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  1. Article ; Online: Gout and hyperuricaemia: a worldwide health issue of joints and beyond.

    Gamala, Mihaela / Jacobs, Johannes W G

    Rheumatology (Oxford, England)

    2019  Volume 58, Issue 12, Page(s) 2083–2085

    MeSH term(s) Global Health ; Gout ; Humans ; Hyperuricemia ; Prevalence ; United States ; Uric Acid
    Chemical Substances Uric Acid (268B43MJ25)
    Language English
    Publishing date 2019-07-12
    Publishing country England
    Document type Editorial ; Comment
    ZDB-ID 1464822-2
    ISSN 1462-0332 ; 1462-0324
    ISSN (online) 1462-0332
    ISSN 1462-0324
    DOI 10.1093/rheumatology/kez272
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  2. Article: A Sex Difference in HandScan Scores in Rheumatoid Arthritis Patients and Controls? An Ongoing Analysis of the Sex Difference and Other Potential Confounders.

    Verhoeven, Maxime M A / Westgeest, Antonius A A / Jacobs, Johannes W G

    The Journal of rheumatology

    2021  Volume 48, Issue 6, Page(s) 950–951

    MeSH term(s) Arthritis, Rheumatoid/diagnostic imaging ; Case-Control Studies ; Female ; Humans ; Longitudinal Studies ; Male ; Sex Characteristics
    Language English
    Publishing date 2021-03-15
    Publishing country Canada
    Document type Letter
    ZDB-ID 194928-7
    ISSN 1499-2752 ; 0315-162X
    ISSN (online) 1499-2752
    ISSN 0315-162X
    DOI 10.3899/jrheum.201555
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  3. Article: Unravelling the Cost of Biological Strategies in Rheumatoid Arthritis: A Kaleidoscope of Methodologies, Interpretations, and Interests.

    Jacobs, Johannes W G / Verhoeven, Maxime M A / Welsing, Paco M J

    The Journal of rheumatology

    2021  Volume 48, Issue 12, Page(s) 1771–1773

    MeSH term(s) Antirheumatic Agents/therapeutic use ; Arthritis, Rheumatoid/drug therapy ; Cost-Benefit Analysis ; Humans
    Chemical Substances Antirheumatic Agents
    Language English
    Publishing date 2021-05-15
    Publishing country Canada
    Document type Journal Article
    ZDB-ID 194928-7
    ISSN 1499-2752 ; 0315-162X
    ISSN (online) 1499-2752
    ISSN 0315-162X
    DOI 10.3899/jrheum.201510
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  4. Article: A prosthetic wrist joint complicated by metallosis and polyethylene synovitis, mimicking low-grade bacterial arthritis.

    Jacobs, Johannes W G / Schuurman, Arnold H

    Clinical and experimental rheumatology

    2020  Volume 39, Issue 2, Page(s) 438

    MeSH term(s) Arthritis, Infectious/diagnosis ; Arthritis, Infectious/etiology ; Hand Joints ; Humans ; Magnetic Resonance Imaging ; Polyethylene ; Synovitis/etiology ; Wrist Joint
    Chemical Substances Polyethylene (9002-88-4)
    Language English
    Publishing date 2020-10-09
    Publishing country Italy
    Document type Letter
    ZDB-ID 605886-3
    ISSN 1593-098X ; 0392-856X
    ISSN (online) 1593-098X
    ISSN 0392-856X
    DOI 10.55563/clinexprheumatol/mxhrig
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  5. Article: The Computer Assisted Management in Early Rheumatoid Arthritis programme tool used in the CAMERA-I and CAMERA-II studies.

    Jacobs, Johannes W G

    Clinical and experimental rheumatology

    2016  Volume 34, Issue 5 Suppl 101, Page(s) S69–S72

    Abstract: The history, issues and result of the development of the computer decision software tool used for the two tight control and treat-to-target CAMERA (Computer Assisted Management in Early Rheumatoid Arthritis) studies are described. The software tool is ... ...

