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Article ; Online: The Potential Environmental and Social Influence of the Inorganic Salt Hydrates Used as a Phase Change Material for Thermal Energy Storage in Solar Installations.

Nartowska, Edyta / Styś-Maniara, Marta / Kozłowski, Tomasz

International journal of environmental research and public health

2023 Volume 20, Issue 2

Abstract: The aim of this article is to assess the potential impact of inorganic salt hydrates used as PCM material in solar installations on the environment and human health and to assess the society's approach to this technology. The properties of salt are ... ...

Abstract	The aim of this article is to assess the potential impact of inorganic salt hydrates used as PCM material in solar installations on the environment and human health and to assess the society's approach to this technology. The properties of salt are discussed in two ways: first, by analyzing the environmental and health problems caused by chemical hazards on the basis of the available material safety data sheets. Secondly, by analyzing the potential disadvantages of salt hydrates in terms of environmental hazards based on the results of experimental studies available in the literature. Then, using questionnaires, the public approach to solar installations with a built-in converter containing salt hydrates is assessed. Disodium hydrogen phosphate dodecahydrate turned out to be the most prospective salt in terms of environmental, thermophysical, and economic properties for use in solar installations. Understanding the attitudes of the local community toward technologies using inorganic salt hydrates will enable appropriate action to be taken in the future to promote their development. Surveys have shown great public concern about their impact on the environment and human health. In this regard, it is necessary to implement information and promotion activities.
MeSH term(s)	Humans ; Prospective Studies ; Hot Temperature
Language	English
Publishing date	2023-01-11
Publishing country	Switzerland
Document type	Journal Article ; Review ; Research Support, Non-U.S. Gov't
ZDB-ID	2175195-X
ISSN	1660-4601 ; 1661-7827
ISSN (online)	1660-4601
ISSN	1661-7827
DOI	10.3390/ijerph20021331
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Article ; Online: Effectiveness of antazoline versus amiodarone, flecainide and propafenone in restoring sinus rhythm at the emergency department.

Springer, Janusz / Pejska, Michalina / Homenda, Wojciech / Zdrojewski, Tomasz / Daniłowicz-Szymanowicz, Ludmiła / Kozłowski, Dariusz

Advances in medical sciences

2024 Volume 69, Issue 2, Page(s) 248–255

Abstract: Purpose: Little is known about the effectiveness of pharmacological cardioversion (PCV) with antazoline in comparison to flecainide. The aim of this study was to compare the effectiveness of antazoline in restoring sinus rhythm (SR) versus amiodarone, ... ...

Abstract	Purpose: Little is known about the effectiveness of pharmacological cardioversion (PCV) with antazoline in comparison to flecainide. The aim of this study was to compare the effectiveness of antazoline in restoring sinus rhythm (SR) versus amiodarone, flecainide and propafenone in a group of emergency department (ED) patients. Materials/methods: This was a single-centre retrospective analysis of patient records from an ED in a large hospital in Poland. We analysed a total of 1878 patient records, divided based on the anti-arrhythmic drug (AAD) administered during PCV: antazoline (n = 1080), antazoline + β-blocker (n = 479), amiodarone (n = 129), flecainide (n = 102), propafenone (n = 88). Of the patients, 63.5 % were female (median 65 years, [19-100]). Results: The percentage of successful PCV was significantly higher in the antazoline group (84.3 %) than in the antazoline + β-blocker (75.8 %, p = 0.0001), propafenone (75.6 %, p = 0.0364) and amiodarone (68.8 %, p < 0.0001) groups. Post-hoc analysis revealed that patients who received PCV with antazoline, antazoline + β-blocker, flecainide and propafenone had significantly shorter time to SR than those who received amiodarone (p < 0.0001). Univariate regression analysis revealed that patients who underwent PCV with antazoline were almost twice as likely to return to SR compared to the other groups (p < 0.0001, OR 1.81, 95 % CI 1.44-2.27). Conclusions: This is the first study comparing the effectiveness of antazoline in PCV versus flecainide in addition to the previously studied amiodarone and propafenone. Our results indicate that antazoline is more effective in restoring SR than amiodarone, flecainide and propafenone. In addition, antazoline restored SR significantly faster than amiodarone or propafenone.
Language	English
Publishing date	2024-04-20
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	2273668-2
ISSN	1898-4002 ; 1896-1126
ISSN (online)	1898-4002
ISSN	1896-1126
DOI	10.1016/j.advms.2024.04.003
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Article ; Online: SENSOR PLATFORM OF INDUSTRIAL TOMOGRAPHY FOR DIAGNOSTICS AND CONTROL OF TECHNOLOGICAL PROCESSES

