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  1. Article ; Online: Flipping hemagglutinin on its head.

    Ferguson, James A / Han, Julianna / Ward, Andrew B

    Nature chemical biology

    2024  

    Language English
    Publishing date 2024-02-06
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2202962-X
    ISSN 1552-4469 ; 1552-4450
    ISSN (online) 1552-4469
    ISSN 1552-4450
    DOI 10.1038/s41589-024-01545-0
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  2. Article ; Online: Playing Chess with HIV.

    Ward, Andrew B

    Immunity

    2019  Volume 50, Issue 2, Page(s) 283–285

    Abstract: HIV envelope glycoprotein (Env) exhibits extreme antigenic variation that can be countered by an amazing class of immunoglobulins known as broadly neutralizing antibodies. Dingens et al. (2019) use saturating mutagenesis of Env to play out all of the ... ...

    Abstract HIV envelope glycoprotein (Env) exhibits extreme antigenic variation that can be countered by an amazing class of immunoglobulins known as broadly neutralizing antibodies. Dingens et al. (2019) use saturating mutagenesis of Env to play out all of the potential bnAb escape strategies and in doing so define the functional epitopes of these important vaccine and immunotherapeutic targets.
    MeSH term(s) Antibodies, Neutralizing ; Epitopes ; HIV Antibodies ; HIV-1/immunology ; env Gene Products, Human Immunodeficiency Virus
    Chemical Substances Antibodies, Neutralizing ; Epitopes ; HIV Antibodies ; env Gene Products, Human Immunodeficiency Virus
    Language English
    Publishing date 2019-03-26
    Publishing country United States
    Document type Journal Article ; Comment
    ZDB-ID 1217235-2
    ISSN 1097-4180 ; 1074-7613
    ISSN (online) 1097-4180
    ISSN 1074-7613
    DOI 10.1016/j.immuni.2019.01.011
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  3. Article: Structure of mechanically activated ion channel OSCA2.3 reveals mobile elements in the transmembrane domain.

    Jojoa-Cruz, Sebastian / Burendei, Batuujin / Lee, Wen-Hsin / Ward, Andrew B

    bioRxiv : the preprint server for biology

    2023  

    Abstract: Members of the OSCA/TMEM63 are mechanically activated ion channels and structures of some OSCA members have revealed the architecture of these channels and structural features that are potentially involved in mechanosensation. However, these structures ... ...

    Abstract Members of the OSCA/TMEM63 are mechanically activated ion channels and structures of some OSCA members have revealed the architecture of these channels and structural features that are potentially involved in mechanosensation. However, these structures are all in a similar state and information about the motion of different elements of the structure is limited, preventing a deeper understanding of how these channels work. Here, we used cryo-electron microscopy to determine high resolution structures of
    Language English
    Publishing date 2023-06-15
    Publishing country United States
    Document type Preprint
    DOI 10.1101/2023.06.15.545135
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  4. Article ; Online: Structure-guided mutagenesis of OSCAs reveals differential activation to mechanical stimuli.

    Jojoa-Cruz, Sebastian / Dubin, Adrienne E / Lee, Wen-Hsin / Ward, Andrew B

    eLife

    2024  Volume 12

    Abstract: The dimeric two-pore OSCA/TMEM63 family has recently been identified as mechanically activated ion channels. Previously, based on the unique features of the structure of OSCA1.2, we postulated the potential involvement of several structural elements in ... ...

    Abstract The dimeric two-pore OSCA/TMEM63 family has recently been identified as mechanically activated ion channels. Previously, based on the unique features of the structure of OSCA1.2, we postulated the potential involvement of several structural elements in sensing membrane tension (Jojoa-Cruz et al., 2018). Interestingly, while OSCA1, 2, and 3 clades are activated by membrane stretch in cell-attached patches (i.e. they are stretch-activated channels), they differ in their ability to transduce membrane deformation induced by a blunt probe (poking). Here, in an effort to understand the domains contributing to mechanical signal transduction, we used cryo-electron microscopy to solve the structure of
    MeSH term(s) Cryoelectron Microscopy ; Arabidopsis/genetics ; Cell Membrane ; Mechanotransduction, Cellular ; Mutagenesis
    Language English
    Publishing date 2024-04-09
    Publishing country England
    Document type Journal Article
    ZDB-ID 2687154-3
    ISSN 2050-084X ; 2050-084X
    ISSN (online) 2050-084X
    ISSN 2050-084X
    DOI 10.7554/eLife.93147
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  5. Article ; Online: Structure of mechanically activated ion channel OSCA2.3 reveals mobile elements in the transmembrane domain.

    Jojoa-Cruz, Sebastian / Burendei, Batuujin / Lee, Wen-Hsin / Ward, Andrew B

    Structure (London, England : 1993)

    2023  Volume 32, Issue 2, Page(s) 157–167.e5

    Abstract: Members of the OSCA/TMEM63 family are mechanically activated ion channels and structures of some OSCA members have revealed the architecture of these channels and structural features that are potentially involved in mechanosensation. However, these ... ...

