-Fat ; Dysbiosis ; Energy Metabolism ; Gastrointestinal Microbiome ; Humans ; Inflammation ; Inflammatory Bowel Diseases
    Chemical Substances Anti-Bacterial Agents
    Language English
    Publishing date 2020-09-29
    Publishing country England
    Document type Journal Article ; Comment
    ZDB-ID 2493722-8
    ISSN 1759-5053 ; 1759-5045
    ISSN (online) 1759-5053
    ISSN 1759-5045
    DOI 10.1038/s41575-020-00373-6
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  2. Article ; Online: Disease Monitoring in Inflammatory Bowel Disease: Evolving Principles and Possibilities.

    Plevris, Nikolas / Lees, Charlie W

    Gastroenterology

    2022  Volume 162, Issue 5, Page(s) 1456–1475.e1

    Abstract: Inflammatory bowel disease is a progressive and debilitating condition. Early and effective treatment using a treat-to-target approach is key to improving patient outcomes. Therefore, proactive monitoring is essential to ensure that treatment strategies ... ...

    Abstract Inflammatory bowel disease is a progressive and debilitating condition. Early and effective treatment using a treat-to-target approach is key to improving patient outcomes. Therefore, proactive monitoring is essential to ensure that treatment strategies are working and targets are being met. In this review we discuss the current monitoring tools available to us and how they can be used. We also discuss the importance of monitoring during key phases of the disease and propose an optimum treat-to-target monitoring strategy for Crohn's disease and ulcerative colitis. Regarding the advent of new technology, we discuss how this may improve our monitoring capabilities and how we envisage future monitoring strategies of inflammatory bowel diseases.
    MeSH term(s) Chronic Disease ; Colitis, Ulcerative/diagnosis ; Colitis, Ulcerative/drug therapy ; Crohn Disease/diagnosis ; Crohn Disease/drug therapy ; Humans ; Inflammatory Bowel Diseases/diagnosis ; Inflammatory Bowel Diseases/therapy ; Treatment Outcome
    Language English
    Publishing date 2022-01-29
    Publishing country United States
    Document type Journal Article ; Review ; Research Support, Non-U.S. Gov't
    ZDB-ID 80112-4
    ISSN 1528-0012 ; 0016-5085
    ISSN (online) 1528-0012
    ISSN 0016-5085
    DOI 10.1053/j.gastro.2022.01.024
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  3. Article ; Online: Reply.

    Kennedy, Nicholas A / Lees, Charlie W

    Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association

    2019  Volume 18, Issue 2, Page(s) 526

    MeSH term(s) Crohn Disease ; Disease Progression ; Feces ; Humans ; Leukocyte L1 Antigen Complex
    Chemical Substances Leukocyte L1 Antigen Complex
    Language English
    Publishing date 2019-07-24
    Publishing country United States
    Document type Letter ; Comment
    ZDB-ID 2119789-1
    ISSN 1542-7714 ; 1542-3565
    ISSN (online) 1542-7714
    ISSN 1542-3565
    DOI 10.1016/j.cgh.2019.07.031
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  4. Article ; Online: COVID-19 and IBD drugs: should we change anything at the moment?

    Lees, Charlie W / Irving, Peter M / Beaugerie, Laurent

    Gut

    2020  Volume 70, Issue 4, Page(s) 632–634

    MeSH term(s) Azathioprine ; COVID-19 ; Humans ; Inflammatory Bowel Diseases/drug therapy ; Infliximab ; Pharmaceutical Preparations ; Registries ; SARS-CoV-2
    Chemical Substances Pharmaceutical Preparations ; Infliximab (B72HH48FLU) ; Azathioprine (MRK240IY2L)
    Language English
    Publishing date 2020-11-19
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Comment
    ZDB-ID 80128-8
    ISSN 1468-3288 ; 0017-5749
    ISSN (online) 1468-3288
    ISSN 0017-5749
    DOI 10.1136/gutjnl-2020-323247
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  5. Article ; Online: What is the Real Impact of Corticosteroids in the Contemporary Treatment of Crohn's Disease?

    Lucas Uemura, Karime / Sousa Freitas Queiroz, Natália / Lees, Charlie W

    Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association

    2021  Volume 20, Issue 2, Page(s) 468–469

    MeSH term(s) Adrenal Cortex Hormones/therapeutic use ; Crohn Disease/drug therapy ; Humans ; Remission Induction
    Chemical Substances Adrenal Cortex Hormones
    Language English
    Publishing date 2021-03-13
    Publishing country United States
    Document type Letter ; Comment
    ZDB-ID 2119789-1
    ISSN 1542-7714 ; 1542-3565
    ISSN (online) 1542-7714
    ISSN 1542-3565
    DOI 10.1016/j.cgh.2021.03.016
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  6. Article ; Online: Innovation in Inflammatory Bowel Disease Care During the COVID-19 Pandemic: Results of a Global Telemedicine Survey by the International Organization for the Study of Inflammatory Bowel Disease.