Krzysztof Król / Tomasz Rymarczyk / Konrad Niderla / Edward Kozłowski

Informatyka, Automatyka, Pomiary w Gospodarce i Ochronie Środowiska, Vol 13, Iss

2023 Volume 1

Abstract: This article presents an industrial tomography platform used to diagnose and control technological processes. The system has been prepared so that it is possible to add individual sensors cooperating with the system of an intelligent cyber-physical ... ...

Abstract	This article presents an industrial tomography platform used to diagnose and control technological processes. The system has been prepared so that it is possible to add individual sensors cooperating with the system of an intelligent cyber-physical platform with an open architecture. Additionally, it is possible to configure and cooperate with external systems freely. As part of the experimental work, a platform has been developed that allows individual subsystems and external customer systems to work together. The cyber-physical system, a new generation of digital systems, focuses mainly on the complex interplay and integration between cyberspace and the physical world. A cyber-physical system consists of highly integrated computational, communication, control and physical elements. The solution focuses mainly on the complex interplay and integration between cyberspace and the physical world.
Keywords	electrical capacitance tomography ; cyber-physical systems ; sensors ; electrical impedance tomography ; Environmental engineering ; TA170-171 ; Environmental sciences ; GE1-350
Language	English
Publishing date	2023-03-01T00:00:00Z
Publisher	Lublin University of Technology
Document type	Article ; Online
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Article ; Online: The Effectiveness of Healthcare System Resilience during the COVID-19 Pandemic: A Case Study.

Borzuchowska, Monika / Kilańska, Dorota / Kozłowski, Remigiusz / Iltchev, Petre / Czapla, Tomasz / Marczewska, Sylwia / Marczak, Michał

Medicina (Kaunas, Lithuania)

2023 Volume 59, Issue 5

Abstract: ... ...

Abstract	Introduction
MeSH term(s)	Humans ; COVID-19 ; Pandemics ; SARS-CoV-2 ; Delivery of Health Care ; Health Personnel
Language	English
Publishing date	2023-05-14
Publishing country	Switzerland
Document type	Case Reports
ZDB-ID	2188113-3
ISSN	1648-9144 ; 1010-660X
ISSN (online)	1648-9144
ISSN	1010-660X
DOI	10.3390/medicina59050946
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Article: Peripheral S100B Protein Levels in Five Major Psychiatric Disorders: A Systematic Review.

Kozlowski, Tomasz / Bargiel, Weronika / Grabarczyk, Maksymilian / Skibinska, Maria

Brain sciences

2023 Volume 13, Issue 9

Abstract: Five major psychiatric disorders: schizophrenia, major depressive disorder, bipolar disorder, autistic spectrum disorder, and attention-deficit/hyperactivity disorder, show a shared genetic background and probably share common pathobiological mechanisms. ...

Abstract	Five major psychiatric disorders: schizophrenia, major depressive disorder, bipolar disorder, autistic spectrum disorder, and attention-deficit/hyperactivity disorder, show a shared genetic background and probably share common pathobiological mechanisms. S100B is a calcium-binding protein widely studied in psychiatric disorders as a potential biomarker. Our systematic review aimed to compare studies on peripheral S100B levels in five major psychiatric disorders with shared genetic backgrounds to reveal whether S100B alterations are disease-specific. EMBASE, Web of Science, and PubMed databases were searched for relevant studies published until the end of July 2023. This study was performed according to the Preferred Reporting Items for Systematic Reviews and Meta-analysis Protocols (PRISMA) guidelines. Overall, 1215 publications were identified, of which 111 full-text articles were included in the systematic review. Study designs are very heterogeneous, performed mostly on small groups of participants at different stages of the disease (first-episode or chronic, drug-free or medicated, in the exacerbation of symptoms or in remission), and various clinical variables are analyzed. Published results are inconsistent; most reported elevated S100B levels across disorders included in the review. Alterations in S100B peripheral levels do not seem to be disease-specific.
Language	English
Publishing date	2023-09-16
Publishing country	Switzerland
Document type	Journal Article ; Review
ZDB-ID	2651993-8
ISSN	2076-3425
ISSN	2076-3425
DOI	10.3390/brainsci13091334
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Article ; Online: Clinical and Laboratory Predictors of Long-Term Outcomes after Catheter Ablation for a Ventricular Electrical Storm.