    Abstract Members of the OSCA/TMEM63 family are mechanically activated ion channels and structures of some OSCA members have revealed the architecture of these channels and structural features that are potentially involved in mechanosensation. However, these structures are all in a similar state and information about the motion of different elements of the structure is limited, preventing a deeper understanding of how these channels work. Here, we used cryoelectron microscopy to determine high-resolution structures of Arabidopsis thaliana OSCA1.2 and OSCA2.3 in peptidiscs. The structure of OSCA1.2 matches previous structures of the same protein in different environments. Yet, in OSCA2.3, the TM6a-TM7 linker adopts a different conformation that constricts the pore on its cytoplasmic side. Furthermore, coevolutionary sequence analysis uncovered a conserved interaction between the TM6a-TM7 linker and the beam-like domain (BLD). Our results reveal conformational heterogeneity and differences in conserved interactions between the TMD and BLD among members of the OSCA family.
    MeSH term(s) Cryoelectron Microscopy ; Ion Channels/metabolism ; Arabidopsis/genetics ; Arabidopsis/metabolism ; Protein Domains ; Arabidopsis Proteins/chemistry ; Calcium Channels/metabolism
    Chemical Substances Ion Channels ; Arabidopsis Proteins ; OSCA1 protein, Arabidopsis ; Calcium Channels
    Language English
    Publishing date 2023-12-15
    Publishing country United States
    Document type Journal Article
    ZDB-ID 1213087-4
    ISSN 1878-4186 ; 0969-2126
    ISSN (online) 1878-4186
    ISSN 0969-2126
    DOI 10.1016/j.str.2023.11.009
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  6. Article ; Online: Partitioning of the denitrification pathway and other nitrite metabolisms within global oxygen deficient zones.

    Zhang, Irene H / Sun, Xin / Jayakumar, Amal / Fortin, Samantha G / Ward, Bess B / Babbin, Andrew R

    ISME communications

    2023  Volume 3, Issue 1, Page(s) 76

    Abstract: Oxygen deficient zones (ODZs) account for about 30% of total oceanic fixed nitrogen loss via processes including denitrification, a microbially mediated pathway proceeding stepwise from ... ...

    Abstract Oxygen deficient zones (ODZs) account for about 30% of total oceanic fixed nitrogen loss via processes including denitrification, a microbially mediated pathway proceeding stepwise from NO
    Language English
    Publishing date 2023-07-20
    Publishing country England
    Document type Journal Article
    ISSN 2730-6151
    ISSN (online) 2730-6151
    DOI 10.1038/s43705-023-00284-y
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  7. Article ; Online: Innovations in structure-based antigen design and immune monitoring for next generation vaccines.

    Ward, Andrew B / Wilson, Ian A

    Current opinion in immunology

    2020  Volume 65, Page(s) 50–56

    Abstract: The recent explosion of atomic-level structures of glycoproteins that comprise the surface antigens of human enveloped viruses, such as RSV, influenza, and HIV, provide tremendous opportunities for rational, structure-based vaccine design. Several ... ...

    Abstract The recent explosion of atomic-level structures of glycoproteins that comprise the surface antigens of human enveloped viruses, such as RSV, influenza, and HIV, provide tremendous opportunities for rational, structure-based vaccine design. Several concepts in structure-based vaccine design have been put into practice and are are well along preclinical and clinical implementation. Testing of these designed immunogens will provide key insights into the ability to induce the desired immune responses, namely neutralizing antibodies. Many of these immunogens in human clinical trials represent only the first wave of designs and will likely require continued tweaking and elaboration to achieve the ultimate goal of enhanced breadth and potency. Considerable effort is now being invested in germline targeting, epitope focusing, and improved immune presentation such as multivalent nanoparticle incorporation. This review highlights some of the recent advances in these areas as we prepare for the next generation of immunogens for subsequent rounds of iterative vaccine development.
    MeSH term(s) Animals ; Antigens/chemistry ; Antigens/genetics ; Antigens/immunology ; Cross Reactions/immunology ; Epitopes/chemistry ; Epitopes/genetics ; Epitopes/immunology ; Germ Cells/immunology ; Host-Pathogen Interactions/immunology ; Humans ; Models, Animal ; Models, Molecular ; Mutation ; Structure-Activity Relationship ; Vaccines/immunology ; Vaccinology/methods ; Vaccinology/trends
    Chemical Substances Antigens ; Epitopes ; Vaccines
    Keywords covid19
    Language English
    Publishing date 2020-04-22
    Publishing country England
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't ; Review
    ZDB-ID 1035767-1
    ISSN 1879-0372 ; 0952-7915
    ISSN (online) 1879-0372
    ISSN 0952-7915
    DOI 10.1016/j.coi.2020.03.013
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  8. Article ; Online: Implementation of a lifestyle and life-skills intervention to prevent weight-gain and cardiometabolic abnormalities in young people with first-episode psychosis as part of routine care: The Keeping the Body in Mind program.