    Lees, Charlie W / Regueiro, Miguel / Mahadevan, Uma

    Gastroenterology

    2020  Volume 159, Issue 3, Page(s) 805–808.e1

    MeSH term(s) Adult ; Betacoronavirus ; COVID-19 ; Coronavirus Infections/prevention & control ; Facilities and Services Utilization/statistics & numerical data ; Female ; Humans ; Inflammatory Bowel Diseases/therapy ; Male ; Middle Aged ; Pandemics/prevention & control ; Pandemics/statistics & numerical data ; Patient Acceptance of Health Care/statistics & numerical data ; Pneumonia, Viral/prevention & control ; Quarantine/statistics & numerical data ; SARS-CoV-2 ; Surveys and Questionnaires ; Telemedicine/methods ; Telemedicine/statistics & numerical data
    Keywords covid19
    Language English
    Publishing date 2020-05-29
    Publishing country United States
    Document type Editorial
    ZDB-ID 80112-4
    ISSN 1528-0012 ; 0016-5085
    ISSN (online) 1528-0012
    ISSN 0016-5085
    DOI 10.1053/j.gastro.2020.05.063
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  7. Article ; Online: Modeling of Treatment Outcomes with Tofacitinib Maintenance Therapy in Patients with Ulcerative Colitis: A Post Hoc Analysis of Data from the OCTAVE Clinical Program.

    Chiorean, Michael / Daperno, Marco / Lees, Charlie W / Bonfanti, Gianluca / Soudis, Dimitrios / Modesto, Irene / Deuring, J Jasper / Edwards, Roger A

    Advances in therapy

    2023  Volume 40, Issue 10, Page(s) 4440–4459

    Abstract: Introduction: Tofacitinib is an oral small molecule Janus kinase inhibitor for the treatment of ulcerative colitis (UC). This post hoc analysis assessed whether various statistical techniques could predict outcomes of tofacitinib maintenance therapy in ... ...

    Abstract Introduction: Tofacitinib is an oral small molecule Janus kinase inhibitor for the treatment of ulcerative colitis (UC). This post hoc analysis assessed whether various statistical techniques could predict outcomes of tofacitinib maintenance therapy in patients with UC.
    Methods: Data from patients who participated in a 52-week, phase III maintenance study (OCTAVE Sustain) and an open-label long-term extension study (OCTAVE Open) were included in this analysis. Patients received tofacitinib 5 or 10 mg twice daily (BID) or placebo (OCTAVE Sustain only). Logistic regression analyses were performed to generate models using clinical and laboratory variables to predict loss of responder status at week 8 of OCTAVE Sustain, steroid-free remission (defined as a partial Mayo score of 0-1 in the absence of corticosteroid use) at week 52 of OCTAVE Sustain, and delayed response at week 8 of OCTAVE Open. Furthermore, differences in loss of response/discontinuation patterns between treatment groups in OCTAVE Sustain were established.
    Results: The generated prediction models demonstrated insufficient accuracy for determining loss of response at week 8, steroid-free remission at week 52 in OCTAVE Sustain, or delayed response in OCTAVE Open. Both tofacitinib doses demonstrated comparable response/remission patterns based on visualizations of disease activity over time. The rectal bleeding subscore was the primary determinant of disease worsening (indicated by an increased total Mayo score), and the endoscopy subscore was the primary determinant of disease improvement (indicated by a decreased total Mayo score).
    Conclusion: Visualizations of disease activity subscores revealed distinct patterns among patients with UC that had disease worsening and disease improvement. The statistical models assessed in this analysis could not accurately predict loss of responder status, steroid-free remission, or delayed response to tofacitinib. Possible reasons include the small sample size or missing data related to yet unknown key variables that were not collected during these trials.
    MeSH term(s) Humans ; Colitis, Ulcerative/drug therapy ; Janus Kinase Inhibitors/therapeutic use ; Remission Induction ; Treatment Outcome ; Clinical Trials, Phase III as Topic
    Chemical Substances Janus Kinase Inhibitors ; tofacitinib (87LA6FU830)
    Language English
    Publishing date 2023-07-31
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 632651-1
    ISSN 1865-8652 ; 0741-238X
    ISSN (online) 1865-8652
    ISSN 0741-238X
    DOI 10.1007/s12325-023-02603-0
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  8. Article ; Online: SARS-CoV-2 vaccination for patients with inflammatory bowel disease - Authors' reply.

    Alexander, James L / Kennedy, Nicholas A / Lees, Charlie W / Ahmad, Tariq / Powell, Nick

    The lancet. Gastroenterology & hepatology

    2021  Volume 6, Issue 7, Page(s) 523–524

    MeSH term(s) COVID-19 ; COVID-19 Vaccines ; Gastroenterology ; Humans ; Inflammatory Bowel Diseases ; SARS-CoV-2 ; Vaccination
    Chemical Substances COVID-19 Vaccines
    Language English
    Publishing date 2021-06-13
    Publishing country Netherlands
    Document type Letter ; Comment
    ISSN 2468-1253
    ISSN (online) 2468-1253
    DOI 10.1016/S2468-1253(21)00194-1
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  9. Article: Innovation in Inflammatory Bowel Disease Care During the COVID-19 Pandemic: Results of a Global Telemedicine Survey by the International Organization for the Study of Inflammatory Bowel Disease

    Lees, Charlie W / Regueiro, Miguel / Mahadevan, Uma

    Gastroenterology

    Keywords covid19
    Publisher WHO
    Document type Article
    Note WHO #Covidence: #436544
    Database COVID19

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  10. Article ; Online: Innovation in Inflammatory Bowel Disease Care During the COVID-19 Pandemic

    Lees, Charlie W. / Regueiro, Miguel / Mahadevan, Uma

    Gastroenterology

    Results of a Global Telemedicine Survey by the International Organization for the Study of Inflammatory Bowel Disease

    2020  Volume 159, Issue 3, Page(s) 805–808.e1

    Keywords Gastroenterology ; covid19
    Language English
    Publisher Elsevier BV
    Publishing country us
    Document type Article ; Online
    ZDB-ID 80112-4
    ISSN 1528-0012 ; 0016-5085
    ISSN (online) 1528-0012
    ISSN 0016-5085
    DOI 10.1053/j.gastro.2020.05.063
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