Sławiński, Grzegorz / Hawryszko, Maja / Dyda-Kristowska, Julia / Królak, Tomasz / Kempa, Maciej / Świetlik, Dariusz / Kozłowski, Dariusz / Daniłowicz-Szymanowicz, Ludmiła / Lewicka, Ewa

Journal of interventional cardiology

2024 Volume 2024, Page(s) 5524668

Abstract: Background: Ventricular electrical storm (VES) is characterized by the occurrence of multiple episodes of sustained ventricular arrhythmias (VA) over a short period of time. Radiofrequency ablation (RFA) has been reported as an effective treatment in ... ...

Abstract	Background: Ventricular electrical storm (VES) is characterized by the occurrence of multiple episodes of sustained ventricular arrhythmias (VA) over a short period of time. Radiofrequency ablation (RFA) has been reported as an effective treatment in patients with ventricular tachycardia (VT). Objective: The aim of the present study was to indicate the short-term and long-term predictors of recurrent VA after RFA was performed due to VES. Methods: A retrospective, single-centre study included patients, who had undergone RFA due to VT between 2012 and 2021. In terms of the short-term (at the end of RFA) effectiveness of RFA, the following scenarios were distinguished: complete success: inability to induce any VT; partial success: absence of clinical VT; failure: inducible clinical VT. In terms of the long-term (12 months) effectiveness of RFA, the following scenarios were distinguished: effective ablation: no recurrence of any VT; partially successful ablation: VT recurrence; ineffective ablation: VES recurrence. Results: The study included 62 patients. Complete short-term RFA success was obtained in 77.4% of patients. The estimated cumulative VT-free survival and VES-free survival were, respectively, 28% and 33% at the 12-month follow-up. Ischemic cardiomyopathy and complete short-term RFA success were predictors of long-term RFA efficacy. Neutrophil to lymphocyte ratio (NLR) and GFR <60 mL/min/1.73 m Conclusion: Ischemic cardiomyopathy and short-term complete success of RFA were predictors of no VES recurrence during the 12-month follow-up, while NLR and GFR <60 ml/min/1.73 m
MeSH term(s)	Humans ; Retrospective Studies ; Treatment Outcome ; Myocardial Ischemia ; Tachycardia, Ventricular/surgery ; Catheter Ablation/adverse effects ; Cardiomyopathies/etiology ; Cardiomyopathies/surgery ; Recurrence
Language	English
Publishing date	2024-02-05
Publishing country	United States
Document type	Journal Article
ZDB-ID	1036325-7
ISSN	1540-8183 ; 0896-4327
ISSN (online)	1540-8183
ISSN	0896-4327
DOI	10.1155/2024/5524668
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Article ; Online: Opioid prescribing attitudes of palliative care physicians versus other specialists: a questionnaire-based survey.

Dzierzanowski, Tomasz / Kozlowski, Michael

Postgraduate medical journal

2021 Volume 98, Issue 1156, Page(s) 119–123

Abstract: Purpose of the study: While opioid overuse is a public health crisis in the USA, opioid analgesics are used suboptimally in Central and Eastern Europe, causing many pain cases to remain untreated or undertreated.: Study design: This questionnaire ... ...