    Curtis, Jackie / Teasdale, Scott B / Morell, Rachel / Wadhwa, Prarthna / Watkins, Andrew / Lederman, Oscar / O'Donnell, Catherine / Fibbins, Hamish / Ward, Philip B

    Early intervention in psychiatry

    2024  

    Abstract: Objectives: In 2013, a cluster-controlled pilot study found the 12-week Keeping the Body in Mind (KBIM) lifestyle and life skills intervention was able to prevent weight gain in a small sample of youth experiencing first-episode psychosis (FEP) with ... ...

    Abstract Objectives: In 2013, a cluster-controlled pilot study found the 12-week Keeping the Body in Mind (KBIM) lifestyle and life skills intervention was able to prevent weight gain in a small sample of youth experiencing first-episode psychosis (FEP) with fewer than 4 weeks of antipsychotic exposure. This study aims to evaluate the effectiveness of KBIM as routine care on anthropometry and metabolic biochemistry in a larger sample of youth with FEP across three community mental health services.
    Method: This retrospective chart audit was conducted on youth with FEP, prescribed a therapeutic dose of antipsychotic medication, and who engaged with KBIM between 2015 and 2019. Primary outcomes were weight and waist circumference. Secondary outcomes were blood pressure, blood glucose, and blood lipids. Outcomes were collected in at baseline and at 12 weeks. Data on program engagement were obtained from the participant's medical file.
    Results: One-hundred and eighty-two people met inclusion criteria, and up to 134 people had baseline and 12-week data on one or more outcome. Mean number of sessions attended was 11.1 (SD = 7.3). Increases in weight and waist circumference were limited to 1.5 kg (SD = 5.3, t(133) = 3.2, p = .002) and 0.7 cm (SD = 5.8, t(109) = 1.2, p = .23) respectively. Eighty-one percent of participants did not experience clinically significant weight gain (>7% of baseline weight). There were no significant changes in blood pressure or metabolic biochemistry.
    Conclusion: The prevention of substantial gains in weight and waist circumference observed in the initial pilot study was maintained with implementation of KBIM as part of routine clinical care for youth with FEP.
    Language English
    Publishing date 2024-02-09
    Publishing country Australia
    Document type Journal Article
    ZDB-ID 2272425-4
    ISSN 1751-7893 ; 1751-7885
    ISSN (online) 1751-7893
    ISSN 1751-7885
    DOI 10.1111/eip.13508
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  9. Article: Anti-Immune Complex Antibodies are Elicited During Repeated Immunization with HIV Env Immunogens.

    Brown, Sharidan / Antanasijevic, Aleksandar / Sewall, Leigh M / Garcia, Daniel Montiel / Brouwer, Philip J M / Sanders, Rogier W / Ward, Andrew B

    bioRxiv : the preprint server for biology

    2024  

    Abstract: Vaccination strategies against HIV-1 aim to elicit broadly neutralizing antibodies (bnAbs) using prime-boost regimens with HIV envelope (Env) immunogens. Early antibody responses to easily accessible epitopes on these antigens are directed to non- ... ...

    Abstract Vaccination strategies against HIV-1 aim to elicit broadly neutralizing antibodies (bnAbs) using prime-boost regimens with HIV envelope (Env) immunogens. Early antibody responses to easily accessible epitopes on these antigens are directed to non-neutralizing epitopes instead of bnAb epitopes. Autologous neutralizing antibody responses appear upon boosting once immunodominant epitopes are saturated. Here we report another type of antibody response that arises after repeated immunizations with HIV Env immunogens and present the structures of six anti-immune complexes discovered using polyclonal epitope mapping. The anti-immune complex antibodies target idiotopes composed of framework regions of antibodies bound to Env. This work sheds light on current vaccine development efforts for HIV, as well as for other pathogens, in which repeated exposure to antigen is required.
    Language English
    Publishing date 2024-03-17
    Publishing country United States
    Document type Preprint
    DOI 10.1101/2024.03.15.585257
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  10. Article ; Online: Author Correction: Structure of the mechanically activated ion channel Piezo1.

    Saotome, Kei / Murthy, Swetha E / Kefauver, Jennifer M / Whitwam, Tess / Patapoutian, Ardem / Ward, Andrew B

    Nature

    2022  Volume 607, Issue 7919, Page(s) E10

    Language English
    Publishing date 2022-07-05
    Publishing country England
    Document type Published Erratum
    ZDB-ID 120714-3
    ISSN 1476-4687 ; 0028-0836
    ISSN (online) 1476-4687
    ISSN 0028-0836
    DOI 10.1038/s41586-022-04976-8
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