    Abstract The history, issues and result of the development of the computer decision software tool used for the two tight control and treat-to-target CAMERA (Computer Assisted Management in Early Rheumatoid Arthritis) studies are described. The software tool is simple and can be used with various protocolled strategies and visit intervals both in clinical trials and daily practice, because it does not dictate strategy steps and is independent of visit intervals. The tool gives information on whether enough improvement since the last visit is present and whether there is remission or not. With this information, strategy steps according to various protocols and treatment arms can be taken.
    MeSH term(s) Antirheumatic Agents/adverse effects ; Antirheumatic Agents/therapeutic use ; Arthritis, Rheumatoid/diagnosis ; Arthritis, Rheumatoid/drug therapy ; Arthritis, Rheumatoid/physiopathology ; Decision Support Systems, Clinical ; Decision Support Techniques ; Disease Progression ; Health Status ; Humans ; Patient Selection ; Predictive Value of Tests ; Remission Induction ; Rheumatology/methods ; Risk Factors ; Severity of Illness Index ; Software ; Therapy, Computer-Assisted ; Time Factors ; Treatment Outcome ; User-Computer Interface
    Chemical Substances Antirheumatic Agents
    Language English
    Publishing date 2016-09
    Publishing country Italy
    Document type Journal Article ; Review
    ZDB-ID 605886-3
    ISSN 1593-098X ; 0392-856X
    ISSN (online) 1593-098X
    ISSN 0392-856X
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    ab Jg. 2022: Lesesaal (EG)

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  6. Article ; Online: The psychological impact of the COVID-19 pandemic on Dutch people with and without an inflammatory rheumatic disease.

    Koppert, Tim Y / Jacobs, Johannes W G / Geenen, Rinie

    Rheumatology (Oxford, England)

    2020  Volume 60, Issue 8, Page(s) 3709–3715

    Abstract: Objectives: To determine the psychological impact of the COVID-19 pandemic on people with and without an inflammatory rheumatic disease and establish whether psychological flexibility buffers this impact.: Methods: From online surveys in the general ... ...

    Abstract Objectives: To determine the psychological impact of the COVID-19 pandemic on people with and without an inflammatory rheumatic disease and establish whether psychological flexibility buffers this impact.
    Methods: From online surveys in the general Dutch population in 2018 and during the peak of the COVID-19 pandemic in 2020, we analysed data of people with (index group, n = 239) and without (control group, n = 1821) an inflammatory rheumatic disease. Worry, stress, mental well-being (SF-36) and psychological flexibility levels were subjected to covariate-adjusted analyses of variance or linear regression analyses.
    Results: During the peak of the COVID-19 pandemic in 2020, as compared with the control group, the index group was more worried about getting infected with the virus (partial η2=0.098; medium effect) and more stressed (partial η2=0.040; small effect). However, as compared with data acquired in 2018, the level of mental well-being during the COVID-19 pandemic peak was not lower in both groups. Levels of psychological flexibility did not moderate associations of group or year with mental well-being.
    Conclusions: Although patients with an inflammatory rheumatic disease were more worried and stressed during the peak of the COVID-19 pandemic, their level of mental well-being was not reduced, which may have prevented us from finding a buffering effect of psychological flexibility. Overall, our results suggest that the psychological impact of the COVID-19 pandemic in patients with inflammatory rheumatic disease is modest, which could imply that common education and health care will do for most patients.
    MeSH term(s) Adolescent ; Adult ; Aged ; Anxiety/epidemiology ; COVID-19/epidemiology ; Comorbidity ; Female ; Follow-Up Studies ; Humans ; Male ; Mental Health ; Middle Aged ; Netherlands/epidemiology ; Pandemics ; Population Surveillance ; Retrospective Studies ; Rheumatic Diseases/epidemiology ; SARS-CoV-2 ; Stress, Psychological/epidemiology ; Young Adult
    Language English
    Publishing date 2020-12-11
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 1464822-2
    ISSN 1462-0332 ; 1462-0324
    ISSN (online) 1462-0332
    ISSN 1462-0324
    DOI 10.1093/rheumatology/keaa842
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  7. Article ; Online: The impact of COVID-19 stress on pain and fatigue in people with and without a central sensitivity syndrome.