Abstract	Purpose of the study: While opioid overuse is a public health crisis in the USA, opioid analgesics are used suboptimally in Central and Eastern Europe, causing many pain cases to remain untreated or undertreated. Study design: This questionnaire study aimed to identify the prevalent prescribing patterns and attitudes and the possible internal impediments to optimal opioid use among palliative care physicians and other specialists in Poland. Results: Tramadol was the most commonly preferred opioid. While palliative care physicians (n=81) used various strong opioids, other physicians (n=87) prescribed mostly buprenorphine, accessible with standard prescription forms. Neither internal prejudices and beliefs nor administrative regulations impede prescribing opioids by palliative care physicians, unlike specialists other than palliative medicine. Special prescription forms for psychoactive medications, fear of drug addiction of their patients and penalties for possible errors on prescriptions affect the latter's optimal prescribing. They also revealed significant gaps in the knowledge of prescribing opioids and would take part in additional training. Palliative care physicians appeared optimally prepared for cancer pain management and report fewer internal barriers than other specialists. Conclusions: Continuous medical education on cancer pain treatment should be provided to all specialists to ensure optimal opioid pharmacotherapy and avoid overprescribing or underprescribing opioids. Administrative restrictions are the main barrier to optimal pain treatment.
MeSH term(s)	Adult ; Analgesics, Opioid/therapeutic use ; Attitude of Health Personnel ; Cancer Pain/drug therapy ; Drug Prescriptions ; Drug Utilization/statistics & numerical data ; Female ; Health Services Accessibility/statistics & numerical data ; Humans ; Male ; Middle Aged ; Palliative Care/methods ; Palliative Care/psychology ; Physicians/psychology ; Poland ; Practice Patterns, Physicians'/statistics & numerical data ; Quality of Health Care ; Surveys and Questionnaires
Chemical Substances	Analgesics, Opioid
Language	English
Publishing date	2021-01-07
Publishing country	England
Document type	Journal Article
ZDB-ID	80325-x
ISSN	1469-0756 ; 0032-5473
ISSN (online)	1469-0756
ISSN	0032-5473
DOI	10.1136/postgradmedj-2020-139152
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Article ; Online: Application of Machine Learning Algorithms to the Discretization Problem in Wearable Electrical Tomography Imaging for Bladder Tracking.

Baran, Bartłomiej / Kozłowski, Edward / Majerek, Dariusz / Rymarczyk, Tomasz / Soleimani, Manuchehr / Wójcik, Dariusz

Sensors (Basel, Switzerland)

2023 Volume 23, Issue 3

Abstract: The article presents the implementation of artificial intelligence algorithms for the problem of discretization in Electrical Impedance Tomography (EIT) adapted for urinary tract monitoring. The primary objective of discretization is to create a finite ... ...

Abstract	The article presents the implementation of artificial intelligence algorithms for the problem of discretization in Electrical Impedance Tomography (EIT) adapted for urinary tract monitoring. The primary objective of discretization is to create a finite element mesh (FEM) classifier that will separate the inclusion elements from the background. In general, the classifier is designed to detect the area of elements belonging to an inclusion revealing the shape of that object. We show the adaptation of supervised learning methods such as logistic regression, decision trees, linear and quadratic discriminant analysis to the problem of tracking the urinary bladder using EIT. Our study focuses on developing and comparing various algorithms for discretization, which perfectly supplement methods for an inverse problem. The innovation of the presented solutions lies in the originally adapted algorithms for EIT allowing for the tracking of the bladder. We claim that a robust measurement solution with sensors and statistical methods can track the placement and shape change of the bladder, leading to effective information about the studied object. This article also shows the developed device, its functions and working principle. The development of such a device and accompanying information technology came about in response to particularly strong market demand for modern technical solutions for urinary tract rehabilitation.
MeSH term(s)	Urinary Bladder/diagnostic imaging ; Urinary Bladder/physiology ; Artificial Intelligence ; Electric Impedance ; Finite Element Analysis ; Tomography/methods ; Algorithms ; Machine Learning ; Wearable Electronic Devices ; Image Processing, Computer-Assisted/methods
Language	English
Publishing date	2023-01-31
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2052857-7
ISSN	1424-8220 ; 1424-8220
ISSN (online)	1424-8220
ISSN	1424-8220
DOI	10.3390/s23031553
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Article ; Online: Implementation of Lean Management Tools Using an Example of Analysis of Prolonged Stays of Patients in a Multi-Specialist Hospital in Poland.

Zdęba-Mozoła, Agnieszka / Kozłowski, Remigiusz / Rybarczyk-Szwajkowska, Anna / Czapla, Tomasz / Marczak, Michał

International journal of environmental research and public health

2023 Volume 20, Issue 2

Abstract: Healthcare institutions in Poland constantly encounter challenges related both to the quality of provided services and to the pressures associated with treatment effectiveness and economic efficiency. The implemented solutions have a goal of improving ... ...

Abstract	Healthcare institutions in Poland constantly encounter challenges related both to the quality of provided services and to the pressures associated with treatment effectiveness and economic efficiency. The implemented solutions have a goal of improving the service quality of lowering the continuously increasing operational costs. The aim of this paper is to present the application of Lean Management (LM) tools in a Polish hospital, which allowed for the identification of prolonged stays as one of the main issues affecting the service costs and the deteriorating financial results of the hospital. The study was conducted in the neurology department and involved an analysis of data for the whole of 2019 and the first half of 2022. In addition, surveys were conducted among the medical staff to help identify the main causes of prolonged stays. Methods of data analysis and feasible solutions were developed in order to improve the economic efficiency of the unit. The analysis shows that the application of LM tools may contribute to improvement in the functioning of hospitals and that further studies should focus on the development of the method to evaluate efficiency of the implemented solutions intended at shortening the hospital stays of the patients.
MeSH term(s)	Humans ; Quality Improvement ; Poland ; Hospital Departments ; Efficiency ; Hospitals ; Efficiency, Organizational
Language	English
Publishing date	2023-01-07
Publishing country	Switzerland
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2175195-X
ISSN	1660-4601 ; 1661-7827
ISSN (online)	1660-4601
ISSN	1661-7827
DOI	10.3390/ijerph20021067
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Article ; Online: Fever-Range Hyperthermia Promotes Macrophage Polarization towards Regulatory Phenotype M2b.

Kozłowski, Henryk Mikołaj / Sobocińska, Justyna / Jędrzejewski, Tomasz / Maciejewski, Bartosz / Dzialuk, Artur / Wrotek, Sylwia

International journal of molecular sciences

2023 Volume 24, Issue 24

Abstract: Fever-range hyperthermia (FRH) is utilized in chronic disease treatment and serves as a model for fever's thermal component investigation. Macrophages, highly susceptible to heat, play a pivotal role in various functions determined by their polarization ... ...

Abstract	Fever-range hyperthermia (FRH) is utilized in chronic disease treatment and serves as a model for fever's thermal component investigation. Macrophages, highly susceptible to heat, play a pivotal role in various functions determined by their polarization state. However, it is not well recognized whether this process can be modulated by FRH. To address this, we used two different macrophage cell lines that were treated with FRH. Next, to define macrophage phenotype, we examined their functional surface markers CD80 and CD163, intracellular markers such as inducible nitric oxide synthase (iNOS), arginase-1 (Arg-1), and the expression of interleukin-10 (IL-10) and tumor necrosis factor α (TNF-α). Additionally, in FRH-treated cells, we analyzed an expression of Toll-like receptor 4 (TLR-4) and its role in macrophage polarization. We also checked whether FRH can switch the polarization of macrophages in pro-inflammatory condition triggered by lipopolysaccharide (LPS). FRH induced M2-like polarization, evident in increased CD163, IL-10, and Arg-1 expression. Notably, elevated COX-2, TNF-α, and TLR-4 indicated potential pro-inflammatory properties, suggesting polarization towards the M2b phenotype. Additionally, FRH shifted lipopolysaccharide (LPS)-induced M1 polarization to an M2-like phenotype, reducing antimicrobial molecules (ROS and NO). In summary, FRH emerged as a modulator favoring M2-like macrophage polarization, even under pro-inflammatory conditions, showcasing its potential therapeutic relevance.
MeSH term(s)	Humans ; Interleukin-10/metabolism ; Lipopolysaccharides/pharmacology ; Lipopolysaccharides/metabolism ; Toll-Like Receptor 4/metabolism ; Tumor Necrosis Factor-alpha/metabolism ; Macrophages/metabolism ; Phenotype ; Hyperthermia, Induced
Chemical Substances	Interleukin-10 (130068-27-8) ; Lipopolysaccharides ; Toll-Like Receptor 4 ; Tumor Necrosis Factor-alpha
Language	English
Publishing date	2023-12-17
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2019364-6
ISSN	1422-0067 ; 1422-0067 ; 1661-6596
ISSN (online)	1422-0067
ISSN	1422-0067 ; 1661-6596
DOI	10.3390/ijms242417574
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