    Koppert, Tim Y / Jacobs, Johannes W G / Lumley, Mark A / Geenen, Rinie

    Journal of psychosomatic research

    2021  Volume 151, Page(s) 110655

    Abstract: Objectives: Stress may augment somatic symptoms in central sensitivity syndromes (CSS) such as fibromyalgia, chronic fatigue syndrome, and irritable bowel syndrome. To test this hypothesis, we examined whether the association between COVID-19 stress and ...

    Abstract Objectives: Stress may augment somatic symptoms in central sensitivity syndromes (CSS) such as fibromyalgia, chronic fatigue syndrome, and irritable bowel syndrome. To test this hypothesis, we examined whether the association between COVID-19 stress and somatic symptom severity would be stronger in people with than without CSS and whether psychological flexibility would buffer the impact of this stress on symptom severity.
    Methods: In a 2-sample, repeated cross-sectional design, we analysed questionnaire data from Dutch people with and without CSS, collected in two independent surveys: before the COVID-19 pandemic (2018; CSS: n = 194, non-CSS: n = 337) and at the peak of the pandemic (2020; CSS: n = 428, non-CSS: n = 1101). Somatic symptom severity, worry and stress due to the pandemic, and psychological flexibility were examined in regression analyses. Two stress operationalisations were analysed: stress levels during the peak of the pandemic, and a comparison of measurements in 2020 and 2018 (assuming higher stress levels in 2020).
    Results: Higher worry and stress during the pandemic (standardized β = 0.14), the presence of a CSS (β = 0.40), and lower psychological flexibility (β = -0.33) were all (p < .0001) associated with more severe somatic symptoms, but the associations of each stress operationalisation with somatic symptoms was not particularly strong in people with CSS (β = -0.026, p = .27; β = -0.037, p = .22), and psychological flexibility (β = -0.025, p = .18; β = 0.076, p = .35) did not buffer this association.
    Conclusions: Findings do not support the hypotheses that COVID-19 stress augments somatic symptoms, particularly in CSS, or that psychological flexibility buffers this impact. Rather, COVID-19-related stress appears to have an uncertain impact on somatic symptoms.
    MeSH term(s) COVID-19 ; Chronic Pain ; Cross-Sectional Studies ; Humans ; Pandemics ; SARS-CoV-2
    Language English
    Publishing date 2021-10-29
    Publishing country England
    Document type Journal Article
    ZDB-ID 80166-5
    ISSN 1879-1360 ; 0022-3999
    ISSN (online) 1879-1360
    ISSN 0022-3999
    DOI 10.1016/j.jpsychores.2021.110655
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  8. Article: Glucocorticoids Are Always Under Suspicion - Is the Perception of Their Risks Unbiased?

    Jacobs, Johannes W G / Pereira DA Silva, José A

    The Journal of rheumatology

    2018  Volume 45, Issue 3, Page(s) 293–296

    MeSH term(s) Arthritis, Rheumatoid ; Glucocorticoids ; Health Expenditures ; Humans
    Chemical Substances Glucocorticoids
    Language English
    Publishing date 2018-03-02
    Publishing country Canada
    Document type Editorial ; Comment
    ZDB-ID 194928-7
    ISSN 1499-2752 ; 0315-162X
    ISSN (online) 1499-2752
    ISSN 0315-162X
    DOI 10.3899/jrheum.171331
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  9. Article ; Online: Remission definitions guiding immunosuppressive therapy in rheumatoid arthritis: which is best fitted for the purpose?

    Duarte, Catia / Ferreira, Ricardo J O / Welsing, Paco M J / Jacobs, Johannes W G / Gossec, Laure / Machado, Pedro M / van der Heijde, Désirée / da Silva, Jose Antonio Pereira

    RMD open

    2024  Volume 10, Issue 1

    Abstract: Objective: To assess which definition of remission best predicts good radiographic outcome (GRO) and good functional outcome (GFO) in rheumatoid arthritis, focusing the updated American College of Rheumatology/European Alliance of Associations for ... ...

    Abstract Objective: To assess which definition of remission best predicts good radiographic outcome (GRO) and good functional outcome (GFO) in rheumatoid arthritis, focusing the updated American College of Rheumatology/European Alliance of Associations for Rheumatology criteria.
    Material and methods: Meta-analyses of individual patient data (IPD) from randomised controlled trials (RCTs). Six definitions of remission were considered: (1) Boolean with Patient Global Assessment (PGA)≤1 (Boolean); (2) Simplified Disease Activity Index (SDAI)≤3.3; (3) Clinical Disease Activity Index (CDAI)≤2.8; (4) Boolean with PGA≤2 (Updated-Boolean); (5) Boolean with Physician Global Assessment (PhGA≤1) replacing PGA (Boolean-PhGA) and (6) Boolean excluding PGA (3VBoolean). GRO was defined as a worsening ≤0.5 units in radiographic score and GFO as a no worsening in Health Assessment Questionnaire (HAQ), that is, ∆HAQ-DI≤0.0 units. Relationships between each remission definition at 6 and/or 12 months and GRO and GFO during the second year were analysed. Pooled probabilities for each outcome for each definition and their predictive accuracy were estimated.
    Results: IPD from eight RCTs (n=4423) were analysed. Boolean, SDAI, CDAI, Updated-Boolean, Boolean-PhGA and 3VBoolean were achieved by 24%, 27%, 28%, 32%, 33% and 43% of all patients, respectively. GRO among patients achieving remission ranged from 82.4% (3VBoolean) to 83.9% (SDAI). 3VBoolean showed the highest predictive accuracy for GRO: 51.1% versus 38.8% (Boolean) and 44.1% (Updated-Boolean). The relative risk of GFO ranged from 1.16 (Boolean) to 1.05 (3VBoolean). However, the proportion of GFO correctly predicted was highest for the 3VBoolean (50.3%) and lowest for the Boolean (43.8%).
    Conclusion: 3VBoolean definition provided the most accurate prediction of GRO and GFO, avoiding the risk of overtreatment in a substantial proportion of patients without increment in radiographic damage progression, supporting the proposal that 3VBoolean remission is preferable to guide immunosuppressive treatment. The patient's perspective, which must remain central, is best served by an additional patient-oriented target: a dual-target approach.
    MeSH term(s) Humans ; Arthritis, Rheumatoid/diagnosis ; Arthritis, Rheumatoid/drug therapy ; Immunosuppression Therapy ; Immunosuppressive Agents/therapeutic use
    Chemical Substances Immunosuppressive Agents
    Language English
    Publishing date 2024-03-04
    Publishing country England
    Document type Journal Article ; Meta-Analysis
    ZDB-ID 2812592-7
    ISSN 2056-5933 ; 2056-5933
    ISSN (online) 2056-5933
    ISSN 2056-5933
    DOI 10.1136/rmdopen-2023-003972
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  10. Article ; Online: An unexpected manifestation of gout.

    Gamala, Mihaela / Jacobs, Johannes W G / Heggelman, Ben G F / Klaasen, Ruth

    Rheumatology (Oxford, England)

    2019  Volume 59, Issue 4, Page(s) 810

    MeSH term(s) Acromioclavicular Joint/diagnostic imaging ; Aged ; Allopurinol/therapeutic use ; Female ; Fluorodeoxyglucose F18 ; Gout/complications ; Gout/diagnostic imaging ; Gout/drug therapy ; Gout Suppressants/therapeutic use ; Humans ; Magnetic Resonance Imaging ; Neck Pain/etiology ; Paresthesia/etiology ; Positron Emission Tomography Computed Tomography ; Radiopharmaceuticals ; Shoulder ; Single Photon Emission Computed Tomography Computed Tomography ; Spondylarthritis/complications ; Spondylarthritis/diagnostic imaging ; Spondylarthritis/drug therapy ; Zygapophyseal Joint/diagnostic imaging
    Chemical Substances Gout Suppressants ; Radiopharmaceuticals ; Fluorodeoxyglucose F18 (0Z5B2CJX4D) ; Allopurinol (63CZ7GJN5I)
    Language English
    Publishing date 2019-09-12
    Publishing country England
    Document type Case Reports ; Journal Article
    ZDB-ID 1464822-2
    ISSN 1462-0332 ; 1462-0324
    ISSN (online) 1462-0332
    ISSN 1462-0324
    DOI 10.1093/rheumatology/kez426
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